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Journal of Forestry Research 2024年第4期35卷 13-33页

作者： Dehui Christina Geng amy li Jieyu Zhang Howie W.Harshaw Christopher Gaston Wanli Wu Guangyu Wang National Park Research Centre Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada Faculty of Applied Science University of British ColumbiaVancouver V6T 1Z3Canada Paul G.Allen School of Computer Science&Engineering University of WashingtonSeattleWA 98195USA Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmonton T6G 2J9Canada Department of Wood Science Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada

COVID-19 posed challenges for global tourism *** in visitor temporal and spatial patterns and their associated determinants pre-and peri-pandemic in Canadian Rocky Mountain National Parks are *** was collected through social media programming and analyzed using spatiotemporal analysis and a geographically weighted regression(GWR)*** highlight that COVID-19 significantly changed park visitation *** tended to explore more remote areas *** GWR model also indicated distance to nearby trails was a significant influence on visitor *** results indicate that the pandemic influenced tourism temporal and spatial *** research presents a novel approach using combined social media big data which can be extended to the field of tourism management,and has important implications to manage visitor patterns and to allocate resources efficiently to satisfy multiple objectives of park management.

关键词： Tourism management Social media big data National parks COVID-19 Geographical weighted regression

Putative Mode of Action of the Monoterpenoids linalool, Methyl Eugenol, Estragole, and Citronellal on ligand-Gated Ion Channels

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Engineering 2020年第5期6卷 541-545页

作者： amy Sli Akimasa Iijima Junhao Huang Qing Xli Yongli Chen College of Natural and Computational Sciences Hawaii Pacific UniversityKaneoheHI 96744USA Department of Molecular Biosciences and Bioengineering University of Hawaii at ManoaHonoluluHI 96822USA Department of Internal Medicine University of Colorado School of MedicineAuroraCO 80045USA

Essential oil has been used as sedatives,anticonvulsants,and local anesthetics in traditional medical remedies;as preservatives for food,fruit,vegetable,and grain storage;and as bio-pesticides for food ***(LL),along with a few other major components such as methyl eugenol(ME),estragole(EG),and citronellal,are the active chemicals in many essential oils such as basil *** oil and the aforementioned monoterpenoids are potent against insect ***,the molecular mechanism of action of these chemical constituents is not well *** is well-known that the c-aminobutyric acid type A receptors(GABAARs)and nicotinic acetylcholine receptor(nAChR)are primary molecular targets of the synthetic insecticides used in the market ***,the GABAAR-targeted therapeutics have been used in clinics for many decades,including barbiturates and benzodiazepines,to name just a *** this research,we studied the electrophysiological effects of LL,ME,EG,and citronellal on GABAAR and nAChR to further understand their versatility as therapeutic agents in traditional remedies and as *** results revealed that LL inhibits both GABAAR and nAChR,which may explain its insecticidal *** is a concentration-dependent,noncompetitive inhibitor on GABAAR,as the half-maximal effective concentration(EC50)values of c-aminobutyric acid(GABA)for the rat a1b3c2L GABAAR were not affected by LL:(36.2±7.9)lmol-1 and(36.1±23.8)μmol·L-1 in the absence and presence of 5 mmol·L-1 LL,*** half-maximal inhibitory concentration(IC50)of LL on GABAAR was approximately 3.2 mmol·*** that multiple monoterpenoids are found within the same essential oil,it is likely that LL has a synergistic effect with ME,which has been previously characterized as both a GABAAR agonist and a positive allosteric modulator,and with other monoterpenoids,which offers a possible explanation for the sedative and anticonvulsant effects and the insecticidal activi

关键词： Essential oil c-Aminobutyric acid type A receptor linalool Monoterpenoid Nicotinic acetylcholine receptor

Hydraulic properties and drought response of a tropical bamboo (Cephalostachyum pergracile)

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Plant Diversity 2024年第3期46卷 406-415页

作者： Wanwalee Kongjarat Lu Han amy Ny Aina Aritsara Shu-Bin Zhang Gao-Juan Zhao Yong-Jiang Zhang Phisamai Maenpuen Ying-Mei li Yi-Ke Zou Ming-Yi li Xue-Nan li lian-Bin Tao Ya-Jun Chen CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China University of the Chinese Academy of Sciences Beijing 100049China T-STAR Core Team Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China School of Biology and Ecology University of MaineOronoMEUSA Climate Change Institute University of MaineOronoME 04469USA School of Biological and Chemical Science Pu’er UniversityXueyuan RoadYunnan 665000China Institute of Ecology and Geobotany School of Ecology and Environmental SciencesYunnan UniversityKunmingYunnan 650091China School of Ecology and Environment Southwest Forestry UniversityKunmingYunnan 650224China Yuanjiang Savanna Ecosystem Research Station Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYuanjiangYunnan 653300China

