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chemometric analysis of an Sanitary Landfill Leachate

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Journal of Water Resource and Protection 2012年第1期4卷 16-24页

作者： ana m.c. Grisa cíntia Paese Oclide José Dotto Ronaldo Nicola mara Zeni 不详

This paper presents a study on the biotic/abiotic conditions of the S?o Giácomo sanitary landfill, located near the city of caxias do Sul, Brazil, through statistical analysis of fourteen physic-chem.cal data sets for the leachate, produced in the garbage dump site over a long period of years. Different chemometric methods are used in the statistical analysis. For example, the correlations between the variables, related to the degraded organic matter and biological activity, are determined by means of multivariate methods. The results highlight that BOD, cOD, VTS, FTS and TS give information on the anaerobic degradation of the organic matter contained in the cells, and suggest that the greater the contribution of the variables with positive weights in Pc1 the greater the level of organic matter degradation. The variables TN, Amon Nit. and alkalinity are related to the biological activity and determine the potency of the variables in relation to time. The greater the contribution of the variables related to organic degradation the greater the values in Pc2 and the lesser the potency of these variables, whose influence is greater in the second stage of anaerobic degradation. The variables of Pc2 is important plans of the contamination of the leached in the bodies hídrics.

关键词： Landfill Leachate Physico-chem.cal Variables chemometric method Principal components analysis

Plasma membrane ca^(2+)-ATPases in the nervous system during development and ageing

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World Journal of Biological chemistry 2010年第7期1卷 229-234页

作者： ana m mata m Rosario Sepulveda Department of Biochemistry and molecular Biology and Genetics Faculty of SciencesUniversity of Extremadura06006 BadajozSpain

calcium signaling is used by neurons to control a variety of functions,including cellular differentiation,synaptic maturation,neurotransmitter release,intracellular signaling and cell *** review focuses on one of the most important ca2+regulators in the cell,the plasma membrane ca2+-ATPase(PmcA),which has a high affinity for ca2+and is widely expressed in *** ontogeny of PmcA isoforms,linked to specific requirements of ca2+ during development of different brain areas,is addressed, as well as their function in the adult *** is based on the high diversity of variants in the PmcA family in brain,which show particular kinetic differences possibly related to specific localizations and functions of the cell. conversely,alterations in the activity of PmcAs could lead to changes in ca2+homeostasis and,consequently,to neural *** involvement of PmcA isoforms in certain neuropathologies and in brain ageing is also discussed.

关键词： calcium Brain ATPase Plasma membrane Differentiation Neurodegeneration

cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P) H multi-photon fluorescence lifetime imaging

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Nano Research 2019年第5期12卷 991-998页

作者： ana R.Faria Oscar F.Silvestre christian maibohm Ricardo m.R.Adao Bruno F.B.Silva Jana B.Nieder Department of Nanophotonics Ultrafast Bio- and Nanophotonics GroupINL - International Iberian Nanotechnology LaboratoryAv.Mestre Jose Veiga s/n4715-330 BragaPortugal Department of Life Sciences INL-International Iberian Nanotechnology LaboratoryAv.Mestre Jose Veiga s/n4715-330 BragaPortugal

Elesclomol (ELc) is an anticancer drug inducing mitochondria cytotoxicity through reactive oxygen ***,for the first time,we encapsulate the poorly water soluble ELc in monoolein-based cubosomes stabilized with Pluronic *** uptake and nanocarrier accumulation close to the mitochondria with sub-m.crometer distance is identified via three-dimensional (3D) confocal m.croscopy and edge-to-edge compartment *** monitor the therapeutic effect of the ELc nanocarrier,we apply for the first time,label-free time-lapse multi-photon fluorescence lifetime imaging m.croscopy (mP-FLIm) to track NAD(P)H cofactors with sub-cellular resolution on live cells exposed to an anticancer *** in vitro cytotoxicity is verified when loading the pre-complexed ELc with copper (ELc-cu).Importantly,for equivalent copper concentration,cubosomes loaded with ELc-cu show higher cytotoxicity compared to the free *** novel nanocarrier shows promising features for system.c ELc-cu administration,and furthermore we establish the mP-FLIm technique for the assessment of anticancer drug delivery systems.

