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Hyperthermic intraperitoneal chemotherapy:Rationale and technique

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 68-75页

作者： Santiago gonzález-Moreno Luis A gonzález-Bayón Gloria Ortega-Pérez Peritoneal Surface Oncology Program Department of Surgical OncologyCentro Oncológico MD Anderson International Espaa28033 MadridSpain

The combination of complete cytoreductive surgery and perioperative intraperitoneal chemotherapy provides the only chance for long-term survival for selected patients diagnosed with a variety of peritoneal neoplasms,either primary or secondary to digestive or gynecologic *** intraperitoneal chemotherapy (HIPEC) delivered in the operating room once the cytoreductive surgical procedure is fi nalized,constitutes the most common form of administration of perioperative intraperitoneal *** may be complemented in some instances with early postoperative intraperitoneal chemotherapy (EPIC).HIPEC combines the pharmacokinetic advantage inherent to the intracavitary delivery of certain cytotoxic drugs,which results in regional dose intensification,with the direct cytotoxic effect of *** exhibits a selective cell-killing effect in malignant cells by itself,potentiates the cytotoxic effect of certain chemotherapy agents and enhances the tissue penetration of the administered *** chemotherapeutic agents employed in HIPEC need to have a cell cycle nonspecific mechanism of action and should ideally show a heat-synergistic cytotoxic *** of HIPEC requires an apparatus that heats and circulates the chemotherapeutic solution so that a stable temperature is maintained in the peritoneal cavity during the *** open abdomen (Coliseum) or closed abdomen technique may be used,with no signif icant differences in eff icacy proven to *** ic technical training and a solid knowledge of regional chemotherapy management are *** about safety of the procedure for operating room personnel are expected but are manageable if universal precautions and standard chemotherapy handling procedures are *** HIPEC drug regimens and dosages are currently in use.A tendency for concurrent intravenous chemotherapy administration (bidirectional chemotherapy,so-called "HIPEC plus") has been observed in rece

关键词： Hyperthermia Intracavitary chemotherapy Peritoneal neoplasms Peritoneal carcinomatosis Cytoreductive surgery

Crosslinked hyaluronic acid with liposomes and crocin for management symptoms of dry eye disease caused by moderate meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1368-1373页

作者： José-María Sánchez-gonzález Concepción De-Hita-Cantalejo María Carmen Sánchez-gonzález Department of Physics of Condensed Matter Optics AreaUniversity of SevilleSeville 41012Spain

AIM:To study the effect of uncrosslinked and crosslinked hyaluronic acid combined with other artificial tear components in patients with dry eye caused by moderate meibomian gland ***:Prospective,single-blind,contralateral eye *** eyes(25 patients)were *** selection for each tear type was random,and the eye drop formulations,0.4%uncrosslinked hyaluronic acid and 0.2%galactoxyloglucan(tear A)and 0.15%crosslinked hyaluronic acid,crocin,and liposomes(tear B)were *** determined dosing schedule was three times a day for six weeks,and the study participants underwent a clinical examination before and 45 d after lubricant *** Schirmer test,tear breakup time(TBUT)test,and Ocular Surface Disease Index(OSDI)questionnaire were applied before and after instillation period with both types of artificial ***:On the Schirmer test,a significant improvement was obtained with both tear A(Panagement symptoms of dry eye disease.

关键词： liposome crosslinked hyaluronic acid meibomian gland dysfunction contact lens dry eye disease

Anthropomorphism Indexes of the Kinematic Chain for Artificial Hands

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Journal of Bionic Engineering 2020年第3期17卷 501-511页

作者： Immaculada Llop-Harillo Antonio Pérez-gonzález Javier Andrés-Esperanza Grupo de Biomecdnicay Ergonomia Departamento de Ingenieria Mecdnicay Construccidny Universitat Jaume I(UJI)Castelldn 12071Spain

Anthropomorphic hands have received increasing research interest in the fields of robotics and *** it is not yet clear how to evaluate their *** in the kinematic chain is essential to achieve both functionality and cosmesis.A few previous works have addressed the definition of anthropomorphism indexes,although they have some limitations in its *** this study,three different anthropomorphism indexes have been defined to compare the kinematic chain of artificial hands with that of the human *** indexes are based on the comparison of:(I)the parameters of the kinematic chain(dimensions,type of joints,orientations and ranges of motion),(2)the reachable workspace,and(3)common grasping *** artificial hands with different degrees of anthropomorphism have been compared using the three Anthropomorphism Indexes of the Kinematic Chain(AIKC).The results show a high correlation between the first and third AIKC for the hands *** second AIKC presents much lower values than the other two,although they are higher for hands that combine abduction/adduction and flexion/extension movements in the kinematic chain of each *** indexes can be useful during the initial stage of designing artificial hands or evaluating their anthropomorphism.

