检索结果-南通市图书馆

Signal Transduction and Targeted Therapy 2022年第5期7卷 1817-1830页

作者： Liwen Yu Jie Zhang amy gao Meng Zhang Zunzhe Wang Fangpu Yu Xiaobin Guo Guohai Su Yun Zhang Meng Zhang Cheng Zhang The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineDepartment of CardiologyQilu HospitalCheeloo College of MedicineShandong UniversityJinanChina Cardiovascular Disease Research Center of Shandong First Medical University Central Hospital Affiliated to Shandong First Medical UniversityJinanChina

The developmental origin,anatomical location,and other factors contribute to aortic heterogeneity in a physiological *** this basis,vascular diseases occur at different ratios based on position specificity,even with the same risk ***,the continuous intersegmental aortic profile has been rarely reported at the single-cell *** reveal aortic heterogeneity,we identified 15 cell subtypes from five continuous aortic segments by marker genes and functional definitions.

关键词： aortic segmental specificity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大屏营销玩转IP

国际品牌观察 2021年第18期 75-76页

作者： amy gao 欢网科技

随着欢网科技进入"亿屏时代",拓展大屏产业空间以及拓界传媒产业成为欢网下一阶段的重要发展方向。围绕"拓界"这一发展战略,欢网科技已大踏步地在内容、资源、数据方面多维拓界。对于"内容拓界"这重要的一环,欢网跟行业众多强大的IP制...

随着欢网科技进入"亿屏时代",拓展大屏产业空间以及拓界传媒产业成为欢网下一阶段的重要发展方向。围绕"拓界"这一发展战略,欢网科技已大踏步地在内容、资源、数据方面多维拓界。对于"内容拓界"这重要的一环,欢网跟行业众多强大的IP制作方达成了战略性合作,希望能够结合优质IP以及欢网本身的终端受众覆盖能力,共同加强客户内容营销体系。

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

品牌如何投放智能大屏？

国际品牌观察 2021年第30期 76-78页

作者：谭北平 amy gao 高婧婷李晓霍宇佳

品牌在营销活动中该如何投放智能大屏?每个广告主的品牌状态、营销目标也不尽相同,广告主应该如何通过智能大屏获得更好的营销效果?常见的营销活动六大目标智能大屏流量价值得到广泛验证和认可,智能大屏的广告产品、数据能力也在迅速...

品牌在营销活动中该如何投放智能大屏?每个广告主的品牌状态、营销目标也不尽相同,广告主应该如何通过智能大屏获得更好的营销效果?常见的营销活动六大目标智能大屏流量价值得到广泛验证和认可,智能大屏的广告产品、数据能力也在迅速发展,但智能大屏的最佳投放方法还需进一步明确。

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

智能大屏的六大投放逻辑

国际品牌观察 2021年第27期 58-60页

作者：谭北平 amy gao 高婧婷李晓霍宇佳

智能大屏具体是什么?为什么营销者在未来五年内必须关注智能大屏的进展?本文希望帮助大家了解的两个认知问题。什么是智能大屏?智能大屏,顾名思义,首先是大屏,这里主要是指在家庭的电视大屏,可能是互联网电视机、可能是电视机加上机顶盒...

智能大屏具体是什么?为什么营销者在未来五年内必须关注智能大屏的进展?本文希望帮助大家了解的两个认知问题。什么是智能大屏?智能大屏,顾名思义,首先是大屏,这里主要是指在家庭的电视大屏,可能是互联网电视机、可能是电视机加上机顶盒,也可能是投影等设备。智能主要是由于接入互联网所带来的改变,内容呈现方式、互动方式、数据与技术能力都相比传统的直播电视有大幅度的升级。

关键词：

An ultrasound elastography method for examining the anterior cruciate ligament

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Natural Science 2013年第8期5卷 23-31页

作者： amy L. Cochran Yingxin gao Center for Applied Mathematics Cornell University Ithaca USA Sibley School of Mechanical and Aerospace Engineering Cornell University Ithaca USA

