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Aquatic physical therapy for Parkinson’s disease

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Advances in Parkinson's Disease 2013年第4期2卷 102-107页

作者： Talita Gianello Gnoato Zotz Eliani Arruda Souza Vera Lúcia Israel ana paula Cunha Loureiro Department of Physical Therapy School of Health and Biosciences Pontifical Catholic University of Paraná Curitiba Brazil Physical Therapy Clinic Curitiba Brazil Physical Therapy Department Federal University of Paraná Curitiba Brazil Physical Therapy Department Federal University of Paraná Matinhos Brazil

One of the predominant effects of PD is alteration of motor skills, which leads to compromised posture and physical balance. Aquatic physical therapy, performed in a heated pool, can serve as one of intervention alternatives for PD carriers. Aim: To analyze the effects of the Halliwick Concept hydrotherapy in acquisition of motor skills in Parkinson’s disease (PD) patients. Methods: A clinical, qualitative method was used to evaluate 7 volunteers (59.85 ± 7.92 years of age, both male and female), who were in II and III stages of PD according to the Hoehn & Yar Scale. The participants were evaluated in the start and end of the interventions phase, and then the evaluation was conducted interventions in a heated pool (32?C - 34?C) twice a week, each session lasting approximately 30 minutes, totaling 10 sessions. The Halliwick Principles’ 3-phase 10-point methods were used for acquisition of aquatic motor skills. Results: They indicate an improvement in their ability to float in prone and supine positions (P = 0.04*) and longitudinal rotation in the bipedal position. Conclusion: The activation of motor control improved the motor skills of the participants.

关键词： Parkinson’s Disease Motor Skills Hydrotherapy Halliwick Concept

Accountant and Accounting beyond Jokes:an analysis of Cartoons(1925-2003)

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Journal of Business Administration Research 2020年第1期3卷 19-31页

作者： ana paula Paulino da Costa Elionor Weffort Joanília Neide de Sales Cia JosilmarCordenonssi Cia Economic Research Foundation Institute Brazil FECAP Brazil University of Sao Paulo Brazil Universidade Presbiteriana Mackenzie Brazil

The main purpose of our paper is to identify and analyse the underlying stereotype attributes concerning accountant,accounting and users through *** so,we aim to capture insights of how this spectrum of society perceives actors involved on accounting *** study also differs from others as our period of analysis is long,79 years,from 1925 to *** we have the advantage of a long period and a popular non-professional database,we can work with multiple actors as accountant,accounting and users,instead of focusing on single *** the richness of database also allowed splitting these main actors in 7 *** order to capture stereotype nuances of multiple actors from a cartoon database,we use discourse analysis method that has been used on other studies of identity but not to study accounting *** cartoons are composed by images and texts to give a message,it is richer to analyze discourse beyond images and *** results are mainly consistent with previous studies although we found some different results when considering different periods of time as well new findings about tax actors such as taxpayers,tax agent and tax accounting.

关键词： Accountant Accounting Stereotypes Cartoons Popularculture

Cell therapy stimulates bone neoformation in calvaria defects in rats subjected to local irradiation

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Animal Models and Experimental Medicine 2019年第3期2卷 169-177页

作者： ana Luisa Riul Sorio paula Katherine Vargas‐Sanchez Roger Rodrigo Fernandes Dimitrius Leonardo Pitol Luiz Gustavo de Sousa Adriano Luiz Balthazar Bianchini Geraldo Batista de Melo Selma Siessere Karina Fittipaldi Bombonato‐Prado Department of Basic and Oral Biology School of Dentistry of Ribeirao PretoUniversity of Sao PauloRibeirao PretoSPBrazil Department of Radiotherapy Triangulo Mineiro Federal UniversityUberabaMinas GeraisBrazil Biomedical Sciences Institute Federal University of UberlandiaUberlandiaMinas GeraisBrazil