关键词： anthropomorphism grasping indexes kinematics multifingered hands

Echo from the underground: the heritage customization of subway infrastructures in Shanghai’s listed areas

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Built Heritage 2021年第1期5卷 4-21页

作者： Plácido gonzález Martínez Tongji University College of Architecture and Urban Planning1239 Siping RoadShanghai 200092China

The design of metro stations constitutes a clear example of the new core role of culture in a city such as Shanghai that remains to be assessed from a critical heritage *** an unexplored dimension of a massive heritage institutional apparatus,metro stations act as‘white canvases’where commercial,political and cultural messages are *** messages contribute to city branding while simultaneously influencing the perception and interpretation of the historic urban landscape above *** research offers insights into the subway stations located in the listed heritage areas of Shanghai and the architectural,artistic and exhibitive resources that‘give character’to these *** research applies visual methods and discursive analysis based on direct observation of these‘characteristic’elements in metro *** paper establishes the argument that the amount and distribution of these characteristic elements in the metro network offers unequal representation of the importance of the heritage areas *** represented,we argue that such features convey renewed narratives of urban identity according to an authorised heritage discourse in *** narratives cater to an image of ideal,harmonious continuity between the past and the future that aims to characterise Shanghai as a Chinese global metropolis.

关键词： Underground station design Infrastructures in listed areas Authorised heritage discourse Heritage conservation in Shanghai City branding

Effect of light on seed germination and seedling shape of succulent species from mexico

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Journal of Plant Ecology 2016年第2期9卷 174-179页

作者： Joel Flores Claudia gonzález-Salvatierra Enrique Jurado División de Ciencias Ambientales Instituto Potosino de Investigación Científica y TecnológicaA.C.Camino a la Presa de San José2055Col.Lomas4SecciónSan Luis PotosíSan Luis Potosí78216México Facultad de Ciencias Forestales Universidad Autónoma de Nuevo LeónCarretera Nacionalkm 145LinaresN.L.67700México

Aims Light requirements for cactus seed germination have been considered to be associated with their adult plant height and seed mass,but this has not been thoroughly studied for other succulent *** order to understand seed photosensitivity from desert species belonging to Asparagaceae(subfamily Agavoideae)and Cactaceae,we performed a germination experiment with and without light for 12 species and 2 varieties from 1 species from the Southern Chihuahuan *** also determined if adult growth is totally determined by seedling‘growth form’in *** We performed a germination experiment using light and darkness for 13 species from Southern Chihuahuan Desert:10 rosette species(Asparagaceae),as well as 1 globose,1 columnar and 2 varieties from 1 depressed-globose species(Cactaceae).The response variables were seed germination percentage and relative light germination(RLG).In addition,in order to determine if adult-globose cacti could have cylindrical seedlings,we calculated the shape index(height/width ratio)for Coryphanta clavata and Mammillaria *** Findings All species were considered neutral *** species had similar seed germination in both light and dark conditions,and three taxa(*** and the two varieties of Ferocactus latispinus)showed higher germination with light than without *** salmiana,*** and the two varieties of *** had higher RLG than the other *** mass was an important factor because with higher seed mass there was lower dependence to *** findings support the hypothesis that small seed mass and light requirements have coevolved as an adaptation to ensure *** adult-globose cactus species,***,and one adult-columnar species,***,had small seeds and neutral *** from these two species exposed to light were cylindrical and those under darkness conditions were *** seeds from this species are able to germinate in

关键词： Asparagaceae Cactaceae Chihuahuan Desert photoblasticism seed germination succulent plants

Breast cancer immunotherapy:Realities and advances

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Cancer Innovation 2024年第5期3卷 23-36页

作者： Aixa Medina Jeismar Carballo Eglys gonzález‐Marcano Isaac Blanca ana F.Convit Jacinto Convit World Organization Inc. Pompano BeachFloridaUSA Facultad de Medicina Universidad Central de VenezuelaCaracasVenezuela Unidad Experimental de Inmunoterapia Fundación Jacinto ConvitCaracasVenezuela

Breast cancer(BC)is the most common malignant tumor and the main cause of death in women *** increased knowledge regarding tumor escape mechanisms and advances in immunology,many new antitumor strategies such as nonspecific immunotherapies,monoclonal antibodies,anticancer vaccines,and oncolytic viruses,among others,make immunotherapy a promising approach for the treatment of ***,these approaches still require meticulous assessment and readjustment as resistance and modest response rates remain important *** this article,we aim to summarize the most recent data available in BC immunotherapy to include the results of ongoing clinical trials and approved therapies used as monotherapies or in combination with conventional treatments.

