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Passive Heating systems:A Case study in a Brazilian Mountainous Region

Journal of Civil Engineering and Architecture 2019年第11期13卷 676-685页

作者： ana Clara l.Pereira ana lúcia t.s.da motta Bruno B.F.da Costa Priscilla C.P.F.de Oliveira thiago V.Miranda Programa de Pós-graduacao em Engenharia Civil Universidade Federal FluminenseRio de Janeiro 22211-200Brazil Departamento de Engenharia Civil da Universidade Federal do Rio de Janeiro—Campus Macaé Rio de Janeiro 22211-200Brazil

the study of thermal comfort in the built environment is of great relevance since it stimulates the development of more sustainable buildings suited to the local climate and able to meet the human need for *** objective of this research was to develop,construct and test a passive heating system adaptable to existing buildings,reducing the need for major interventions and increasing thermal comfort in the indoor *** adopted methodological approach was a case study in a single-family residence located in the Brazilian city of Petrópolis,a mountainous region with a humid subtropical climate and a rigorous *** proposed passive heating system is totally isolated,thus mitigating air infiltration and promoting increase of temperature in the internal environment through the absorption of solar energy and greenhouse *** kind of solution is especially interesting for residents of this region,since most of the city buildings are not adequately prepared to handle low ***,given local climatic conditions,residents need to spend a lot of money on the acquisition and operation of electric or gas heating *** results indicated that the developed system,in fact,increased the temperature of the studied room when compared to an adjacent room,which did not receive the *** findings of this paper,therefore,provide a valuable reference for experts and practitioners in the selection of heating systems to be used in cold regions,and proved that passive systems can provide thermal comfort at the same time that optimize the interaction of the building with the local ecosystem.

关键词： Passive heating systems thermal comfort bioclimatic architecture sustainable buildings

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Immunology demystified: A guide for transplant hepatologists

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World Journal of transplantation 2024年第1期14卷 48-61页

作者： Iva Kosuta tomislav Kelava ana Ostojic Vibor sesa Anna Mrzljak Hrvoje lalic Department of Intensive Care Medicine University Hospital Centre ZagrebZagreb 10000Croatia Department of Physiology School of MedicineUniveristy of ZagrebZagreb 10000Croatia laboratory for Molecular Immunology Croatian Institute for Brain ResearchZagreb 10000Croatia Department of Gastroenterology and Hepatology Liver Transplant CenterUniversity Hospital Centre ZagrebZagreb 10000Croatia Department of Medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia Department of Physiology University of Zagreb School of MedicineZagreb 10000Croatia laboratory for Cell Biology Croatian Institute for Brain ResearchUniversity of Zagreb School of MedicineZagreb 10000Croatia Department of laboratory Immunology Clinical Department of Laboratory DiagnosticsUniversity Hospital Center ZagrebZagreb 10000Croatia

liver transplantation has become standard practice for treating end-stage liver *** success of the procedure relies on effective immunosuppressive medications to control the host's immune *** the liver's inherent capacity to foster tolerance,the early post-transplant period is marked by significant immune *** ensure favorable outcomes,it is imperative to identify and manage various rejection types,encompassing t-cell-mediated,antibody-mediated,and chronic ***,the approach to prescribing immunosuppressants relies heavily on clinical judgment rather than evidencebased *** that the majority of patients will require lifelong immunosuppression as the mechanisms underlying operational tolerance are still being investigated,healthcare providers must possess an understanding of immune responses,rejection mechanisms,and the pathways targeted by immunosuppressive *** knowledge enables customization of treatments and improved patient care,even though a consensus on an optimal immunosuppressive regimen remains elusive.

关键词： liver transplantation Allograft rejection Operational immune tolerance Immune reaction Immunosuppression

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Academic stress Assessment Using Virtual Reality as an Educational tool in spine surgery

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Open Journal of Modern Neurosurgery 2024年第2期14卷 114-123页

作者： Diana Chávez lizárraga Jesús Alberto Pérez Contreras Fernando Alvarado Gómez Evelyn Quintero Medina Emmanuel Cantú Chávez Iván Ulises sámano lópez ana sofía Peña Blesa Department of Neurosurgery ángeles Pedregal Ciudad de México México Department of traumatology and Orthopedics Hospital Santa Fe Bogotá Colombia

