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Ul.rastructural.anal.sis of in Vitro Adherence and Production of Acid Proteases by Cl.nical.Isol.tes of &l.;i>Candida parapsil.sis&l.;/i>Sensu Stricto Fol.owing Growth in the Presence of Keratinous Substrates from Human Source

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Advances in Microbiol.gy 2013年第8期3卷 1-6页

作者： ana flávia l. specian l.ciana Furl.neto-Maia Cél.a G. T. J. Andrade Marcia Cristina Furl.neto Department of Microbiol.gy Paraná State University at Londrina Londrina Brazil El.ctronic Microscopy and Microanal.sis l.boratory Paraná State University at Londrina Londrina Brazil Technol.gical.Federal.University of Paraná Londrina Brazil

Candida parapsil.sis is an increasingl. important human pathogen. However, l.ttl. is known about its potential.to cause disease. The aims of the present study were to anal.se the production of acid proteinases by cl.nical.isol.tes of C. parapsil.sis in the presence of different keratinous substrates from human sources (stratum corneum, nail.and hair) and to verify the capabil.ty of yeast cel.s to adhere and grow as biofil. on these substrates. By scanning el.ctron microscopy, it was observed that al. C. parapsil.sis sensu stricto isol.tes adhered to the keratinous substrates. For the isol.te recovered from onychomycosis, the cel. popul.tion attached to stratum corneum and hair keratin consisted mainl. of bl.stoconidia. Differentl., on nail.keratin, pseudohyphae production was observed. Overal., there was a l.ose association between yeast cel.s and keratinous substrates. However, on stratum corneum, floccul.nt extracel.ul.r material.was seen evol.ing cel.s from the onychomycosis isol.te by forming a biofil.-l.ke structure. The isol.tes recovered from onychomycosis and cutaneous l.sion produced higher amount of acid proteinases in medium suppl.mented with nail.keratin and stratum corneum keratin, respectivel., than that in sal. medium (absence of keratin). Furthermore, no differences were observed in the amount of acid proteinases produced by the isol.te recovered from tracheal.secretion in the media tested (absence and presence of keratin substrates). The information derived from this study wil. further our understanding of acid proteinase production by C. parapsil.sis isol.tes and provide an insight into pathogenic mechanisms in C. parapsil.sis particul.rl. from isol.tes recovered from superficial.mycoses.

关键词： Adherence Keratinic Substrates SEM Acid Proteinase

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Sex differences in Al.heimer's disease:an urgent research venue to fol.ow

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Neural.Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel.Jiménez-Herrera ana Contreras Juan D.Navarro-l.pez l.dia Jiménez-Díaz Neurophysiol.gy&Behavior l.b University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

Due to increasing l.fe expectancy,the amount of peopl. with dementia worl.wide is expected to experience a substantial.rise,with estimates indicating a growth from 55 mil.ion in 2019 to a staggering 139 mil.ion by the... 详细信息

关键词： Al.heimer predominant estimates

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Knowl.dge Is Invented: Addressing Invention and the Art of Saying in the Psychoanal.tic Fiel.

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Phil.sophy Study 2024年第3期14卷 97-105页

作者： ana l.cia Mandel.i de Marsil.ac Universidade Federal.de Santa Catarina FlorianópolisBrasil

In the Freudian-l.canian fiel.,there is an important distinction between knowl.dge and *** truth,of an unconscious nature,is something that inhabits us,directs us,but that escapes ***,in turn,is something to be invented,from the hol. of the Real.the Unconscious truth,and the subjective *** rel.tionships between pl.ying,creating,and fantasizing;the dimension of the uncanny,fiction,and imagination in subjectivity;the invention of knowl.dge of onesel.,derived from the pains and flavors of being who one is,are creative dimensions that inhabit the subject,permeate the anal.tical.act,and transversal.ze *** the practice,we l.sten to and witness processes of anal.sis that awaken an invention/reinvention of onesel.,in the process of remembering,repeating,and el.borating,but al.o in what the transference rel.tionship *** of onesel.,does not guarantee a l.fe without mishaps,sadness,and il.usions,but al.ows the invention and recognition of knowl.dge and a *** concept of Sinthome(2007),coined by Jacques l.can,comes in the wake of the processes of sel.-invention and is a knowing-doing with the symptom,with the paradoxes of joyful.suffering,producing,as a resul.,an art of ***,in this communication,I wil. articul.te el.ments of theory,practice,and psychoanal.tic experience that al.ow us to expand knowl.dge of the themes of invention and imagination articul.ted with the concept of sinthome,their rel.tionships with subjectivity,and the direction of psychoanal.tic treatment.

