检索结果-南通市图书馆

Cognitive Ability in Elderly in a City in Northeastern Brazil: An analytical Study

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Nursing 2016年第9期6卷 712-721页

作者： Francisca Patrícia Barreto de Carvalho Glauber Weder dos Santos Silva Clélia Albino Simpson ana Géssica Costa Martins Narjara beatriz Queiroz da Silva Mônica Gisele Costa Pinheiro João Evangelista da Costa Lucídio Clebeson de Oliveira Amélia Carolina Lopes Fernandes Francisco Arnoldo Nunes de Miranda State University of Rio Grande do Norte Mossoró Brazil Federal University of Rio Grande do Norte Natal Brazil

To analyze the cognitive ability of elderly people assisted by the Family Health Strategy (FHS) in a northeastern Brazilian city, a cross-sectional, analytical study was conducted with 406 elderly assisted by the FHS in Mossoro-RN, Brazil, from March to May 2014. The data were collected through two validated questionnaires. For the data analysis, the Alpha Cronbach’s, Kruskal-Wallis test, chi-square and Pearson correlation statistical tests were applied. There was a predominance of women (67.98%) in the survey. Among the respondents, 50% had an index of up to 27 points in Pfeffer Instrument, identifying greater degree of dependence in performing instrumental daily activities related to mobility in the community (39.7%) and financial management (57.1%). On Mini-Mental State Examination (MMSE), 75% of seniors had an index above 27 points, with the scores classification as standard (50.99%), mild (25.12%), moderate (22.66%) and severe (1.23%). Although changes have been identified in cognitive performance and independence of elderly people in some areas, these difficulties do not completely affect the lives and daily activities of the elderly.

关键词： Primary Health Care Geriatric Assessment Cognitive Aging Geriatric Nursing

Current role of capsule endoscopy in Crohn's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2016年第17期8卷 572-583页

作者： Marisol Luján-Sanchis Laura Sanchis-Artero Laura Larrey-Ruiz Laura Peno-Munoz Paola Nunez-Martinez Génesis Castillo-López Lara González-González Carlos Boix Clemente Cecilia Albert Antequera ana Durá-Ayet Javier Sempere-garcia-Argüelles Digestive Diseases Unit General University Hospital of Valencia 46014 Valencia Spain

Capsule endoscopy (CE) currently plays an important role in Crohn’s disease (CD). It is a noninvasive technique that has led to a breakthrough in the endoscopic diagnosis of diseases of the small intestine. Its superior diagnostic performance and excellent safety profile lead to its considerable acceptance on the part of the patient. This paper reviews current indications of CE in three stages of clinical practice: Suspected CD, unclassified colitis and its extensive role in diagnosed CD. The diagnostic and therapeutic impact of the results of CE on the monitoring of this disease is also reviewed. Knowledge of its applications, the interpretation of its results in an appropriate context and the existence of a validated endoscopic activity index could change the way in which these patients are managed. The definition of mucosal healing and postoperative recurrence by means of endoscopic scoring systems will endow CE with new applications in the management of CD in the near future.

关键词： Capsule endoscopy Inflammatory bowel disease Crohn&rsquo s disease

High Sugar-Fat Diet Induces Metabolic-Inflammatory Disorders Independent of Obesity Development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2019年第6期10卷 664-677页

作者： Jéssica Leite garcia Fabiane Valentini Francisqueti ana Paula da Costa Rodrigues Ferraz Artur Junio Togneri Ferron Mariane Róvero Costa Cristina Schmitt Gregolin Dijon Henrique Salomé de Campos Klinsmann Carolo dos Santos Igor Otávio Minatel Camila Renata Corrêa Medical School S&#227 o Paulo State University (UNESP) Botucatu Brazil Institute of Bioscience S&#227 o Paulo State University (UNESP) Botucatu Brazil