Introduction: the evaluation of academic stress in medical students and residents is a topic of significant interest, given the considerable challenges they face during their learning process with traditional teaching methods. the use of technologies like virtual reality presents an opportunity to enhance their skills through simulations and training. the main objective of this study is to qualitatively assess the stress levels experienced by medical students and residents by integrating virtual reality into their current learning methods, aiming to improve their ability to manage stressors in their practice. Material and Methods: A questionnaire was conducted with 12 medical students and 12 traumatology and orthopedics residents. the purpose of the questionnaire was to evaluate the levels of academic stress using the sIsCO inventory. the stress levels were calculated by transforming average values into percentages, and the following criteria were assigned: 0 to 33% for Mild stress, 34 to 66% for Moderate stress, and 67 to 100% for Deep stress. then, a virtual reality class focused on spine surgery was provided. Both medical students and residents were trained using the Non Nocere sharpsurgeon software platform and Oculus Quest 2 virtual reality glasses. At the end of the session, a second questionnaire related to the practice with virtual reality was conducted with the same evaluation criteria and a comparative analysis was carried out. Results: 12 undergraduate students from Hospital Angeles Mexico, CDMX and 12 traumatology and orthopedics residents at Hospital santa Fe, Bogota were evaluated. the students in CDMX reported an average qualitative stress of 28.50% during habitual practices, which decreased to an average of 14.67% after virtual reality practice. Residents in Bogotá experienced an average qualitative stress of 30.50% with their current learning methods but this reduced to an average of 13.92% after using virtual reality. these findings indicate that t

关键词： Virtual Reality Academic stress learning strategies spine surgery training

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From strength to precision: A systematic review exploring the clinical utility of 7-tesla magnetic resonance imaging in abdominal imaging

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World Journal of Radiology 2024年第1期16卷 20-31页

作者： Arosh s Perera Molligoda Arachchige ana Claudia teixeira de Castro Gonçalves Ortega Federica Catapano letterio s Politi Michael N Hoff Faculty of Medicine Humanitas UniversityPieve Emanuele 20072MilanItaly Department of Biomedical sciences Humanitas UniversityPieve Emanuele 20072MilanItaly IRCCs Humanitas Research Hospital Rozzano 20089MilanItaly Department of Neuroradiology IRCCS Humanitas Research HospitalRozzano 20089MilanItaly Department of Radiology and Biomedical Imaging University of CaliforniaSan FranciscoCA 94143United States

BACKGROUND After approval for clinical use in 2017 early investigations of ultra-high-field abdominal magnetic resonance imaging(MRI)have demonstrated the feasibility as well as diagnostic capabilities of liver,kidney,and prostate MRI at ***,the elevation of the field strength to 7-tesla not only brought advantages to abdominal MRI but also presented considerable challenges and drawbacks,primarily stemming from heightened artifacts and limitations in specific Absorption Rate,***,evidence in the literature is relatively scarce concerning human studies in comparison to phantom/animal studies which necessitates an investigation into the evidence so far in humans and summarizing all relevant *** to offer a comprehensive overview of current literature on clinical abdominal 7t MRI that emphasizes current trends,details relevant challenges,and provides a concise set of potential *** this systematic review adheres to Preferred Reporting Items for systematic Reviews and Meta-analyses guidelines.A PubMed search,utilizing Medical subject Headings terms such as"7-tesla"and organ-specific terms,was conducted for articles published between January 1,1985,and July 25,*** criteria included studies exploring 7t MRI for imaging human abdominal organs,encompassing various study types(in-vivo/ex-vivo,method development,reviews/meta-analyses).Exclusion criteria involved animal studies and those lacking extractable *** selection involved initial identification via title/abstract,followed by a full-text review by two researchers,with discrepancies resolved through *** extraction covered publication details,study design,population,sample size,7t MRI protocol,image characteristics,endpoints,and *** the systematic review included a total of 21 *** distribution of clinical 7t abdominal imaging studies revealed a predominant focus on the prostate(n=8),followed by the kidney(n=6)and the hepato

关键词： 7-tesla magnetic resonance imaging Abdominal Prostate Kidney Renal Pancreas Hepatobiliary liver small bowel

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Periodontal disease:A silent factor in the development and progression of diabetic retinopathy

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World Journal of Diabetes 2024年第8期15卷 1672-1676页

