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Patient State Index Detects Changes in Cereb.al b.ood Flow and May Predict New Ischemic Lesions during Carotid Stenting—Case Report

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Open Journal of Anesthesiology 2015年第1期5卷 20-22页

作者： ana b. fernández Department of Anesthesiology Intensive Care and Pain Treatment Nuestra Sra De Candelaria University Hospital Santa Cruz de Tenerife Canary Islands Spain

Carotid angioplasty and stenting (CAS) was developed to b. a less invasive and complex procedure compared to carotid endarterectomy (CEA). It has emerged as an alternative for patients who are considered to have high surgical risks due to medical comorb.dities or anatomical high-risk features [1]. The procedure is usually done under local anesthesia with light sedation, with the sub.equent expectation of less neurologic injury, venous thromb.emb.lisms, and myocardial infarctions—all well-known clinical risks of undergoing surgical procedures under general anesthesia. CAS, however, carries some increased risks of arterial dissection, dislocation of atherothromb.tic deb.is and emb.lization to the b.ain or eye, late emb.lization due to thromb.s formation on the damaged plaque, and b.adycardia and hypotension as a result of carotid sinus stimulation. Electroencephalography can detect cereb.al ischemia and hypoxia along with measuring hypnotic effects, b.t has not b.en reported to b. used during CAS to signal impending neurological deficit and allow for intervention to prevent stroke. We report on the use of patient state index (PSI), an electroencephalographic (EEG) derived variab.e used b. SEDLine monitor (Masimo Inc., San Diego, CA) to monitor changes in cereb.al b.ood flow during carotid angioplasty and stenting in an awake patient under local anesthesia. PSI was developed to measure the level of hypnosis and sedation during anesthesia and in the ICU. The PSI is b.sed on quantitative electroencephalogram features, recorded from anterior and posterior scalp sites, as input to a multivariate algorithm that quantifies the most prob.b.e level of anesthesia or sedation. The PSI is reported as a range from 0 to 100, with decreasing values indicating increasing levels of anesthesia or sedation. Adequate depth of anesthesia is reflected b. PSI value of 25 - 50, and a fully awake state b. a PSI of 100 [2]. Other EEG analysis techniques have b.en explored to detect changes in

关键词： Patient State Index (PSI) Carotid Angioplasty Cereb.al Ischemia EEG analysis

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Malignant Cereb.al Edema Secondary to Gliadel Wafers in the Early Postsurgical Period

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Open Journal of Anesthesiology 2015年第4期5卷 72-74页

作者： ana b. fernández Antonio Garcia Eglis Lazo Department of Anesthesiology Intensive Care and Pain Treatment Nuestra Sra de Cande-laria University Hospital Santa Cruz de Tenerife Spain Department of Neurosurgery Nuestra Sra de Candelaria University Hospital Santa Cruz de Tenerife Spain

High grade gliomas are the commonest intrinsic b.ain tumours and account for more average years of life lost than all the common cancers. It has b.come the commonest cause of cancer death in men under the age of 45 and women under the age of 35. Although surgical resection can greatly reduce tumour b.lk, complete excision is virtually impossib.e due to the infiltrative nature of these tumours. In an attempt to treat the infiltrating tumour cells, there has b.en much interest in using local therapies inserted at the time of surgery. The authors report a case of fatal cereb.al edema unresponsive to aggressive medical and surgical assessment that finally evolved to premature death in the early postsurgical period, after the craniotomy and implantation of Gliadel wafers. They note that high doses of dexamethasone were insufficient to prevent cereb.al edema and death. A search for corticosteroid use and dosing for patients treated with Gliadel wafers in the pub.ished literature revealed no recommendations on the doses of steroids to b. administered. In our opinion this is a very important issue and mayb. the key point for the treatment of this disease, and may need to b. addressed with treatment guidelines in the near future in order to ensure b.tter results on patient’s survival. Prior to this case review there had b.en two similar report b.t a later presentation. So we think that this is the first case report of acute fulminant cereb.al edema secondary to gliadel wafers in the early period.

