检索结果-南通市图书馆

SARS-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid β42-mediated neurodegeneration

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1385-1392页

作者： Aditi singh Anuradha Venkatakrishnan Chimata Prajakta Deshpande Soumya Bajpai Anjali Sangeeth Mrigendra Rajput amit singh Department of Biology University of DaytonDaytonOHUSA Premedical Program University of DaytonDaytonOHUSA Center for Tissue Regeneration and Engineering at Dayton(TREND) University of DaytonDaytonOHUSA The Integrative Science and Engineering Center University of DaytonDaytonOHUSA Center for Genomic Advocacy(TCGA) Indiana State UniversityTerre HauteINUSA

Infection caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV2)virus,responsible for the coronavirus disease 2019(COVID-19)pandemic,induces symptoms including increased inflammatory response,severe acute respiratory syndrome(SARS),cognitive dysfunction like brain fog,and cardiovascular ***-term effects of SARS-CoV2 COVID-19 syndrome referred to as post-COVID-19 syndrome on age-related progressive neurodegenerative disorders such as Alzheimer's disease remain *** the targeted misexpression of individual SARS-CoV2 proteins in the retinal neurons of the Drosophila melanogaster eye,we found that misexpression of nonstructural protein 3(Nsp3),a papain-like protease,ablates the eye and generates dark necrotic *** misexpression of Nsp3 in the eye triggers reactive oxygen species production and leads to apoptosis as shown by cell death reporters,terminal deoxynucleotidyl transferase(TdT)dUTP Nick-end labeling(TUNEL)assay,and dihydroethidium ***,Nsp3 misexpression activates both apoptosis and autophagy mechanism(s)to regulate tissue *** expression of SARS-CoV2 Nsp3 in murine neuroblastoma,Neuro-2a cells,significantly reduced the metabolic activity of these cells and triggers cell *** of SARS-CoV2 Nsp3 in an Alzheimer's disease transgenic fly eye model(glass multiple repeats[GMR]>amyloidβ42)further enhances the neurodegenerative rough eye phenotype due to increased cell *** findings suggest that SARS-CoV2 utilizes Nsp3 protein to potentiate cell death response in a neurodegenerative disease background that has high pre-existing levels of neuroinflammation and cell death.

关键词： Alzheimer's disease apoptosis autophagy COVID-19 Drosophila necrosis Neuro-2a cells neurodegeneration post COVID-19 syndrome SARS-CoV2

Evaluating Fertilization Effects on Soil Physical Properties Using a Soil Quality Index in an Intensive Rice-Wheat Cropping System

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2016年第6期26卷 887-894页

作者： Bappa DAS Debashis CHAKRABORTY Vinod Kumar singh Mukhtar AHMED amit Kumar singh Arijit BARMAN Division of Agricultural Physics Indian Agricultural Research InstituteNew Delhi 110012(India) Project Directorate for Farming Systems Research ModipuramMeerut 250110(India) Division of Soil Science and Agricultural Chemistry Indian Agricultural Research InstituteNew Delhi 110012(India)

Soil quality assessment has been suggested as an effective tool for evaluating sustainability of soil and crop management *** objective of this study was to develop a sensitive soil quality index(SQI) based on bulk density(BD),water-holding capacity(WHC),water-stable aggregates(WSA),aggregate mean weight diameter(AMWD),total organic C(TOC) and C input to evaluate the important rice-wheat cropping system on an Inceptisol in India.A long-term experiment has been conducted for 18 years at the Indian Council of Agricultural Research-Indian Institute of Farming Systems Research,Modipuram,*** treatments selected for this study were comprised of a no-fertilizer control and N,P and K fertilizers(NPK) combined with Zn and S fertilizers(NPK+ Zn+S),farmyard manure(NPK+FYM),green gram residues(NPK+GR) and cereal residues(NPK+CR),laid out in a randomized complete block design with three *** samples were collected and analyzed for BD,WHC,WSA and *** analysis revealed that both rice and wheat yields signi?cantly increased with the increases in AMWD,TOC and C input,but decreased with the increase in *** SQI values were then generated based on regression analysis of BD,WSA,AMWD,TOC and C input with rice and wheat yields for the 0–15 and 15–30 cm soil layers,*** analyses between crop yields and SQI values showed a quadratic type of relation with the coeffcient of determination(R^2) varying from 0.78 to *** regard to soil sustainability,applying crop residues to both rice and wheat could maintain soil quality for a longer period,whereas the highest yields of both the crops were recorded in the NPK+Zn+S *** regression equations developed in this study could be used to monitor soil quality in a subhumid tropical rice-wheat cropping system.

