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Journal of Materials Science & Technology 2015年第8期31卷 806-814页

作者： A.Barroso-Bogeat M.Alexandre-franco c.Fernndez-Gonzlez V.Gómez-Serrano Department of Organic and Inorganic chemistry Faculty of SciencesUniversity of Extremadura

In catalysis processes, activated carbon （Ac） and metal oxides （MOs） are widely used either as catalysts or as catalyst supports because of their unique properties. A combination of Ac and MO nanoparticles in a single hybrid material usually entails both chemical and microstructural changes, which may largely influence the potential catalytic suitability and performance of the resulting product. Here, the prepa- ration of a wide series of Ac-MO hybrid catalysts is studied. Three series of such catalysts are prepared by support first of MO （Al2O3, Fe2O3, SnO2, TiO2, WO3, and ZnO） precursors on a granular Ac by wet impregnation and oven-drying at 120 ℃, and by subsequent heat treatment at 200 or 850℃ in inert atmosphere. Both the chemical composition and microstructure are mainly investigated by powder X-ray diffraction. Yield and ash content are often strongly dependent on the MO precursor and heat treatment temperature, in particular for the Sn catalysts. With the temperature rise, trends are towards the transformation of metal hydroxides into metal oxides, crystallinity improvement, and occurrence of drastic composition changes, ultimately leading to the formation of metals in elemental state and even metal carbides. Reaction paths during the preparation are explored for various hybrid catalysts and new insights into them are provided.

关键词： Activated carbon Metal oxides Hybrid catalysts Preparation Microstructural characterization X-ray diffraction

Elevated nitric oxide and 3',5' cyclic guanosine monophosphate levels in patients with alcoholic cirrhosis

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World Journal of Gastroenterology 2008年第2期14卷 236-242页

作者： cíntia Siqueira Miguel carneiro de Moura ana Júlia Pedro Paula Rocha center of Gastroenterology Institute of Molecular Medicine School of Medicine University of Lisbon Portugal Department of Medicine Ⅱ University Hospital of Santa MariaLisbonPortugal

AIM: To evaluate whether serum levels of nitric oxide (NO ·) and plasma levels of cyclic guanosine monophosphate (cGMP) and total glutathione (GSH) are altered in patients with alcoholic cirrhosis and to examine their correlation with the severity of liver ***: Twenty-six patients with alcoholic liver cirrhosis were studied. Serum levels of NO · and plasma levels of cGMP and GSH were measured in 7 patients with compensated alcoholic cirrhosis (child-Pugh A) and 19 patients with advanced cirrhosis (child-Pugh B and c). The model for end-stage liver disease (MELD) score was evaluated. Sixteen healthy volunteers served as controls. Liver enzymes and creatinine levels were also ***: NO · and cGMP levels were higher in patients with child-Pugh B and c cirrhosis than in child-Pugh A cirrhosis or controls (NO ·: 21.70 ± 8.07 vs 11.70 ± 2.74; 21.70 ± 8.07 vs 7.26 ± 2.47 μmol/L, respectively; P cGMP: 20.12 ± 6.62 vs 10.14 ± 2.78; 20.12 ± 6.62 vs 4.95 ± 1.21 pmol/L, respectively; P child-Pugh B and c cirrhosis than in patients with child-Pugh A cirrhosis or controls (16.04 ± 6.06 vs 23.01 ± 4.38 or 16.04 ± 6.06 vs 66.57 ± 26.23 μmol/L, respectively; P cant correlation between NO · and cGMP levels in all patients with alcoholic cirrhosis. A significant negative correlation between reduced glutathione/glutathione disulfide and the MELD score was found in all cirrhotic ***: Our results suggest a role for oxidative stress in alcoholic liver cirrhosis, which is more significant in decompensated patients with higher levels of NO ·and cGMP and lower GSH levels than in compensated and control patients. Altered mediator levels in decompensated patients may influence the hemodynamic changes in and progression of liver disease.

关键词： Oxidative stress Nitric oxide Alcoholic cirrhosis Fibrosis Model for end-stage liver disease