关键词： Malignant Glioma Carmustine Wafer Cereb.al Edema Cytotoxic Effect

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Protein kinase clk/STY is differentially regulated during erythroleukemia cell differentiation: a b.as toward the skipped splice variant characterizes postcommitment stages

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Cell Research 2005年第7期15卷 495-503页

作者： ana GARCíA-SACRISTáN■,María J. fernández-NESTOSA,Pab.o HERNández,Jorge b.SCHVARTZMAN,Dora b. KRIMER Department of Cell and Developmental b.ology Centro de Investigaciones b.ológicas Consejo Superior de InvestigacionesCientíficas Ramiro de Maeztu 9 Madrid 28040 Spain Instiute of Molecular Medicine 1649-028 Lisb.n Medical School Lisb.n Portugal Department of Cell and Developmental b.ology Centro de Investigaciones b.ológicas Consejo Superior de InvestigacionesCientíficas Ramiro de Maeztu 9 Madrid 28040 Spain Department of Cell and Developmental b.ology Centro de Investigaciones b.ológicas Consejo Superior de InvestigacionesCientíficas Ramiro de Maeztu 9 Madrid 28040 Spain Department of Cell and Developmental b.ology Centro de Investigaciones b.ológicas Consejo Superior de InvestigacionesCientíficas Ramiro de Maeztu 9 Madrid 28040 Spain Department of Cell and Developmental b.ology Centro de Investigaciones b.ológicas Consejo Superior de InvestigacionesCientíficas Ramiro de Maeztu 9 Madrid 28040 Spain

Clk/STY is a LAMMER protein kinase capab.e to phosphorylate serine/arginine-rich (SR) proteins that modulate pre-mRNA splicing. Clk/STY alternative splicing generates transcripts encoding a full-length kinase and a truncated catalyti-cally inactive protein. Here we showed that clk/STY, as well as other memb.rs of the family (e.g. clk2, clk3 and clk4),are up-regulated during HMb.-induced erythroleukemia cell differentiation. mRNAs coding for the full-length and thetruncated forms were responsib.e for the overall increased expression. In clk/STY, however, a switch was ob.erved forthe ratio of the two alternative spliced products. In undifferentiated cells the full-length transcript was more ab.ndantwhereas the transcript encoding for the truncated form predominated at latter stages of differentiation. Surprisingly,overexpression of clk/STY did not alter the splicing switch upon differentiation in MEL cells. These results suggest thatclk/STY might contrib.te to control erythroid differentiation b. a mechanism that implicates a b.lance b.tween thesetwo isoforms.

关键词： clk/STY LAMMER kinase alternative splicing erythroleukemia cells.

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Impacts of PI3K/protein kinase b.pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María fernanda González ana María Avalos Lisette Leyton Cellular Communication Lab.ratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias b.omédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most ab.ndant type of glial cell in the central nervous *** injury and inflammation,astrocytes b.come reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contrib.te to b.th neurotoxic and neuroprotective responses,***,this b.nary classification does not fully capture the diversity of astrocyte responses ob.erved across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation b. interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase b.AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte b.havior,as evidenced b. in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κb.serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield b.neficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and b.ain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

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Neural Regeneration Research 2022年第3期17卷 625-631页

作者： Lorena Perdices Lorena Fuentes-b.oto Francisco Segura ana Cavero Elvira Orduna-Hospital Gema Insa-Sánchez ana Isab.l Sánchez-Cano Laura fernández-Sánchez Nicolás Cuenca Isab.l Pinilla Aragón Institute for Health Research(IIS Aragón) ZaragozaSpain Pharmacology Physiology&Legal and Forensic MedicineUniversity of ZaragozaZaragozaSpain Department of Applied Physics University of ZaragozaZaragozaSpain Health Sciences Faculty San Jorge UniversityVillanueva de GállegoSpain Department of Ophthalmology Miguel Servet University HospitalZaragozaSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain Department of Surgery Gynecology and ObstetricsUniversity of ZaragozaZaragozaSpain/Department of OphthalmologyLozano Blesa University HospitalZaragozaSpain

Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor *** has b.en reported to b. related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),the most ab.ndant catechin-b.sed flavonoid in green tea leaves,has significant antioxidant,anti-carcinogenic,antimicrob.al,and neuroprotective ***,given its low molecular weight and hydrophilic properties,can cross the b.ood-retinal b.rrier and is ab.e to reach different ocular tissues such as the lens,cornea,and *** has b.en shown to provide retinal protection against ischemia;sodium nitroprusside-,N-methyl-D-aspartate-,lipopolysaccharide-,light-,sodium iodate-,or H2 O2-induced damage and diab.tic *** suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as *** aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23 H line 1,the model of *** P23 H rats were crossed with pigmented Long Evans rats to produce offspring exhib.ting the clinical features of *** P23 H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans *** treated with EGCG showed b.tter visual and retinal electrical function with increased contrast sensitivity and b.wave values compared with those ob.erved in P23 H rats treated with *** reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase *** differences were ob.erved in visual acuity,nitrate levels,nitrite levels or glutathione S-transferase *** conclusion,EGCG not only reduced the loss of visual function in P23 H rats b.t also improved the levels of antioxidant enzymes and reduced oxidative *** study was approved b. the Institutional Animal Care and Use Committee(CE

关键词： antioxidants contrast sensitivity electroretinogram green tea neurodegeneration oxidative stress retinal degeneration retinitis pigmentosa systemic visual acuity

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Ni/Al Intermetallics Plasma Transferred Arc Processing

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材料热处理学报 2004年第05B期25卷 948-951页

作者： Veronica A. b. Almeida ana Sofia C. M. D'Oliveira Master student - PIPE Federal University of Parana Curitiba/BrazilMechanical Engineering Department Federal University of Parana Curitiba/Brazil

In-situ alloy development during surface processing allows for a limitless materials selection to protect components exposed to severe service conditions. In fact surface alloying offers the possib.lity to strengthen surface components with alloys that would not b. possib.e to process otherwise. This work used Plasma transferred arc (PTA) hardfacing for surface alloying. Different amounts of aluminium powder, 5-25%, were added to a Ni b.sed superalloy, from Hastealloy C family, in the atomized form. The mixture was homogeneized in a b.ll mill and PTA deposited on carb.n steel sub.trate. The influence of different processing parameters on the final surface alloy was evaluated as current intensity and depositing velocity were varied. Coatings were characterized b. optical and scanning electronic microscopy, X-ray diffraction and Vickers microhardness profiles, under a 500g load. Results showed that PTA hardfacing is an adequate surface alloying. For the conditions tested increasing hardness was ob.ained b. solid solution for the lower amounts of Al added and due to the new intermetallic phases for the richer Al mixture.

关键词： PTA合金等离子转移电弧 Ni/Al金属互化物表面处理

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Synthesis of activated carb.ns from b.ack sapote seeds,characterization and application in the elimination of heavy metals and textile dyes

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Chinese Journal of Chemical Engineering 2020年第2期28卷 613-623页

作者： Alejandra Alicia Peláez-Cid Vincent Romero-Hernández ana María Herrera-González Alejandro b.utista-Hernández Oscar Coreno-Alonso Facultad de Ingeniería Benemérita Universidad Autónoma de PueblaMexico Instituto de Ciencias b.sicas e Ingeniería Universidad Autónoma del Estado de HidalgoMexico División de Ingenierías Universidad de GuanajuatoMexico

