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DNA damage levels in systemic lupus erythematosus patients with low disease activity:An evaluation by comet assay

Advances in Bioscience and Biotechnology 2012年第7期3卷 983-988页

作者： Thais Muniz Montalvao ana luisa miranda-vilela Mariana Matos Roll Cesar Koppe Grisolia Leopoldo Santos-Neto University Hospital of Brasilia University of BrasiliaBrasiliaBrazil Laboratory of Genetic Toxicology Institute of Biological SciencesUniversity of BrasiliaBrasiliaBrazil Department of Genetics and Morphology Laboratory of GeneticsInstitute of Biological SciencesUniversity of BrasiliaBrasiliaBrazil Faculty of Medicine University of BrasiliaBrasiliaBrazil

Oxidative stress has been implicated in the inflammatory process of Systemic Lupus Erythematosus (SLE), particularly by the formation of anti-DNA autoantibodies, which can lead to DNA damage. The aim of this study was to investigate, through comet assay, whether the level of DNA damage in SLE patients is different from that of healthy subjects. Twenty-five adult SLE patients with SLEDAI up to ten, and 25 healthy subjects were paired according to age, gender and Body Mass Index (BMI). Other anthropometric variables were also assessed. Comet assay was assessed as the marker of oxidative stress described as DNA Damage (DD) percentage. Waist Circumference (WC), Hip Circumference (HC) and BMI were also performed. Exclusion criteria for patients and controls comprised smoking and other chronic disorders. Level of damage index was remarkably higher in SLE patients than in controls, and no significant differences between the groups were found for age, BMI, WC and HC. No stratification concerning gender was performed, since there were just two males per group. No correlation was observed between BMI and DD (%). DD increased in SLE, which reflects the oxidant/antioxidant imbalance in these patients. These findings support an association between oxidative stress and SLE. This stronger correlation observed in patients with low disease activity may be useful in elucidating the mechanisms of disease pathogenesis.

关键词： Systemic Lupus Erythematosus DNA Damage Comet Assay Oxidative Stress

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High aluminum concentration and initial establishment of Handroanthus impetiginosus : clues about an Al non-resistant species in Brazilian Cerrado

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Journal of Forestry Research 2020年第6期31卷 2075-2082页

作者： Ane Marcela das Chagas Mendon ca Jean Marcel Sousa Lira ana Luiza de Oliveira vilela Daniel Amorim Vieira Nayara Cristina de Melo Joao Paulo Rodrigues Alves Delfi no Barbosa Programa de Pós-Graduacao em Fisiologia Vegetal Departamento de BiologiaUniversidade Federal de LavrasLavrasMG 37200-000Brazil Programa de Pós-Graduacao em Ciências Ambientais Instituto de Ciências ExatasUniversidade Federal de AlfenasAlfenasMG 37130-001Brazil Programa de Pós-Graduacao em Fitotecnia Departamento de AgriculturaUniversidade Federal de LavrasLavrasMG 37200-000Brazil Instituto Federal de Educacao Ciência e Tecnologia do Pará BelémPA 66093-020Brazil

Cerrado soils are acidic and nutrient-poor,with high content of solubilized Al 3+.Plants growing in these conditions may display adaptations to cope with high aluminum concentrations especially during early developmental *** investigated leaf nutritional status,and photosynthetic and growth characteristics during the initial establishment of Handroanthus impetiginosus(*** Dc.)Mattos,a secondary tree species distributed in the Brazilian *** goal was to understand leaf-level traits related to diff erent aluminum *** plants were cultivated in four diff erent aluminum sulfate concentrations:0,1,2,and 4 mM Al,for 40 *** performed analyses of growth,leaf gas exchange,chloroplast pigment content,and leaf mineral *** observed a linear increase of Al leaf content as a function of Al concentration in the nutrient *** grown in 1 mM Al showed a remarkable increase of K leaf content,net photosynthesis,stomatal conductance,and transpiration,while in 4 mM Al there were reductions of N,P,and K contents,gas exchange characteristics,and *** did not have mechanisms of avoidance,compartmentalization,or resistance to high Al ***,this species showed a hormetic response,with low Al concentrations stimulating and high Al concentrations inhibiting plant responses.

