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Drinking plain water is associated with decreased risk of depression and anxiety in adults:Results from a large cross-sectional study

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World Journal of Psychiatry 2018年第3期8卷 88-96页

作者： Fahimeh Haghighatdoost Awat Feizi Ahmad Esmaillzadeh Nafiseh Rashidi-Pourfard ammar hassanzadeh keshteli Hamid Roohafza Payman Adibi Food Security Research Center Isfahan University of Medical Sciences Department of Community Nutrition School of Nutrition and Food ScienceIsfahan University of Medical Sciences Biostatistics and Epidemiology Department School of Health and Psychosomatic Research CenterIsfahan University of Medical Sciences Psychosomatic Research Center Isfahan University of Medical Sciences Department of Community Nutrition School of Nutritional Sciences and DieteticsTehran University of Medical Sciences Shahid Motahari Hospital Department of Medicine University of Alberta Integrative Functional Gastroenterology Research Center Isfahan University of Medical Sciences Gastroenterology Section Department of Internal MedicineIsfahan University of Medical Sciences

AIM To investigate the relation between plain water drinking and risk of depression and anxiety among a large sample of Iranian *** A total of 3327 Iranian general adults were included in this cross-sectional study. Validated Iranian version of the Hospital Anxiety and Depression Scale was used to assess anxiety and depression. Water consumption was assessed by asking about the number of glasses of water that consumed daily. Water consumption was categorized into < 2, 2-5, and ≥ 5 glasses of water/*** In the crude model, the lowest level of water drinking(< 2 glasses/d) compared with reference group(≥ 5 glasses/d) doubled the risk of depression and anxiety(P < 0.0001). After adjusting potential confounders, this inverse link remained significant for depression(OR: 1.79; 95%CI: 1.32, 2.42; P < 0.0001), but not for anxiety(OR: 1.49; 95%CI: 0.98, 2.25; P = 0.109). In stratified analyses by sex, after controlling for potential confounders, water drinking < 2 glasses/d was associated with 73% and 54% increment in the risk of depression in men and women, respectively(P < 0.05), whilst no significant association was observed for anxiety either in men or in *** We found inverse associations between plain water consumption and depression. Also, these findings showed a tended risky association, but not statistically significant, between lower levels of water consumption and anxiety. These findings warrant evaluation in prospective and clinical trials studies to establish the plausible role of water in mental health status.

关键词： Water Anxiety Depression Psychological disorders Iranian

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Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: A review

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World Journal of Gastroenterology 2015年第4期21卷 1081-1090页

作者： ammar hassanzadeh keshteli Vickie E Baracos Karen L Madsen Department of Medicine University of AlbertaEdmontonAlberta T6G 2E1Canada Department of Oncology University of AlbertaCross Cancer InstituteEdmontonAlberta T6G 2E1Canada

Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases(IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hyperhomocysteinemia may contribute to increased risk of colorectal cancer in IBD patients.

关键词： Hyperhomocysteinemia Colorectal cancer Inflammator

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Consumption of spicy foods and the prevalence of irritable bowel syndrome

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World Journal of Gastroenterology 2013年第38期19卷 6465-6471页

作者： Ahmad Esmaillzadeh ammar hassanzadeh keshteli Maryam Hajishafiee Awat Feizi Christine Feinle-Bisset Peyman Adibi Food Security Research Center Isfahan University of Medical SciencesIsfahan 81745-151Iran Department of Community Nutrition School of Nutrition and Food ScienceIsfahan University of Medical SciencesIsfahan 81745-151Iran Department of Medicine University of AlbertaEdmontonAlberta T6G 2E1Canada Department of Epidemiology and Biostatistics School of Public HealthIsfahan University of Medical SciencesIsfahan 81745-151Iran Centre of Research Excellence in Translating Nutritional Science to Good Health University of Adelaide Discipline of MedicineAdelaideSouth Australia 5000Australia Integrative Functional Gastroenterology Research Center Isfahan University of Medical SciencesIsfahan 81745-319Iran Department of Internal Medicine School of MedicineIsfahan University of Medical SciencesIsfahan 81745-319Iran