Many different techniques may b. used to remove industrial pollutants from wastewater. Adsorption using activated carb.n has b.en reported to b. an effective method. This work proposes the use of a vegetab.e residue(b.ack sapote seeds) as a raw material for its synthesis. These carb.ns were chemically activated using phosphoric acid and carb.nized at 673 and 873 K. Adsorption isotherms were constructed for the textile dyes on the carb.ns, and this data was treated using Langmuir’s equation to quantitatively describ. the adsorption process. The synthesized carb.ns were characterized using FTIR, EA, SEM, Nitrogen adsorption(specific surface areas of 879 and 652 m2·g-1), and their points of zero charge(2.1 and 2.3). It was possib.e to adsorb.b.th heavy metals and textile dyes present in aqueous solutions and wastewaters using these activated carb.ns. Heavy metals were adsorb.d almost completely b. b.th carb.ns. Cationic dyes where adsorb.d(58–59.8 mg·g-1) in greater amounts compared to anionic dyes(10–58.8 mg·g-1). The amount of anionic dyes adsorb.d increased almost 30% b. changing the pH of the solutions. One of the carb.ns was thermally regenerated on three occasions without losing its adsorption capacity and it was proved in a flow system.

关键词： Activated carb.ns b.ack sapote seeds Heavy metal adsorption Textile dye adsorption Wastewater treatment

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Unveiling the controversial mechanism of reversib.e Na storage in TiO2 nanotub. arrays： Amorphous versus anatase TiO2

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Nano Research 2017年第8期10卷 2891-2903页

作者： Federico b.lla ana b. Munoz-Garcia Giuseppina Meligrana Andrea Lamb.rti Matteo Destro Michele Pavone Claudio Gerb.ldi GAME Lab CHENERGY Group Department of Applied Science and Technology - DISAT Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy Department of Chemical Sciences University of Naples Fedefico II Via Cintia 21 University Campus of Monte Sant'Angelo 80126 Napoli Italy MPMNT Group Department of Applied Science and Technology - DISAT Politecnico di Torino Corso Duca degli Abruzzi 24 10129 Torino Italy LITHOPS S.r.l. Strada del Portone 61 10137 Torino Italy

Due to their inherent safety, low cost, and structural stab.lity, TiO2 nanostructures represent a suitab.e choice as anode materials in sodiumion b.tteries. In the recent years, various hypotheses have b.en proposed regarding the actual mechanism of the reversib.e insertion of sodium ions in the TiO2 structure, and previous reports are often controversial in this respect. Interestingly, when tested as b.nder- and conducting additive-free electrodes in lab.ratory-scale sodium cells, amorphous and crystalline （anatase） TiO2 nanotub.lar arrays ob.ained b. simple anodic oxidation exhib.t peculiar and intrinsically different electrochemical responses. In particular, after the initial electrochemical activation, anatase TiO2 shows excellent rate capab.lity and very stab.e long-term cycling performance with larger specific capacities, and thus a clearly superior response compared with the amorphous counterpart. To ob.ain deeper insight, the present materials are thoroughly characterized b. scanning electron microscopy and ex situ X-ray diffraction, and the insertion of sodium ions in the TiO2 b.lk phases is systematically modeled b. density functional theory calculations. The present results may contrib.te to the development of more systematic screening approaches to identify suitab.e active materials for highly efficient sodium-b.sed energy storage systems.

关键词： sodium b.ttery TiO2 nanotub. array anode modeling insertion mechanism

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b.ndab.e tub.-shaped supercapacitor b.sed on reduced graphene oxide and Prussian b.ue coated carb.n fib.r yarns for energy storage

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Journal of Energy Chemistry 2018年第3期27卷 866-873页

作者： Mohd.Khalid ana M.b.Honorato Department of Macromolecular Science and Engineering Case Western Reserve University

Carb.n fib.r yarns（CFY） are promising as a new type of flexib.e b.ilding b.ocks for the construction of flexib.e architectures for the energy storage applications. The main hurdle with CFY is how to make them high energy and power capab.e b. using economically and environmentally viab.e materials. Here,we report reduced graphene oxide（r GO） and Prussian b.ue（Pb. coated CFY, derived from a facile electrochemical process at room temperature for supercapacitor electrodes. The Pb.coated CFY and r GO coated CFY electrodes exhib.t the excellent gravimetric capacitance of 339 F/g and 160.2 F/g, respectively, in aqueous KCl electrolyte in three-electrode cell configuration. When we coupled these electrodes inside the flexib.e plastic tub. and separated b. the electrolyte wet filter paper in order to construct flexib.e architecture, the resulting device delivers excellent specific energy of 52.1 Wh/kg and 26.5 Wh/kg with offering specific power of 3100 W/kg and 14400 W/kg respectively, under a wide operating potential of1.8 V with excellent rate capab.lity. The device shows high tolerance towards b.nding, and retained its efficiency to the capacitance after b.ing b.nt at an angle of 360° for 200 b.nding cycles.

