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Persistent EGFR/K-RAS/SIAh pathway activation drives chemo-resistance and early tumor relapse in triple-negative breast cancer

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Cancer Drug Resistance 2022年第3期5卷 691-702页

作者： amy h.tang Richard A.hoefer Mary L.Guye harry D.Bear Department of Microbiology and Molecular Cell Biology Leroy T.Canoles Jr.Cancer Research CenterEastern Virginia Medical SchoolNorfolkVA 23507USA School of Systems Biology George Mason UniversityManassasVA 20110USA Sentara Cancer Network Sentara HealthcareNorfolkVA 23507USA Sentara Surgery Specialists Surgical OncologySentara CarePlex HospitalNewport NewsVA 23606USA Division of Surgical Oncology Departments of Surgery and Microbiology and ImmunologyMassey Cancer CenterVirginia Commonwealth UniversityRichmondVA 23298-0011USA

Triple-negative breast cancer(TNBC)is the most aggressive breast cancer *** disproportionately affects BRCA mutation carriers and young women,especially African American(AA)*** TNBC is a heterogeneous and molecularly unstable disease that challenges our ability to apply personalized *** the approval of immune checkpoint blockade(ICB)for TNBC,the addition of pembrolizumab to systemic chemotherapy has become standard of care(SOC)in neoadjuvant systemic therapy(NST)for high-risk early-stage *** plus chemotherapy significantly increased the pathologic complete response(pCR)and improved event-free survival in ***,clinical uncertainties remain because similarly treated TNBC partial responders with comparable tumor responses to neoadjuvant therapy often experience disparate clinical *** methods fall short in accurately predicting which high-risk patients will develop chemo-resistance and tumor ***,novel treatment strategies and innovative new research initiatives are *** propose that the EGFR-K-RAS-SIAh pathway activation is a major tumor driver in chemoresistant *** high expression of SIAh in residual tumors following NACT/NST reflects that the EGFR/K-RAS pathway remains activated(ON),indicating an ineffective response to *** chemoresistant tumor clones persist in expressing SIAh(SIAh^(high/ON))and are linked to early tumor relapse and poorer ***,the loss of SIAh expression(SIAh^(Low/OFF))in residual tumors post-NACT/NST reflects EGFR/K-RAS pathway inactivation(OFF),indicating effective therapy and chemo-sensitive tumor ***^(Low/OFF) signal is linked to tumor remission and better prognosis post-NACT/***,SIAh is well-positioned to become a novel tumor-specific,therapy-responsive,and prognostic ***,this new biomarker(SIAh^(high/ON))could be used to quantify therapy response,predict chemo-resistance,and identi

关键词： Triple-negative breast cancer(TNBC) chemo-resistance seven in absentia(SINA)and human homologs of SINA(SIAh)E3 ligase ubiquitin-mediated proteolysis EGFR/K-RAS/SIAh pathway activation in TNBC neoadjuvant chemotherapy prognosis patient risk stratification detection of chemo-resistance precision quantification of therapy efficacy and treatment optimization

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Network Embedding Algorithm for Vulnerability Assessment of Power Transmission Lines Using Integrated Structure and Attribute Information

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 351-360页

作者： Xianglong Lian Tong Qian Zepeng Li Xingyu Chen Wenhu tang Q.h.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China

In power systems,failures of vulnerable lines can trigger large-scale cascading failures,and vulnerability assessment is dedicated to locating these lines and reducing the risks of such *** on a structure and attribute network embedding(SANE)algorithm,a novel quantitative vulnerability analysis method is proposed to identify vulnerable lines in this ***,a two-layered random walk network with topological and electrical properties of transmission lines is ***,based on the weighted degree of nodes in the two-layered network,the inter-layer and intra-layer walking transition probabilities are developed to obtain walk ***,a Word2Vec algorithm is applied to obtain lowdimension vectors representing transmission lines,according to obtained walk sequences for calculating the vulnerability index of transmissions ***,the proposed method is compared with three widely used methods in two test *** show the network embedding based method is superior to those comparison methods and can provide guidance for identifying vulnerable lines.