作者： sarah Monserrat lomelíMartínez Irán Cortés trujillo Melissa Martínez Nieto ana Esther Mercado González Department of Medical and life sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Wellbeing and SustainableCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Antiguo Hospital Civil de Guadalajara“Fray Antonio Alcalde” Guadalajara 44280Mexico

the global increase in the prevalence of type 2 diabetes mellitus(t2DM)and its complications presents significant challenges to public ***,periodontal disease(PD)was recognized as a factor that is likely to influence the progression of t2DM and its complications due to its potential to exacerbate systemic inflammation and oxidative *** this editorial,we comment on the article published by thazhe Poyil et al in the very recent issue of the World Journal of Diabetes in 2024,which investigated the correlation between PD and diabetic retinopathy(DR)in t2DM patients,with emphasis on the association between periodontal swollen surface area,glycated hemoglobin(HbA1c),interleukin-6(Il-6),and lipoprotein(a).the findings by thazhe Poyil et al are significant as they demonstrate a strong link between PD and DR in t2DM *** correlation highlights the importance of addressing periodontal health in diabetes management to potentially reduce the risk and severity of DR,a complication of *** integration of periodontal evaluation and treatment into diabetes care protocols may lead to improved glycemic control and better overall outcomes for t2DM patients.A few studies have established an interconnection between PD and diabetic complication,specifically DR,in t2DM patients,which we aim to highlight in this *** was placed on the different mechanisms that suggest a bidirectional relationship between PD and t2DM,where the presence of periodontal inflammation negatively influenced glycemic control and contributed to the development and progression of DR through shared inflammatory and vascular *** article highlights the importance of collaboration amongst diabetes specialists,ophthalmologists,periodontists,and public health professionals to advance the prevention,early detection,and treatment of PD and *** will improve the health and quality of life of t2DM ***,the editorial highlights the need for further re

关键词： type 2 diabetes mellitus Periodontal disease Periodontitis Diabetic retinopathy Editorial

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Digestive and breast cancer patients managed during the first wave of COVID-19 pandemic:short and middle term outcomes

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World Journal of Methodology 2024年第2期14卷 107-126页

作者： Jacobo trébol ana Carabias-Orgaz María Carmen Esteban-Velasco Asunción García-Plaza Juan Ignacio González-Munoz ana Belén sánchez-Casado Felipe Carlos Parreno-Manchado Marta Eguía-larrea José Antonio Alcázar-Montero Cirugía General y del Aparato Digestivo Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain Cirugía Universidad de SalamancaSalamanca 37007SalamancaSpain Oftalmología Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain

BACKGROUND the first wave of coronavirus disease 2019(COVID-19)pandemic in spain lasted from middle March to the end of June *** population was subjected to lockdown periods and scheduled surgeries were discontinued or reduced during variable *** our centre,we managed patients previously and newly diagnosed with *** established a strategy based on limiting perioperative social contacts,preoperative screening(symptoms and reverse transcriptionpolymerase chain reaction)and creating separated in-hospital COVID-19-free pathways for non-infected *** also adopted some practice modifications(surgery in different facilities,changes in staff and guidelines,using continuously changing personal protective equipment…),that supposed new *** to analyse cancer patients with a decision for surgery managed during the first wave,focalizing on outcomes and pandemic-related *** We prospectively included adults with a confirmed diagnosis of colorectal,oesophago-gastric,liver-pancreatic or breast cancer with a decision for surgery,regardless of whether they ultimately underwent *** analysed short-term outcomes[30-d postoperative morbimortality and severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)infection]and outcomes after 3 years(adjuvant therapies,oncological events,death,sARs-CoV-2 infection and vaccination).We also investigated modifications to usual *** From 96 included patients,seven didn’t receive treatment that period and four never(3 due to COVID-19).Operated patients:28 colon and 21 rectal cancers;laparoscopy 53.6%/90.0%,mortality 3.57%/0%,major complications 7.04%/25.00%,anastomotic leaks 0%/5.00%,3-years disease-free survival(DFs)82.14%/52.4%and overall survival(Os)78.57%/76.2%.six liver metastases and six pancreatic cancers:no mortality,one major complication,three grade A/B liver failures,one bile leak;3-year DFs 0%/33.3%and Os 50.0%/33.3%(liver metastases/pancreatic carcinoma).5 g

关键词： COVID-19 sARs-CoV-2 Colon cancer Rectal cancer Breast cancer liver cancer Pancreatic cancer Gastric cancer Oesophageal cancer surgery

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Development of a warning score for early detection of colorectal anastomotic leakage:Hype or hope?

