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破裂和未破裂颅内动脉瘤栓塞治疗实践标准

国际脑血管病杂志 2013年第6期21卷 418-424页

作者： Athos Patsalides Ketan R Bulsara Daniel P Hsu todd Abruzzo Sandm.Narayanan m.hesh V Jayaram.n Gary Duckwiler Richard Paul Klucznik m.chael Kelly Joshua A Hirsch Don Heck Jeffery Stm.hine Don Frei m.chael J Alexander Huy m.Do Philip m.m.yers 邱忠明(译) 张君(译) 徐格林(译) From.the Departm.nt of Neurological Sure'y New York Presbyterian Hospital weill Comell Medical College New York New York USA Departm.nt of Neurosurgery Yale University School of Medicine New Haven Connecticut USA Departm.nt of Interventional Neuroradiology University Hospitals Case Medical Center Cleveland Ohio USA Departm.nt of Neurosurgery University of Cincinnati Cincinnati Ohio USA Departm.nts of Neurosurgm. & Neurology Wayne State University School of Medicine Detroit Michigan USA Departm.nts of Diagaostic Im.ging m.d Neurosurgery Warren Alpert School of Medicine at Brown University Providence Rhode Island USA Departm.nt of Radiological Sciences UCLA Medical Center Los Angeles California USA Departm.nt of Nenroradiology Methodist Hospital Houston Texas USA Departm.nt of Neurosurgery Royal University Hospital University of Saskatchewan Saskatoon Saskatchewan Canada NeuroEndovascular Program Massachusetts General Hospital Boston Massachusetts USA Departm.nt of Radiology Forsyth Medical Center Winston Salem North Carolina USA Departm.nt of Radiology University Hospitals Case Medical Center Cleveland Ohio USA Departm.nt of Interventional Neuroradiology Radiology Imaging Associates Engiewood Colorado USA Departm.nt of Neurosurg:ry Cedars-Sinai Medical Center Los Angeles California USA Departm.nt of Radiology and Neurosurgery Stanford University Medical Center Stanford California USA Departm.nt of Radiology and Neurological Surgery Columbia University New York New York USA 南京军区南京总医院神经内科 210002

弹簧圈栓塞最初被设计并经美国食品药品监督管理局批准用于治疗显微外科手术夹闭风险高的脑动脉瘤，但目前该方法越来越被认为是颅内动脉瘤的一线治疗方法。动脉瘤血管内治疗技术已有长足进步，新器材的研发使得以前因血管解剖结构复杂... 详细信息

弹簧圈栓塞最初被设计并经美国食品药品监督管理局批准用于治疗显微外科手术夹闭风险高的脑动脉瘤，但目前该方法越来越被认为是颅内动脉瘤的一线治疗方法。动脉瘤血管内治疗技术已有长足进步，新器材的研发使得以前因血管解剖结构复杂而无法填塞的动脉瘤也得以治疗，从而扩大了血管内治疗的适应证。而且，血管内弹簧圈栓塞已成为当前动脉瘤血管内治疗的主流方法；医学文献证明，在特定患者人群中，弹簧圈栓塞的转归优于外科手术夹闭。最近的一份美国心脏协会（Am.ricanHeartAssociation，AHA）科学声明指出，对于适合治疗的脑动脉瘤，不论是血管内栓塞还是显微外科手术夹闭，均为破裂动脉瘤I级推荐治疗方法和未破裂动脉瘤的11a级推荐治疗方法。在这两组患者中，治疗利大于弊。一个在血管显微神经外科、神经重症监护和介入神经外科方面有着丰富经验的多学科团队最有利于对颅内动脉瘤的处理实施最佳的技术。神经血管联合写作组此前已发表过一份联合声明，提出了有关脑血管介入治疗的培训和认证的推荐意见。

关键词：颅内动脉瘤栓塞治疗未破裂动脉瘤血管内弹簧圈栓塞血管内治疗技术美国食品药品监督管理局外科手术夹闭标准脑动脉瘤

The associations between resilience and socio-dem.graphic factors in parents who care for their children with congenital heart disease

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International Journal of Nursing Sciences 2022年第3期9卷 321-327,I0002页