关键词： breast cancer immunotherapy metastatic disease therapy combination tumor microenvironment

Fe-dependent cellular alterations of oxidative balance in aquatic *** be ferroptosis involved?

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BIOCELL 2023年第5期47卷 1177-1189页

作者： PAULA MARIELA gonzÁlez JOAQUIN CABRERA SUSana PUNTARULO Fisicoquímica Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresC1113 AADArgentina Instituto de Bioquímica y Medicina Molecular(IBIMOL) CONICET-Universidad de Buenos AiresBuenos AiresC1113 AADArgentina

The purpose of this review is to briefly summarize the central role of iron(Fe)in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic *** ferroptotic cells or tissues,the intracellular Fe level increases;meanwhile the treatment with Fe chelators limits *** algae can assimilate Fe from the environment through several mechanisms,and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic *** central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell *** animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to *** ferroptosis reaction can be regulated through the antioxidant defense system,in combination with the protein degradation structure,metabolism,and gene *** depletion of nonenzymatic antioxidants like reduced glutathione(GSH)in animals,and the reduction of both GSH and ascorbate in photosynthetic organisms,are characteristic features of ***,ferroptosis can be prevented if Fe chelators,certain antioxidants,and specifically regulating genes are ***,the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously *** more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.

关键词： Glutathione Labile Fe pool Lipid peroxidation Oxidative stress

High CO_(2)permeation using a new Ce_(0.85)Gd_(0.15)O_(2-δ)-LaNiO_(3)composite ceramic–carbonate dual-phase membrane

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Journal of Environmental Sciences 2024年第6期140卷 219-229页

作者： Daniela gonzález-Varela JFrancisco Gómez-García Gustavo Tavizon Heriberto Pfeiffer Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico Departamento de Física y Química Teórica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico 不详

This work shows the synthesis,characterization and evaluation of dense-ceramic membranes made of Ce_(0.85)Gd_(0.15)O_(2-δ)-LaNiO_(3)(CG-LN)composites,where the fluorite-perovskite ratio(CG:LN)was varied as follows:75:25,80:20 and 85:15 wt.%.Supports were initially characterized by XRD,SEM and electrical conductivity(using vacuum and oxygen atmospheres),to determine the composition,microstructural and ionic-electronic conductivity ***,supports were infiltrated with an eutectic carbonates mixture,producing the corresponding dense dual-phase membranes,in which CO_(2)permeation tests were ***,CO_(2)permeation experiments were performed from 900 to 700℃,in the presence and absence of oxygen(flowed in the sweep membrane side).Results showed that these composites possess high CO_(2)permeation properties,where the O_(2)addition significantly improves the ionic conduction on the sweep membrane ***,the GC80-LN20 composition presented the best results due to the following physicochemical characteristics:high electronic and ionic conductivity,appropriate porosity,interconnected porous channels,as well as thermal and chemical stabilities between the composite support and carbonate phases.

关键词： CO_(2)permeation Doped CeO_(2) LaNiO_(3) Impedance Ceramic carbonate membrane

PANoptosis:new insights in regulated cell death in ischemia/reperfusion models

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Neural Regeneration Research 2023年第2期18卷 342-343页

作者： Paloma gonzález-Rodríguez Arsenio Fernández-López Área de Biología Celular Instituto de BiomedicinaUniversidad de LeónSpain

See related article,pp 357-363The first study describing the cell death and destruction of tissues,organs,and organ systems as programmed events during the development of multicellular organisms was performed by JW Saunders Jr in *** term apoptosis was introduced by Kerr,Wyllie,and Currie in 1972 to describe a programmed phenomenon opposite to mitosis in the regulation of animal cell ***,a description of ectodermal cell lineages as programmed cell death in the worm Caenorhabditis elegans was publishedby JE Sulston and HR Horvitz in 1976.

关键词： organs insight opposite