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Horticulture Research 2021年第1期8卷 2404-2415页

作者： Greg S.Goralogia Glenn T.Howe amy M.Brunner Emily Helliwell Michael F.Nagle Cathleen Ma Haiwei lu Amanda l.Goddard Anna C.Magnuson amy l.Klocko Steven H.Strauss Department of Forest Ecosystems and Society Oregon State UniversityCorvallisORUSA Department of Forest Resources and Environmental Conservation Virginia TechBlacksburgVAUSA Department of Biology University of Colorado Colorado SpringsColorado SpringsCOUSA

The spread of transgenes and exotic germplasm from planted crops into wild or feral species is a difficult problem for public and regulatory acceptance of genetically engineered plants,particularly for wind-pollinated trees such as *** report that overexpression of a poplar homolog of the floral repressor SHORT VEGETATIVE PHASE-lIKE(SVl),a homolog of the Arabidopsis MADS-box repressor SHORT VEGETATIVE PHASE(SVP),delayed the onset of flowering several years in three genotypes of field-grown transgenic *** expression of SVl correlated with a delay in flowering onset and lower floral abundance,and did not cause morphologically obvious or statistically significant effects on leaf characteristics,tree form,or stem *** effects on reproductive and vegetative phenology in spring was modest and *** results suggest that use of SVl and related floral repressors can be useful tools to enable a high level of containment for vegetatively propagated short-rotation woody energy or pulp crops.

关键词： field planted crops

The role of tropomodulin1 in the migration inhibition of macrophage induced by oxlDl

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The role of tropomodulin1 in the migration inhibition of mac...

Atypical presentation of a hepatic artery pseudoaneurysm:A case report and review of the literature

第十一届全国生物力学学术会议暨第十三届全国生物流变学学...

作者： Weijuan Yao Fang Ding Yuan Wu Xifu Wang lide Xie l.amy Sung Hemorheology Center Department of Physiology and PathophysiologyPeking University Health Science Center Chengde Medical College Emergency Department Beijing Anzhen HospitalCapital Medical University Department of Bioengineering University of California

Objective:The migration inhibition of macrophage is the core event in the development of *** the mechanisms remain *** low density lipoprotein(oxlDl)is one of the main factors that inhibit macrophage *** cytoskeletal proteins determine the deformability and migration of the ***1(Tmod1)is a cytoskeleton protein that caps the pointed end of actin filaments and plays an im-

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World Journal of Hepatology 2016年第18期8卷 779-784页

作者： Casey M luckhurst Chelsey Perez amy l Collinsworth Jose G Trevino Department of Surgery Colleges of MedicineUniversity of Florida Health Science Center Department of Surgery Colleges of MedicineUniversity of FloridaHealth Science Center Department of Pathology Colleges of MedicineUniversity of Florida Health Science Center

Classically, hepatic artery pseudoaneurysms(HAPs) arise secondary to trauma or iatrogenic causes. With an increasing prevalence of laparoscopic procedures of the hepatobiliary system the risk of inadvertent injury to arterial vessels is increased. Pseudoaneurysm formation post injury can lead to serious consequences of rupture and subsequent hemorrhage, therefore intervention in all identified visceral pseudoaneurysms has been advocated. A variety of interventional methods have been proposed, with surgical management becoming the last step intervention when minimally invasive therapies have failed. The authors present a case of a HAP in a 56-year-old female presenting with jaundice and pruritis suggestive of a Klatskin's tumor. This presentation of HAP in a patient without any significant past medical or surgical intervention is atypical when considering that the majority of HAP cases present secondary to iatrogenic causes or trauma. Multiple minimally invasive approaches were employed in an attempt to alleviate the symptomology which included jaundice and associated inflammatory changes. Ultimately, a right hepatic trisegmentectomy was required to adequately relieve the mass effect on biliary outflow obstruction and definitively address the HAP. The presentation of a HAP masquerading as a malignancy with jaundice and pruritis, rather than the classic symptoms of abdominalpain, anemia, and melena, is unique. This presentation is only further complicated by the absent history of either trauma or instrumentation. It is important to be aware of HAPs as a potential cause of jaundice in addition to the more commonly thought of etiologies. Furthermore, given the morbidity and mortality associated with pseudoaneurysm rupture, intervention in identifiable cases, either by minimally invasive or surgical interventions, is recommended.