关键词： cubosomes mitoch on dria reactive oxyge n species elesclomol NAD(P)H fluoresce nee lifetime anticancer therapy

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Forensic Sciences Research 2019年第3期4卷 257-266页

作者： Benito morentin m.Paz Suárez-mier ana monzó Pilar molina Joaquín S.Lucena Section of Forensic Pathology Basque Institute of Legal MedicineBilbaoSpain Histopathology Service Department of MadridNational Institute of Toxicology and Forensic SciencesSpain Forensic Pathology Service Institute of Legal Medicine and Forensic SciencesValenciaSpain Forensic Pathology Service Institute of Legal Medicine and Forensic SciencesSevilleSpain

This is a multicentre forensic study that identifies all sports-related sudden deaths (SRSDs) in young people,due to myocardial diseases (mDs) that occurred in a large area of *** aim of the study is to assess the epidemiology,causes of death,and sport activities associated with these *** is a retrospective study based on forensic autopsies performed in the provinces of Biscay,Seville,Valencia and in the jurisdiction covered by the National Institute of Toxicology and Forensic Sciences in madrid (Spain).The retrospective study encompasses from 2010 to *** sudden cardiac deaths (ScDs) in persons 1-35years old were *** total number of ScDs were divided into death occurred during exercise (SRSD) and death during rest,sleep or normal activities (non-SRSD).Each of these two groups was subdivided according to the cause of death into mD (primary cardiomyopathies and myocarditis) and ***-pathological,toxicological and genetic characteristics of SRSD due to mD were *** the 8-year study period,we identified 645 cases of ScD in the young: 75 SRSD (11.6%) and 570 non-SRSD (88.4%).mD was diagnosed in 33 (44.0%) of the SRSD and in 112 (19.6%) of the non-SRSD *** cases of SRSD due to mD were males (mean age (24.0±7.6) years) practicing recreational sports (85%).SRSDs were more frequent in arrhythmogenic cardiomyopathy (Acm) (37%) and hypertrophic cardiomyopathy (Hcm) (24%),followed by myocarditis (15%) and idiopathic left ventricular hypertrophy (ILVH) (9%).Only in five cases of SRSD the mD responsible of death (Hcm) had been diagnosed in *** symptoms related to the disease were present in other seven patients (six of them with Acm).Postmortem genetic studies were performed in 15/28 (54%) primary cardiomyopathies with positive results in 12 (80%) *** most frequent sports disciplines were football (49%) followed by gymnastics (15%) and running (12%).In Spain,SRSD in young people due to mDs occurs in mal

关键词： Forensic sciences forensic pathology sudden cardiac death sports myocardial diseases autopsy young

Adsorption of neodymium,terbium and dysprosium using a synthetic polymer-based magnetic adsorbent

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Journal of Rare Earths 2023年第11期41卷 1796-1804,I0006页

作者： Hamedreza Javadian mehdi Taghavi montserrat Ruiz Inderjeet Tyagi majid Farsadrooh ana maria Sastre Department of chem.cal Engineering ETSEIBUniversitat Politècnica de CatalunyaDiagonal 64708028BarcelonaSpain Department of chemistry Faculty of ScienceShahid Chamran University of Ahvaz61357-43337Iran Department of chem.cal Engineering EPSEVGUniversitat Politècnica de CatalunyaAv.Víctor Balaguers/n08800Vilanova i la GeltrúSpain centre for DNA Taxonomy Molecular Systematics DivisionZoological Survey of IndiaKolkata700053India Renewable Energies Research Laboratory Department of ChemistryFaculty of ScienceUniversity of Sistan and BaluchestanP.O.Box 98135674ZahedanIran

In this study,a polyamide with methine-thiophene and pyrimidine linkages(poly(pyrimidine-thiophene-amide)(PPTA))was ***,magnetic PPTA(m-PPTA)was synthesized using the hydrothermal *** products were analyzed by Fourier-transform infrared spectroscopy(FTIR),nuclear magnetic resonance(NmR),X-ray diffraction(XRD),thermogravimetric analysis(TGA),field-emission scanning electron m.croscopy(FE-SEm),and a vibrating-sample magnetometer(VSm).The nanocomposite exhibits a saturation magnetization of 50.44 emu/g recorded by VSm *** ability of m-PPTA to bind dysprosium(Dy^(3+)),terbium(Tb^(3+)),and neodymium(Nd^(3+))was *** 0.15 g of m-PPTA to test the adsorption of the rare earth elements(50 mg/L)at pH=5.5,the percentage of adsorption for Dy^(3+),Tb^(3+),and Nd^(3+)is 98.41%,97.48%and 95.67%,***-second-order(PSO)significantly fits the adsorption kinetic *** equation was used to describe the adsorption equilibrium data of Dy^(3+)and Tb^(3+),while Langmuir model was used to simulate Nd^(3+)adsorption *** the temperature leads to an increase in the performance of m-PPTA,and an endotherm.c adsorption process was confirmed by the positive values ofΔ*** four adsorption-desorption cycles,the efficiency of adsorption of Dy^(3+),Tb^(3+),and Nd^(3+)by m-PPTA is88.75%,86.37%,and 84.64%,*** antagonism effect is observed for the adsorption of the individual ions in a ternary solution.

