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Targeting the premetastatic niche:epigenetic therapies in the spotlight

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1871-1872页

作者： Vivien Low John Blenis ana P.gomes Meyer Cancer Center Weill Cornell MedicineNew YorkNYUSA Department of Pharmacology Weill Cornell MedicineNew YorkNYUSA

The treatment of metastatic cancers remains a challenge in the clinic,with recurrences persisting at high rates even after surgical resection of primary *** the perseverance of circulating tumor cells after resection,this phenomenon is abetted by the formation of the premetastatic niche(PMN),a distant environment ripe for the colonization of new metastases,which is conditioned by factors and extracellular vesicles secreted by the primary *** their recent paper,Lu et *** how such PMNs in the lung can be disrupted by low-dose adjuvant epigenetic therapy,and propose a novel therapeutic avenue to supplement tumor resection.

关键词： metastatic epigenetic al

XEN^(■) implant and trabeculectomy medium-term quality of life assessment and comparison of results

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1941-1944页

作者： ana Luisa Basilio Nuno Moura-Coelho Ines Passos Mariana Sa Cardoso Isabel Domingues Maria Reina rita Flores Teresa gomes Ophthalmology Department Central Lisbon Hospital Center Lisbon 1169050Portugal

AIM: To evaluate and compare the quality of life of patients submitted to XEN~? implant or trabeculectomy and the relationship with potentially involved ***: A cross-sectional study of patients with advanced open-angle glaucoma who underwent implantation of XEN~?(group 1) and trabeculectomy(group 2) between October 2015 and February 2017. The studied variables were: age, gender, follow-up time, need of topical anti-hypertensive therapy, visual acuity and intraocular pressure(IOP). The quantification of the quality of life was attained through the Glaucoma Symptom Scale(GSS) questionnaire. RESULTS: Totally 34 eyes(34 patients) were included, 17 in each group. The mean GSS scores for group 1 were 42.6±6.8(median, 47; p25, 36.5; p75, 48.5) and for group 2 it was 41.6±7.0(median, 43; p25, 36.5; p75, 47.0; P=0.34). There was a strong negative correlation between the need for topical anti-hypertensive drugs and the GSS result in both groups(r=-0.88, Panalysis demonstrates the noninferiority of medium-term quality of life of one group in relation to the other(XEN~? implant and trabeculectomy). The number of topical anti-hypertensive drugs and IOP negatively influenced the quality of life.

关键词： quality of life XEN^(■) trabeculectomy

Influence of train speed and its mitigation measures in the short-and long-term performance of a ballastless transition zone

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铁道工程科学:英文版 2023年第4期31卷 309-324页

作者： ana Ramos Rui Calçada António gomes Correia Department of Civil Engineering Faculty of EngineeringUniversity of PortoCONSTRUCT-LESEPortoPortugal Department of Civil Engineering University of MinhoISISEGuimarãesPortugal

The ballastless track is nowadays the most popular railway system due to the required low number of maintenance opera-tions and costs,despite the high *** gradual change from ballasted to ballastless tracks has been occurring in Asia,but also in Europe,increasing the number of transition *** transition zones are a special area of the railway networks where there is an accelerated process of track degradation,which is a major concern of the railway infrastructure ***,the accurate prediction of the short-and long-term performance of ballastless tracks in transition zones is an important topic in the current paradigm of building/rehabilitating high-speed *** work purposes the development of an advanced 3D model to study the global performance of a ballastless track in an embankment-tunnel transition zone considering the influence of the train speed(220,360,500,and 600 km/h).Moreover,a mitigation measure is also adopted to reduce the stress and displacements levels of the track in the transition.A resilient mat placed in the tunnel and embank-ment aims to soften the *** behaviour of the track with the resilient mat is evaluated considering the influence of the train speed,with special attention regarding the critical *** used methodology is a novel and hybrid approach that allows including short-term and long-term performance,through the development of a powerful 3D model combined with the implementation of a calibrated empirical permanent deformation model.