关键词： bulk density C input integrated nutrient management total organic C water-holding capacity water-stable aggregates

Effects of supplemental xylanase and xylooligosaccharides on production performance and gut health variables of broiler chickens

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第1期13卷 166-180页

作者： amit K.singh Birendra Mishra Michael R.Bedford Rajesh Jha Department of Human Nutrition Food and Animal SciencesUniversity of Hawaii at ManoaHonoluluHI 96822USA AB Vista Feed Ingredients MarlboroughWiltshireUK

Background:This study evaluated the effects of supplemental xylanase and xylooligosaccharides(XOS)in a cornsoybean meal(SBM)-based diet on growth performance and intestinal health of broilers.A total of 288 day-old chicks(Cobb 500)were allocated to 36 floor pens(8 birds/pen)equally in 9 dietary treatments in a 3×3 factorial *** treatments were combinations of 3 levels of xylanase(0,0.005% and 0.01% Econase XT)and 3 levels of prebiotics(0,0.005% and 0.01% XOS)added to basal mash diets formulated in three phases(starter,d 0-14;grower,d 15-28;finisher,d 29-42).The feed intake and body weights were recorded *** d 42,ileal sections were collected for histomorphometric and gene expression analysis,and cecal content was collected for determining short-chain fatty acids(SCFA)and ***:Xylanase linearly(P0.05).Supplemental xylanase and XOS did not affect average daily feed intake and feed conversion ratio(P>0.05).Xylanase and XOS did not change villus height(VH)or crypt depth(CD)ratio(P>0.05).However,xylanase exhibited a trend(P=0.097)on VH:CD *** inclusion of 0.01%XOS without xylanase increased the level of IL-10(a marker of anti-inflammatory cytokine)and IL-4(a T-cell differentiation cytokine)genes compared with control(P0.05).However,the mean proportion of family Ruminococcaceae was increased by the supplemental 0.01% xylanase(P<0.01).Conclusion:It can be concluded that XOS can enhance cecal fermentation,while xylanase can increase the body weight gain along with the ferment

关键词： Gene expression Histomorphology Microbiota Poultry Prebiotics Short-chain fatty acid Xylooligosaccharide

Fermentation characteristics of resistant starch, arabinoxylan, andβ-glucan and their effects on the gut microbial ecology of pigs:A review

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2019年第3期5卷 217-226页

作者： Utsav P.Tiwari amit K.singh Rajesh Jha Department of Human Nutrition Food and Animal Sciences College of Tropical Agriculture and Human ResourcesUniversity of Hawaii at Manoa

Dietary fibers(DF)contain an abundant amount of energy,although the mammalian genome does not encode most of the enzymes required to degrade ***,a mutual dependence is developed between the host and symbiotic microbes,which has the potential to extract the energy present in these *** fibers escape digestion in the foregut and are fermented in the hindgut,producing shortchain fatty acids(SCFA)that after the microbial ecology in the gastrointestinal tract(GIT)of *** of the carbohydrates are fermented in the proximal part,allowing protein fermentation in the distal part,resulting in colonic *** structures of resistant starch(RS),arabinoxylan(AX),and β-glucan(βG)are complex;hence,makes their way into the hindgut where these are fermented and provide energy substrates for the colonic epithelial *** microbes have different preferences of binding to different *** RS,AX and βG act as a unique substrate for the microbes and modify the relative composition of the gut microbial *** granule dimension and surface area of each substrate are different,which influences the penetration capacity of *** and xylan are 2 different hemicelluloses,but arabinose is substituted on the xylan backbone and occurs in the form of *** of xylan produces butyrate primarily in the small intestine,whereas arabinose produces butyrate in the large *** of RS and forms of βG also exert beneficial effects by producing different metabolites and modulating the intestinal ***,it is important to have information of different types of RS,AX and(3 G and their roles in microbial modulation to get the optimum benefits of fiber fermentation in the *** review provides relevant information on the similarities and differences that exist in the way RS,AX,and βG are fermented,and their positive and negative effects on SCFA production and gut microbial ecology of *** insights will help nutr

关键词： Butyrate Fermentation Gut ecology Microbiota Short-chain fatty acids Swine

Case study of high waves in the South Pacific generated by Tropical Cyclone Harold in 2020