关键词： Klatskin tumor Cholangitis Hepatic artery pseudoaneurysm Biliary obstruction Trisegmentectomy

利用有机酸添加剂减少加工后肉鸡的沙门氏菌污染

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国外畜牧学（猪与禽） 1990年第2期10卷 40-41页

作者： amy l. Izat 王步覃美国阿肯色大学家禽产品

美国每年都有1～2％的人受沙门氏菌病之苦。禽肉和禽蛋产品频频被控为沙门氏菌污染源。人们不懈地努力要弄清家禽是在何处污染上沙门氏菌和其它病原微生物的,现已发现了许多可能的污染源,其中包括父母代种鸡群、孵化厂、垫料、鸟兽、饲... 详细信息

美国每年都有1～2％的人受沙门氏菌病之苦。禽肉和禽蛋产品频频被控为沙门氏菌污染源。人们不懈地努力要弄清家禽是在何处污染上沙门氏菌和其它病原微生物的,现已发现了许多可能的污染源,其中包括父母代种鸡群、孵化厂、垫料、鸟兽、饲料、运输工具、加工设备等。一般认为,胴体的初次污染来自肉鸡的肠道。目前已采取了一定的管理措施以减少污染的发生。宰前停食的措施,显著减少了加工过程中发现的细菌数量。此外,加工过程中大量用水也减少了细菌污染。

关键词：有机酸添加剂加工肉鸡沙门氏菌

Cell based therapy aides in infection and inflammation resolution in the murine model of cystic fibrosis lung disease

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Stem Cell Discovery 2013年第2期3卷 139-153页

作者： Tracey l. Bonfield Donald lennon Santosh K. Ghosh amy M. DiMarino Aaron Weinberg Arnold I. Caplan Department of Pediatric Pulmonology Case Western Reserve University Cleveland USA

Cystic fibrosis (CF) is a genetically inherited disease which is characterized by excessive inflammation and inability to resolve infection with pathogens such as Pseudomonas aeruginosa. Treatment options have improved with correctors and potentiators, but a cure remains elusive. Human mesenchymal stem cells (hMSCs) have the potential to be both anti-inflammatory and anti-microbial, which makes them ideal candidates for exploration as an innovative new therapeutic for CF. Using a sublethal CF mouse model of chronic Pseudomonas aeruginosa infection, we show that hMSCs and wild type bone marrow derived macrophages (BMM) have the capacity to attenuate inflammation while at the same time improving the ability to resolve infection. Animals infected with bacteria and treated with hMSCs and BMM had less weight lost, decreased pro-inflammatory cytokines, decreased severity of gross lung pathology as well as clinical score. Importantly, even though the inflammation was decreased in vivo, both BMM and hMSC treatment resulted in significant decrease in lung bacterial load. The improvement in the CF model was consistent with hMSC induced anti-inflammatory and anti-microbial activity which may involve the cathelicidin ll-37. These studies suggest that both healthy MSCs and BMM may provide important new direction toward cell based therapies in CF.

关键词： Inflammation Mesenchymal Stem Cells Antimicrobial Activity

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医生是否应该让患者参与医疗决策

医学与哲学 2005年第12X期26卷 79-80页

作者： McGuire amy l.JD PhD McCullough laurence B.PhD 郭肖华阎茹（译）不详广州中医药大学人文学院广州中医药大学管理学院

美国法院要求医生在确定治疗方案时必须得到患者的知情同意.而近来伦理学家提出,尊重患者的自主权不仅要使其知情,还应让病人在医疗决策中发挥作用.然而有调查结果显示,事实上病人在参与医疗决策时起到的作用微乎其微.尽管医生也在为患... 详细信息

美国法院要求医生在确定治疗方案时必须得到患者的知情同意.而近来伦理学家提出,尊重患者的自主权不仅要使其知情,还应让病人在医疗决策中发挥作用.然而有调查结果显示,事实上病人在参与医疗决策时起到的作用微乎其微.尽管医生也在为患者罗列出各种医疗方案,但多数医生并不希望由病人参与决策.而这些调查对为什么有时候病人不能充分参与医疗决策并未作出深入探讨,并忽视了对医生就病人参与医疗决策的认知分析.因此,笔者希望通过本次调查,在医生对患者参与医疗决策的态度、医生的态度如何影响病人以及临床医疗决策的构建等方面,做一次试探性、描述性的研究.