关键词： Network embedding random walk transmission lines vulnerability assessment

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A novel cascaded h-bridge photovoltaic inverter with flexible arc suppression function

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Global Energy Interconnection 2024年第4期7卷 513-527页

作者： Junyi tang Wei Gao College of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108P.R.China

This paper presents a novel approach that simultaneously enables photovoltaic(PV)inversion and flexible arc suppression during single-phase grounding *** compensate for ground currents through an arc-elimination function,while outputting a PV direct current(DC)power *** method effectively reduces the residual grounding *** reduce the dependence of the arc-suppression performance on accurate compensation current-injection models,an adaptive fuzzy neural network imitating a sliding mode controller was *** online adaptive adjustment law for network parameters was developed,based on the Lyapunov stability theorem,to improve the robustness of the inverter to fault and connection ***,a new arc-suppression control exit strategy is proposed to allow a zerosequence voltage amplitude to quickly and smoothly track a target value by controlling the nonlinear decrease in current and reducing the regulation *** results showed that the proposed method can effectively achieve fast arc suppression and reduce the fault impact current in single-phase grounding *** to other methods,the proposed method can generate a lower residual grounding current and maintain good arc-suppression performance under different transition resistances and fault locations.

关键词： Photovoltaic inverter Flexible arc suppression Adaptive control Fuzzy neural network Sliding mode control Exit strategy

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Effect of succinic acid on morphology transformation of the anhydrous magnesium carbonate particles prepared by magnesium chloride hexahydrate and urea

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Particuology 2024年第7期90卷 209-217页

作者： Song Liu Guojun Cheng Zhongfeng tang School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Anhui Province Key Laboratory of Environment-friendly Polymer Materials Anhui UniversityHefei230601China

The homogeneous and controllable morphology of anhydrous magnesium carbonate(MgCO_(3))particles with excellent properties is difficult to obtain because of a variety of synthetic *** effect of succinic acid as a crystal modifier on the particle morphology transformation of anhydrous MgCO_(3)was investigated by the hydrothermal *** effect of the addition of succinic acid on the particles was similar to that of temperature *** morphology of particles with a folded diamond-like shape was gradually uniform,and the particle size was between 3.3 and 7.5μ*** MgCO_(3)particles prepared at ph 9 could easily agglomerate,and the average particle size increased from diamond-like to cube-like as the reaction time *** interaction between succinic acid and magnesium ions at different concentrations was the main factor responsible for the morphological *** ph,temperature,and time affected the molecular motion rate and crystal growth.

关键词： MgCO_(3) MgCl_(2)·6h_(2)O Urea Succinic acid Morphology

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Inheritance of the exciton geometric structure from Bloch electrons in two-dimensional layered semiconductors

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Frontiers of physics 2024年第4期19卷 25-35页

作者： Jianju tang Songlei Wang hongyi Yu Author information-1.Guangdong Provincial Key Laboratory of Quantum Metrology and Sensing&School of Physics and Astronomy Sun Yat-sen University(Zhuhai Campus)Zhuhai 519082China State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen University(Guangzhou Campus)Guangzhou 510275China

We theoretically studied the exciton geometric structure in layered semiconducting transition metal *** on a three-orbital tight-binding model for Bloch electrons which incorporates their geometric structures,an effective exciton hamiltonian is constructed and solved perturbatively to reveal the relation between the exciton and its electron/hole *** show that the electron−hole Coulomb interaction gives rise to a non-trivial inheritance of the exciton geometric structure from Bloch electrons,which manifests as a valley-dependent center-of-mass anomalous hall velocity of the exciton when two external fields are applied on the electron and hole constituents,*** obtained center-of-mass anomalous velocity is found to exhibit a non-trivial dependence on the fields,as well as the wave function and valley index of the *** findings can serve as a general guide for the field-control of the valley-dependent exciton transport,enabling the design of novel quantum optoelectronic and valleytronic devices.

关键词： transition metal dichalcogenides exciton geometric structure Berry curvature van der Waals stacking

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Microstructure and mechanical properties stability of pre-hardening treatment in Al-Cu alloys for pre-hardening forming process

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 539-551页

作者： Liping tang Pengfei Wei Zhili hu Qiu Pang hubei Longzhong laboratory Xiangyang 441000China hubei Key Laboratory of Advanced Technology for Automotive Components School of Automotive EngineeringWuhan University of TechnologyWuhan 430070China hubei Engineering Research Center for Green&Precision Material Forming Wuhan University of TechnologyWuhan 430070China Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of Education School of Machinery and AutomationWuhan University of Science and TechnologyWuhan 430081China