关键词： Hormesis Low Al concentration Al toxicity Cerrado species Carbon assimilation

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Skin models of cutaneous toxicity,transdermal transport and wound repair

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Burns & Trauma 2023年第1期11卷 393-407页

作者： Inês vilela de Sousa Miguel J.S.Ferreira Luís B.Bebiano Sandra Simões ana Filipa Matos Rúben F.Pereira Pedro L.Granja i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoRua Dr.Manuel Pereira da Silva4200-393 PortoPortugal INEB-Instituto de Engenharia Biomédica Universidade do PortoRua do Campo Alegre8234150-180 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugal FEUP-Faculdade de Engenharia da Universidade do Porto Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and Engineering&Henry Royce InstituteEngineering Building AThe University of ManchesterOxford RoadManchester M139PLUK ISEP-Instituto Superior de Engenharia do Porto Universidade do PortoRua Dr.António Bernardino de Almeida 4314200-072 PortoPortugal iMed.ULisboa Faculty of PharmacyUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal Faculty of Pharmacy Universidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive ***,the barrier properties of the skin,along with its multilayer structure,impose severe restrictions on drug transport and ***,bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin *** though in vivo research is often preferred to study biological processes involving the skin,in vitro and ex vivo strategies have been gaining increasing relevance in recent ***,there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted ***,microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin *** in miniaturization,automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust,high-throughput manner,while being compliant with regulatory issues,standards and *** this review,skin models for transdermal transport,wound repair and cutaneous toxicity will be discussed with a focus on high-throughput *** microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models,both in terms of complexity and throughput.

关键词： Skin In vitro models Ex vivo models Transdermal transport assays Wound healing assays Toxicity assays Microfluidic chip Skin-on-a-chip

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Current role and future perspectives of cardiac rehabilitation in coronary heart disease

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World Journal of Cardiology 2021年第12期13卷 695-709页

作者： Eduardo M vilela Ricardo Ladeiras-Lopes ana Joao Joana Braga Susana Torres Sofia Viamonte José Ribeiro Madalena Teixeira José P Nunes Ricardo Fontes-Carvalho Department of Cardiology Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4434-502Portugal Department of Surgery and Physiology Cardiovascular Research Unit(UnIC)Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Centro de Reabilitação do Norte Centro Hospitalar de Vila Nova de Gaia/EspinhoVila Nova de Gaia 4405-565Portugal Faculty of Medicine University of PortoPorto 4200-319Portugal

Ischaemic heart disease(IHD)is a major cause of morbidity and mortality *** there have been major advances in this field,these patients are still a higher risk *** such,strategies to mitigate risk and tailor secondary prevention measures are of the utmost *** rehabilitation(CR),encompassing several domains including exercise training,cardiovascular risk factor optimization,nutritional and psychological assessments,as well as other ancillary interventions has shown to be one of the pillars in the contemporary management of patients with ***,CR is associated with several benefits in this population,ranging from functional capacity to improvements in *** this,there are still several issues concerning the optimal application of CR which are still not fully ascertained,such as lack of referral and completion,as well as questions related to programme design(particularly among patients with multiple comorbidities).In this review,we aim at presenting a pragmatic overview on the current role of CR in the management of individuals with IHD,while also discussing some of the caveats in the current data,as well as future concepts which could help improve the uptake and personalization of this pivotal time-tested intervention.

关键词： Cardiac rehabilitation Secondary prevention Myocardial infarction Ischaemic heart disease Cardiovascular diseases

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Advances and horizons for artificial intelligence of endoscopic screening and surveillance of gastric and esophageal disease

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Artificial Intelligence in Medical Imaging 2022年第3期3卷 70-86页

作者： Byung Soo Yoo Kevin V Houston Steve M D'Souza Alsiddig Elmahdi Isaac Davis ana vilela Parth J Parekh David A Johnson Department of Internal Medicine Eastern Virginia Medical SchoolNorfolkVA 23507United States Department of Internal Medicine Virginia Commonwealth UniversityRichmondVA 23298United States Division of Gastroenterology Department of Internal MedicineEastern Virginia Medical SchoolNorfolkVA 23507United States

The development of artificial intelligence in endoscopic assessment of the gastrointestinal tract has shown progressive enhancement in diagnostic *** review discusses the expanding applications for gastric and esophageal *** gastric section covers the utility of AI in detecting and characterizing gastric polyps and further explores prevention,detection,and classification of gastric *** esophageal discussion highlights applications for use in screening and surveillance in Barrett's esophagus and in high-risk conditions for esophageal squamous cell ***,these discussions highlight applications for use in assessing eosinophilic esophagitis and future potential in assessing esophageal microbiome changes.

