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Tibolone Reverses NAFLD in Ovariectomised Rats by Reducing Adiposity and Insulin Resistance

Journal of Pharmacy and Pharmacology 2019年第4期7卷 148-164页

作者： Lilian Brites Campos-Shimada Eduardo Hideo Gilglioni Danielle Aparecida Munhos Hermoso ana julia dos reis buzzo Rosangela Fernandes Garcia Elismari Rizato Martins-Maciel Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria Laboratory of Experimental Steatosis Department of BiochemistryState University of MaringáMaringá87020900Brazil Department of Physiological Sciences State University of MaringáMaringá87020900Brazil Department of Biomedicine Centro Universitario IntegradoCampo Mourao 87300970Brazil

This study aimed to investigate the effects of tibolone,a synthetic steroid,on several metabolic dysfunctions induced by oestrogen deficiency,in ***(OVX)rats were used as animal model of postmenopausal metabolic *** OVX rats were treated with daily doses of tibolone(0.16 mg/kg)and the results were compared with control(sham-operated)and OVX untreated *** reduced the adiposity and the visceral adipocyte size in OVX *** insulin sensitivity was also improved,and a decrease in the activity of the adipose tissue hormone-sensitive lipase enzyme was *** lower lipolysis by visceral adipocytes,associated with the recovery of peroxisomalβ-oxidation by tibolone may have contributed to the reversion of NAFLD in treated OVX *** reduction of liver lipid contents resulted in a general improvement in the liver redox *** addition,tibolone reduced the mitochondrial ROS generation and restored the activity of glucose-6-phosphate *** also exerted antioxidant effects on inguinal adipose *** exerted several beneficial effects on cellular and metabolic dysfunctions induced by ovariectomy in *** important mode of action of tibolone was the reduction of the visceral adipocyte size,corroborating the relationship between this one and the development and progression of several comorbidities associated with metabolic syndrome.

关键词： Tibolone ovariectomy hepatic steatosis obesity oxidativestress

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Prevalence of sarcopenia using different methods in patients with non-alcoholic fatty liver disease

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World Journal of Hepatology 2022年第8期14卷 1643-1651页

作者： Naiade Silveira Almeida Raquel Rocha Claudineia Almeida de Souza ana Carolina Sirelli da Cruz Bruna dos reis Ribeiro Luiza Valois Vieira Carla Daltro Rafael Silva Manoel Sarno Helma Pinchemel Cotrim Programa de Pós-Graduação em Medicina e Saúde Universidade Federal da BahiaSalvador 40110-060BABrazil Departamento de Ciência da Nutrição Escola de NutriçãoUniversidade Federal da BahiaSalvador 40110-060Brazil Caliper Clínica e Escola de Imagem Salvador 41810-012Brazil

BACKGROUND Sarcopenia is a clinical condition associated with several liver diseases and it includes non-alcoholic fatty liver disease(NAFLD)in its broad spectrum as steatosis,steatohepatitis and ***,the criteria to define sarcopenia are diverse,and even those established in consensus have been discussed regarding their performance in making an accurate *** To evaluate the prevalence of sarcopenia,using different methods,in patients with NAFLD,and its association with clinical-anthropometric *** This was an observational study of outpatients with *** was defined by the European Working Group Consensus on Sarcopenia in Older People of 2010(EWGSOP1)and 2018(EWGSOP2).The skeletal muscle index was used to estimate muscle mass,handgrip strength was assessed using the dynamometer and physical performance by walking a distance of four meters at usual walking *** non-invasive fibrosis scores,fibrosis-4(FIB-4)index and Aspartate aminotransferase to platelet ratio index(APRI),were used to assess the absence and presence of *** Fifty-seven individuals with NAFLD were evaluated,the mean age(SD)was 52.7(11.3)years and 75.4%were *** assessed by FIB-4 and APRI was observed in 3.7%and 16.6%of patients with NAFLD,*** diagnosis of sarcopenia was identified only by EWGSOP1 in 3.5%of NAFLD patients,and the prevalence of probable/pre-sarcopenia was higher using the EWGSOP2 consensus at 26.3%,when compared to 1.8%with *** defined by EWGSOP1,was associated with grade I steatosis,but without overweight(P0.05).EWGSOP2 showed a greater number of patients with probable sarcopenia,and who were overweight(12(80.0%)),with a higher degree of steatosis[11(73.3%)and presence of fibrosis(1(6.7%),FIB-4 and 3(20.0%),APRI]compared to EWGSOP1[1(100%),0(0.0%),0(0.0%),FIB-4 and 0(0.0%),APRI,respectively].CONCLUSION The presen