在线全文

学校读者我要写书评

暂无评论

Tropical Cyclone Research and Review 2024年第3期13卷 147-160页

作者： amit singh Nadao Kohno Hironori Fudeyasu Research Institute of Environment and Information Sciences Yokohama National UniversityYokohamaJapan Meteorological Research Institute Japan Meteorological AgencyTsukubaJapan Typhoon Science and Technology Research Center Yokohama National UniversityYokohamaJapan Fiji Meteorological Service Fiji

This study highlighted a high wave case by severe tropical cyclone Harold and conducted a simulation with a newly developed wave forecasting system for the South Pacific based on the Japan Meteorological Agency third generation wave model(JMA MRI-III)using the National Center for Environment Prediction Global Forecast System(GFS)*** was a very intense tropical cyclone(TC)and very high waves up to 10 m affected parts of Vanuatu and *** model results were reasonable and verified against observations of orbital satellites and a wave buoy at Komave in *** statistical verifications were carefully *** Root Mean Squared Error(RSME),Scatter Index(SI),Bias and R2 are all showing very impressive *** new wave forecasting system is the first high resolution operational model at Fiji Meteorological Service(FMS),which covers the whole Fiji *** system will provide guidance to FMS in preparing marine alerts and warning better and more confidence in providing the marine forecast accurately.

关键词： A wave forecasting system The South pacific Tropical cyclone harold

Dietary supplementation of dried plum:a novel strategy to mitigate heat stress in broiler chickens

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2021年第3期12卷 1056-1072页

作者： Sanjeev Wasti Nirvay Sah amit K.singh Chin N.Lee Rajesh Jha Birendra Mishra Department of Human Nutrition Food and Animal Sciences University of Hawaii at ManoaHonoluluHI 96822USA

Background:Heat stress is a significant problem in the poultry industry,causing a severe economic loss due to its detrimental effects on chickens’health and *** plum(DP)is a good source of minerals,vitamins,antioxidants,and phenolic *** have suggested that DP has several health benefits,such as maintaining the body’s redox system,immune status,and calcium *** on the health benefits of DP,we hypothesized that the dietary supplementation of DP would alleviate the detrimental effects of heat stress on broiler ***:To test the hypothesis,day-old broiler chicks(n=72)were randomly allocated to three treatment groups(n=24/group):no heat stress(NHS),heat stress(HS),and heat stress with dried plum(HS+DP),and reared under standard *** inclusion of 2.5%DP in the feed of the HS+DP group was made during the treatment period,while birds in other groups were provided with a standard finisher *** 21 days,birds in the HS and HS+DP groups were exposed to cyclic heat stress conditions(33℃ for 8 h during daytime)for 3 weeks,while those in the NHS group were reared under normal conditions(22-24℃).Weekly body weight and feed intake were recorded to calculate the average daily gain(ADG),average daily feed intake(ADFI),and feed conversion ratio(FCR).Heat stress significantly decreased the final body weight,ADG,ADFI,and increased FCR compared to the NHS group,whereas dietary supplementation of DP significantly improved these growth performance parameters compared to the HS ***,supplementation of DP significantly increased the expression of heat shock protein-related genes(HSF1,HSF3,HSP70,and HSP90),antioxidant-related genes(SOD1,SOD2,GPX1,GPX3,PRDX1,and TXN),tight junction-related genes(CLDN1,and OCLN),and immune-related genes(IL4,MUC2)in the ileum as compared to the HS *** microbiota analysis showed significant enrichment of Bacillales,Christensenellaceae,Bacillaceae,Peptostreptococcaceae,and Anaerot

关键词： Dried plum Gene expression Heat stress Microbiota Mitigation

Pitting corrosion resistance and bond strength of stainless steel overlay by friction surfacing on high strength low alloy steel

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2015年第3期11卷 299-307页

作者： amit Kumar singh G.Madhusudhan REDDY K.Srinivas RAO Defence Metallurgical Research Laboratory Andhra University