Roots and rhizomes of wild Asparagus:Nutritional composition,bioactivity and nanoencapsulation of the most potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni ana Júlio celestino Santos-Buelga ana M.gonzalez-Paramas Patrícia Filipe Patricia Rijo Sofia A.costa Lima Salette Reis Angela Fernandes Isabel c.F.R.Ferreira Virginia Fernandez-Ruiz Patricia Morales Guido Flamini Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia cBIOS-Research center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Department of Biomedical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for Medicines(iMed.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal centro de Investigacao de Montanha(cIMO) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Department of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartimento di Farmacia University of Pisavia Bonanno 656126PisaItaly centro Interdipartimentale di Ricerca“Nutraceutica e Alimentazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly center for Marine Sciences(ccMar) University of AlgarveGambelas Campus8005-139FaroPortugal Department of chemistry and Pharmacy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconomy at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional composition and bioactive properties of roots and rhizomes of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver primary cell was used to check the hepatotoxicity of *** revealed that Asparagus samples are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/MS characterization of infusions allowed the identification and quantitation of 7 phenolic compounds,all hydroxycinnamoyl derivatives,with caffeic acid as the most *** infusion contained the highest amounts of these *** also exhibited the highest antioxidant activity in all assays,with Ec_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 mg/mL for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 primary cell cultures(GI_(50)>400μg/mL).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double emulsion *** size was about 260 nm and a polydispersity index around 0.1,with a zeta potential of about-36 mV,as well as a good encapsulation efficiency of approximately 83%.Their morphology was analysed by SEM and spherical polymeric nanoparticles with a smooth surface were *** and DSc were also performed,which allowed corroborating the efficacy of the encapsulation and to confirm the production of a stable and robust system to load Asparagus *** developed nanoparticles are expected to be used as delivery systems for bioactive compounds of *** and they could be used as an innovative dietary supplement.

关键词： Asparagus stipularis Nutritional composition Antioxidant activity Nanoparticles PLGA

Functional data-driven framework for fast forecasting of electrode slurry rheology simulated by molecular dynamics

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npj computational Materials 2022年第1期8卷 1524-1532页

作者： Marc Duquesnoy Teo Lombardo Fernando caro Florent Haudiquez Alain c.Ngandjong Jiahui Xu Hassan Oularbi Alejandro A.franco Laboratoire de Réactivitéet chimie des Solides(LRcS) UMR CNRS 7314Universitéde Picardie Jules VerneHub de l’Energie15rue Baudelocque80039AmiensCedexFrance ALISTORE-European Research Institute FR CNRS 3104Hub de l’Energie15rue Baudelocque80039AmiensCedexFrance Reseau sur le Stockage Electrochimique de l’Energie(RS2E) FR CNRS 3459Hub de l’Energie15rue Baudelocque80039AmiensCedexFrance Institut Universitaire de France 103 Boulevard Saint Michel75005ParisFrance

The computational simulation of the manufacturing process of lithium-ion battery composite electrodes based on mechanistic models allows capturing the influence of manufacturing parameters on electrode ***,ensuring that these properties match with experimental data is typically computationally *** this work,we tackled this costly procedure by proposing a functional data-driven framework,aiming first to retrieve the early numerical values calculated from a molecular dynamics simulation to predict if the observable being calculated is prone to match with our range of experimental values,and in a second step,recover additional values of the ongoing simulation to predict its final *** demonstrated this approach in the context of the calculation of electrode slurries *** report that for various electrode chemistries,the expected mechanistic simulation results can be obtained 11 times faster with respect to the complete simulations,while being accurate with a R^(2)_(score) equals to 0.96.

关键词： properties electrode dynamics

analysis of the bacterial community composition in acidic well water used for drinking in Guinea-Bissau,West Africa

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Journal of Environmental Sciences 2014年第8期26卷 1605-1614页

作者： ana Machado Adriano A.Bordalo Laboratory of Hydrobiology and Ecology Institute of Biomedical SciencesUniversity of PortoPorto 4050-313Portugal cIIMAR/cIMAR-Interdisciplinary centre of Marine and Environmental Research University of PortoPorto 4050-123Portugal

Potable water is a resource out of reach for millions worldwide,and the available water may be chemically and microbiologically compromised. This is particularly acute in Africa,where water-networks may be non-existent or restricted to a small fraction of the urban population,as in the case of Guinea-Bissau,West Africa. This study was carried out seasonally in Bolama（11°N）,where unprotected hand-dug wells with acidic water are the sole source of water for the population. We inspected the free-living bacterial community dynamics by automated rRNA intergenic spacer analyses,quantitative polymerase chain reaction and cloning *** results revealed a clear seasonal shift in bacterial assemblage composition and microbial abundance within the same sampling site. Temperature,pH and turbidity,together with the infiltration and percolation of surface water,which takes place in the wet season,seemed to be the driving factors in the shaping and selection of the bacterial community and deterioration of water quality. analysis of 16 S rDNA sequences revealed several potential pathogenic bacteria and uncultured bacteria associated with water and sediments,corroborating the importance of a culture-independent approach in drinking water monitoring.