关键词： Non-alcoholic fatty liver disease Sarcopenia Muscle strength Physical performance Liver fibrosis

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Characteristics relating to the interiorization of acquired immunodeficiency syndrome in Brazil: a cross-sectional study

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Infectious Diseases of Poverty 2015年第1期4卷 234-238页

作者： Gabriel de Deus Vieira ana Raquel Paz dos reis Francisco Ormidiel Teles de Alcântara Augusto Karina reis Martins Paulo Roberto Fernes Kern Thairini Fuza de Souza Sérgio de Almeida Basano Luís Marcelo Aranha Camargo Camila Maciel de Sousa Departament of Medicine São Lucas CollegePorto VelhoRondôniaBrazil Tropical Medicine Center of Rondônia Porto VelhoRondôniaBrazil Institute of Biomedical Sciences 5 University of São PauloMonte NegroRondôniaBrazil

Background:In recent years there has been changes in the social and geographic profile of acquired immunodeficiency syndrome(AIDS).The aim of this study was to evaluate the internalization of AIDS in the state of Rondônia,***:In Rondônia,1473 AIDS cases were reported,with an average annual incidence of 15.8/100,000 persons(42.7%women).The most common mode of viral transmission was sexual(96.5%),and the majority of the individuals had not completed their primary education(64.8%).There was heterogeneity in relation to case distribution,involving almost all of the municipalities in the *** average annual mortality rate was 2.5/100,000 ***:Rondônia has a higher incidence of AIDS than the national average and the northern *** to provide access to treatment and follow-up of these individuals should be implemented,prioritizing areas where the incidence is higher and decentralizing the treatment of patients with AIDS in the state.

关键词： Epidemiology Aids Residence characteristics Amazo

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NATURAL AND ANTHROPOGENIC FACTORS CONTROLLING GULLY EROSION IN THEBASALTIC UPLAND OF SOUTHERN BRAZIL

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International Journal of Sediment Research 2005年第3期20卷 57-69页

作者： ana C. VIERO,Nilza M. dos reis CASTRO ,Joel A. GOLDENFUM ,Alfonso RISSO CPRM-Geological Survey of Brazil Rua Banco da Provincia 105 Porto Alegre RS 840-030 Brazil

This paper describes an analysis of natural and anthropogenic factors controlling the evolution of gullies in a rural basin in the basaltic upland in the State of Rio Grande do Sul, Southern Brazil. In this region of deep ferrallitic soils with more than 60% clay, runoff and erosion are of increasing concern. In the Tabo?o drainage basin (100 km2), gully erosion was studied in a field survey that measured rills and gullies. Eighty-four gullies were identified. They had an average length of 136 m, were 10 m wide, and 3 m deep and had a volume of 15.458 m3. Each gully was characterised in terms of factors that included slope, geological structure, presence of piping, drainage, soil use, and the presence of surface and subsurface flow. On average, the main channels had knickpoints varying from 2 m to 7 m, and their evolution in the vertical plane increased until bed-rock basalt material was reached, after which gullies increase in width and length. Gully development was also monitored from 1991 to 2003. Subsurface flow appears to be the principal agent controlling their development. Results show that both natural (slope, surface curvature, geological structure and rainfall) and anthropogenic (soil use, road construction) factors are important in gully development. The change in cultural practices throughout the drainage basin from conventional to direct seeding has led to increased subsurface flow, which was more important than surface runoff in causing erosion. However, the higher rainfall during El Ni?o Southern Oscillation (ENSO) events and the consequently higher subsurface flow were the dominant factors. From 1991 to 2003 a total land loss of 1,013 m3 was observed in one gully, with 236 m3 lost during the 1992 ENSO and 702 m3 during the 1997 ENSO; 95% of the total volume lost occurred during ENSO periods.