Background:The purpose of the study was to analyze the effect of cell therapy on the repair process in calvaria defects in rats subjected to ***:Bone marrow mesenchymal cells were characterized for osteoblastic *** of male Wistar rats were irradiated(20 Gy)and,after 4 weeks,osteoblastic cells were placed in surgically created defects in irradiated(IRC)and control animals(CC),paired with untreated irradiated(IR)and control(C)*** 30 days,histological and microtomographic evaluation was performed to establish significant(P<0.05)differences among the ***:Higher alkaline phosphatase detection and activity,along with an increase in mineralized nodules,in the IRC,C and CC groups compared to the IR group,confirmed an osteoblastic *** showed impaired bone neoformation following irradiation,affecting bone marrow *** therapy in the IRC group improved bone neoformation compared to the IR *** revealed increased bone volume,bone surface and trabecular number in IRC group compared to the IR ***:Cell therapy may improve bone neoformation in defects created after irradiation.

关键词： calvaria cell therapy irradiation osteoblasts rats

Cardiac mass in a patient with colorectal cancer:“Not all that glitters is gold!”

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World Journal of Cardiology 2011年第3期3卷 98-100页

作者： Rui Providência ana Botelho paula Mota Rui Catarino António Leito-Marques Department of Cardiology Coimbra's Hospital Center Department of Radiology Coimbra's Hospital Center

When performing echocardiography in a 74-year-old woman admitted with non ST elevation myocardial infarction and concomitant colorectal cancer(CC),a dense calcification of the mitral annulus was detected. Differential diagnosis between secondary metastasis and other etiologies of cardiac masses was essential for staging and therapeutic *** imaging with echocardiography alongside a computed tomography scan and cardiac magnetic resonance was crucial for the final diagnosis of caseous calcification of the mitral annulus(CCMA).CCMA is briefly reviewed and some possible explanations for the previously undescribed association of CC with CCMA are suggested.

关键词： Pathologic calcification Mitral valve Colorectal cancer Cardiac metastasis

The New Rigid Element for Laminated Cylindrical Shell

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Journal of Mechanics Engineering and Automation 2014年第11期4卷 900-904页

作者： Oscar Bayardo Ramos Lovón ana paula Ferreira Ramos Selma Hissae Shimura da Nobrega Department of Science and Technology UFERSA (University Federal Rural of Semi-Arido) Carafibas 59780-000 Brazil Department of Civil Engineering UFRN (University Federal of Rio Grande do Norte) Natal 59072-970 Brazil

Thermal effects are incorporated into developed discrete layer mechanics for two-dimensional cylindrical shells structures. Finite element equations are developed according to layerwise theory of laminated structure. Following the layerwise theory, a variable kinematic model that incorporates mechanics and thermal conditions is also presented. The new element has a field of displacement compatible with the cylindrical shell element or plate and it can be used as a rigid element for this structural *** the laminate model construction, adjacent layers are arranged as bonded layers. The layer has a unique constant thickness that can be different to each layer. The fiber reinforced is used and the fibers in a laminate may be oriented arbitrarily. The shear stress is adopted equal to zero because the thin thickness, on the other hand, the normal stress is maintained in order to ensure the compatibility of stress in material. The previously authors of this methods neglect the implications of thermal effects on cylindrical shells structures. Thermal effects become important when the structure has to operate in either extremely hot or cold temperature environments. These extreme conditions may severely affect the response of structure in two distinct ways：（1） induction of thermal stresses due to differences in the coefficients of thermal expansion between the various composite plies and layers and （2） temperature dependence of the elastic properties. Only a limited amount of work has been reported concerning this topic. All in all, the main contribution of this work is the consideration of this kinematic for cylindrical shells that incorporate mechanics and thermal conditions. In addition, numerical results are presented to demonstrate the capability of the current formulation to represent the behavior of cylindrical shells with these characteristics.

关键词： Two-dimensional cylindrical shells layerwise rigid element.