关键词： Water quality Microbial community ARISA qPcR Drinking water Africa

Gold Nanozymes:From concept to Biomedical Applications

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Nano-Micro Letters 2021年第1期13卷 138-173页

作者： Javier Lou‑franco Bhaskar Das christopher Elliott cuong cao Institute for Global Food Security School of Biological SciencesQueen’s University of Belfast19 Chlorine GardensBelfast BT95DLUK Present Address:Department of Biotechnology and Medical Engineering National Institute of Technology RourkelaRourkelaIndia

In recent years,gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase,oxidase,catalase,superoxide dismutase or ***,merged with their ease of synthesis,tunability,biocompatibility and low cost,makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical ***,over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential *** review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties,as well as external parameters such as pH or ***,real applications often require specific biorecognition elements to be immobilized onto the nanozymes,leading to unexpected positive or negative effects on their ***,rational design of efficient nanozymes remains a challenge of paramount *** implementation paths have already been explored,including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase *** review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities,as more than one of them could ***,further toxicity studies are required to ensure the applicability of gold nanozymes in *** challenges and future prospects of gold nanozymes are discussed in this review,whose significance can be anticipated in a diverse range of fields beyond biomedicine,such as food safety,environmental analyses or the chemical industry.

关键词： Gold nanoparticles catalysis Nanozymes Diagnosis Nanomedicine

围术期神经肌肉阻滞的管理:欧洲麻醉和重症监护学会临床指南

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中华麻醉学杂志 2024年第6期44卷 641-656页

作者： Thomas Fuchs-Buder carolina S.Romero Heidrun Lewald Massimo Lamperti Arash Afshari ana-Marjia Hristovska Denis Schmartz Jochen Hinkelbein Dan Longrois Maria Popp Hans Dde Boer Massimiliano Sorbello Radmilo Jankovic Peter Kranke 法国南锡大学医学院附属医院麻醉学、重症监护与围术期医学科法国南锡54000 巴伦西亚大学综合医院麻醉与重症监护科西班牙巴伦西亚46014 慕尼黑工业大学麻醉学与重症监护科德国慕尼黑80333 克利夫兰阿布扎比诊所麻醉学研究所阿联酋阿布扎比31250 哥本哈根大学医院小儿和产科麻醉科丹麦哥本哈根2100 哥本哈根大学医院麻醉学与重症监护科丹麦赫维德2650 布鲁塞尔自由大学Erasme医院麻醉科比利时布鲁塞尔1070 科隆大学医院麻醉学与重症监护科德国科隆50937 巴黎大学附属比查特克劳德伯纳德医院麻醉学与重症监护医学科法国巴黎75018 维尔茨堡大学医院麻醉学、危重病医学、急诊医学和疼痛医学科德国维尔茨堡97080 格罗宁根大学医院麻醉学、疼痛医学与程序性镇静与镇痛科荷兰格罗宁根9713 GZ 卡坦尼亚大学医院麻醉与重症监护科意大利卡坦尼亚95123 尼什大学医学院尼什临床中心麻醉学与重症治疗科塞尔维亚尼什18000

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(Europea... 详细信息

近来的研究表明,由于围术期神经肌肉阻滞管理不当,肌肉松弛药(肌松药)残留阻滞及其术后并发症的发生率居高不下。需要重视神经肌肉功能监测仪、肌松药及其拮抗剂的合理应用,以利于改善神经肌肉阻滞管理。欧洲麻醉和重症监护学会(European Society of anaesthesiology and Intensive care,ESAIc)首次发布围术期神经肌肉阻滞管理临床指南,旨在为临床医生提供最佳医疗管理的循证建议,以提高围术期患者安全。本指南主要聚焦在3个临床问题:肌松药是否有助于成人气管插管?神经肌肉阻滞深度是否影响腹部手术患者的预后?肌松药残留阻滞的诊断和治疗策略有哪些?根据PIcO原则(患者、干预、对照、结局;patient,intervention,comparator,outcome;PIcO)构建临床问题并进行文献检索。初始纳入的临床研究为24 000篇,采用逐步筛选策略,最终临床研究88篇纳入指南分析。应用GRADE方法学(Grading of Recommendations,Assessment,Development and Evaluation,GRADE)对结局指标证据、质量等级进行评价。运用两轮德尔菲法收集专家组建议并形成统一推荐:R1推荐应用肌松药辅助气管插管(1A)。R2推荐应用肌松药以减少气管插管导致的咽部和(或)喉部损伤(1c)。R3推荐在快速顺序诱导插管(rapid sequence induction intubation,RSII)时使用短效肌松药,例如琥珀胆碱1 mg/kg或罗库溴铵0.9~1.2 mg/kg(1B)。R4推荐在需要改善外科手术条件时,加深神经肌肉阻滞深度(1B)。R5尚无足够的证据推荐深度神经肌肉阻滞可减轻术后疼痛或降低围术期并发症的发生率(2c)。R6推荐在拇内收肌处刺激尺神经,定量监测神经肌肉阻滞深度以排除肌松药残留阻滞(1B)。R7推荐应用舒更葡糖钠逆转甾体类肌松药(罗库溴铵、维库溴铵)诱导的深、中及浅度神经肌肉阻滞(1A)。R8推荐在使用新斯的明前,TOFr自行恢复至>0.2,并继续定量监测神经肌肉功能,直至TOFr超过0.9(1c)。

