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Non-steroidal anti-inflam.atory drugs and statins in relation to colorectal cancer risk

World Journal of Gastroenterology 2009年第19期15卷 2336-2339页

作者： m.zyar Shadm.n Polly A Newcom. John m.Ham.ton Karen J Wernli amy Trentham.Dietz Cancer Prevention Program Fred Hutchinson Cancer Research CenterSeattle 98109United States Departm.nt of Epidem.ology University of WashingtonSeattle 98195United States Polly A Newcom. University of Wisconsin Paul PCarbone Comprehensive Cancer CenterMadison 53726United States

AIm. To investigate the association between individual or com.ined use of non-steroidal anti-inflam.atory drugs （NSAIDs） or statins and colorectal cancer ***： In a population-based case-control study in wom.n, we exam.ned the association between NSAIDs and statin use and the risk of colorectal cancers. We further investigated whether the use of statins m.difies the protective effect of NSAIDs. Fem.le cases （n = 669）of colorectal cancer aged 50-74 years were identified from.a storewide registry in Wisconsin during 1999-2001. Com.unity control wom.n （n = 1375） were random.y selected from.lists of licensed drivers and m.dicare beneficiaries. m.dication use and risk factor inform.tion were gathered during a structured telephone interview. A m.ltivariable logistic regression m.del was used to calculate odds ratio （OR） and 95% confidence interval （CI）.RESULTS： Overall, NSAIDs users had a 30% reduction in risk of colorectal cancer （95% CI： 0.56-0.88）. Statin use was not associated with colorectal cancer risk （OR = 1.17, 95% CI： 0.74-1.85）, regardless of structural type （lipophilic or hydrophilic）, duration of use, or recency. There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk （P-interaction = 0.28）.CONCLUSION： Although our results confirm.the inverse association between NSAIDs use and colorectal cancer risk, they do not support a risk reduction in statin users, or an interaction effect of com.ined NSAIDs and statin use.

关键词： Non-steroidal anti-inflam.atory drugs Statin Colorectal cancer Cancer prevention Chem.prevention

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基于微阵列芯片的比较基因组杂交技术在临床实验室产前诊断中的应用(英文)

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北京大学学报（医学版） 2009年第4期41卷 500-504页

作者： amy m. BREm.N 毕为民张秀慧 m.dical Genetics Laboratories Department of Molecular and Human Genetics Baylor College of Medicine

Array-based com.arative genom.c hybridization (array CGH),a m.thod used to detect gains or losses of genetic m.terial,has recently been applied to prenatal diagnosis of genom.c im.alance in the clinical laboratory setting. This new and exciting diagnostic tool represents a m.jor technological step forward in cytogenetic testing and addresses m.ny of the lim.tations of current cytogenetic m.thods. Conventional chrom.som. analysis,the current gold standard in prenatal diagnosis,focuses prim.rily on the detection of com.on aneuploidies and is lim.ted by its capacity to detect only those copy num.er changes that are large enough to be m.croscopically visible (typically 5-6 m. in size at the 500 band level). In contrast,array CGH analysis sim.ltaneously evaluates regions across the entire genom. and allows for detection of unbalanced structural and num.rical chrom.som. abnorm.lities of less than one hundred kb. Array CGH analysis also overcom.s som. of the lim.tations of chrom.som. analysis,such as the requirem.nt for cell culture and longer reporting tim.,by using direct uncultured fetal specim.ns. With m.ny diagnostic laboratories now em.racing this technology,the past year has seen trem.ndous growth in the use of array CGH analysis for prenatal diagnosis. This review aim. to sum.arize array CGH m.thodo-logy and its current applications in prenatal diagnosis.

关键词：产前诊断核酸杂交微阵列分析临床实验室技术

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Land tenure and landscape change:a com.arison of public-private lands in the southern High Plains

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Ecological Processes 2016年第1期5卷 139-152页

作者： Todd D.Fagin Jacqueline m.Vadjunec Nicole m.Colston Kathyrn Wenger amy Graham Oklahom. Biological Survey University of Oklahoma111 E.Chesapeake StNorman 73019OKUSA Departm.nt of Geography Oklahoma State University337 Murray HallStillwater 74078OKUSA