关键词： Ballastless track Train speed Numerical modelling Transition zone Critical speed

Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance

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Chinese Journal of Cancer 2013年第7期32卷 365-370页

作者： ana R.gomes Fung Zhao Eric W.F.Lam Department of Surgery and Cancer Imperial College LondonHammersmith Hospital Campus

The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation,progression,and drug *** research shows that FOXM1 is a direct transcriptional target of FOXO3a,a vital downstream effector of the PI3K-AKT-FOXO signaling *** addition,FOXM1 and FOXO3a also antagonize each other's activity by competitively binding to the same target genes,which are involved in chemotherapeutic drug sensitivity and *** the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients,and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.

关键词：转录因子耐药性叉头致癌性化疗药物生物标志物竞争力敏感性

analysis of genetic relationship among Arbutus unedo L. genotypes using RAPD and SSR markers

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Journal of Forestry Research 2013年第2期24卷 227-236页

作者： Filomena gomes rita Costa Maria M. Ribeiro Elisa Figueiredo Jorge M. Canhoto CERNAS Departamento Florestal Escola Superior Agrária Coimbra INRB Instituto Nacional de Recursos Biológicos Departamento de Recursos Naturais e Desenvolvimento Sustentável Escola Superior Agrária Centre of Functional Ecology Department of Life Sciences University of Coimbra

The strawberry tree （Arbutus unedo L.） is an underutilized, drought tolerant, fire resistant species with a south western distribution in Europe, and with ecological and putative socio-economical impact in Portugal and Mediterranean countries. Our aim was to develop an appropriate set of molecular markers to enable genetic diversity to be assessed and to fingerprint Arbutus unedo genotypes for breeding and conservation purposes in Portugal. Twenty-seven trees from a broad geographic range were screened with 20 random amplified polymorphic DNA （RAPD primers） and 11 microsatellite markers （SSR）. The RAPDs generated 124 bands, 57.3% of which were polymorphic, with an expected heterozygosity of 27%. We cross-amplified 11 SSR primers developed for Vaccinium spp., and 5 were found to be polymorphic in A. unedo, with 75% of expected heterozygosity, a number of alleles of 11.6, a null allele frequency of 7.6% and a polymorphic information content of 71%. Although the SSRs were more polymorphic and informative than the RAPDs, both markers displayed high genetic variability with the gathered data. No geographic pattern was observed in the genetic variation distribution based on both marker systems, and the lack of correlation between genetic and geographical matrices was confirmed by Mantel tests. Likely, no correlation was found between pairwise SSR and RAPD band-sharing matrices. These results and their implications on A. unedo breeding and conservation programs are discussed.

关键词： Ericaceae fingerprinting geographic pattern molecular markers strawberry tree.

Antioxidant Migration Studies in Chitosan Films Incorporated with Plant Extracts

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Journal of Renewable Materials 2018年第5期6卷 548-558页

作者： Victor gomes Lauriano Souza Patricia Freitas Rodrigues Maria Paula Duarte ana Luisa Fernando MEtRiCS Departamento de Ciências e Tecnologia da BiomassaFaculdade de Ciências e Tecnologia(FCT)Universidade NOVA de LisboaCampus da Caparica2829-516 CaparicaPortugal CENIMAT/I3N Departamento de Ciências dos MateriaisFaculdade de Ciências e Tecnologia(FCT)Universidade NOVA de LisboaCampus da Caparica2829-516 CaparicaPortugal

The aim of this work was to develop an active biopolymer based on chitosan by incorporating natural *** essential oils(ginger,rosemary,sage,tea tree and thyme)and six hydro-alcoholic extracts(from ginger,green and black tea,kenaf leaves,rosemary and sage plants)were *** assays were carried out to evaluate the films’activity,and total phenolic content and antioxidant activity were monitored in the simulant during *** between natural compounds and polymeric matrix was evaluated by FTIR *** diffusion of the phenolic compounds was not detected in the films incorporated with hydro-alcoholic extracts(HAEs),indicating their entrapment in the *** was observed in the films with essential oils(EOs),and biobased films incorporated with ginger,sage or rosemary essential oils,presented the highest diffusion and antioxidant activity in the simulant,highlighting their functionality and potential to be used as food active packaging material.