关键词：神经肌肉阻滞神经肌肉功能肌松药临床指南罗库溴铵琥珀胆碱外科手术定量监测

Exocytosis,endocytosis and recycling of secretory vesicles in neuroendocrine cells,and its regulation by cortical actin

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BIOcELL 2022年第8期46卷 1867-1873页

作者： ana M.cÁRDENAS I.GALLO FERNANDO D.MARENGO centro Interdisciplinario de Neurociencia de Valparaíso Facultad de CienciasUniversidad de ValparaísoValparaíso2360102Chile Instituto de Fisiología Biología Molecular y NeurocienciasCONICET.Departamento de Fisiología y Biología Molecular y CelularFacultad de Ciencias Exactas y Naturales Universidad de Buenos AiresBuenos Aires1428Argentina

The cortical actin network is a mesh of filaments distributed beneath the plasmalemma that dynamically reacts in response to *** dynamic network of cortical filaments,together with motor myosin partners,adjusts the plasmalemma tension,organizes membrane protein microdomains,remodels the cell surface and drives vesicle motion in order to fine-tune exocytosis,endocytosis and recycling of secretory *** this review,we discuss how these mechanisms work in secretory cells.

关键词： cortical actin Neuroendocrine cell chromaffin cell Exocytosis Endocytosis

Effect of the Inclusion of chestnut in the Finishing Diet on Volatile compounds of Dry-cured Ham from celta Pig Breed

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Journal of Integrative Agriculture 2013年第11期12卷 2002-2012页

作者： José M Lorenzo Javier carballo Daniel franco centro Tecnológico de la carne de Galicia Rúa Galicia No 4Parque Tecnológico de GaliciaSan Cibrán das Vias rea de Tecnología de los Alimentos Facultad de Ciencias de OurenseUniversidad de Vigo

The effect of the inclusion of chestnut in pigs ifnishing diet on volatile compounds of dry-cured celta ham was studied. Twelve hams of each type （from three different pigs ifnishing diets：concentrate （cO）, mixed （MI） and chestnut （cH）） were used. Volatiles were extracted using a purge-and-trap method and analyzed by gas chromatography/mass spectrometry （Gc/MS）. Thirty-nine volatile compounds were identified in dry-cured celta ham samples. Most abundant volatiles in ham samples were aldehydes, which represented respectively, 53% （cO）, 51% （MI） and 46% （cH） of the total volatile composition. With the exception of 2-butenal, 2-methyl, all aldehydes were affected by feeding system. On the other hand, hydrocarbons n-alkanes were the second major group in the volatile proifle of dry-cured celta hams and represented 28.9, 35.7 and 32.4%of the total volatile composition for cO, MI and cH groups, respectively. Ham samples from chestnut group showed a higher content of alcohols and this result could be related with the inclusion of chestnut in the ifnishing diet of pigs. Principal component analysis showed a good separation among groups. The discriminant analysis selected eight variables （butanoic acid, hexanal, octanal, nonenal （E）, decenal （E）, tetradecane, decane trimethyl and pyridine 2-methyl） and calculated two discriminating functions to predict if chestnut has been included in the ifnishing diet. Thus, it was possible to discriminate between groups fed with ifnishing diets containing chestnuts in their composition （mixed and chestnut group）.

关键词： dry-cured ham chestnut volatile compound finishing diet discriminant analysis

Positive and Nontrivial Solutions for the Urysohn Integral Equation

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1745-1750页

作者： Daniel franco Gennaro INFANTE Donal O'REGAN Departamentode Matemática Aplicada Universidad Nacional de Educación a Distancia Dipartimentodi Matematica Universitàdella Calabria Department of Mathematics National University of Ireland

We establish new criteria for the existence of either positive or nonzero solutions of the Urysohn integral equation. We also discuss the existence of an interval of positive eigenvalues and sufficient conditions for the existence of at least a positive eigenvalue with a nonzero or positive eigenfunction for the Urysohn integral operator. Among others, we employ techniques based on fixed point index theory for compact maps, which are new for this type of equation.

关键词： Urysohn integral equation positive solutions eigenvalues