Bamboo plants are an essential component of tropical ecosystems,yet their vulnerability to climate extremes,such as drought,is poorly understood due to limited knowledge of their hydraulic *** pergracile,a commonly used tropical bamboo species,exhibited a substantially higher mortality rate than other co-occurring bamboos during a severe drought event in 2019,but the underlying mechanisms remain *** study investigated the leaf and stem hydraulic traits related to drought responses,including leaf-stem embolism resistance(P50leaf;P50stem) estimated using optical and X-ray microtomography methods,leaf pressure-volume and water-releasing ***,we investigated the seasonal water potentials,native embolism level(PLC) and xylem water source using stable *** found that *** exhibited strong resistance to embolism,showing low P50leaf,P50stem,and turgor loss point,despite its rapid leaf water ***,its leaves displayed greater resistance to embolism than its stem,suggesting a lack of effective hydraulic vulnerability segmentation(HVS) to protect the stem from excessive xylem *** the dry season,approximately 49% of the water was absorbed from the upper 20-cm-deep soil ***,significant diurnal variation in leaf water potentials and an increase in midday PLC from 5.87±2.33% in the wet season to 12.87±4.09%in the dry season were *** summary,this study demonstrated that the rapid leaf water loss,high reliance on surface water,and a lack of effective HVS in *** accelerated water depletion and increased xylem embolism even in the typical dry season,which may explain its high mortality rate during extreme drought events in 2019.

关键词： Climate change Drought Hydraulic safety Hydraulic vulnerability segmentation Stable isotope Tree mortality

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马岩松：对话山水

艺术与设计 2015年第2期4卷 86-91页

作者： amy li

2014年，声卡斯叙事艺术博物馆创始人乔治卢卡斯向全球多位世界级建筑大师发出了邀请，希望在芝加哥这座谱写了美国现代建筑艺术史的城市，建造一座超越时代、充满想象力的作品。而最终，马岩松领衔的MAD事务所再次以其浪漫而富于启发... 详细信息

2014年，声卡斯叙事艺术博物馆创始人乔治卢卡斯向全球多位世界级建筑大师发出了邀请，希望在芝加哥这座谱写了美国现代建筑艺术史的城市，建造一座超越时代、充满想象力的作品。而最终，马岩松领衔的MAD事务所再次以其浪漫而富于启发的与自然合为一体的方案胜出，也因此成为历史上首位在西方世界里设计标志性文化建筑的中国建筑师。

关键词：山水对话松艺术博物馆中国建筑师建筑大师现代建筑文化建筑

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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

作者：李雪柏(amy li)

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu liu Michael Chopp Michael Millman Yanfeng li Pasquale Cepparulo amy Kemper Chao li li Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

汇聚世界先进制造装备透视行业未来发展趋势——CIMT 2011圆满落幕

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航空制造技术 2011年第11期54卷 70-71页

作者：泰山

在北京暖暖的春光中,满载各方赞誉的第十二届中国国际机床展览会(CIMT 2011)圆满落下帷幕。中国国际机床展览会由中国机床工具工业协会主办,自1989年创办至今已经走过了23年历程,成功举办了12届。本届CIMT 2011展会更是取得了空前的成功... 详细信息

在北京暖暖的春光中,满载各方赞誉的第十二届中国国际机床展览会(CIMT 2011)圆满落下帷幕。中国国际机床展览会由中国机床工具工业协会主办,自1989年创办至今已经走过了23年历程,成功举办了12届。本届CIMT 2011展会更是取得了空前的成功,展会汇聚了来自全球28个国家和地区的1400多家业界厂商,众多知名企业悉数参展,使用了中国国际展览中心(新馆)全部8个展馆和1个临时馆,展出面积达12万m2。无论展会规模、展商数量、观众人数、展品数量和水平、展会成交额,还是国家领导人及社会各界的关注程度,都创造了历届CIMT展会和全国同类展会之最。

关键词： CIMT 2011 机床工具展会机床行业数控机床机床协会国际论坛重大专项全球业界柔性生产线柔性制造系统

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数控加工技术及应用调查报告

航空制造技术 2011年第11期 70-71页

作者：泰山金卯

数控技术是现代制造技术的基础,它的广泛应用使普通机械被数控机械所代替,使全球制造业发生了根本变化。在电子信息技术普遍应用及快速发展的基础上,为了实现自动化、柔性化、集成化的生产,同时提高产品质量、提高劳动生产率,现代制造... 详细信息