Background: The modern dietary habit, which is rich in refined carbohydrates and saturated fats, increases the risk of chronic diseases due to the proinflammatory effect of these nutrients. Aim: To evaluate the impact of high sugar-fat diet in the development of metabolic-inflammatory disorders in non-obese animals. Methods: Male Wistar rats were distributed into two groups according to the diet: control and high sugar-fat for 30 weeks. It was analyzed: dietary efficiency;chow, water and caloric intake;metabolic and hormonal profile in plasma and inflammatory cytokines in epididymal adipose tissue. Data were compared by Student’s t test or by Mann-Whitney U test with p Results: HSF presented lower chow intake, higher water consumption and dietary efficiency with no difference in the caloric intake. The final body weight (FBW) and weight gain (WG) were lower in the HSF group and there was no difference in the adiposity index (AI). HSF diet-induced hyperglycemia and hyperinsulinemia with no difference for Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Triglycerides, uric acid, adiponectin and leptin levels were higher in the HSF group. The HSF group showed increased interleukin-6 (IL-6) and tumoral necrosis factor-alpha (TNF-α) levels in epidydimal adipose tissue. The urinary protein-creatinine ratio and albuminuria were higher in the HSF group. Conclusion: HSF diet intake is directly involved in the development of metabolic-inflammatory disorders independent of obesity, dissociating the view that increased adiposity is the major risk factor for complications commonly found in obese individuals.

关键词： High Sugar-Fat Diet Western Diet Adipose Tissue Cytokines Metabolic Disorders

AB079. HER2 as a possible therapeutic target in squamous cell carcinoma of the conjunctiva

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Annals of Eye Science 2018年第1期 485-485页

作者： Paulina García de Alba Graue Evangelina Esposito Pablo Zoroquiain ana beatriz Toledo Dias Miguel Burnier MUHC-McGill Ocular Pathology Laboratory McGill UniversityMontrealQCCanada Department of Ophthalmology McGill UniversityMontrealQCCanada

Background:Invasive squamous carcinoma(SCC)is the most frequent malignant neoplasia of the conjunctiva,33%of which will metastasize.C-erbB-2/neu(HER2)is an oncogene associated with poor prognosis,metastatic potential and aggressive behavior in several tumors,including breast,stomach,among ***2 amplification is also associated with the response to anti-HER2 *** aim of this study is to evaluate HER2 expression in the progression of ocular surface squamous neoplasia(OSSN)and as a potential therapeutical ***:Ninety-eight OSSN lesions including 17 papillomas(P),27 conjunctival intraepithelial neoplasia(CIN)I,19 CIN II,13 CIN III,and 11 SCC were *** conjunctivas from normal human eyes(NHE)were also included in the *** was performed to analyze HER2(clone 29D8)expression,which was graded as follows:complete membrane staining in more than 10%of malignant cells(3+);week to moderate complete staining in more than 10%of malignant cells(2+);none or fewer than 10%cells staining(0 to 1+,respectively).Positive HER2 was considered when a score 2+or 3+was *** carcinoma with HER2 amplification was used as a positive *** technique was performed in the positive cases to confirm *** analysis was performed using Fisher’s exact ***:HER2 positive expression was detected in 6%of P(100%score 2+),11%of CIN I(100%score 2+),32%of CIN II(100%score 2+),30%of CIN III(100%score 2+),29%of SCC(50%score 2+and 50%score 3+).Benign lesions showed lower HER2 expression than in situ(P=0.03)and invasive tumors(P=0.02).No correlation between HER2 and age or tumor thickness in SCC was found(P>0.05).Conclusions:HER2 is expressed in conjunctival ***,one third of SCC were graded as 2+or 3+.These results support the evaluation of anti-HER2 therapy in conjunctival ***-clinical trials should be performed to determine the importance of this marker in conjunctival SCC for predicting response

关键词： HER2 invasive squamous carcinoma conjunctiva

Interleukin 28B-related polymorphisms: A pathway for understanding hepatitis C virus infection?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第42期19卷 7399-7404页

作者： Raquel Francine Liermann garcia Simone Moreira ana Lucia de Araújo Ramos Leslie Ecker Ferreira Angelo Alves de Mattos Cristiane Valle Tovo Lysandro Alsina Nader Juliene Antonio Ramos Edson Rondinelli Arnaldo de Jesus Dominici Christian Evangelista garcia Mauro de Souza Leite Pinho Carlos Eduardo Brando-Mello Cristiane Alves Villela-Nogueira Paulo Henrique Condeixa de Frana Departamento de Medicina Universidade da Regio de Joinville/UnivilleJoinville89219-719 Santa CatarinaBrazil Departamento de Clinica Médica e Cirurgia Geral Hospital Municipal So José Joinville89202-000 Santa CatarinaBrazil Departamento de Clínica Médica Servio de HepatologiaFaculdade de Medicina/Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro21941-913 Rio de JaneiroBrazil Servio de Gastroenterologia e Hepatologia Irmandade da Santa Casa de Misericórdia/ISCMPAPorto Alegre90020-090 Rio Grande do SulBrazil Servio de Endoscopia Universidade Federal de Pelotas/UFPelPelotas96010-610 Rio Grande do SulBrazil Instituto de Biofísica Carlos Chagas Filho/UFRJ 21941-902 Rio de JaneiroBrazil Departamento de Gastroenterologia Hospital Universitário da Universidade Federal do Maranh o/UFMASo Luis65020-560 MaranhoBrazil Servio de Gastroenterologia Hospital Universitário Gaffrée Guinle/HUGG/UNIRIO20270-004 Rio de JaneiroBrazil