关键词： Polyamide Lanthanides magnetic nanocomposite Adsorption Rare earth elements

Expect the unexpected:Brown tumor of the mandible as the first manifestation of primary hyperparathyroidism

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World Journal of clinical cases 2024年第7期12卷 1200-1204页

作者： ana majic Tengg maja cigrovski Berkovic Ivan Zajc Ivan Salaric Danko müller Iva markota Department of Endocrinology DiabetesMetabolic Diseases and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Department for Sport and Exercise medicine Faculty of Kinesiology University of ZagrebZagreb 10000Croatia Department of Oral Surgery Clinical Hospital DubravaZagreb 10000Croatia University of Zagreb School of Dental medicine Zagreb 10000Croatia clinical Department of Pathology and cytology Clinical Hospital DubravaZagreb 10000Croatia

Hyperparathyroidism(HPT)is a condition in which one or more parathyroid glands produce increased levels of parathyroid hormone(PTH),causing disturbances in calcium *** commonly HPT presents with asymptomatic hypercalcemia but the clinical spectrum may include disturbances reflecting the combined effects of increased PTH secretion and *** tumors are rare,benign,tumor-like bone lesions,occurring in 1.5%to 4.5%of patients with HPT,as a complication of an uncontrolled disease pathway,and are nowadays rarely seen in clinical *** tumor can appear either as a solitary or multifocal lesion and usually presents as an asymptomatic swelling or a painful exophytic ***,it can cause a pathological fracture or skeletal pain and be radiologically described as a lytic bone *** diagnosis of a brown tumor in HPT is typically confirmed by assessing the levels of serum.calcium,phosphorus,and *** when present,brown tumor is quite pathognomonic for HPT,the histologic finding often suggests a giant cell tumor,while clinical presentation might suggest other more frequent pathologies such as metastatic *** of brown tumors frequently focuses on managing the underlying HPT,which can often lead to regression and resolution of the lesion,without the need for surgical ***,in refractory cases or when dealing with large symptomatic lesions,surgical treatment may be necessary.

关键词： Brown tumor Hyperparathyroidism Lytic bone lesions Giant cell tumor

An illustrated checklist of m.crofaunal molluscs from soft-sediments of the Abrolhos Parcel(northeastern,Brazil)with 15 new records

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Journal of Oceanology and Limnology 2021年第2期39卷 671-682页

作者： Flávia maria Pereira da cOSTA ana maria Setubal PIRES-VANIN Departamento de Oceanografi a Biológica Instituto Oceanográfi coUniversidade de São PauloSão Paulo 05508-120Brazil

comprehensive understanding of marine biodiversity is essential for conservation,especially for vulnerable *** this paper,we implemented and illustrated a checklist of molluscs from the Abrolhos Parcel,Brazil,the most important coralline area in South Atlantic *** list features 100 species belonging to 4 classes and 85 genera,of which 15 are new records for Bahia State,northeast *** results highlight the potential for new records in the *** species came from 54 unconsolidated sediment samples collected from the bottom of the reef with a 0.042-m^(2) van Veen *** the listed species,curveulima sp.,Notarchus *** Guyanella clenchi are new records for the South Atlantic,while caecum metamorphosicum,Eratoidea janeiroensis,Volvarina serrei,Solemya notialis,Solariorbis shimeri,and Amphithalamus glabrus are endem.c to Brazilian waters.A comparison of our results with those obtained in other reef environments indicates that the Abrolhos Parcel has a rich malacofauna and suggests that many more species can still be found with more samplings.