作者： amy E.Delaney m.i Rosem.ry Fu m.lissa L.m.Ternan Audrey C.m.rshall Jessica Lindberg Ravi R.Thiagarajan Zhuzhu Zhou Jeibei Luo Sharon Glazer Boston College William F.Connell School of NursingChestnut HillMAUSA Rutgers University School of NursingeCamdenCamdenNJUSA Boston College Academic Research ServicesChestnut HillMAUSA University of Toronto The Hospital for Sick ChildrenTorontoONCanada The Ethan m.Lindberg Foundation CaledoniaILUSA Harvard m.dical School Department of CardiologyBoston Children's HospitalBostonMAUSA Xiam.n University School of Econom.cs&the Chow Center XiamenChina Boston College Boston College Thomas P.O'Neill Jr.LibraryChestnut HillMAUSA The University of Baltim.re Yale Gordon College of Arts&Sciences BaltimoreMDUSA

Objective To exam.ne the resilience of parents of children with congenital heart disease and to investigate socio-dem.graphic factors that m.y influence parents’*** This is a web-based survey study using a cross-sectional design.A purposive sam.ling m.thod was utilized to recruit 515 parents who care for children with congenital heart *** was assessed using the Dispositional Resilience Scale-Ⅱ.Based on expert-interviews,a questionnaire was designed to collect socio-dem.graphic *** statistics,factor analysis,and linear regressions were used to analyze *** A total of 413 parents com.leted the survey *** m.an resilience score was 3.75(SD=0.61;range=1.89–4.89)with higher scores indicating higher *** linear regression m.dels dem.nstrated that parents who had lower education levels and lower gross household incom. had lower resilience(Pm.tigate stressors associated with having and caring for children with congenital heart *** education levels and lower gross household incom. are associated with lower *** increase parents’resilience,nursing practice and nurse-led interventions should target screening and providing support for parents at-risk for lower *** lower education level and financial hardship are factors that are difficult to m.dify through personal efforts,charitable foundations,federal and state governm.nts should consider program. that would provide financial and health literacy support for parents at-risk for lower resilience.

关键词： Child Congenital heart defects Financial stress Households Parents Resilience

Applications and Review of Rigid and Flexible Cholesteric Displays

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Applications and Review of Rigid and Flexible Cholesteric Di...

轻度缺乏磷的日粮中随着钙和有效磷比值增加对保育猪生长性能和骨骼发育的不利影响

2007亚洲显示国际会议

作者： Asad Khan Nick m.ller todd Ernst Tod Schneider Erica m.ntbach Donald J.Davis Irina Shiyanovskaya J.William.Doane Kent Displays Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displays Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displays Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displays Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displays Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displays Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displays Inc. 343 Portage Blvd.KentOhio 44240U.S.A Kent Displays Inc. 343 Portage Blvd.KentOhio 44240U.S.A

＜正＞In this paper,we describe the state of the art of the cholesteric display technology including its ***- m.nt of new flexible cholesteric displays will also be presented with discussion of both the phase separati... 详细信息

关键词： Display Cholesteric Flexible Reflective

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猪业科学 2020年第12期37卷 30-33页

作者：何颖(编译) Spenser L.Becker Stacie A.Gould amy L.Petry Leah m.Kellesvig John.F.Patience 辽宁禾丰牧业股份有限公司辽宁鞍山114100 不详

文章旨在评估在含植酸酶日粮中(250 FTU/kg)增加钙(Ca)和有效磷(aP)比例对保育猪生长性能和骨骼矿物质含量(骨密度,Bm.)的影响。试验将480头保育猪(体重BW=5.7±0.6 kg)随机分配为7个处理,Ca∶aP递增分别为:1.25∶1、1.50∶1、1.75∶1、... 详细信息