关键词： Artificial intelligence Endoscopy Gastric cancer Gastric polyps Barrett’s esophagus Esophageal cancer

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Antifungal Susceptibility Profile <i>In Vitro</i>Fungal Air in a Hospital Environment

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Open Journal of Medical Microbiology 2018年第3期8卷 35-46页

作者： Otávio vilela de Figueiredo Luiz Francisley de Paiva Matheus Valejo Peixoto Pedro Guilherme Paula Bariani Thiago Silva Pinto Manoel Araujo Teixeira ana Beatriz Alkmim Teixeira-Loyola School of Medicine University of the Sapucai Valley Pouso Alegr Minas Gerais Brazil Research Laboratory University of the Sapucai Valley Pouso Alegre Minas Gerais Brazil Department of Biology University of the Sapucai Valley Pouso Alegre Minas Gerais Brazil Department of Microbiology University of the Sapucai Valley Pouso Alegre Minas Gerais Brazil

Purpose: The aim of this study was to isolate and identify potentially pathogenic airborne fungi from Hospital das Clínicas Samuel Libanio in the city of Pouso Alegre-MG and evaluate their susceptibility to natural and industrial products. Methods: The air collection was performed by passive sedimentation in the morning during the autumn and winter seasons. Petri dishes were open as the location of air conditioning. The isolates were subjected to pathogenicity test. The identification of the fungi was performed according to the macroscopic evaluation and micromorphology. Potentially pathogenic isolates were susceptibility tested by disc diffusion method. The agents used were insecticides and industrial cleaning products and essential oils of citronella plants, lemon grass, eucalyptus and Melaleuca extracted by steam distillation method. Results: We obtained a total of 356 fungal isolates. The inside door environments were 126 (35.39%) and the outside environments were 230 (64.6%) isolates. The 22 (6.18%) isolates from the inside and 25 (6.18%) outside the hospital showed pathogenic potential. This isolates were identified as Acremonium spp., A. niger, A. terreus, A. versicolor, Curvularia sp., Penicillium sp. and Scopulariopsis sp. Susceptibility testing it was observed that most of the isolates were susceptible to the principle product containing sodium hypochlorite. Citronella oil showed enormous potential inhibition against all isolates. Already lemon grass oil was effective only against isolates of Penicillium spp. Conclusions: All genres identified are significant allergens, which can cause respiratory disease in both immunocompromised individuals such as asthmatics and people with any immune deficit. The monitoring of environmental sources should be performed, especially in special areas with immunocompromised patients. Despite efforts to try to reduce fungal infections hospital there are still flaws in the strategies employed.

关键词： Fungi Air Conditioning Housekeeping Hospital Disk Diffusion Antimicrobial Tests

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Quality of Seeds of Upland Rice Lines Adapted to the State of Minas Gerais, Brazil

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American Journal of Plant Sciences 2015年第12期6卷 1920-1927页

作者： Heloisa Oliveira dos Santos Flávia Barbosa Silva Botelho ana Cláudia de Amorim Fonseca Ricardo Kenji Uenojo Marcela Pedroso Mendes Edila vilela de Resende Von Pinho Department of Agriculture Federal University of Lavras Lavras Brazil