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World Journal of Gastrointestinal surgery 2022年第11期14卷 1297-1309页

作者： Nuno J G Rama Óscar lourenço Patrícia C motta lima Maria Pedro s Guarino Diana Parente Ricardo Castro ana Bento anabela Rocha Fernando Castro-Poças João Pimentel Division of Colorectal surgical Leiria Hospital CentreLeiria 2410-021Portugal Abel salazar Biomedical Institute University of OportoOporto 4099-002Portugal Center for Innovative Care and Health technology(citechCare) Polytechnic of LeiriaLeiria 2410-541Portugal Faculty of Economics CeBERUniversity of CoimbraCoimbra 3000-137Portugal Division of Clinical Pathology Leiria Hospital CentreLeiria 2410-541Portugal Division of surgical Oporto Hospital CentreOporto 4099-001Portugal Department of Gastroenterology Santo António HospitalPorto Hospital CenterOporto 4099-001Portugal Institute of Biomedical sciences Abel salazar University of OPortoOporto 4099-001Portugal Faculty of Medicine University of CoimbraCoimbra 3004-531Portugal Division of surgical Montes Claros HospitalCoimbra 3030-320Portugal

BACKGROUND Colorectal anastomotic leakage(CAl),a severe postoperative complication,is associated with high morbidity,hospital readmission,and overall healthcare *** detection of CAl remains a challenge in clinical ***,some decision models have been developed to increase the diagnostic accuracy of this *** to develop a score based on easily accessible variables to detect CAl *** Based on the least absolute shrinkage and selection operator method,a predictive classification system was developed[Early ColoRectAl leakage(E-CRAll)score]from a prospective observational,single center cohort,carried out in a colorectal division from a non-academic *** score performance and CAl threshold from postoperative day(POD)3 to POD5 were *** on a precise analytical decision model,the standard clinical practice was compared with the E-CRAll adoption on POD3,POD4,or POD5.A cost-minimization analysis was conducted,on the assumption that all alternatives delivered similar health-related *** In this study,396 patients who underwent colorectal resection surgery with anastomosis,and 6.3%(n=25)developed *** of the patients who developed CAl(n=23;92%)were diagnosed during the first hospital admission,with a median time of diagnosis of 9.0±6.8 *** POD3 to POD5,the area under the receiver operating characteristic curve of the E-CRAll score was 0.82,0.84,and 0.95,*** POD5,if a threshold of 8.29 was chosen,87.4%of anastomotic failures were identified with E-CRAll ***,score usage could anticipate CAl diagnosis in an average of 5.2 d and 4.1 d,if used on POD3 and POD5,*** of score adoption,episode comprehensive costs were markedly greater(up to four times)in patients who developed CAl in comparison with patients who did not develop ***,the use of the E-CRAll warning score was associated with cost savings of€421442.20,with most(92.9%)of the savings from patients

关键词： anastomotic leakage Colorectal surgery Biomarkers score Costs

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Usefulness of serum C-reactive protein and calprotectin for the early detection of colorectal anastomotic leakage:A prospective observational study

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World Journal of Gastroenterology 2022年第24期28卷 2758-2774页

作者： Nuno J G Rama Marlene C C lages Maria Pedro s Guarino Óscar lourenço Patrícia C motta lima Diana Parente Cândida s G silva Ricardo Castro ana Bento anabela Rocha Fernando Castro-Pocas João Pimente Colorectal surgical Division Leiria Hospital CentreLeiria 2410-021Portugal Abel salazar Biomedical Institute(ICBAs) University of OportoOporto 4099-002Portugal Center for Innovative Care and Health technology(citechCare) Polytechnic of LeiriaLeiria 2410-541Portugal Faculty of Economics CeBERUniversity of CoimbraCoimbra 3000-137Portugal Clinical Pathology Division Leiria Hospital CentreLeiria 2410-541Portugal surgical Division Oporto Hospital CentreOporto 4099-001Portugal Department of Gastroenterology Santo António HospitalPorto Hospital CenterPorto 4099-001Portugal Institute of Biomedical sciences Abel salazar University of PortoPorto 4099-001Portugal Faculty of Medicine University of CoimbraCoimbra 3004-531Portugal surgical Division Montes Claros HospitalCoimbra 3030-320Portugal