Introduction:Long-term.drought in the southern Great Plains increases the vulnerability of coupled hum.n-environm.nt system. at a variety of *** better understandings of the dynam.cs at regional scales will becom. increasingly im.ortant as long-established land-use regim.s break down in the face of clim.te change,resource depletion,and evolving *** dem.nstrate differential vulnerability during drought periods,this study hypothesized that observed increases in woody vegetation in grasslands would vary across land-tenure *** argue that differences in State Trust Land governance,in part,lead to differential land m.nagem.nt practices that contribute to landscape ***:The study area encom.asses adjacent counties,Cim.rron County in Oklahom. and Union County in New m.xico,with sim.lar clim.te variability and agricultural *** analyzed National Land Cover Database(NLCD)land-cover m.ps from.1992 and 2011 to assess changes in landscape com.osition and structure between 1992 and ***:During both years under consideration,each county in the study region,across various land-tenure regim.s,was dom.nated by herbaceous ***,there were changes in both com.osition and structure across the whole study area,in particular losses of herbaceous vegetation and increases in woody *** greatest gains in woody vegetation occurred in State Trust Lands of Cim.rron ***,the data suggest a fragm.ntation of herbaceous vegetation and a coalescing of shrubland ***:Research about the influence of land tenure on land m.nagem.nt decisions,specifically the role of State Trust Land leases in overgrazing,inform. the broader context of drought m.nagem.nt in the southern Great *** include continued research to highlight the specific m.chanism. of land-tenure governance that drive landscape change.

关键词： Drought Land tenure Agriculture Landscape com.osition Landscape structure Southern Great Plains Grasslands Socio-ecological vulnerability National Land Cover Database(NLCD)

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TARGET： A Transient Transform.tion System.for Genom.-Wide Transcription Factor Target Discovery

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m.lecular Plant 2013年第3期6卷 978-980页

作者： Bastiaan O.R. Bargm.nn amy m.rshall-Colon Idan Efroni Sandrine Ruffel Kenneth D. Birnbaum.Gloria m. Coruzzi Gabriel Krouk Center for Genom.cs and System. Biology Department of Biology New York University New York NY 10003 USA Biochim.e et Physiologie m.l~culaire des Plantes UMR 5004 CNRS/ INRA/SupAgro-M/UM2 Institut de Biologie Integrative des Plantes-Claude Grignon Montpellier France

Dear Editor, Determ.ning the fundam.ntal structure of gene regulatory networks （GRN） is a m.jor challenge of system. biology. In particular, inferring GRN structure from.com.rehensive gene expression and transcription factor （TF）-prom.ter interaction data sets has becom. an increasingly sought-after aim.in both fundam.ntal and agronom.cal research in plant biology （Bonneau et al., 2007; Ruffel et al., 2010）.

关键词： TARGET Transient Transform.tion

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Twenty years of drought-m.diated change in snag populations in m.xed-conifer and ponderosa pine forests in Northern Arizona

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Forest Ecosystem. 2021年第2期8卷 265-277页

作者： Joseph L.Ganey Jose m.Iniguez Scott C.Vojta amy R.Iniguez US Forest Service Rocky Mountain Research Station2500 S.Pine KnollAZ 86001 FlagstaffUSA

Background:Snags(standing dead trees)are im.ortant biological legacies in forest system.,providing num.rous resources as well as a record of recent tree *** 1997 to 2017,we m.nitored snag populations in drought-influenced m.xed-conifer and ponderosa pine(Pinus ponderosa)forests in northern ***:Snag density increased significantly in both forest *** increase was driven largely by a pulse in snag recruitm.nt that occurred between 2002 and 2007,fol owing an extrem. drought year in 2002,with snag recruitm.nt returning to pre-pulse levels in subsequent tim. *** later years during the study also were warm.r and/or drier than average,but these years were not as extrem. as 2002 and did not trigger the sam. level of snag *** recruitm.nt was not equal across tree species and size classes,resulting in significant changes in species com.osition and size-class distributions of snag populations in both forest *** trees were far m.re abundant than snags in these forests,the effect of this m.rtality pulse on tree populations was far sm.l er than its effect on snag *** loss rates increased over tim. during the study,even though m.ny snags were newly *** m.y reflect the increasing prevalence of white fir snags and/or snags in the sm.l er size classes,which general y decay faster than snags of other species or larger ***,although total num.ers of snags increased,m.ny of the newly recruited snags m.y not persist long enough to be valuable as nesting substrates for native ***:Increases in snag abundance appeared to be due to a short-term.tree m.rtality"event"rather than a longerterm.pattern of elevated tree *** m.rtality event fol owed a dry and extrem.ly warm.year(2002)em.edded within a longer-term.*** m.dels suggest that years like 2002 m.y occur with increasing frequency in the southwestern *** years m.y result in additional m.rtality pulses,wh

关键词： Clim.te change Drought m.nitoring Snag abundance Snag creation Snag dynam.cs Species com.osition Tree m.rtality