关键词： Active packaging antioxidant activity biopolymers chitosan phenolic content

加夫列尔·加西亚·马尔克斯图书馆,巴塞罗那,西班牙

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世界建筑 2024年第5期 76-81页

作者：无 Elena Orte Guillermo Sevillano Marta Romero Jesús Lopez Luis Sierra ana Patricia Minguito Pablo Corroto María Abellán Sara Contreras ritaÁlvarez Tabio MiguelÁngel Maure Jesús Granada(摄影) SUMA建筑设计事务所不详

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计... 详细信息

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计成一座雕塑式实体建筑,让人联想到堆叠的书籍及其折叠的书页。该馆坐落在一处高架广场上,方便周围行人来往。同时,它又在空地上悬挑而出,门廊由现有的树木环绕,形成了一座城市大厅。不同大小及结构的开口定义了其不同立面与周围环境的关系。

关键词：巴塞罗那普罗旺斯周围环境加布里埃尔加西亚·马尔克斯图书馆关联式西班牙

Risk assessment of CO_2 injection processes and storage in carboniferous formations:a review

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Journal of Rock Mechanics and Geotechnical Engineering 2011年第1期3卷 39-56页

作者： Sousa Luis Sousa rita gomes ana Vargas Jr.Eurípedes State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology University of Porto Massachusetts Institute of Technology Catholic University of Rio de Janeiro

Over the last decades,people from almost all over the world have realized that it is necessary to quickly develop strategies for the control and reduction of greenhouse gases (GHG) *** various GHGs,carbon dioxide (CO2) is the most abundant *** underground storage involves less risk and lower levels of *** paper briefly describes the most effective technologies available in the market for background processes to storage (capture and transport) CO2,as well as the more secure solutions for its storage,in particular for the geological storage in carboniferous *** paper also outlines the methodologies for the risk assessment involved in storage of CO2,with a particular focus on cases where the injection is made into unminable coal seams and in abandoned *** used for risk analysis are described in detail with particular emphasis on Bayesian network (BN).Some applications regarding the risk assessment of CO2 injection processes and CO2 storage in carboniferous formations and contamination of aquifers are presented and ***,based on the applications of BN,several conclusions are drawn.

关键词： risk assessment underground storage of CO2 coalmines monitoring

Kriging Geostatistical Methods for Travel Mode Choice: A Spatial Data analysis to Travel Demand Forecasting

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Open Journal of Statistics 2016年第3期6卷 514-527页

作者： Viviani Antunes gomes Cira Souza Pitombo Samille Santos Rocha ana rita Salgueiro Department of Transportation Engineering University of S&atilde o Paulo S&atilde o Carlos Brazil Department of Geology Federal University of Ceará Fortaleza Brazil

This paper aims to compare the results of two techniques of Kriging (Ordinary Kriging and Indicator Kriging) that are applied to estimate the Private Motorized (PM) travel mode use (car or motorcycle) in several geographical coordinates of non-sampled values of the concerning variable. The data used was from the Origin/Destination and Public Transportation Opinion Survey, carried out in 2007/2008 at S?o Carlos (SP, Brazil). The techniques were applied in the region with 110 sample points (households). Initially, Decision Tree was applied to estimate the probability of mode choice in surveyed households, thus determining the numeric variable to be used in Ordinary Kriging. For application of Indicator Kriging it was used the variable “main travel mode” in a discrete manner, where “1” represented the use of PM travel mode and “0” characterized others travel modes. The results obtained by the two spatial estimation techniques were similar (Kriging maps and cross-validation procedure). However, the Indicator Kriging (KI) obtained the highest number of hit rates. In addition, with the KI it was possible to use the variable in its original form, avoiding error propagation. Finally, it was concluded that spatial statistics was thriving in travel demand forecasting issues, giving rise, for the both Kriging methods, to a travel mode choice surface on a confirmatory way.

关键词： Geostatistics Kriging Travel Mode Choice Spatial Estimation