Linking the spatiotemporal variation of litterfall to standing vegetation biomass in Brazilian savannas

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Journal of Plant Ecology 2020年第5期13卷 517-524页

作者： Alan N.Costa Jeane R.Souza Karyne M.Alves Anderson Penna-Oliveira Geisciele paula-Silva Ingrid S.Becker Kelly Marinho-Vieira ana L.Bonfim Alessandra Bartimachi Ernane H.M.Vieira-Neto Instituto de Biologia Universidade Federal de UberlândiaUberlândia 38405-320MGBrazil Instituto de Biotecnologia Universidade Federal de GoiásCatalão 75704-000GOBrazil Department of Wildlife Ecology and Conservation University of FloridaGainesvilleFL 32611USA

Aims Litterfall at a global scale is affected by climate,edaphic features and vegetation structure,with litter production increasing from grasslands to forests following the rise in standing ***,at landscape scales,the same relationship between litter production and vegetation structure has rarely been studied and comparisons of litterfall patterns between adjacent,structurally distinct communities are ***,we use a standardized methodology to describe the structural differences among four savanna physiognomies and analyze their relationship with changes in litterfall across the *** We evaluated the woody vegetation structure and composition in 48 sites,equally distributed across four physiognomies and monitored the monthly litter production from April 2014 to March *** Findings Results showed that the density,basal area,cylindrical volume and aboveground biomass of woody vegetation differ among physiognomies,increasing consistently from cerrado ralo,cerrado típico,cerrado denso and cerradã***,we found a strong and positive relationship between aboveground biomass and annual litter production,with litter yield increasing from 0.9 to 8.4 Mg ha^(−1)across different physiognomies,following the increment in vegetation *** production was seasonal and similar among vegetation types,increasing during the dry *** comprised the dominant fraction(approx.85%)and litterfall seasonality primarily resulted from the concentration of leaf shedding during dry ***,the temporal pattern of litterfall throughout the year showed a gradual reduction in the seasonality from open to closed vegetation types,likely following the decrease of deciduous species abundance in the plant *** results showed that changes in vegetation structure may affect spatial and temporal litterfall patterns in different physiognomies,which co-occur across the Cerrado landscape,with potential implications for the overall f

关键词： Cerrado ecosystem functioning habitat heterogeneity Neotropical savannas nutrient cycling

Base Excision Repair Inhibition by Methoxyamine Impairs Growth and Sensitizes Osteosarcoma Cells to Conventional Treatments

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Journal of Cancer Therapy 2014年第4期5卷 307-314页

作者： ana paula Montaldi Julia Alejandra Pezuk Elza Tiemi Sakamoto-Hojo Luiz Gonzaga Tone María Sol Brassesco Department of Biology Faculty of Philosophy Sciences and Letters at Ribeirao Preto University of Sao Paulo Sao Paulo Brazil Department of Genetics Faculty of Medicine of Ribeirao Preto University of Sao Paulo Sao Paulo Brazil Department of Pediatrics Faculty of Medicine of Ribeirao Preto University of Sao Paulo Sao Paulo Brazil

The outcome of patients with osteosarcoma has not significantly improved in the last three decades. Therefore, there is still a need for the development of more effective therapeutic strategies. Methoxyamine (MX) is a base excision repair (BER) inhibitor that has shown anticancer potential by sensitizing a variety of tumor cells to ionizing radiation and chemotherapeutic drugs. In the present study, the in vitro antiproliferative effects of MX were evaluated in two osteosarcoma cell lines, HOS and MG-63. Evaluation of the influence on radiosensitivity and drug interactions in simultaneous treatments with methotrexate, doxorubicin, and cisplatin was also performed. Exposure to MX significantly decreased cell proliferation and mediated a substantial increase of apoptosis. Moreover, our results showed that MX synergized with ionizing radiation in both cell lines while potentiated the antitumor effects of cisplatin and methotrexate. Altogether, the results presented herein demonstrate the feasibility of inhibiting the BER pathway, which may in future be a promising strategy for overcoming intrinsic tumor resistance and to improve the outcome of patients with osteosarcoma.