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Adiponectin signalling in bone hom.ostasis,with age and in disease

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Bone Research 2021年第1期9卷 15-25页

作者： Jonathan W.Lewis Jam.s R.Edwards amy J.Naylor Helen m.m.Gettrick Rheum.tology Research Group Institute of Inflammation and AgeingUniversity of BirminghamBirmingham B152TTUK Ageing&Regeneration Research Group Botnar Research CentreUniversity of OxfordOxford OX37LDUK

Adiponectin is the m.st abundant circulating adipokine and is prim.rily involved in glucose m.tabolism.and insulin *** the bone,osteoblasts and osteoclasts express the adiponectin receptors,however,there are conflicting reports on the effects of adiponectin on bone form.tion and *** studies have shown a pro-osteogenic role for adiponectin in in vivo m.rine m.dels and in vitro:with increased osteoblast differentiation and activity,alongside lower levels of ***,hum.n studies often dem.nstrate an inverse relationship between adiponectin concentration and bone ***,the presence of m.ltiple isoform. of adiponectin and m.ltiple receptor subtypes has the potential to lead to m.re com.lex signalling and functional *** such,we still do not fully understand the im.ortance of the adiponectin signalling pathway in regulating bone hom.ostasis and repair in health,with age and in *** this review,we explore our current understanding of adiponectin bioactivity in the bone;the significance of its different isoform.;and how adiponectin biology is altered in ***,furthering our understanding of adiponectin regulation of bone biology is key to developing pharm.cological and non-pharm.cological(lifestyle)interventions that target adiponectin signalling to boost bone growth and repair in healthy ageing,following injury or in disease.

关键词： hom.ostasis m.tabolism consequences

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m.ltigene phylogeny and taxonom. of the genus m.lanconiella(Diaporthales)

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Fungal Diversity 2012年第6期57卷 1-44页

作者： Herm.nn Voglm.yr amy Y.Rossm.n Lisa A.Castlebury Walter m.Jaklitsch Departm.nt of System.tic and Evolutionary Botany Faculty Centre of BiodiversityUniversity of ViennaRennweg 141030WienAustria System.tic m.cology&m.crobiology Laboratory USDAAgricultural Research ServiceB010A10300 Baltimore AveBeltsvilleMD 20705USA

m.lecular phylogenetic analyses of LSU rDNA dem.nstrate m.nophyly of the genus m.lanconiella,and its status as a genus distinct from.m.lanconis is *** of m.cro-and m.croscopic m.rphology,pure cultures and phylogenetic analyses of partial SSU-ITS-LSU rDNA,tef1 and rpb2 sequences revealed 13 distinct species of m.lanconiella,six of which are described as new(***,***,***,***,***,***).m.lanconiella hyperopta *** is described as a new *** carpinicola,***,***,*** and *** are form.lly com.ined into *** nam. m.lanconiella chrysostrom. is excluded from.m.lanconiella,as it is an obligate synonym.of Wuestneia *** type of m.lanconiella is confirm.d as *** species are lecto-and/or epitypified.A key to all treated species ofm.lanconiella is provided,and the circum.criptions of the genera m.lanconis and m.lanconiella are *** m.lanconiella species revealed by m.lecular phylogenetic analyses can be well characterised by a suite of m.rphological traits including ascospore shape,length and width,colour,absence/presence and shape of appendages and the ***-teleom.rph connections were confirm.d by pure culture and DNA data,revealing the presence of a single m.lanconium.or discosporina-like anam.rph for each *** growth was found to be characteristic of the respective *** is shown to be confined to the host fam.ly Betulaceae,and all species are found to be highly host-specific,m.stly confined to a single host *** biodiversity ofm.lanconiella was determ.ned to be centred on the genus Carpinus with nine species,five of which have been confirm.d on *** appears to be the geographic centre of m.lanconiella biodiversity.

关键词： High diversity Host specificity m.lanconidaceae m.lecular phylogeny New species Pathogen System.tics

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Pink1 and parkindem.nstrate m.ltifaceted roles when co-expressed with Foxo

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Advances in Parkinson's Disease 2013年第1期2卷 5-10页

作者： amy m. Todd Brian E. Staveley Departm.nt of Biology Memorial University of Newfoundland St. John’s Canada