数控技术是现代制造技术的基础,它的广泛应用使普通机械被数控机械所代替,使全球制造业发生了根本变化。在电子信息技术普遍应用及快速发展的基础上,为了实现自动化、柔性化、集成化的生产,同时提高产品质量、提高劳动生产率,现代制造工业领域已经开始大规模使用数字化技术进行生产加工。而作为高技术工业的顶点,航空航天领域采用当今最先进的材料,并且完成产品的零部件众多,其对数控加工技术的需求更加迫切。本刊以"数控加工技术及应用调查"为主题展开调查,希望能归纳出数控加工技术的应用现状、问题和发展趋势,为数控系统生产商、数控机床企业、最终用户和专业协会等提供有价值的参考。本次调查采用调查问卷形式,主要面向数控设备供应商、企业用户、科研机构等3个方面展开。在数控设备供应商方面方面,主要针对沈阳机床、齐二机床、上海重型机床厂有限公司、瑞士宝美技术有限公司、北一大隈等知名供应商;航空企业用户主要包括中航飞机起落架有限责任公司、航天科工集团第九研究院8605厂、北京凯普精益机电技术有限公司北京卫星制造厂、北京航空精密机械所等;科研机构包括哈尔滨工业大学、北京航空航天大学、南京航空航天大学、西北工业大学、中国质量协会全国数控设备用户委员会等。这些企业、厂商和科研机构为我们提供了很多关于数控机床方面的信息,给予了本次调查极大的支持。

关键词：数控加工技术数控技术现代制造技术应用现状数控机床数控系统

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复合材料专用设备与技术调查报告

航空制造技术 2010年第21期53卷 58-63页

作者：泰山侧卫《航空制造技术》编辑部

广泛采用自动化设备是复合材料构件生产发展的趋势,也是提高产品质量和增强质量稳定性的重要手段。为了增强科研机构、厂家和用户之间的沟通和联系,以便更好地推进复合材料专用设备与技术的研发进程,本刊特别设计了本调查,本调查以"复... 详细信息

广泛采用自动化设备是复合材料构件生产发展的趋势,也是提高产品质量和增强质量稳定性的重要手段。为了增强科研机构、厂家和用户之间的沟通和联系,以便更好地推进复合材料专用设备与技术的研发进程,本刊特别设计了本调查,本调查以"复合材料专用设备与技术"为主题,主要调查对象涉及设备制造商、航空企业用户和科研机构。其中,设备制造商包括美国格柏科技,HEATCON复合维修系统公司,西班牙***,北京长征中装科技有限公司,法国弗雷斯特里内机床集团等;航空企业用户包括成都飞机工业(集团)有限公司,第一飞机设计研究院,北京航空制造工程研究所,中国空空导弹研究院等;科研机构包括北京航空航天大学,南京航空航天大学,西北工业大学,哈尔滨工业大学等。通过对复合材料专用设备使用情况、用户需求、用户期望、发展趋势等方面进行分析,为设备制造商的生产和用户的选择提供参考。

关键词：复合材料构件专用设备调查报告技术北京航空航天大学航空制造工程南京航空航天大学设备制造商

Large‑scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1466-1481页

作者： Di Zhao Ranran liu Xiaodong Tan Huimin Kang Jie Wang Zheng Ma Haiquan Zhao Hai Xiang Zhengfen Zhang Hua li Guiping Zhao Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and EngineeringFoshan UniversityFoshanChina State Key Laboratory of Animal Biotech Breeding Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijingChina Guangdong Tinoo’s Foods Group Co. Ltd.QingyuanChina

Background Carcass traits are crucial indicators of meat production ***,the molecular regulatory mechanisms associated with these traits remain *** In this study,we conducted comprehensive transcriptomic and genomic analyses on 399 Tiannong partridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regulatory *** on association analyses with the elastic net(EN)model,we identified 12 candidate genes(amy1A,AP3B2,CEBPG,EEF2,EIF4EBP1,FGFR1,FOXD3,GOLM1,LOC107052698,PABPC1,SERPINB6 and TBC1D16)for 4 carcass-related traits,namely live weight,dressed weight,eviscerated weight,and breast muscle ***6 was identified as the only overlapping gene by 3 analyses,EN model analysis,weighted gene co-expression network analysis and differential expression ***-level experiments confirmed that SERPINB6 promotes the proliferation of chicken DF1 cells and primary *** expression genome-wide association study and association analysis indicated that rs317934171 is the critical site that enhances SERPINB6 ***,a dual-luciferase reporter assay proved that gga-miR-1615 targets the 3′UTR of *** Collectively,our findings reveal that SERPINB6 serves as a novel gene for chicken carcass traits by promoting fibroblast and myoblast ***,the downstream variant rs317934171 regulates SERPINB6 *** results identify a new target gene and molecular marker for the molecular mechanisms of chicken carcass traits.

关键词： Carcass traits Chicken Genome SERPINB6 Transcriptome