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Non-steroidal anti-inflammatory drugs and statins in relation to colorectal cancer risk

World Journal of Gastroenterology 2009年第19期15卷 2336-2339页

作者： Mazyar Shadman Polly A Newcomb John M Hampton Karen J Wernli amy trentham-dietz Cancer Prevention Program Fred Hutchinson Cancer Research CenterSeattle 98109United States Department of Epidemiology University of WashingtonSeattle 98195United States Polly A Newcomb University of Wisconsin Paul PCarbone Comprehensive Cancer CenterMadison 53726United States

AIM： To investigate the association between individual or combined use of non-steroidal anti-inflammatory drugs （NSAIDs） or statins and colorectal cancer ***： In a population-based case-control study in women, we examined the association between NSAIDs and statin use and the risk of colorectal cancers. We further investigated whether the use of statins modifies the protective effect of NSAIDs. Female cases （n = 669）of colorectal cancer aged 50-74 years were identified from a storewide registry in Wisconsin during 1999-2001. Community control women （n = 1375） were randomly selected from lists of licensed drivers and Medicare beneficiaries. Medication use and risk factor information were gathered during a structured telephone interview. A multivariable logistic regression model was used to calculate odds ratio （OR） and 95% confidence interval （CI）.RESULTS： Overall, NSAIDs users had a 30% reduction in risk of colorectal cancer （95% CI： 0.56-0.88）. Statin use was not associated with colorectal cancer risk （OR = 1.17, 95% CI： 0.74-1.85）, regardless of structural type （lipophilic or hydrophilic）, duration of use, or recency. There was no evidence of an interaction between NSAIDs and statins and colorectal cancer risk （P-interaction = 0.28）.CONCLUSION： Although our results confirm the inverse association between NSAIDs use and colorectal cancer risk, they do not support a risk reduction in statin users, or an interaction effect of combined NSAIDs and statin use.

关键词： Non-steroidal anti-inflammatory drugs Statin Colorectal cancer Cancer prevention Chemoprevention

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