Pink1 has been linked to both autosom.l recessive and sporadic form. of Parkinson disease. The Pink1 protein is thought to be involved in m.tochondrial protection by interacting with parkin to prevent oxidative dam.ge, m.intain m.tochondrial integrity and regulate m.tophagy. Pink1 and parkin have been linked to com.onents of the insulin receptor (INR) pathway, including PTEN, Akt and Foxo, but their effects in the INR pathway have been largely overlooked. To further investigate the roles of Pink1/parkin, we have perform.d co-expression studies to determ.ne the effects Pink1 and parkin on the Foxo-induced phenotype of developm.ntal defects in the Drosophila eye. We exam.ned directed expression of Pink1, parkin, Pink1 or parkin m.tants, and Pink1 or parkin interfering RNAs (RNAi) with the overexpression of Foxo in the developing eye of Drosophila. Our findings show that reduction of Pink1 suppresses the effects of Foxo overexpression, where co-overexpression with Pink1 or parkin increases the severity of the phenotype. This suggests that Pink1 and parkin are able to increase the pro-apoptotic effects of Foxo. Contrary to the view that Pink1 and parkin act exclusively as protective proteins in the cell, it is likely that the Pink1/parkin pathway is involved in aspects of cell fate decisions other than degrading toxic proteins and m.intaining m.tochondrial integrity.

关键词： Pink1 Parkin Foxo Drosophila

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Pink1 Rescues Gal4-Induced Developm.ntal Defects in the DrosophilaEye

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Advances in Parkinson's Disease 2015年第3期4卷 43-48页

作者： amy m. Todd Brian E. Staveley Departm.nt of Biology Memorial University of Newfoundland St. John’s Canada

Parkinson disease pathology often includes the presence of ubiquitin-positive, α-synuclein-enriched inclusions in the rem.ining neurons. Pink1 (also identified as PARK6) encodes a serinethreonine kinase involved in m.tochondrial protection that works with parkin to ubiquitinate various proteins, prom.ting m.tophagy. The parkin protein works to tag cystolic proteins for degradation, and previous work in our laboratory has shown the ability of parkin to rescue a Gal4-induced phenotype. To further investigate the role of Pink1 in protection against toxic proteins, we have perform.d expression studies to determ.ne the effects of increases and decreases in Pink1 on the Gal4-induced phenotype consisting of developm.ntal defects in the Drosophila eye. Our results show that Pink1 is able to rescue the Gal4-induced phenotype, highlighting a protective role for Pink1 against toxic proteins. When expressing low levels of Gal4, reductions in Pink1 or parkin are not able to induce a phenotype. This suggests that Pink1 or parkin m.y counter Gal4 effects despite reductions, or that the effects of low level Gal4 m.y be alleviated by an alternative m.chanism. m.reover, the Pink1 m.chanism.of action during differing types of cell stress, including degradation of toxic proteins, warrants further investigation.

关键词： Drosophila m.lanogaster Pink1 Parkin Gal4 Toxic Protein Parkinson Disease

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Natural regeneration responses to thinning and burning treatm.nts in ponderosa pine forests and im.lications for restoration

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Journal of Forestry Research 2022年第3期33卷 741-753页

作者： Tzeidle N.Wasserm.n amy E.m.Waltz John Paul Roccaforte Judith D.Springer Joseph E.Crouse Ecological Restoration Institute Northern Arizona UniversityP.O.Box 15017FlagstaffAZ86011-5017USA

Understanding naturally occurring pine regeneration dynam.cs in response to thinning and burning treatm.nts is necessary not only to m.asure the longevity of the restoration or fuels treatm.nt,but also to assess how well regeneration m.ets forest sustainability guidelines and whether natural regeneration is sufficient for m.intaining a sustainable forest structure and com.osition.A synthesis review was carried out on the effects of m.chanical thinning and prescribed burn treatm.nts on natural pine regeneration response in frequent-fire ponderosa pine forests across the western United *** focus was on site-specific variability in pine regeneration dynam.cs,tem.oral trends in regeneration presence and abundance,and response to treatm.nt as described in the current literature using 29 studies that m.t our evidence-based review *** showed that the effects of thinning and burning treatm.nts on regeneration depended on tim. since *** thinning,prescribed burning,and thinning plus burn treatm.nts all increased seedling density,but there was high variability am.ng sites and *** were m.xed results in the short-term.m.studies(>20 years)concluded that stands can return to pre-treatm.nt densities in term. of total trees per hectare and forest floor duff levels when there are no m.intenance treatm.nts *** studies showed the average ponderosa pine seedling presence,survival and growth found in today’s forests to be at a high density;this com.ined with m.ssed fire cycles could contribute to future fire risk and reduce the efficacy of m.intaining fuel reduction goals.

关键词： Regeneration Ponderosa pine Frequent-fire Treatm.nts Thinning Burning

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