关键词： Gully Geological structure Subsurface flow No-tillage ENSO

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Cochlear Implant in a Patient with Arnold-Chiari Syndrome

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Case Reports in Clinical Medicine 2018年第2期7卷 162-167页

作者： Maria Stella Arantes do Amaral Daniela Soares Fonseca Antonio Carlos dos Santos Henrique Furlan Pauna Eduardo T. Massuda ana Cláudia Mirandola Barbosa reis Miguel Angelo Hyppolito Department of Ophthalmology Otorhinolaryngology Head and Neck Surgery Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Postgraduate Program in Oftalmology Otorrhinolaryngology and Head and Neck Surgery of the FMRP/USP-Medical Sciences Department of Ophthalmology Otorhinolaryngology Head and Neck Surgery Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Department of Clinical Medicine (Center of Image Sciences and Medical Physics) Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil Department of Health Sciences RCS—Ribeir&#227 o Preto Medical School University of S&#227 o Paulo S&#227 o Paulo Brazil

Objective: To verify the efficacy of cochlear implantation in a patient with Arnold-Chiari syndrome. Design: Review of a medical chart from a patient with Arnold-Chiari syndrome that underwent to cochlear implant surgery. Case report: A 6 year-old female, with meningomyelocele and congenital hydrocephalus, deaf in the past 3 years, after meningitis. At that time, she used oral language with adequate speech development. Tone audiometry revealed bilateral profound sensorineural hearing loss. The MRI was compatible with the Arnold-Chiari syndrome. Cochlear implantation was performed on the left ear with MED-EL? Implant (model SONATATi100). Currently, the child is 12 year-old, performs speech therapy three times a week, with good hearing and language development. Conclusion: Despite the presence of Arnold-Chiari syndrome (Chiari type II) with neurological disorders and with ventriculoperitoneal shunt, patient had good hearing results after cochlear implant surgery.

关键词： Audiometry Cochlear Implant Sensorineural Hearing Loss Arnold-Chiari Syndrome Deafness Central Nervous System Malformation

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Demographic Expansion and Contraction in a Neotropical Fish during the Late Pleistocene-Holocene

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Open Journal of Statistics 2019年第4期9卷 470-483页

作者： Carolina L. N. Costa S. Ivan Perez José Louvise Carlos H. Tonhatti Rute B. G. Clemente-Carvalho ana C. Petry S. F. dos reis Programa de Pós-Graduacao em Ecologia Universidade Estadual de Campinas Sao Paulo Brazil División Antropología Facultad de Ciencias Naturales y Museo Universidad Nacional de La Plata CONICET La Plata Argentina Faculdade do Vale do Jaguaribe Ceará Brazil Programa de Pós-Graduacao em Genética Universidade Estadual de Campinas Sao Paulo Brazil Deparment of Biology Queen’s University Ontario Canada Núcleo em Ecologia e Desenvolvimento Sócio-Ambiental de Macaé Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Departamento de Biologia Animal Universidade Estadual de Campinas Sao Paulo Brazil

Demographic changes during the late Pleistocene-Holocene left signatures in the DNA of contemporary populations. These signatures reveal demographic phenomena like the increase or decrease in effective population size. In this paper we searched for signatures of demographic change in the DNA of the Neotropical freshwater fish Poecilia vivipara. Also, we investigated whether demographic changes are correlated with palaeoclimatic events of the late Pleistocene-Holocene, in particular, if changes in effective population size are correlated with expansion and contraction of available habitats, induced by global ice-volume changes and sea-level fluctuations. We used Bayesian Skyline Plot (BSP) analysis with sequences from the mitochondrial gene cytochrome b to estimate the ancestral demography of the Neotropical freshwater fish P. vivipara. To test the assumptions of neutrality and absence of population structure we used Tajima’s D and Spatial analysis of Molecular Variance (SAMOVA), respectively. Effective population size of P. vivipara remained stable until 75,000 years ago, increased by 10-fold reaching a maximum at approximately 25,000 years ago, then suddenly declined at the Pleistocene-Holocene boundary. Variation in effective population size in P. vivipara correlates with expansion and contraction of habitats induced by sea-level fluctuations, caused by the advance and retreat of ice sheets during the Last Glacial Maximum (LGM).