We introduce an ultrasound elastography method for examining the ACL. It consisted of imaging the distal ACL while applying a drawer test and analyzing the resulting displacement and strain maps, where a map refers to how a variable is distributed spatially throughout an image. Our method was applied to healthy knees of cadaveric sheep to determine whether 1) our method can consistently generate displacements and strain maps in healthy ACLs;2) displacement and strain maps are repeatable;and 3) healthy ACLs experience similar maps. We found that our method could consistently provide displacements and strain maps of the distal ACL region. Moreover, these ACLs experienced displacement and strain maps that were positively-correlated between trials, knees, and specimens. This correlation was statistically significant between pairs of trials and between left and right knees (p < 0.05). These results suggest that the maps are indeed repeatable and similar for healthy ACLs.

关键词： Anterior Cruciate Ligament Ultrasound Elastography Strain Imaging Strain Patterns

Development and Demonstration of Australian First Working Sodium Guide Star Laser

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optics and Photonics Journal 2022年第4期12卷 88-100页

作者： Yue gao Yanjie Wang amy Chan Ben Greene EOS Defence Systems Pty Ltd. Canberra Australia

The Australian first working sodium guide star laser system has been designed and developed for various astronomical and space-related applications. A completely diode-pumped pulsed system was developed initially followed by a largely fiber-based continuous wave (CW) system operating at 589 nm achieved through a unique wavelength conversion scheme by combining 1342 and 1050 nm through a sum frequency generation process. For the CW system, single-mode laser beams at both 1342 and 1050 nm are achieved from fiber-based seed oscillators and fiber amplifiers. The output power of ~25 W at 1342 nm is achieved from a single frequency fiber Raman amplifier. Output power up to 70 W at 1050 nm is achieved from a Yb-doped fiber pre-amplifier followed by a Yb-doped fiber power amplifier. For the sum frequency generation process, optimum focusing parameters are evaluated and determined. The CW system has generated more than 20 W output power at 589 nm, a circularly polarised beam with a good beam quality, spectral linewidth ≤ 2 MHz, and the laser output locked on the sodium D2 line at 589.159 nm. The system has been successfully demonstrated at EOS Space Research Centre, Mt Stromlo, Canberra, and become the Australian first working sodium guide star laser system.

关键词： Fiber Laser Continuous Wave Laser Pulsed Laser Diode Pump Solid State Sum Frequency Generation Adaptive Optics Sodium Laser Guide Star

Hydraulic properties and drought response of a tropical bamboo (Cephalostachyum pergracile)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2024年第3期46卷 406-415页

作者： Wanwalee Kongjarat Lu Han amy Ny Aina Aritsara Shu-Bin Zhang gao-Juan Zhao Yong-Jiang Zhang Phisamai Maenpuen Ying-Mei Li Yi-Ke Zou Ming-Yi Li Xue-Nan Li Lian-Bin Tao Ya-Jun Chen CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China University of the Chinese Academy of Sciences Beijing 100049China T-STAR Core Team Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China School of Biology and Ecology University of MaineOronoMEUSA Climate Change Institute University of MaineOronoME 04469USA School of Biological and Chemical Science Pu’er UniversityXueyuan RoadYunnan 665000China Institute of Ecology and Geobotany School of Ecology and Environmental SciencesYunnan UniversityKunmingYunnan 650091China School of Ecology and Environment Southwest Forestry UniversityKunmingYunnan 650224China Yuanjiang Savanna Ecosystem Research Station Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYuanjiangYunnan 653300China