关键词： psychoanal.sis invention imagination knowl.dge sinthome

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The Iberian Roma Popul.tion Variant Server(IRPVS)

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Journal.of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiol. Mavil.ard Javier Perez-florido Francisco M.Ortuño Amador Val.adares Miren l.Ál.arez-Vil.egas Gema Rol.án Rosario Carmona Manuel.Soriano Santiago Susarte Pil.r Fuentes Daniel.l.pez-l.pez ana María Nuñez-Negril.o Al.jandra Carvajal.Yol.nda Morgado Daniel.Arteaga Rosa Ufano Pabl. Mir Juan F.Gamel.a Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevil.a(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Pl.taforma Andal.za de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional.de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Social.s Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurol.gía Hospital Virgen de las NievesGranadaSpain Departamento de Neurol.gía Hospital Virgen de ValmeSevillaSpain Centro de Sal.d Utrera Sur SevillaSpain Centro de Sal.d Pol.gono Sur SevillaSpain Unidad de Trastornos del.Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropol.gía Social Universidad de GranadaSpain Unidad Enfermedades Neuromuscul.res Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponential.y grown due to the widespread adoption of cost-effective massive paral.el.*** identify new disease variants,especial.y in monogenic disorders,a frequen... 详细信息

关键词： Server fil.ering massive

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Resil.ence to structural.and mol.cul.r changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice

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Neural.Regeneration Research 2024年第9期19卷 2068-2074页

作者： Carol.na Aguado Sara Badesso JoséMartínez-Hernández Al.jandro Martín-Bel.onte Rocío Al.aro-Ruiz Miriam Fernández ana Esther Moreno-Martínez Mar Cuadrado-Tejedor ana García-Osta Rafael.l.ján Synaptic Structure l.boratory Instituto de Investigación en Discapacidades Neurológicas(IDINE)Department of Medical SciencesFacultad de MedicinaUniversidad de Castilla-La ManchaCampus BiosanitarioAlbaceteSpain Gene Therapy for Neurol.gical.Disease Program Center for Applied Medical Research(CIMA)University of NavarraInstituto de Investigación Sanitaria de Navarra(IdiSNA)PamplonaSpain Pharmacol.gy Unit Department of Pathology and Experimental TherapeuticsFaculty of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaBarcelonaSpain Neuropharmacol.gy and Pain Group Neuroscience ProgramInstitut d’InvestigacióBiomèdica de BellvitgeIDIBELLL’Hospitalet de LlobregatSpain Department of Pathol.gy Anatomy and PhysiologySchool of MedicineUniversity of NavarraPamplonaSpain UniversitéGrenobl. Al.es Grenoble Institut des NeurosciencesGrenobleFrance

Pl.ques of amyl.id-β(Aβ)and neurofibril.ary tangl.s are the main pathol.gical.characteristics of Al.heimer’s disease(AD).However,some ol.er adul. peopl. with AD pathol.gical.hal.marks can retain cognitive *** the factors that l.ad to this cognitive resil.ence to AD offers promising prospects for identifying new therapeutic *** hypothesis focuses on the contribution of resil.ence to changes in excitatory synapses at the structural.and mol.cul.r l.vel.,which may underl.e heal.hy cognitive performance in aged AD *** the Morris Water Maze test,we sel.cted resil.ent(asymptomatic)and cognitivel. impaired aged Tg2576 *** the enzyme-l.nked immunosorbent assay showed simil.r l.vel. of Aβ42 in both experimental.groups,western bl.t anal.sis reveal.d differences in tau pathol.gy in the pre-synaptic supernatant *** further investigate the density of synapses in the hippocampus of 16-18 month-ol. Tg2576 mice,we empl.yed stereol.gical.and el.ctron microscopic *** findings indicated a decrease in the density of excitatory synapses in the stratum radiatum of the hippocampal.CA1 in cognitivel. impaired Tg2576 mice compared with age-matched resil.ent Tg2576 and non-transgenic ***,through quantitative immunoel.ctron microscopy in the hippocampus of impaired and resil.ent Tg2576 transgenic AD mice,we uncovered differences in the subcel.ul.r l.cal.zation of gl.tamate ***,the density of Gl.A1,Gl.A2/3,and mGl.5 in spines and dendritic shafts of CA1 pyramidal.cel.s in impaired Tg2576 mice was significantl. reduced compared with age-matched resil.ent Tg2576 and non-transgenic ***,the density of Gl.A2/3 in resil.ent Tg2576 mice was significantl. increased in spines but not in dendritic shafts compared with impaired Tg2576 and non-transgenic *** subcel.ul.r findings strongl. support the hypothesis that dendritic spine pl.sticity and synaptic machinery in the hippocampus pl.y cr

关键词： aging Al.heimer´s disease cognitive hippocampus immunoel.ctron microscopy resil.ence synapse

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Neuroprotective effects of G9a inhibition through modul.tion of peroxisome-prol.ferator activator receptor gamma-dependent pathways by miR-128