关键词： Ancestral Population Dynamics Coalescence Bayesian Skyline Plot Mitochondrial DNA Last Glacial Maximum

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Biomedical Perspectives About Women with Chronic Pelvic Pain:A Qualitative analysis

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International Journal of Clinical Medicine 2012年第5期3卷 411-418页

作者： Paula P.Souza Adriana P.M.S.Romao ana Marcia S.Nakano Julio C.Rosa-e-Silva Francisco J.Candido-dos-reis Antonio A.Nogueira Omero B.Poli-Neto Department of Gynaecology and Obstetrics School of Medicine University HospitalUniversity of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil Department of Public Health School of NursingUniversity of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil School of Medicine University Hospital University of Sao Paulo at Ribeirao PretoRibeirao PretoBrazil

Because the aetiology of chronic pelvic pain is complex, studies of the condition involve extensive investigation but provide few conclusions. Numerous studies have addressed the experiences of women with chronic pelvic pain, as well as the interaction between those women and their health care providers. Our objective was to investigate how physicians at a specialised clinic perceive the medical care provided to such women. This was a qualitative study employing semi-structured interviews and content analysis. We interviewed seven physicians at the Chronic Pelvic Pain Outpatient Clinic of the University Hospital, Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, Brazil. Medical training and practice constituted the central theme of the study, which was subdivided into categories addressing the influence that the current medical training has on the type of medical care provided to women with chronic pelvic pain. Medical practice has been characterised by a reductionist approach to health and illness, as well as by the fragmentation of health care. These characteristics are, to a certain extent, the result of the biomedical model of education, which has been predominant, ignoring social, cultural, psychological and emotional aspects. There is a need to shift the medical paradigms toward a humanistic model of health care. We hope that we have provided a critical view of current medical training and practice, as well as of their effects in various health care settings, particularly in the provision of care to women with chronic pelvic pain.

关键词： Chronic Pelvic Pain Biomedical Model Qualitative Research

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Tomatoes Maturation analysis with Reflectance Spectral Images

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Journal of Agricultural Science and Technology(B) 2017年第6期7卷 426-431页

作者： julia Lopes Governici Rodrigo Magalhaes Faria Rodolpho Cesar dos reis Tinini Barbara Janet Teruel Mederos Department of Agricultural Engineering Federal University of Vifosa Vifosa Minas Gerais 36570-000 Brazil Department of Plant Science Federal University of Vigosa Vicosa Minas Gerais 36570-000 Brazil Agricultural Sciences Institute Federal University of Minas Gerais Montes Claros Minas Gerais 39404-547 Brazil College of Agricultural Engineering The State University of Campinas Campinas Sao Paulo 13083-875 Brazil

The demands for high quality products are increasing in the market, so several tests are performed. These analyses are destructive, time consuming and sometimes expensive. The spectral imaging technique is an alternative that can reduce costs and time and increase the efficiency and cost-effectiveness of these analyses. In this context, the aim of this study was to verify the spectral behavior of the tomato in function of the maturation and its potential use for non-destructive evaluation of food quality. Eighty tomatoes of the Italian group were selected in four stages of maturation (green, pink, light red and red). Images were collected in wavelengths 480 nm to 710 nm (every 10 nm). After the images were collected, the fruits were submitted to the physical-chemical analyses. The following parameters were analyzed: color, color index (CI), pH, soluble solids (SS), total titratable acidity (TTA) and ratio (SS/TTA). After characterization the mean spectrum was obtained by the extraction of the spectral characteristics. It was observed that the spectral behavior was the same for all stages of maturation. It was possible to differentiate the green tomatoes in the wavelengths from 520 nm to 560 nm and from 610 nm to 660 nm. These intervals represent the area of reflection of chlorophyll and lycopene, respectively. Near the wavelength 560 nm, the highest absorbance was recorded by ripe tomatoes due to the concentration of lycopene. It is concluded that the best wavelengths for analysis are those in which green has the highest reflectance and it is possible to apply this technique for non-destructive analysis of the maturation of tomatoes.