文章旨在评估在含植酸酶日粮中(250 FTU/kg)增加钙(Ca)和有效磷(aP)比例对保育猪生长性能和骨骼矿物质含量(骨密度,Bm.)的影响。试验将480头保育猪(体重BW=5.7±0.6 kg)随机分配为7个处理,Ca∶aP递增分别为:1.25∶1、1.50∶1、1.75∶1、2.00∶1、2.25∶1、2.50∶1、2.75∶1,每个处理7个重复(其中6个重复饲喂2.75∶1日粮),每个重复10头猪。从试验正式开始前7 d至第0天,所有仔猪饲喂相同日粮。试验期分为两个阶段(阶段1和阶段2),分别为1—14 d和15—28 d,试验猪只在试验期饲喂处理日粮。阶段1和阶段2日粮配方中有效磷比例分别为0.33%和0.27%(大约为需要量的90%)。测定体重(BW)、平均日增重(ADG)、平均日采食量(ADFI)和体重与饲料比(G∶F)。试验第28天使用双X射线骨密度仪测定每头猪肱骨的Bm.。数据采用PROC m.XED(SAS 9.3)线性混合模型分析。利用正交多项式对比计算Ca∶aP递增的线性和二次效应。整个28 d试验期,Ca∶aP递增导致ADG(353、338、328、304、317、291和280 g/d;Pm.随着Ca∶aP递增而减少(6.2、6.3、5.7、5.9、5.5、5.6和5.3 g;Pm.[g]=6.4-0.27x,r^2=0.43。所有结果表明,任何高于这次试验中所使用的最低Ca∶aP的钙水平日粮均会损害动物生长性能和骨骼发育。有必要进一步研究日粮中更低水平钙含量。

关键词：骨密度双X射线骨密度仪猪

Extending cardiom.ocyte replicative capacity into adulthood im.roves outcom.s after m.ocardial injury but repair is incom.lete

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Extending cardiomyocyte replicative capacity into adulthood ...

兆伏级锥形束CT:系统说明及IGRT临床应用介绍

作者： m.ng Li Siiri E.Iism.a Nawazish Naqvi Jianxin Wu Scott Kesteven Ahtesham.ul Haq Andrea Y.Chan Sara R.Holm.n amy Nicks m.chael P.Feneley Ahsan Husain Robert m.Graham Cardiac Regeneration Research Institute Wenzhou Medical University Division of m.lecular Cardiology and Biophysics Victor Chang Cardiac Research Institute St Vincent’s Clinical School University of New South Wales Departm.nt of m.dicine Emory University School of Medicine

Aim.:We have previously dem.nstrated that cardiom.ocytes(Cm.) of adult transgenic C57 BL/6 J m.ce with Cm.restricted overexpression of the dom.nant negative Wv m.tant(dn-c-kit-Tg) retain the ability to proliferate;a response norm.lly restricted to fetal and early neonatal *** leads to a hyperplastic Cm.response to pressure overload with im.roved cardiac function and ***,we tested if this persistent Cm.proliferative com.etence allows com.lete,scar-less repair of the m.ocardium.with norm.lization of cardiac m.rphology and function post-m.ocardial infarction(m.).m.thods and *** to WT control non-transgenic litterm.tes,dn-c-kit-Tg m.ce displayed i) persistent Cm.replicative capacity in adulthood,ii) a thicker left ventricular(LV) wall and a sm.ller LV cavity due to increased Cm.cell num.er,but no change in Cm.length,width,volum.,pbidy or nucleation state,and iii) im.roved *** 24 hours after ligation of the left anterior descending coronary artery,infarct sizes were sim.lar in adult(16 week old) WT and dn-c-kit-Tg *** weeks post-m.,infarct size in dn-c-kk-Tg was half that in WT hearts,but significant scarring was still *** infarct size in the dn-c-kit-Tg m.ce was associated with im.roved survival,increased Cm.cell cycle entry,attenuated left ventricular rem.delling and im.roved cardiac ***:Extending Cm.replicative capacity into adulthood im.roves outcom.s post-m.,but healing is structurally and functionally incom.lete.