Surface modification is essential for improving the service properties of components. Cladding is one of the most widely employed methods of surface modification. Friction surfacing is a candidate process for depositing the corrosion resistant coatings. Being a solid state process, it offers several advantages over conventional fusion based surfacing process. The aim of this work is to identify the relationship between the input variables and the process response and develop the predictive models that can be used in the design of new friction surfacing applications. In the current work, austenitic stainless steel AISI 304 was friction surfaced on high strength low alloy steel substrate. Friction surfacing parameters,such as mechtrode rotational speed, feed rate of substrate and axial force on mechtrode, play a major role in determining the pitting corrosion resistance and bond strength of friction surfaced coatings. Friction surfaced coating and base metal were tested for pitting corrosion by potentiodynamic polarization technique. Coating microstructure was characterized using optical microscopy, scanning electron microscopy and X-ray diffraction. Coatings in the as deposited condition exhibited strain-induced martensite in austenitic matrix. Pitting resistance of surfaced coatings was found to be much lower than that of mechtrode material and superior to that of substrate. A central composite design with three factors(mechtrode rotational speed, substrate traverse speed, axial load on mechtrode) and five levels was chosen to minimize the number of experimental conditions. Response surface methodology was used to develop the model. In the present work, an attempt has been made to develop a mathematical model to predict the pitting corrosion resistance and bond strength by incorporating the friction surfacing process parameters.

关键词：奥氏体不锈钢摩擦堆焊粘结强度低合金高强度抗蚀性钢表面耐点蚀性能

Current therapeutic modalities and chemopreventive role of natural products in liver cancer:Progress and promise

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2023年第1期15卷 1-18页

作者： amit Kumar singh Shiv Vardan singh Ramesh Kumar Shashank Kumar Sabyasachi Senapati Abhay K Pandey Department of Botany Government Naveen Girls CollegeBalod(Hemchand Yadav University)DurgChattisgarhIndia Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia Department of Biochemistry School of Basic and Applied SciencesCentral University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia

Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year,with an estimated 5-year survival rate of 30%–35%after *** carcinoma(HCC)constitutes a significant subtype of liver cancer(approximate75%)and is considered primary liver *** for liver cancer mainly depends on the stage of its progression,where surgery including,hepatectomy and liver transplantation,and ablation and radiotherapy are the prime *** advanced liver cancer,various drugs and immunotherapy are used as first-line treatment,whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic *** and lenvatinib are first-line therapies,while regorafenib and ramucirumab are secondline *** metabolic and signaling pathways such as Notch,JAK/STAT,Hippo,TGF-β,and Wnt have played a critical role during HCC *** has also been implicated in liver ***-induced toxicity is a key obstacle in the treatment of liver cancer,necessitating the development of effective and safe medications,with natural compounds such as resveratrol,curcumin,diallyl sulfide,and others emerging as promising anticancer *** review highlights the current status of liver cancer research,signaling pathways,therapeutic targets,current treatment strategies and the chemopreventive role of various natural products in managing liver cancer.

关键词： Liver cancer Hepatocellular carcinoma Signaling pathways Therapeutic targets Natural products Chemopreventive

Effect of friction stir processing on corrosion of Al-TiB2 based composite in 3.5 wt.% sodium chloride solution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2019年第7期29卷 1383-1392页

作者： Ritukesh SHARMA amit Kumar singh amit ARORA S. PATI P. S. DE School of Minerals Metallurgical and Materials Engineering Indian Institute of Technology Bhubaneswar India Materials Science and Engineering Indian Institute of Technology Gandhinagar India

The microstructure and corrosion behavior of as-cast and friction stir processed in-situ Al-TiB2 based composite in 3.5 wt.% sodium chloride solution were investigated. The microstructure was characterized using X-ray diffractometry, scanning electron microscopy and electron backscattered diffraction technique while corrosion behavior was evaluated using linear/cyclic potentiodynamic, electrochemical impedance spectroscopy and ASTM–G67 tests. The composite contains sub-micron TiB2 particles in an aluminum matrix with both blocky and fine clusters of Al3Ti agglomerated around TiB2 and displays a low uniform corrosion rate. It is also resistant to pitting as substantiated by the absence of a positive loop in cyclic potentiodynamic tests. This is due to the non-conductive nature of TiB2 particles and a controlled amount of blocky Al3Ti phase. However, both friction stir processed and as-cast composites are susceptible to inter-granular corrosion where Al3Ti and TiB2 at grain boundaries provide initiation sites for corrosion. Electrochemical impedance study attributes this to the adverse effect of Al3Ti and TiB2 on the protective oxide surface film, which increases with immersion time.

关键词： friction stir processing corrosion behavior Al composite electrochemical impedance spectroscopy (EIS)