关键词： Osteosarcoma Methoxyamine BER Cell Lines

High Remission Rates in a Brazilian Cohort of Initial Rheumatoid Arthritis after 15 Years of Follow-Up

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第2期11卷 53-63页

作者： Heloisa Lima Heller ana paula Gomides Reis Cleandro Albuquerque Isadora Jochims Luciana Muniz Talita Yokoy Licia Mota Centro Universitário de Brasília UniCEUB Brasília Brasil Universidade de Brasília UnB Brasília Brasil

Introduction: Rheumatoid arthritis (RA) is a chronic systemic rheumatic disease which is usually treated with corticosteroids and immunobiologicals. The goal of this article is to carry out an assessment of disease a... 详细信息

ana;">Introduction: Rheumatoid arthritis (RA) is a chronic systemic rheumatic disease which is usually treated with corticosteroids and immunobiologicals. The goal of this article is to carry out an assessment of disease activity indices in a cohort of patients with rheumatoid arthritis. Patients and Methods: This is a prospective cohort study. Individuals from the Initial Rheumatoid Arthritis Brasília Cohort, which is an incident cohort of early RA diagnosed patients, were monitored at the Rheumatology Service of the Hospital Universitário de Brasília (HUB), University of Brasília (UnB), Brazil. A cross-sectional analysis was carried out from 2017 to 2018 to evaluate patients with 15 or more years of follow-up, through a direct interview and review of medical records. The main focus of the study is on the assessment of disease activity, based on the indices: 28-joint Disease Activity Score based on Creactive protein (DAS 28 CPR) and based on erythrocyte sedimentation rate (DAS 28 ESR), Clinical Disease Activity Index (CDAI), and Simple Disease Activity Index (SDAI). The reference remission criteria used were the Composite Disease Activity Indices. Results: 107 patients were evaluated, mostly women, mean age of 55.1 years. Concerning the disease characteristics, 75.5% of the patients were positive for rheumatoid factor and 12 (11.3%) had documented erosive disease. The mean Health Assessment Questionnaire (HAQ) at the time of assessment was 0.6 (median 0.35). The indices analyzed showed: DAS28-ESR 48.6% of patients were in remission and 12.1% had low activity levels, DAS28-CRP 55.1% and 11.2%, SDAI 42% and 26.1%, CDAI 41.1% and 27.1%. These remission and low disease activity levels are higher than those generally found in the literature. Conclusion: This study presents a cohort of patients with RA who started treatment at an early stage

关键词： Rheumatoid Arthritis Remission Induction Therapeutics

Late diagnosis and TCD8 immune response profile of cutaneous tuberculosis: A case report

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Open Journal of Immunology 2012年第3期2卷 125-131页

作者： Bruna Daniella de Souza Silva Sueli Lemes de ávila Alves André Kipnis ana paula Junqueira-Kipnis Departamento de Microbiologia Imunologia Patologia e Parasitologia Instituto de Patologia Tropical e Saúde Pública Universidade Federal de Goiás Goiania/GO Brazil Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros LACEN/GO Goiania/GO Brazil

Introduction: Cutaneous tuberculosis (CTB) is a rare form of extra-pulmonary tuberculosis that, when associated with late diagnosis, worsen the quality of life of the sick individuals. This report presents a case of late diagnosis of CTB. Unusual clinical manifestations retarded the correct tuberculosis diagnosis for more than a year. The immune response elicited by this type of tuberculosis as well as the factors that might contribute to the delay in diagnosis was evaluated and discussed. Methodology: Clinical evaluation and flow cytometric analyses of PBMC were realized for a case of CTB and a healthy individual as a control. Results: M. tuberculosis specific TCD8+ cell response was analyzed by flow cytometry and revealed positive cells for IL-17, IL-10, TGF-β and IDO. The CTB patient presented higher percentage of those cells when compared to a healthy donor. However, TCD8 cells positive for the important protective cytokine, IFN-γ was decreased in the CTB patient. Conclusion. The assessment of the M. tuberculosis specific TCD8+ immune response showed a regulatory/modulatory phenotype with a reduced IFN-γ response when compared to the healthy control that could have contributed to the CTB infection.

关键词： Cutaneous tuberculosis Late Diagnosis CD8+ T Cells