In the final stages of a plant breeding program, a crucial step is the multiplication of seeds in production fields. Besides a solid planning, the seeds multiplication needs a special attention to guarantee seeds with high quality, genetic integrity, high germination and vigor to the farmer. The aim of this study was to evaluate the physiologic quality, enzymatic expression and respiratory activity of seeds of 20 elite upland rice lines adapted to the state of Minas Gerais, Brazil, from the upland rice breeding program from three Brazilians research institutions. The quality parameters evaluated were root protrusion, number of normal seedlings in the germination test, number of normal seedlings in the germination first count, initial stand from emergence test, speed of emergence index, seedlings shoot and root length, percentage of O2 and CO2 from respiratory activity and the expression pattern of the enzymes alcohol dehydrogenase (ADH) and malate dehydrogenase (MDH). The seeds quality varied among lines, allowing the selection of lines with best performance. The respiratory activity was lower in seeds of lines with high quality. The enzyme ADH was an excellent marker to infer about the quality of seeds, and the variation in the expression of MDH did not depend on the quality of rice seeds. The lines BRS Esmeralda, CMG1896 and CMG1509 showed high physiologic quality in their seeds, and therefore, they should receive higher attention in rice breeding programs.

关键词： Oriza sativa Physiologic Quality Enzymatic Expression Respiratory Activity Vigor

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Phenotypic and Enzymatic analyses of Upland Rice Lines Seeds under No-Tillage

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American Journal of Plant Sciences 2015年第12期6卷 1981-1989页

作者： Heloisa Oliveira dos Santos Flávia Barbosa Silva Botelho Ricardo Kenji Uenojo ana Cláudia de Amorim Fonseca Marcela Pedroso Mendes Edila vilela de Resende Von Pinho Maria Laene Moreira de Carvalho Department of Agriculture Federal University of Lavras Lavras Brazil

Over 40% of the agricultural area in Brazil corresponds to no-tillage farming. Although it is evident the importance of obtaining upland rice cultivars adapted to this cropping system, researches in this sense are still incipient and breeders do not have cultivars available to recommend with enough security. The aim of this study was to evaluate phenotypic characters favorable to the no-tillage system in order to establish the basis for upland rice breeding programs interested in this cropping system. The seeds of twenty elite inbred lines from the Upland Rice Breeding Program from the Brazilian research institutions UFLA, EMBRAPA and EPAMIG were evaluated at the Central Seeds Lab from the Agriculture Department of UFLA following a randomized block design with four replicates. The characters evaluated were seedlings emergence (SE), green matter yield (GM), dry matter yield (DM), photosynthetic activity (PA), and superoxide dismutase activity (SOD). The quality parameters evaluated were obtained by a germination test (GT), germination first count (GFC), emergence test (E), initial stand (IS), and alpha-amylase expression. The lines CMG 2074, CMG 1967, CMG 2017, BRSMG Caravera and CMG 2097 showed higher SOD content in the enzymatic analyses, and consequently higher tolerance to abiotic stresses that could be caused by no-tillage. Considering the evaluation of agronomic traits, the line CMG 1967 showed the best performance in no-tillage soil and, therefore, should receive higher attention in Upland Rice Breeding Programs.

关键词： Oriza sativa Physiologic Quality Enzymatic Expression Cropping System Vigor

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Stability of the Antioxidant Activity of Flavonoids after Gamma Irradiation

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Food and Nutrition Sciences 2011年第5期2卷 490-493页

作者： Antonio Fernando de Melo Vaz Marthyna Pessoa de Souza Adriana Carla Cavalcante Malta Argolo ana Maria Mendonca de Albuquerque Melo Maria Luiza vilela Oliva Haroldo Sátiro Xavier Luana Cassandra Breitenbach Barroso Coelho Maria Tereza dos Santos Correia Department of Biochemistry Federal University of PernambucoRecifeBrazil Department of Biophysics and Radiobiology Fed-eral University of PernambucoRecifeBrazil Department of Biochemistry Federal University of Sao PauloSao PauloBrazil Department of Pharmaceutical Science Federal University of PernambucoRecifeBrazil

Food irradiation has the purpose of destroying insects or microorganisms, thereby increasing the safety and shelf life of foods. Flavonoids are ubiquitous plant secondary products with radical scavenger ability. In the present study their antioxidant stability after gamma irradiation was evaluated. The flavonoids showed fast scavenger ability measured with the 2.2-diphenyl-1-picrylhydrazyl radical (DPPH) after high doses of radiation. The low damage caused by irra- diation on antioxidant capacity of the flavonoids shows their potential use in combating chemical oxidation of bio- molecules in irradiated foods.

关键词： Flavonoid Food Irradiation Scavenger Capacity Gamma Irradiation

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