AIM:To analyze the role of rs12979860 and rs8099917polymorphisms in hepatitis C virus(HCV)genotype 1infection of ***:A total of 145 adult patients diagnosed with genotype 1 chronic hepatitis C(CHC)who had completed a 48-wk regimen of pegylated-interferonα-2a or-2b plus ribavirin combination therapy were recruited from six large urban healthcare centers and199 healthy blood donors(controls)from a single site between January 2010 and January *** on the patients’response to treatment was *** chain reaction-restriction fragment length polymorphism genotyping of the interleukin(IL)28B gene fragment encompassing the single nucleotide polymorphisms(SNPs)rs12979860(C/T)and rs8099917(T/G)was carried out for 79 of the CHC patients and 199 of the ***-directional amplicon sequencing of the two SNPs was carried out for the remaining 66 CHC ***:SNP rs12979860 genotyping was successful in 99.5%of the controls and 97.2%of the CHC patients,whereas the SNP rs8099917 genotyping was successful in 95.5%of the controls and 100%of the CHC *** genotype and allele distributions for both rs12979860 and rs8099917 were significantly different between the control and CHC patient groups,with significantly higher genotype frequencies of CC and TT in the controls(P=0.037 and 0.046,respectively)and of TT and GG in the CHC patients(P=0.0009and 0.0001,respectively).analysis of the CHC patients who achieved sustained virological response(SVR)to treatment(n=55)indicated that the rs12979860 C allele and CC genotype were predictors of SVR(P=0.02).No significant correlation was found between rs8099917 genotypes and treatment response,but carriers of the T allele showed significantly higher rates of SVR(P=0.02).Linkage disequilibrium analysis of the group that achieved SVR showed a significant association between rs12979860 and rs8099917(P=0.07).CONCLUSION:The higher allele frequency of rs12979860 C and rs8099917 T observed in non-HCVinfec

关键词： Hepatitis C Interleukin 28B Single nucleotide polymorphisms Sustained virological response Brazil

Interferon Regulatory Factor 5 and Renin-Angiotensin-Aldosterone System Polymorphisms in Coronary Artery Disease: An Overview of Experimental and Clinical Studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2021年第7期11卷 332-341页

作者： Jorge Luis Bermudez-Gonzalez Rodrigo Dagio-Cuellar Cristina Villarreal-Guerrero ana Gilabert-garcia Luis Angel Ferral-Barbabosa Joaquin Berarducci Jose Luis Siller-Nava Jose Antonio Luna-Alvarez-Amezquita Javier Iván Armenta-Moreno Nilda Espínola-Zavaleta Erick Alexanderson-Rosas Juan Ignacio Straface National Institute of Cardiology Ignacio Chavez Mexico City Mexico Medicine Faculty of National Autonomous University of Mexico Mexico City Mexico

Heart diseases are the main cause of mortality in Mexico, being coronary heart disease the most frequent in the country. Its high prevalence makes important the study of the pathophysiology and the search for prognostic factors. Different genes and polymorphisms promote atherogenesis and coronary artery disease, they affect inflammatory and vascular pathological processes. ana;">Interferon regulatory factor 5 (IRF5) is associated with coronary heart disease, it promotes chronic inflammation and cytokines release;it could trigger immune reactions and its activating receptors express in the vascular endothelium. Besides, polymorphisms in the renin-angiotensin-aldosterone system (RAAS) are implied with coronary disease, they are found in angiotensinogen (AGT), angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and angiotensin-converting enzyme (ACE) genes. These genetic polymorphisms are associated with a prothrombotic state, endothelial dysfunction, and immune activation. Multiple experimental studies showed that chronic activation of RAAS and chronic expression of IRF5 generates an environment prone to the development of atherosclerosis, and autoimmune and cardiovascular diseases. Studying these specific genes and their relationship with coronary heart disease will allow a better understanding of the pathological process and possibly the quest for new treatments.