BACKGROUND Colorectal anastomotic leakage(CAl)is one of the most dreaded complications after colorectal surgery,with an incidence that can be as high as 27%.this event is associated with increased morbidity and mortality;therefore,its early diagnosis is crucial to reduce clinical consequences and *** biomarkers have been suggested as laboratory tools for the diagnosis of *** to assess the usefulness of plasma C-reactive protein(CRP)and calprotectin(ClP)as early predictors of *** A prospective monocentric observational study was conducted including patients who underwent colorectal resection with anastomosis,from March 2017 to August *** were divided into three groups:G1–no complications;G2–complications not related to CAl;and G3–*** biomarkers were measured and analyzed in the first 5 postoperative days(PODs),namely white blood cell(WBC)count,eosinophil cell count(ECC),CRP,ClP,and procalcitonin(PCt).Clinical criteria,such as abdominal pain and clinical condition,were also *** correlation between biomarkers and CAl was *** operating characteristic(ROC)curve analysis was used to compare the accuracy of these biomarkers as predictors of CAl,and the area under the ROC curve(AUROC),specificity,sensitivity,positive predictive value,and negative predictive value(NPV)during this period were *** In total,25 of 396 patients developed CAl(6.3%),and the mean time for this diagnosis was 9.0±6.8 *** operative characteristics,such as surgical approach,blood loss,intraoperative complications,and duration of the procedure,were notably related to the development of *** length of hospital stay was markedly higher in the group that developed CAl compared with the group with complications other than CAl and the group with no complications(median of 21 d vs 13 d and 7 d respectively;Pl pain,the best predictive performance was on POD4 and POD5,with the largest AUROC of 0.84 on ***

关键词： anastomotic leakage Colorectal surgery Biomarkers C-reactive protein Calprotectin

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Biodiversity responses to insular fragmentation in Amazonia: two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： ana Filipa Palmeirim Maíra Benchimol danielle storck-tonon Anderson sBueno Isabel lJones Gilmar Klein Carlos APeres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOlIs Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e sistemas de Produção Agrícola(PPGAsP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams landbridge local extinctions species-area relationships species diversity tropical forests

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long chikungunya?An overview to immunopathology of persistent arthralgia

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World Journal of Virology 2024年第2期13卷 48-57页

作者： Jayme Euclydes Picasky silveira-Freitas Maria luiza Campagnolo Mariana dos santos Cortez Fabrício Freire de Melo ana Carla Zarpelon-schutz Kádima Nayara teixeira Campus toledo Universidade Federal do ParanáToledoParaná85919-899Brazil Instituto Multidisciplinar em saúde Universidade Federal da BahiaCampus Anísio TeixeiraVitória da ConquistaBahia 45029-094Brazil Programa de Pós-graduação em Biotecnologia PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil Programa Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil

Chikungunya fever(CF)is caused by an arbovirus whose manifestations are extremely diverse,and it has evolved with significant severity in recent *** clinical signs triggered by the Chikungunya virus are similar to those of other ***,fever starts abruptly and reaches high levels,followed by severe polyarthralgia and myalgia,as well as an erythematous or petechial maculopapular rash,varying in severity and *** 40%to 60%of affected individuals report persistent arthralgia,which can last from months to *** symptoms of CF mainly represent the tissue tropism of the virus rather than the immunopathogenesis triggered by the host's immune *** main mechanisms associated with arthralgia have been linked to an increase in t helper type 17 cells and a consequent increase in receptor activator of nuclear factor kappa-Βligand and bone *** review suggests that persistent arthralgia results from the presence of viral antigens post-infection and the constant activation of signaling lymphocytic activation molecule family member 7 in synovial macrophages,leading to local infiltration of CD4+t cells,which sustains the inflammatory process in the joints through the secretion of pro-inflammatory *** term"long chikungunya"was used in this review to refer to persistent arthralgia since,due to its manifestation over long periods after the end of the viral infection,this clinical condition seems to be characterized more as a sequel than as a symptom,given that there is no active infection involved.

关键词： Chikungunya Immunopathology Inflammation process Persistent arthralgia signaling lymphocytic activation molecule family member 7

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