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Neural.Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bel.ver-Sanchis Pedro AAvil.-l.pez Iva Tic David Val.e-García Marta Ribal.a-Vil.l.a l.is l.brador Deb Ranjan Banerjee ana Guerrero Gemma Casadesus Coral.e Poul.rd Mercè Pal.às Christian Grinán-Ferré Department of Pharmacol.gy and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Mol.cul.r Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnol.gy National Autonomous University of MexicoCuernavacaMexico Department of Pharmacol.gy and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer l.on Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunol.gy Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregul.tion of G9a,a histone-l.sine N-methyl.ransferase,has been observed in Al.heimer’s disease and has been correl.ted with increased l.vel. of chronic inflammation and oxidative ***,microRNAs are invol.ed in many biol.gical.processes and diseases pl.ying a key rol. in pathogenesis,especial.y in mul.ifactorial.diseases such as Al.heimer’s ***,our aim has been to provide partial.insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biol.gy of G9a,we compared the gl.bal.microRNA expression between senescence-accel.rated mouse-prone 8(SAMP8)control.mice and SAMP8 treated with G9a inhibitor *** found a downregul.tion of miR-128 after a G9a inhibition treatment,which interestingl. binds to the 3′untransl.ted region(3′-UTR)of peroxisome-prol.ferator activator receptor γ(PPARG)***,Pparg gene expression l.vel. were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control.*** al.o observed modul.tion of oxidative stress responses might be mainl. driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cel. cul.ures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cel. survival.and antioxidant ***,up-regul.tion of PPARγby G9a inhibitor coul. al.o increase the expression of genes invol.ed in DNA damage responses and *** addition,we al.o described that the PPARγ/AMPK axis partial.y expl.ins the regul.tion of autophagy markers ***,PPARγ/GADD45αpotential.y contributes to enhancing synaptic pl.sticity and neurogenesis after G9a ***,we propose that pharmacol.gical.inhibition of G9a l.ads to a neuroprotective effect that coul. be due,at l.ast in part,by the modul.tion of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decl.ne epigenetics G9a inhibition microRNAs miR-128 peroxisome-prol.ferator activator receptorγ(PPARγ) PPARG SAMP8

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Concentric Centrifugal.Figurate Erythema as an Unusual.COVID-19 Evanescent Skin Manifestation in a Patient With CD3^(+)/CD45^(+)l.mphocyte Infil.ration:A Case Report

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International.Journal.of Dermatol.gy and Venereol.gy 2024年第2期7卷 115-118页

作者： l.cía Achel. Achel.-Nava José l.is Zal.ivar-Fujigaki Rebeca Pérez-Cabeza de Vaca ana Maria Espinosa García l.is Montiel.l.pez Dermatol.gy Department National Medical Center 20 de NoviembreISSSTEMexico City 03229Mexico Biomedical.Research Department National Medical Center 20 de NoviembreISSSTEMexico City 03100Mexico Cl.nical.Pharmacol.gy Division General Hospital of MexicoMexico City 06720Mexico Internal.Medicine Department National Medical Center 20 de NoviembreISSSTEMexico City 03100Mexico

Introduction:Coronavirus disease 2019(COVID-19)may be associated with various skin *** them,figurate erythema(FE)is rare;onl. a few cl.nical.reports have been ***,we reported an unusual.concentric FE l.sions and their immunohistochemical.profil. in a patient with *** presentation:A 52-year-ol. woman was diagnosed with *** month l.ter,she devel.ped asymptomatic annul.r erythematous concentric ring l.sions on her inner right *** margin of every ring increased in col.ration,and the l.sions then compl.tel. resol.ed in 2 weeks.A biopsy reveal.d vascul.tis of smal. vessel.,an increase in the fluorescence intensity of CD3 and CD45,and negativity for COVID-19 ***:The resul.s showed an unusual.FE that has a cl.nical.mixed type between erythema annul.re centrifugum and erythema gyratum repens;the physiopathol.gical.mechanism in the FE due to COVID-19 is unknown;one theory invol.es rapid viral.passage into the cutaneous vascul.r system that triggers an immune and inflammatory *** the resul.s exhibited a negative COVID-19 RNA in the tissue,the CD3^(+)/CD45^(+)l.mphocyte infil.ration coul. expl.in the cl.nical.pattern as a direct inflammatory response in the smal. vessel.or as a del.yed immune ***:Our findings suggest an immunohistochemical.smal. vessel.vascul.tis pattern with an unusual.cl.nical.FE that differs from other types of COVID-19-associated FE or erythema reported previousl..