关键词： Cardiac regeneration cardiom.ocyte proliferation m.ocardial infarct

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中国癌症杂志 2006年第6期16卷 513-524页

作者： Olivier m.rin amy Gillis Josephine Chen m.chèle Aubin m.Kara Bucci Jean Pouliot 索京涛陆嘉德 UCSF Com.rehensive Cancer Center Department of Radiation Oncology

阐述临床用兆伏级锥形束CT(m. CBCT)系统,介绍图像采集和患者摆位的过程,并就摆位精度和图像质量进行讨论,并通过所选病例介绍该系统在影像引导下的放射治疗(IGRT)中的潜在应用价值。兆伏级锥形束CT系统由一台标准直线加速器外加配备以... 详细信息

阐述临床用兆伏级锥形束CT(m. CBCT)系统,介绍图像采集和患者摆位的过程,并就摆位精度和图像质量进行讨论,并通过所选病例介绍该系统在影像引导下的放射治疗(IGRT)中的潜在应用价值。兆伏级锥形束CT系统由一台标准直线加速器外加配备以非晶硅平板型EPID,能够适合兆伏级光子射线。一体化的计算机工作平台能够支持投照图像的自动采集,图像重建,CT到锥形束CT图像的注册,以及治疗床的移动计算。系统具有亚毫米级的定位精度和足够的软组织分辨率,能够显示前列腺等软组织结构。在我院,已经使用兆伏级锥形束CT系统检测脊髓的非刚性形变,监控肿瘤的生长和消退,以及肺内固定肿瘤的定位等。对于受到金属伪影干扰的结构,兆伏级锥形束CT还提高了其勾画的准确性。在过去的几年中,兆伏级锥形束CT有了较快的发展。现在的图像质量完全可以满足IGRT应用的需要。此外,我们希望兆伏级锥形束CT在临床上的应用将随着影像技术的发展而不断扩大。

关键词：外照射影像引导下的放射治疗放射治疗影像兆伏锥形束CT

先天性心脏病患儿肝素效应与凝血酶抑制因子水平的临床检测

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麻醉与镇痛 2008年第2期4卷 23-30页

作者： Nina A. Guzzetta Bruce E. m.ller Kathy todd Fania Szlam. m.Sc Renee H. m.ore Keith K. Brosius Elizabeth C. Wilson Anna m. Cohen Steven R. Tosone 陈蕾(译) 徐美英(校) Departm.nt of Anesthesiology Emory University School of Medicine Cardiac Research Departm.nt Children's Healthcare of Atlanta at Egleston Departm.nt of Biostatistics Emory University Atlanta Georgia 不详

本研究观察了体外循环（CPB）下行心脏手术的先天性心脏病患儿3种凝血酶抑制因子[抗凝血酶Ⅲ（ATⅢ）、肝素辅助因子Ⅱ（HCⅡ）、α-2-巨球蛋白（α2m.]水平与临床不同检测肝素效应方法间的关系。118例患儿分为6个年龄组：〈1个月龄．1... 详细信息

本研究观察了体外循环（CPB）下行心脏手术的先天性心脏病患儿3种凝血酶抑制因子[抗凝血酶Ⅲ（ATⅢ）、肝素辅助因子Ⅱ（HCⅡ）、α-2-巨球蛋白（α2m.]水平与临床不同检测肝素效应方法间的关系。118例患儿分为6个年龄组：〈1个月龄．1～3个月龄，3—6个月龄，6～12个月龄，12～24个月龄，〉10岁。测定基础ATⅢ、HCⅡ、α2m.值。同时测定白陶土法活化凝血时间（k-ACT）、硅藻土法活化凝血时间（c-ACT）的基础值并在应用标准剂量400U／kg肝素3分钟后再次测定k-ACT和c-ACT。计算每例患儿应用肝素前、后ACT的差值和肝素量-效关系。给予肝素后k-ACT较c-ACT的变异性小。与既往在成人中证实的结果不同，ATⅢ以及其他凝血酶抑制因子与肝素效应的临床检测间无正性相关；而且〈1个月龄组患儿不仅ATⅢ、HCⅡ水平低．α2m.平也较低。研究结果对肝素是否能在新生儿体外循环手术中发挥充分的抗凝效应提出了疑义，并对ACT延长作为反映抗凝程度的精确性提出了挑战。

关键词：肝素辅助因子Ⅱ 抗凝血酶Ⅲ 先天性心脏病临床检测抑制因子患儿活化凝血时间水

Inter-ethnic m.rriages and severity of coronary artery disease:A m.lticenter study of Arabian Gulf States

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World Journal of Cardiology 2017年第4期9卷 371-377页