关键词：光谱特征西红柿成熟图象反射成像技术非破坏性食物质量

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Pressure Ulcers in Institutionalized Elderly People:Association of Sociodemographic and Clinical Characteristics and Risk Factors

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Open Journal of Nursing 2017年第1期7卷 111-122页

作者： Suellen Duarte de Oliveira Matos Iraktania Vitorino Diniz Adriana Lira Rufino de Lucena Smalyanna Sgren da Costa Andrade Karen Krystine Goncalves de Brito Elizabeth Souza Silva de Aguiar Emanuelle Malzac Freire de Santana Mailson Marques de Sousa ana Paula Marques Andrade de Souza Hemílio Fernandes Campos Coelho Mirian Alves da Silva Marta Miriam Lopes Costa Maria julia Guimaraes Oliveira Soares Simone Helena dos Santos Oliveira Graduate Program in Nursing Universidade Federal da ParaíbaJoao PessoaBrazil Departament of Statistics Universidade Federal da ParaíbaParaíbaBrazil

Objective: To evaluate the association of socio-demographic and clinical characteristics, and risk factors with occurrence of pressure ulcers in institutionalized elderly people. Method: This cross-sectional, analytical study, in quantitative approach, performed from the database analysis linked to the project “Pressure Ulcer in institutionalized elderly people: Association of incidence with the risk factors to functional and nutritional assessment” developed in six long-stay institutions for the elderly people in João Pessoa. Data were analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0. Associations were made through chi square test and Odds Ratio. Results: The clinical conditions of significant associations with the occurrence of pressure ulcers were the variables neurological disorders (p = 0.011) and visual impairment (p = 0.005). As for risk factors, the most important was fecal incontinence (p Conclusion: The analysis of the associations pointed out problems that require intervention in order to prevent health implications of the elderly people and to minimize the risk and occurrence of this injury.

关键词： Elderly People Institutions for the Elderly People Pressure Ulcer Health Profile Risk Factors

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Transcranial direct current electrical stimulation in combination with aerobic exercise:A pilot study in post-COVID-19 systemic autoimmune rheumatic patients

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World Journal of Rheumatology 2023年第1期11卷 1-12页

作者： Rafael Giovani Missé Alexandre Moura dos Santos Isabela Bruna Pires Borges Marlise Sítima Mendes Simões Lorenza Rosa Silvério Bruna Lindoso Correia ana Wook Sook Kim Aline Marques Caetano Sandra Gofinet Pasoto Carla Gonçalves Schahin Saad Diogo Souza Domiciano Clarice Tanaka julia Maria D’Andrea Greve Abrahão Fontes Baptista Samuel Katsuyuki Shinjo Division of Rheumatology Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Departamento de Fisioterapia Fonoaudiologia e Terapia OcupacionalHospital das Clínicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloNúcleo de Assistência e Pesquisa em NeuromodulaçãoSao PauloBrazil Laboratório de Estudos do Movimento Instituto de Ortopedia e TraumatologiaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil

BACKGROUND Systemic autoimmune rheumatic diseases(SARDs)are a group of diseases with multiorgan involvement and a high prevalence of chronic pain and *** with SARDs and post-coronavirus disease 2019(COVID-19)syndrome experience aggravation of *** this context,it is essential to establish strategies to reduce chronic pain and fatigue and improve quality of *** To assess the efficacy of transcranial direct current stimulation(tDCS)for the treatment of fatigue and pain-associated post-COVID-19 syndrome in patients with *** This study included nine patients with different types of *** patients had reverse transcription-polymerase chain reaction(RT-PCR)test confirmed COVID-19 as well as significant,persistent fatigue and pain that began to worsen after *** tDCS was administered in five daily sessions(2mA,20 min).Concomitantly,patients were involved in aerobic exercise *** participants were evaluated using specific questionnaires and strength assessment by handgrip and physical function by timed-up-and-go test and sit-to-stand test at baseline(within one week before tDCS protocol),and one week after tDCS *** all procedures,the patients’treatments remained *** The sample comprised eight women and one man with a mean age of 48.7±9.6 *** the tDCS protocol,pain and fatigue significantly improved on the visual analog scale(P<0.05).The physical function also improved 9.5±2.7 vs 6.8±0.8(P=0.001)for timed-up-go-test and 10.3±3.7 vs 15.1±4.0(P=0.037)for sit-to-stand *** of the patients experienced any adverse *** The present study showed that tDCS in combination with aerobic exercise was effective in improving physical function,and reducing fatigue/pain in SARDs patients with post-COVID-19 syndrome.

关键词： Autoimmune diseases COVID-19 Fatigue Neuromodulation Physical function Rheumatic diseases Pain

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