The stability of the microstructure and mechanical properties of the pre-hardened sheets during the pre-hardening forming(PhF)process directly determines the quality of the formed *** microstructure stability of the pre-hardened sheets was in-vestigated by differential scanning calorimetry(DSC),transmission electron microscopy(TEM),and small angle X-ray scattering(SAXS),while the mechanical properties and formability were analyzed through uniaxial tensile tests and formability *** results in-dicate that the mechanical properties of the pre-hardened alloys exhibited negligible changes after experiencing 1-month natural aging(NA).The deviations of ultimate tensile strength(UTS),yield strength(YS),and sheet formability(Erichsen value)are all less than 2%.Also,after different NA time(from 48 h to 1 month)is applied to alloys before pre-hardening treatment,the pre-hardened alloys possess stable microstructure and mechanical properties as ***,with the extension of NA time before pre-hardening treatment from 48 h to 1 month,the contribution of NA to the pre-hardening treatment is *** a yield strength increment of 20 MPa is achieved,with no loss in *** limited enhancement is mainly attributed to the fact that only a limited number of clusters are transformed into Guinier-Preston(GP)zones at the early stage of pre-hardening treatment,and the formation ofθ''phase inhibits the nucleation and growth of GP zones as the precipitated phase evolves.

关键词： Al-Cu alloy pre-hardened alloy natural aging mechanical properties microstructure

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Recent advances in g-C_(3)N_(4)-based direct Z-scheme photocatalysts for environmental and energy applications

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Chinese Journal of Structural Chemistry 2024年第2期43卷 66-84页

作者： Xiaoming Fu haibo huang Guogang tang Jingmin Zhang Junyue Sheng hua tang School of Intelligent Engineering and Technology Jiangsu Vocational College of Finance&EconomicsHuai'anJiangsu223003PR China School of Modem Equipment Manufacturing Changzhou Institute of Light Industry Technology ChangzhouJiangsu213164PR China School of Environmental Science and Engineering Qingdao UniversityQingdao266071PR China School of Materials Science and Engineering Hainan UniversityHaikou570228PR China

In the midst of the rapid advancement of photocatalysis,direct Z-scheme heterojunction photocatalysts have emerged as a powerful solution to address environmental challenges and the looming energy *** precise engineering of direct Z-scheme heterojunction photocatalysts proves highly beneficial in optimizing their elec-tronic structure,ultimately enhancing their photocatalytic ***,graphitic carbon nitride(g-C_(3)N_(4))has recently gained recognition as a leading candidate for the creation of direct Z-scheme heterojunctions,owing to its favorable attributes such as a moderate band-gap(2.7 eV),high reduction potential and abundant active *** this review,we offer a concise overview of the fundamental principles and recent advancements in g-C_(3)N_(4)-based direct Z-scheme photocatalytic ***,we delve into the various practical applica-tions of g-C_(3)N_(4)-based direct Z-scheme photocatalysts,specifically in the realms of energy conversion and envi-ronmental *** applications include the removal of contaminant pollutants through photocatalytic degradation,water splitting(comprising h_(2)-generation,O_(2)-evolution,and overall water splitting),and CO_(2)***,we present comprehensive characterization methods and strategies aimed at further enhancing the photocatalytic activity of g-C_(3)N_(4)-based direct Z-scheme photocatalytic *** conclude,this review offers summarizing insights and a brief discussion on future challenges and prospects pertaining to g-C_(3)N_(4)-based direct Z-scheme *** believe that this review will inspire continued exploration and foster a deeper understanding of the groundbreaking possibilities within photocatalytic *** also provides valuable guidance for the design and construction of innovative direct Z-scheme photocatalysts.

关键词： Carbon nitride Photocatalyst Z-scheme systems Environmental remediation Energy conversion

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Response and assembly of abundant and rare taxa in Zaopei under different combination patterns of Daqu and pit mud:from microbial ecology to Baijiu brewing microecosystem

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Food Science and human Wellness 2024年第3期13卷 1439-1452页

作者： Yu Mu Jun huang Rongqing Zhou Suyi Zhang hui Qin hanlan tang Qianglin Pan huifang tang College of Biomass Science and Engineering Sichuan UniversityChengdu 610065China National Engineering Research Center of Solid-State Manufacturing Luzhou 646000China Luzhou Laojiao Co. Ltd.Luzhou 646699China