关键词： Bivalvia Gastropoda m.cromolluscs Scaphopoda Solenogastres southwest Atlantic

canine Leptospirosis Serology in Southern mexico city

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Open Journal of medical m.crobiology 2016年第4期6卷 171-180页

作者： Ignacio martínez-Barbabosa Edubiel Arturo Alpizar-Sosa Dolores Guadalupe Gavaldón-Rosas Luís Pedro moles-cervantes marcia Gutiérrez cárdenas Rafael García-González m.chael Shea ana maría Fernández-Presas Health Attention Department Human Parasitology Laboratory Universidad Autónoma Metropolitana-Xochimilco México DF México Animal and Agriculture Production Department Universidad Autónoma Metropolitana-Xochimilco México DF México m.crobiology and Parasitology Department School of Medicine Universidad Autónoma de México México DF México Education and communication Department Universidad Autónoma Metropolitana-Xochimilco México DF México

Background: Leptospirosis is an important zooanthroponotic disease spread worldwide which infection is recognized as a re-emergent disease. Leptospirosis is a system.c disease of humans and domestic animals, mainly dogs, cattle and swine, characterized by fever, renal and hepatic insufficiency, pulmonary manifestations and reproductive failure. Objective: To study the seroprevalence of anti-Leptospira antibodies in an urban canine population. materials and methods: The study was performed in march 2014 in stray dogs that had been captured in the districts of coyoacan, Iztapalapa, Iztacalco and Benito Juarez in mexico city;117 dogs were analyzed, from each of which 5 ml of blood were obtained. Serology was performed using a mAT test (m.croscopic Agglutination Test), finding that the antigens corresponded to 13 serotypes of Leptospirainterrogans. Three age groups were formed: Group 1) younger than a year (n = 28), Group 2) 1 to 6 years (n = 75), and Group 3) older than 6 years (n = 14). Results: Of the analyzed sera, 28.2% were seropositive to one or more Leptospira serotypes, 74% of the positive seracoagglutinated with two or more serotypes. The most frequent serotypes were: canicola, Icterohaemorrhagiae and Portland-vere. Serotypes canicola, Pyrogenes, and Bratislava resulted statistically significant (p 0.001). The presence of anti-Leptospira antibodies in the blood of animals of 1 to 6 years resulted with a p 0.001. The sera from Iztapalapa reacted to nine serotypes. conclusion: The 28.2% of seropositivity indicates Leptospira transmission in the canine population that was studied could exhibit a potential public health risk.

关键词： Leptospira Leptospirosis canicola Icterohaemorrhagiae Dogs

communication between bone marrow mesenchymal stem.cells and multiple myeloma cells:Impact on disease progression

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World Journal of Stem.cells 2023年第5期15卷 421-437页

作者： Daniel García-Sánchez Alberto González-González ana Alfonso-Fernández mónica Del Dujo-Gutiérrez Flor m Pérez-campo Department of molecular Biology_IDIVAL Faculty of MedicineUniversity of CantabriaSantander 39011CantabriaSpain Servicio de Traumatología y cirugía Ortopédica Hospital Universitario Marqués de ValdecillaInstituto de Investigación Sanitaria Valdecilla(IDIVAL)Facultad de MedicinaUniversidad de CantabriaSantander 39008CantabriaSpain

multiple myeloma(mm)is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow(Bm).The interaction between mm.cells and the Bm m.croenvironment,and specifically Bm mesenchymal stem.cells(Bm-m.cs),has a key role in the pathophysiology of this *** data support the idea that Bm-m.cs not only enhance the proliferation and survival of mm.cells but are also involved in the resistance of mm.cells to certain drugs,aiding the progression of this hematological *** relation of mm.cells with the resident Bm-m.cs is a two-way *** modulate the behavior of Bm-m.cs altering their expression profile,proliferation rate,osteogenic potential,and expression of senescence *** turn,modified Bm-m.cs can produce a set of cytokines that would modulate the Bm m.croenvironment to favor disease *** interaction between mm.cells and Bm-m.cs can be mediated by the secretion of a variety of soluble factors and extracellular vesicles carrying m.croRNAs,long non-coding RNAs or other ***,the communication between these two types of cells could also involve a direct physical interaction through adhesion molecules or tunneling ***,understanding the way this communication works and developing strategies to interfere in the process,would preclude the expansion of the mm.cells and might offer alternative treatments for this incurable disease.

关键词： multiple myeloma mesenchymal stem.cells Bone marrow m.croenvironment Soluble factors Extra-cellular vesicles cells adhesion molecules Tunnellingnanotubes