关键词：医疗决策患者参与医生病人参与治疗方案尊重患者调查结果医疗方案认知分析伦理学

Beyond the Pediatric end-stage liver disease system: Solutions for infants with biliary atresia requiring liver transplant

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World Journal of Gastroenterology 2014年第32期20卷 11062-11068页

作者： Mary Elizabeth M Tessier Sanjiv Harpavat Ross W Shepherd Girish S Hiremath Mary l Brandt amy Fisher John A Goss Department of Pediatrics Baylor College of Medicine and Texas Children’s Hospital Department of Pediatrics Baylor College of Medicine and Texas Children’s Hospital Houston Department of Surgery Baylor College of Medicine and Texas Children’s HospitalHouston

Biliary atresia(BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant, with up to one half of BA children needing a transplant by age two. In the current pediatric end-stage liver disease system, children with BA face the risk of not receiving a liver in a safe and timely manner. In this review, we discuss a number of possible solutions to help these children. We focus on two general approaches:(1) preventing/delaying need for transplantation, by optimizing the success of the Kasai operation; and(2) expediting transplantation when needed, by performing techniques other than the standard deceased-donor, whole, ABO-matched organ transplant.

关键词： Biliary atresia liver transplantation Pediatric li

Assessment of Risk of Carrier Waves in the Assisted Reproductive laboratory

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Open Journal of Obstetrics and Gynecology 2015年第10期5卷 535-541页

作者： Samuel D. Prien Jessica Smith Christy Barron Joseph Martin Naghma Farooqi Alita loveless amy Van Gheem lindsay l. Penrose Department of Animal and Food Sciences Texas Tech University Lubbock USA Department of Obstetrics and Gynecology Texas Tech University Health Sciences Center Lubbock USA

Assisted reproductive technology (ART) laboratories represent the marriage of the most basic of biological activities with the most cutting edge technologies. While this association has worked well, the mixture of biology and technology can create risks to normal embryo development. Recently a significant amount of literature has explored the risks of manmade, electrically induced magnetic fields and carrier waves on reproduction, which some studies have suggested will lower functional gamete numbers in the males and potentially induce genetic issues in embryos. However, little is known about these phenomena within the ART laboratory, a laboratory filled with electronic equipment. The object of the present study was to explore the potential exposure of gametes and early stage embryos to two of the most prevalent fields and waves utilized in manmade technologies seen in the general environment, electromagnetic fields (EMF) and radio frequency waves (RF), and determine the effect varying levels of these energetic forces had on gamete function and embryo development. Results indicated that while extremely high concentrations of EMF (approximately 50-100X of laboratory background) caused negative outcomes in both gametes and embryos, levels consistent will the majority of lab equipment did not appear to impact growth, or function. Further, even extremely high RF appeared to have no impact cellular function. Results suggest few issues with EMF or RF on gamete and embryo function at normal laboratory levels for the relatively short exposure times seen in the ART laboratory.

关键词： Assisted Reproductive Technologies Electromagnetic Fields Radio Frequency Waves Embryos Sperm

Diagnostic Utility of Performing Flow Cytometry on Provider-Submitted Endoscopically Collected Gastrointestinal Samples

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Open Journal of Blood Diseases 2020年第1期10卷 1-11页

作者： Regina M. Plummer amy K. Beckman Meghan M. Hupp Elizabeth l. Courville Sarah A. Williams Michael A. linden Division of Hematopathology Department of Laboratory Medicine and Pathology University of Minnesota Minneapolis MN USA

Multicolor flow cytometry (MFC) is essential to the diagnosis of non-Hodgkin lymphoma (NHl). In our institution, MFC specimens are submitted by pathologists or an ordering provider. As endoscopy has revolutionized the ability to biopsy the gastrointestinal (GI) tract, our lab increasingly receives provider-submitted, endoscopically-acquired GI biopsies (PEGIB) for MFC analysis. This study evaluates the clinical utility of MFC performed on PEGIB and proposes a new testing algorithm to enhance the pathology team’s role in MFC test utilization. Fifty-five archival PEGIB MFC cases were identified and histories were reviewed. MFC was non-contributory to the overall diagnosis in 85% of PEGIB. Retroactively implementing an algorithm that used PEGIB permanent section screening to triage the 55 archival cases resulted in the appropriate identification of 100% of specimens whose diagnosis would have benefitted from MFC analysis, and the optimization of test utilization by decreasing unnecessary MFC studies.

关键词： Flow Cytometry Endoscopic Biopsies GI Biopsies Endoscopy Quality Improvement

巨噬细胞Tmod1参与调控高胆固醇和高基质硬度联合诱导下动脉粥样硬化斑块的形成

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巨噬细胞Tmod1参与调控高胆固醇和高基质硬度联合诱导下动脉粥样...