AIM:To explore the association between consumption of spicy foods and prevalence of irritable bowel syndrome(IBS)among Iranian ***:In this cross-sectional study,data from4763 Iranian adult participants were *** of spicy foods was estimated using a dietary habits questionnaire that included a question on spicy foods consumption:"how frequently do you use spicy foods(pepper,curry,ginger,cinnamon and turmeric)during a week?"Participants could respond to the question by choosing one of these choices:never,1-3 times,4-6times,7-9 times,or more than 10 times per week.A modified Persian version of the RomeⅢquestionnaire was used to determine the prevalence of ***:IBS was prevalent in 21.7%(18.6%of men and 24.1%of women)of the study *** controlling for potential confounders including dietary behaviors,those consuming spicy foods≥10 times per week were 92%more likely to have IBS compared with those who never consumed spicy foods(OR=1.92;95%CI:1.23-3.01,Ptrend<0.01).The association remained significant even after taking lactose intolerance into account(OR=1.85;95%CI:1.18-2.90,Ptrend<0.01).Stratified analysis by gender revealed that the association between consumption of spicy foods and IBS was not significant in men;however,a significant association was found among women after taking potential cofounders,including meal regularity and lactose intolerance,into *** who consumed spicy foods≥10 times per week were two times more likely to have IBS compared with those who never consumed spicy foods(OR=2.03;95%CI:1.09-3.77,Ptrend=0.02).CONCLUSION:Consumption of spicy foods is directly associated with IBS,particularly in ***,prospective studies are warranted to(1)examine this association in other populations;and(2)evaluate whether dietary interventions,for example a reduction in spice consumption,would improve IBS symptoms.

关键词： Spice Diet Condiments Red pepper Irritable bowel syndrome Functional gastrointestinal disorders

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Path analysis of relationship among personality, perceived stress, coping, social support, and psychological outcomes

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World Journal of Psychiatry 2016年第2期6卷 248-256页

作者： Hamidreza Roohafza Awat Feizi Hamid Afshar Mina Mazaheri Omid Behnamfar ammar hassanzadeh-keshteli Peyman Adibi Cardiac Rehabilitation Research Center Cardiovascular Research InstituteIsfahan University of Medical Sciences Department of Biostatistics and Epidemiology School of HealthIsfahan University of Medical Sciences Psychosomatic Research Center Isfahan University of Medical Sciences Isfahan Cardiovascular Research Center Cardiovascular Research InstituteIsfahan University of Medical Sciences Department of Medicine University of Alberta Integrative Functional Gastroenterology Research Center Isfahan University of Medical Sciences

AIM: To provide a structural model of the relationship between personality traits, perceived stress, coping strategies, social support, and psychological outcomes in the general ***: This is a cross sectional study in which the study group was selected using multistage cluster and convenience sampling among a population of 4 million. For data collection, a total of 4763 individuals were asked to complete a questionnaire on demographics, personality traits, life events, coping with stress, social support, and psychological outcomes such as anxiety and depression. To evaluate the comprehensive relation-ship between the variables, a path model was ***: The standard electronic modules showed that personality traits and perceived stress are important determinants of psychological outcomes. Social support and coping strategies were demonstrated to reduce the increasing cumulative positive effects of neuroticism and perceived stress on the psychological outcomes and enhance the protective effect of extraversion through decreasing the positive effect of perceived stress on the psychological outcomes. CONCLUSION: Personal resources play an important role in reduction and prevention of anxiety and depression. In order to improve the psychological health, it is necessary to train and reinforce the adaptive coping strategies and social support, and thus, to moderate negative personality traits.

关键词： Structural equations model Personality traits Stressful life events Social support Coping strategies Depression and anxiety

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Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study

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World Journal of Gastroenterology 2017年第21期23卷 3890-3899页

作者： ammar hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman Department of Medicine Division of Gastroenterology and CEGIIRUniversity of Alberta Department of Biological Sciences University of Alberta Department of Agricultural Food and Nutritional ScienceFaculty of AgriculturalLife and Environmental SciencesUniversity of Alberta Department of Computing Science University of Alberta

AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) *** In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo.

关键词： Ulcerative colitis Relapse Metabolomics Diet Fecal calprotectin

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