关键词： Interferon Regulatory Factor 5 (IRF5) Angiotensin-Converting Enzyme (ACE) Angiotensinogen (AGT) Angiotensin II Type 1 Receptor (AT1R) Angiotensin II Type 2 Receptor (AT2R) Polymorphisms

Management of primary achalasia: The role of endoscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2015年第6期7卷 593-605页

作者： Marisol Luján-Sanchis Patricia Suárez-Callol ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos Luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-garcia-Argüelles Pilar Canelles-Gamir Enrique Medina-Chuliá Digestive Diseases Unit General University Hospital of Valencia

Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment.

关键词： Achalasia Endoscopic treatment Dilation Botulinum toxin Myotomy

上皮结缔组织移植治疗牙龈退缩的组织学与临床研究:附1例报告

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国口腔医学继续教育杂志 2018年第6期21卷 341-348页

作者： ana-Maria garcia-De-la-Fuente Luis Antonio Aguirre-Zorzano Ruth Estefania-Fresco Laia Roig-Odena Jose-Manuel Aguirre-Urizar 张路(译) 李煌(审) 不详江苏省南京市口腔医院 210000

目的:上皮结缔组织移植(SCTG)被认为是治疗牙龈萎缩的金标准。出于伦理原因,大多数研究只报告临床结果.而不报告组织学结果。材料与方法:本研究报道一位20岁的女性,表现为下颌左中切牙局部牙龈退缩5毫米,她接受了SCTG治疗。结果:根据最... 详细信息

目的:上皮结缔组织移植(SCTG)被认为是治疗牙龈萎缩的金标准。出于伦理原因,大多数研究只报告临床结果.而不报告组织学结果。材料与方法:本研究报道一位20岁的女性,表现为下颌左中切牙局部牙龈退缩5毫米,她接受了SCTG治疗。结果:根据最初的治疗方案,在11个月后拔牙,并进行组织学研究,发现有胶原纤维的结缔组织新附着直接垂直插入牙本质区和新的牙骨质区(1.37mm)。

关键词：结缔组织移植移植治疗牙龈退缩组织学临床研究上皮牙龈萎缩临床结果

Development of Baccharis dracunculifolia(Asteraceae)Essential Oil Nanoemulsion and Its Biological Activity on Pre-pupae of Cochliomyia hominivorax(Diptera:Calliphoridae)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmacy and Pharmacology 2019年第6期7卷 293-308页

作者： Jaqueline Seugling Shirley Kuhnen Giuliano Pereira de Barros Maria beatriz Velerinho Letícia Mazzarino Patrizia ana Bricarello Animal Parasitology Laboratory Agrarian Sciences CenterFederal University of Santa CatarinaFlorianópolis 88034-001Brazil Biochemical and Animal Morphophysiology Laboratory Agrarian Sciences CenterFederal University of Santa CatarinaFlorianópolis 88034-001Brazil NanobioMat Agrarian Sciences CenterFederal University of Santa CatarinaFlorianópolis 88034-001Brazil

Myiasis is considered a serious medical condition in animals and humans that occurs predominantly in tropical *** hominivorax is one of the main fly species that causes myiasis and the actual geographic distribution includes the Caribbean and all of South America,except *** use of synthetic insecticides and endectocides in livestock for the myiasis treatment has resulted in insect resistance,while also causing residuals in the environment and contamination of animal food *** active compounds are considered an alternative for the sustainable management of insects,as they are biodegradable and less damaging to the *** study developed a nanoemulsion containing the essential oil of Baccharis dracunculifolia and evaluated its in vitro effects on *** *** pressure homogenization was used to develop the *** tests were carried out with the tested products using 15 larvae/repetition,for a total of 150 larvae per *** different concentrations of the nanoemulsion were tested shortly after preparation and after 120 days of *** the fresh formulation,at concentrations of 5,7.5,10,13.5,and 15%(w/v)we found mortality of 28,48,70,84,and 97%,respectively,while for the stored formulation,we found mortality of 17,36,51,81,and 92%.The larvicidal effect was similar,except for the concentrations of 5 and 10%(w/v)(p<0.05).Our results show that the natural based *** nanoemulsion can be considered a promising alternative for the treatment and control of myiasis caused by ***.

关键词： Natural products insecta phytotherapy larvicidal activity myiasis