The quality and aroma of strong-flavor Baijiu are mainly dependent on Daqu,pit mud(PM),and the interaction of ***,little is known about how their combination patterns affect the microbiome and metabolome of Zaopei,especially the metabolic function of rare ***,an experiment on industrial size was designed to assess the effects of 6 combinations(3 kinds of Daqu×2 kinds of PM)on the composition and assembly of different taxa,as well as the flavor *** results showed that Zaopei's microbiota was composed of a few abundant taxa and enormous rare taxa,and rare bacterial and abundant fungal subcommunities were significantly affected by combination *** assembly processes of abundant/rare taxa and bacterial/fungal communities were distinct,and environmental changes mediated the balance between stochastic and deterministic processes in rare bacteria ***,specific combination patterns improved the flavor quality of Zaopei by enhancing the interspecies interaction,which was closely related to rare taxa,especially rare *** findings highlighted that rare bacteria might be the keystone in involving community interaction and maintaining metabolic function,which provided a scientific foundation for better understanding and regulating the brewing microbiota from the viewpoint of microbial ecology.

关键词： Bioaugmented Daqu Artificial pit mud Abundant and rare taxa Community assembly Metabolic function

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A passive sampler for synchronously measuring inorganic and organic pollutants in sediment porewater:Configuration and field application

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Journal of Environmental Sciences 2024年第2期136卷 201-212页

作者： Pei Lei Mingying Chen Nan Rong Wenzhong tang hong Zhang School of Environment Nanjing Normal UniversityNanjing 210023China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhou 510530China State Environmental Protection Key Laboratory of Water Environmental Simulation and Pollution Control Guangzhou 510530China University of Chinese Academy of Sciences Beijing 100049China

In situ measurement of multiple pollutants coexisting in sediment porewater is an essential step in comprehensively assessing the bioavailability and risk of pollutants,but to date,this needs to be better *** this study,a passive sampler,consisting of an“I-shaped”supporting frame and inorganic/organic sampling units,incorporating equilibrium dialysis theory and kinetic/equilibrium sorption principle,was developed for the synchronous measurement of inorganic(e.g.,phosphorus and metal(loid)s)and organic pollutants(e.g.,parent and substituted PAhs).The equilibrium time and sampling rates were explored in laboratory tests to support in situ *** of pollutants in porewater within a vertical resolution of centimeters,i.e.,1 cm and 2 cm for inorganic and organic pollutants,respectively,were obtained by field deployment of the sampler for further estimation of diffusive fluxes across the sediment-water *** results suggested that the role of sediments for a specific pollutant may change(e.g.,from“sink”to“source”)during the sampling *** study demonstrated the feasibility of synchronous measurement of inorganic and organic pollutants in sediment porewater by the passive *** addition,it provided new insight for further investigation into the combined pollution effects of various pollutants in sediments.

关键词： Passive sampling Bioavailability Polycyclic aromatic hydrocarbons Combined pollution Diffusive flux

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An interesting synergistic effect of heteronuclear dual-atom catalysts for hydrogen production:Offsetting or promoting

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Nano Research 2024年第6期17卷 5742-5752页

作者： Zhonghao Wang Wei tang Jialin Liu Gang Zhou School of Science Hubei University of TechnologyWuhan 430068China

To elucidate the synergistic effect of dual-atom catalysts(DACs)at the microscopic level,we propose and construct a prototype heteronuclear system,CuNi/TiO_(2),in which the two elements of a pair have significantly different d electron-donating abilities,as a piece in the *** density functional theory calculations,we investigate charge-dependent configurations of Cu-Ni dimers anchored on TiO_(2)by the mixing of individual constituent *** d electron-donating ability determines deposition sequence and position of transition metal atoms on oxides,establishing dimer pattern and metal-support *** interaction between Cu and Ni,beyond the coordination environment,predominately contributes to the synergistic effect.A complex adsorption-reduction behavior of h species on CuNi/TiO_(2)is *** reaction mechanism and catalytic activity of CuNi/TiO_(2)for hydrogen production are *** room temperature and high h coverages,CuNi/TiO_(2)shows better performance and efficiency than Ni1/TiO_(2).Our findings provide a new understanding of the synergistic effect on structure-activity relationships of supported dimers,which would be beneficial in the future design of various DACs or even atomically dispersed metal catalysts.

关键词： dual-atom catalysts heteronuclear/homonuclear dimers synergistic effect density functional theory hydrogen production

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