Bamboo plants are an essential component of tropical ecosystems,yet their vulnerability to climate extremes,such as drought,is poorly understood due to limited knowledge of their hydraulic *** pergracile,a commonly used tropical bamboo species,exhibited a substantially higher mortality rate than other co-occurring bamboos during a severe drought event in 2019,but the underlying mechanisms remain *** study investigated the leaf and stem hydraulic traits related to drought responses,including leaf-stem embolism resistance(P50leaf;P50stem) estimated using optical and X-ray microtomography methods,leaf pressure-volume and water-releasing ***,we investigated the seasonal water potentials,native embolism level(PLC) and xylem water source using stable *** found that *** exhibited strong resistance to embolism,showing low P50leaf,P50stem,and turgor loss point,despite its rapid leaf water ***,its leaves displayed greater resistance to embolism than its stem,suggesting a lack of effective hydraulic vulnerability segmentation(HVS) to protect the stem from excessive xylem *** the dry season,approximately 49% of the water was absorbed from the upper 20-cm-deep soil ***,significant diurnal variation in leaf water potentials and an increase in midday PLC from 5.87±2.33% in the wet season to 12.87±4.09%in the dry season were *** summary,this study demonstrated that the rapid leaf water loss,high reliance on surface water,and a lack of effective HVS in *** accelerated water depletion and increased xylem embolism even in the typical dry season,which may explain its high mortality rate during extreme drought events in 2019.

关键词： Climate change Drought Hydraulic safety Hydraulic vulnerability segmentation Stable isotope Tree mortality

维普期刊数据库

Prunus genetics and applications after de novo genome sequencing:achievements and prospects

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2019年第1期6卷 1222-1246页

作者： Maria JoséAranzana Véronique Decroocq Elisabeth Dirlewanger Iban Eduardo Zhong Shan gao Ksenija Gasic amy Iezzoni Sook Jung Cameron Peace Humberto Prieto Ryutaro Tao Ignazio Verde Albert G.Abbott Pere Arús IRTA Centre de Recerca en Agrigenòmica CSIC-IRTA-UAB-UBCampus UABEdifici CRAGCerdanyola del Vallès(Bellaterra)08193 BarcelonaSpain UMR 1332 BFP INRAUniversity of BordeauxA3C and Virology Teams33882 Villenave-d’Ornon CedexFrance Allergy Research Center Zhejiang University310058 HangzhouChina Clemson University ClemsonSC 29634USA Department of Horticulture Michigan State University1066 Bogue StreetEast LansingMI 48824-1325USA Department of Horticulture Washington State UniversityPullmanWA 99164-6414USA Biotechnology Laboratory La Platina Research StationInstituto de Investigaciones AgropecuariasSanta Rosa11610 La PintanaSantiagoChile Laboratory of Pomology Graduate School of AgricultureKyoto UniversityKyoto 606-8502Japan Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria(CREA)-Centro di ricerca Olivicoltura Frutticoltura e Agrumicoltura(CREA-OFA)RomeItaly University of Kentucky 106 T.P.Cooper HallLexingtonKY 40546-0073USA

Prior to the availability of whole-genome sequences,our understanding of the structural and functional aspects of Prunus tree genomes was limited mostly to molecular genetic mapping of important traits and development of EST *** public release of the peach genome and others that followed,significant advances in our knowledge of Prunus genomes and the genetic underpinnings of important traits *** this review,we highlight key achievements in Prunus genetics and breeding driven by the availability of these whole-genome *** the structural and evolutionary contexts,we summarize:(1)the current status of Prunus whole-genome sequences;(2)preliminary and ongoing work on the sequence structure and diversity of the genomes;(3)the analyses of Prunus genome evolution driven by natural and man-made selection;and(4)provide insight into haploblocking genomes as a means to define genome-scale patterns of evolution that can be leveraged for trait selection in pedigree-based Prunus tree breeding programs ***,we summarize recent and ongoing work that leverages whole-genome sequences to identify and characterize genes controlling 22 agronomically important Prunus *** include phenology,fruit quality,allergens,disease resistance,tree architecture,and ***,we explore the application of sequence-based marker-assisted breeding technologies and other sequence-guided biotechnological approaches for Prunus crop ***,we present the current status of publically available Prunus genomics and genetics data housed mainly in the Genome Database for Rosaceae(GDR)and its updated functionalities for future bioinformatics-based Prunus genetics and genomics inquiry.