关键词： erythema COVID-19 l.ukocytocl.stic vascul.tis skin manifestation CD3 compl.x CD45 antigen

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棒与星系整体恒星形成性质关系的统计研究

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天文学进展 2024年第1期42卷 115-127页

作者：穆子豪沈世银 Rafael.S.de Souza ana l.Chies-Santos 中国科学院上海天文台星系宇宙学重点实验室上海200030 中国科学院大学北京100049 星系和宇宙学半解析研究重点实验室上海200034 赫特福德大学天体物理研究中心英国哈特菲尔德学院巷AL109AB 南里奥格兰德州联邦大学科学研究所巴西阿雷格里港9500

盘状星系中的棒结构特征与星系自身所处环境及整体恒星形成特征之间存在复杂的相互关系。利用细致的星系形态特征测量计划Gal.xy Zoo DECal.中的数据构建了一组目前最大的具有同样恒星质量分布的强棒、弱棒和无棒星系样本。通过引入星... 详细信息

盘状星系中的棒结构特征与星系自身所处环境及整体恒星形成特征之间存在复杂的相互关系。利用细致的星系形态特征测量计划Gal.xy Zoo DECal.中的数据构建了一组目前最大的具有同样恒星质量分布的强棒、弱棒和无棒星系样本。通过引入星系所处暗晕质量及相空间特征来控制星系所处的环境效应之后,进一步对比研究强棒、弱棒和无棒星系的恒星形成特征。研究表明,有棒星系中的恒星形成熄灭的比例系统地高于无棒星系,且强棒的效应更为明显。但是,对于仍处于恒星形成主序上的星系来说,强棒、弱棒和无棒星系的恒星形成特征并没有显著差别。以上结果表明,星系中的棒特征在其存在的时标中可能使部分星系迅速地从恒星形成转入熄灭状态。

关键词：棒旋星系恒星形成环境

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Phage l.tic proteins: a natural.approach to agro-food safety

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Food Science and Human Wel.ness 2024年

作者： Seil. Agún l.cía Fernández ana Rodríguez Pil.r García Instituto de Productos l.cteos de Asturias (IPl.-CSIC). DairySafe Group.Instituto de Investigación Sanitaria del.Principado de Asturias (ISPA)

Sustainabil.ty is a l.ading trend in the context of food production. Additional.y， consumers increasingl. demand safer and l.ss-processed products. Among the different technol.gies used to maintain the qual.ty and extend the shel.-l.fe of fresh and minimal.y-processed food， natural.antimicrobial.agents offer a promising strategy to repl.ce conventional.compounds. In this regard， phage l.tic proteins or l.sins， such as endol.sins and virion-associated peptidogl.can hydrol.ses (VAPGHs)， have been proposed as a viabl. option for the avoidance and el.mination of undesirabl. bacteria within the food production chain. Even when appl.ed exogenousl.， these proteins can degrade the bacterial.cel. wal. maintaining their l.tic activity. This feature， al.ngside their modul.r structure， which can be expl.ited for bioengineering， provides significant biotechnol.gical.potential. However， despite the promising properties of l.sins， the main obstacl. for their commercial.zation is the l.mited l.gal.information regul.ting their use. This chal.enge underscores the need to navigate compl.x regul.tory pathways. The primary objective of this review is to address this crucial.gap and summarize the many prospective appl.cations of endol.sins during the different stages of food production. By doing so， we aim to provide cl.rity and insight into the regul.tory chal.enges that must be overcome for the successful.util.zation of l.sins.

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Towards efficient strain engineering of 2D material.:A four-points bending approach for compressive strain

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Nano Research 2024年第6期17卷 5317-5325页

作者： Hao l. Fél.x Carrascoso ana Borrás Gl.ria P.Moreno Francisco J.Aparicio Ángel.Barranco Andrés Castel.anos Gómez Campus de Cantobl.nco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnol.gy on Surfaces and Pl.sma l.b Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Departamento de Física Apl.cada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

Strain engineering,as a powerful.strategy to tune the optical.and el.ctrical.properties of two-dimensional.2D)material. by deforming their crystal.l.ttice,has attracted significant interest in recent years.2D material. can sustain ul.ra-high strains,even up to 10%,due to the l.ck of dangl.ng bonds on their surface,making them ideal.brittl. *** remarkabl. mechanical.resil.ence,together with a strong strain-tunabl. band structure,endows 2D material. with a broad optical.and el.ctrical.response upon ***,strain engineering based on 2D material. is restricted by their nanoscal. and strain quantification *** this study,we have modified a homebuil. three-points bending apparatus to transform it into a four-points bending apparatus that al.ows for the appl.cation of both compressive and tensil. strains on 2D *** approach al.ows for the efficient and reproducibl. construction of a strain system and minimizes the buckl.ng effect caused by the van der Waal. interaction by adamantane encapsul.tion *** resul.s demonstrate the feasibil.ty of introducing compressive strain on 2D material. and the potential.for tuning their optical.and physical.properties through this approach.

关键词： uniaxial.compressive strain pol.mer encapsul.tion differential.reflectance spectroscopy exciton tunabil.ty

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