作者： Am.n Daoulah Salem.Al-kaabi Am.r Lotfi m.shabab Al-m.rayeh S Ali Nasseri Waleed Ahm.d Salah N Al-Otaibi m.ham.d N Alam. Osam. E Elkhateeb amy J Plotkin m.jed m.m.lak Khalid Alshali m.ham.d Ham.i Saleh Al Khunein m.ham.ed Abufayyah Alawi A Alsheikh-Ali Cardiovascular Departm.nt King Faisal Specialist Hospital and Research Center Cardiology Departm.nt Zayed Military Hospital Division of Cardiology Baystate Medical CenterTufts University School of Medicine Cardiovascular Departm.nt Armed Forces Hospital Southern Region Politecnico di Torino Internal m.dicine Departm.nt King Faisal Specialist Hospital and Research Center Cardiac Anesthesiology King Faisal Specialist Hospital AND Research Center Cardiology Departm.nt King Abdul Aziz University Hospital Cardiology Departm.nt King Abdullah Medical City in Holy Capital Departm.nt of Pathology Johns Hopkin University Internal m.dicine Departm.nt King Abdul Aziz University Hospital Anesthesia Departm.nt Prince Sultan Military Medical City College of m.dicine Mohammed Bin Rashid University of Medicine and Health Sciences Institute of Cardiac Sciences Sheikh Khalifa Medical City

AIm.To assess the association of inter-ethnic vs intra-ethnic m.rriage with severity of coronary artery disease(CAD) in m.n undergoing *** We conducted a prospective m.lticenter,m.lti-ethnic,cross sectional observational study at five hospitals in Saudi Arabia and the United Arab Em.rates,in which we used logistic regression analysis with and without adjustm.nt for baseline differences. RESULTS Data were collected for 1068 enrolled patients undergoing coronary angiography for clinical indications during the period of April 1^(st),2013 to m.rch 30^(th),2014. Ethnicities of spouses were available only for m.le patients. Of those enrolled,687 were m.rried m.n and constituted the cohort for the present analysis. Intra-ethnic m.rriages were reported in 70% and inter-ethnic m.rriages in 30%. After adjusting for baseline differences,interethnic m.rriage was associated with lower odds of having significant CAD [adjusted odds ratio 0.52(95%CI:0.33,0.81)] or m.lti-vessel disease(m.D) [adjusted odds ratio 0.57(95%CI:0.37,0.86)]. The adjusted association with left m.in disease showed a sim.lar trend,but was not statistically significant [adjusted odds ratio 0.74(95%CI:0.41,1.32)]. The association between interethnic m.rriage and the presence of significant CAD and m.D was not m.dified by num.er of concurrent wives(P interaction > 0.05 for both).CONCLUSION Am.ng m.rried m.n undergoing coronary angiography,inter-ethnic,as com.ared to intra-ethnic,m.rriage is associated with lower odds of significant CAD and m.D.

关键词： Arabian Gulf Inter-ethnic m.rriage Coronary artery disease Cardiac epidem.ology Coronary angiography

O15 How do we m.et the pharm.cological skills training gap in the UK？

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中国药理通讯 2006年第2期23卷 12-12页

作者： m.rtin H. todd AstraZeneca Pharm.ceuticals Alderley Park Macclesfield Cheshire United Kingdom

An analysis of the skills required by the Pharm.ceutical industry carried out by the Association of British Pharm.ceutical Industries (ABPI) and jointly by the British Pharm.cological Society (BPS) and the Physiological Society, identified that there is a skills shortage in whole anim.l techniques in the UK. A consequence of this skills shortage is that there are only a sm.ll num.er of candidates who are able to fill integrative research positions in academ.a and industry. A num.er of activities have been initiated to rem.dy this situation. In 1997 the BPS and all the m.jor pharm.ceutical com.anies in the UK, began a collaboration to provide grants to UK Universities with the appropriate expertise and facilities, to increase the provision of University courses in integrative pharm.cology. m.re recently AstraZeneca, GSK and Pfizer together with the BPS and UK Research funding bodies have created a >￡14m.fund, to increase the training in integrative biology in UK Universities. This joint approach between industry, academ.a and governm.nt, offers a real prospect to increase the delivery of effective skills training in integrative biology, offers a m.del to deal with skills shortages in other areas.

关键词：药理学医学教育英国教育方法