关键词： Carb.n fib.r yarns b.ndab.e supercapacitor Energy density Power density

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Cyclophilins A and b.oppositely regulate renal tub.lar epithelial cell phenotype

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Journal of Molecular Cell b.ology 2020年第7期12卷 499-514页

作者： Eduard Sarró Mónica Durán ana Rico Diana b.u-Teen Vanesa fernández-Majada Anthony J.Croatt Karl A.Nath Maria Teresa Salcedo Justin H.Gundelach Daniel b.tlle Richard J.b.am Anna Meseguer Renal Physiopathology Group CIBBIM-NanomedicineVall d’Hebron Research Institute08035 BarcelonaSpain Cardiovascular Diseases Group Vall d’Hebron Research Institute08035 BarcelonaSpain b.omimetic Systems for Cell Engineering Lab.ratory Institute for Bioengineering of Catalonia(IBEC)The Barcelona Institute of Science and Technology(BIST)08028 BarcelonaSpain Division of Nephrology and Hypertension and Department of Medicine Mayo ClinicRochesterMN 55905USA Department of Pathology Hospital Universitari Vall d’Hebron08035 BarcelonaSpain Department of Pediatric and Adolescent Medicine College of MedicineMayo ClinicRochesterMN 55905USA Department of b.ochemistry and Molecular b.ology College of MedicineMayo ClinicRochesterMN 55905USA Division of Nephrology and Hypertension Northwestern University Feinberg School of MedicineChicagoIL 60611USA Department of Immunology College of MedicineMayo ClinicRochesterMN 55905USA Departament de b.oquímica i b.ologia Molecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de Barcelona08193 BellaterraSpain Red de Investigación Renal(REDINREN) Instituto de Salud Carlos III-FEDER28040 MadridSpain

Restoration of kidney tub.lar epithelium following sub.ethal injury sequentially involves partial epithelial–mesenchymal transition(pEMT),proliferation,and further redifferentiation into specialized tub.le epithelial cells(TECs).b.cause the immunosuppressant cyclosporine-A produces pEMT in TECs and inhib.ts the peptidyl-prolyl isomerase(PPIase)activity of cyclophilin(Cyp)proteins,we hypothesized that cyclophilins could regulate TEC *** we demonstrate that in cultured TECs,CypA silencing triggers loss of epithelial features and enhances transforming growth factorβ(TGFβ)-induced EMT in association with upregulation of epithelial repressors Slug and *** pro-epithelial action of CypA relies on its PPIase *** contrast,Cypb.emerges as an epithelial repressor,b.cause Cypb.silencing promotes epithelial differentiation,prevents TGFβ-induced EMT,and induces tub.lar structures in 3D *** addition,in the kidneys of Cypb.knockout mice sub.ected to unilateral ureteral ob.truction,inflammatory and pro-fib.otic events were *** silencing/knockout leads to Slug,b.t not Snail,*** support of Slug expression depends on its endoplasmic reticulum location,where it interacts with calreticulin,a calcium-b.ffering chaperone related to Slug *** Cypb.silencing reduces ionomycin-induced calcium release and Slug upregulation,we suggest that Slug expression may rely on Cypb.modulation of calreticulin-dependent calcium *** conclusion,this work uncovers new roles for CypA and Cypb.in modulating TEC plasticity and identifies Cypb.as a druggab.e target potentially relevant in promoting kidney repair.

关键词： cyclophilins epithelial phenotype Slug TGFβ UUO fib.osis

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