关键词： Prunus breeding achievements

基质金属蛋白酶-26在多种肿瘤组织及平滑肌细胞中的表达(英文)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

癌症 2009年第11期28卷 1168-1175页

作者：赵云阁肖爱珍 Qing-Xiang amy Sang Department of Chemistry and Biochemistry and Institute of Molecular Biophysics Florida State University

背景与目的:基质金属蛋白酶(matrix metalloproteinases,MMPs)在多种癌组织中表达升高。MMP-26在前列腺癌和乳腺癌组织中高表达,通过裂解纤维连接蛋白和Ⅳ型胶原蛋白,并激活酶原型MMP-9(一种强效明胶酶)来促进人前列腺癌细胞的转移。本... 详细信息

背景与目的:基质金属蛋白酶(matrix metalloproteinases,MMPs)在多种癌组织中表达升高。MMP-26在前列腺癌和乳腺癌组织中高表达,通过裂解纤维连接蛋白和Ⅳ型胶原蛋白,并激活酶原型MMP-9(一种强效明胶酶)来促进人前列腺癌细胞的转移。本研究旨在探索MMP-26在多种人类肿瘤组织中的表达谱。方法:以免疫组化法及多重组织芯片检测MMP-26的蛋白表达;以RT-PCR检测冠状动脉平滑肌细胞中的MMP-26mRNA表达。结果:与相应正常组织相比,MMP-26在乳腺癌、结肠癌、肺癌、脑肿瘤、头颈部肿瘤、前列腺癌和黑色素瘤组织中的表达显著升高(P0.05)。胃癌、直肠癌、甲状腺癌、气管癌和胰腺癌中也检出MMP-26表达。MMP-26表达于前列腺及相应血管的平滑肌细胞。冠状动脉平滑肌细胞中也检出MMP-26mRNA表达。结论:MMP-26表达可能与多种人类肿瘤有关,可作为这些肿瘤早期诊断的分子指标。MMP-26也可能参与人前列腺和心血管系统的平滑肌功能。

关键词：基质金属蛋白酶-26 组织芯片综合形态测量学分析人类肿瘤平滑肌细胞

维普期刊数据库

Engineering immunosuppressive drug-resistant armored(IDRA)SARS-CoV-2 T cells for cell therapy

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第11期20卷 1300-1312页

作者： Qi Chen Adeline Chia Shou Kit Hang amy Lim Wee Kun Koh Yanchun Peng Fei gao Jili Chen Zack Ho Lu-En Wai Kamini Kunasegaran Anthony Tanoto Tan Nina Le Bert Chiew Yee Loh Yun Shan Goh Laurent Renia Tao Dong Anantharaman Vathsala Antonio Bertoletti Emerging Infectious Disease Program Duke-NUS Medical SchoolSingaporeSingapore National University Centre for Organ Transplantation National University HospitalSingaporeSingapore MRC Human Immunology Unit MRC Weatherall Institute of Molecular MedicineRadcliffe Department of MedicineUniversity of OxfordOxfordUK Lion TCR Pte Ltd SingaporeSingapore A*STAR ID labs Agency for ScienceTechnology and ResearchSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Singapore Immunology Network A*STARSingaporeSingapore

Solid organ transplant(SOT)recipients receive immunosuppressive drugs(ISDs)and are susceptible to developing severe ***,we analyze the Spike-specific T-cell response after 3 doses of mRNA vaccine in a group of SOT patients(n=136)treated with different *** demonstrate that a combination of a calcineurin inhibitor(CNI),mycophenolate mofetil(MMF),and prednisone(Pred)treatment regimen strongly suppressed the mRNA vaccine-induced Spike-specific cellular *** defects have clinical consequences because the magnitude of vaccine-induced Spike-specific T cells was directly proportional to the ability of SOT patients to rapidly clear SARS-CoV-2 after breakthrough *** then compensate for the T-cell defects induced by immunosuppressive treatment and to develop an alternative therapeutic strategy for SOT patients,we describe production of 6 distinct SARS-CoV-2 epitope-specific ISD-resistant T-cell receptor(TCR)-T cells engineered using the mRNA electroporation method with reactivity minimally affected by mutations occurring in Beta,Delta,Gamma,and Omicron *** strategy with transient expression characteristics marks an improvement in the immunotherapeutic field and provides an attractive and novel therapeutic possibility for immunosuppressed COVID-19 patients.

关键词： T cell therapy Transplantation SARS-CoV-2 Immunosuppressive drug resistant T cells