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Bioactive peptides in fermented foods and their application:a critical review

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Systems Microbiology and Biomanufacturing 2023年第1期3卷 88-109页

作者： Rounak Chourasia Loreni Chiring Phukon Md Minhajul Abedin Srichandan Padhi Sudhir P.singh amit Kumar Rai Institute of Bioresources and Sustainable Development(DBT‑IBSD) Regional CentreTadongSikkimIndia Centre of Innovative and Applied Bioprocessing(DBT-CIAB) Sector‑81S.A.S.NagarMohaliPunjabIndia Institute of Bioresources and Sustainable Development(DBT-IBSD) Mizoram NodeAizawlMizoramIndia

Bioactive peptides are released during the production of fermented dairy,vegetables,fruits,legumes,fish,and meat *** proteolytic specificity of lactic acid bacteria,Bacillus spp.,yeasts,and mold,apart from their ability to synthesize bioactive peptides,plays an important role in the generation of specific bioactive peptides in traditional fermented *** fermentation using defined starter strains has been explored for the development of bioactive peptides enriched novel fermented foods with potential *** peptides enriched foods exert diverse health benefits,such as antioxidant,antihypertensive,antidiabetic,and immunomodulatory *** peptides can be used as alternatives to synthetic compounds due to negligible side effects and high valuation in the nutraceutical and functional food ***,challenges associated with the identification,quantification,organoleptic properties,and bioavailability of bioac-tive peptides need to be addressed before exploiting the potential of bioactive peptides in the functional food *** the present review,we have discussed the production of bioactive peptides in diverse fermented *** and sequence specificity of peptides and their effect on the expression of distinct health beneficial effects have been *** potential of utilizing these bioactive peptides for the development of novel functional fermented foods is *** advances in peptide identification,quantification,debittering of peptides,and increasing peptide bioavailability have been explained.

关键词： Bioactive peptides Fermented foods Health benefits Nutraceuticals Functional foods Bioavailability

Comparison of efficacy of metformin and D-chiro-inositol on clinical biomarkers in patients with polycystic ovarian syndrome:an open label study

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Global Health Journal 2023年第3期7卷 147-152页

作者： Gaurika Aggarwal Shikha Gupta Ojus Sardana Harleen Pratima Kumari Rupinder Kaur Thakur Gurjeet singh amit Sharma Ravinder singh Neelam Hospital Near Chitkara UniversityRajpuraPunjab 140401India Department of Pharmacy Practice Chitkara College of PharmacyChitkara UniversityRajpuraPunjab 140401India Department of Pharmacy Practice ISF College of PharmacyMogaPunjab 142001India

Objective:Polycystic ovary syndrome(Pcos)is a pathophysiological disorder affecting reproductive and metabolic indices in *** present study was designed to compare the efficacy of metformin and D-chiroinositol in PcoS ***:In a tertiary care hospital in North India,prospective observational research was undertaken on 1o0 patients with PCOS,which was diagnosed based on European Society of Human Reproduction and Embryology Guidelines and ultrasound of lower *** study involves various clinical characteristics into consideration for the determination of statistical significance(P<0.05)in PCOS ***'s t-test along with the association between PCOS and patients taking metformin and D-chiro-inositol,as well as their impact on various biochemical parameters,were investigated finally using Pearson Correlation ***:This study comprises 50 patients taking metformin and 50 patients taking D-chiro-inositol in women suffering from *** mass index(BMI)and waist-to-hip ratio(WHR)were statistically significant(P<0.05)within the groups of both metformin and *** parameters such as luteinizing hormone(LH),follicle stimulating hormone(FSH),anti-mullerian hormone(AMH)and glycated hemoglobin(HbA1c)were found to be statistically significant(P<0.05)in both ***,FSH and AMH(14.40±0.52;14.28±0.53;1.99±0.10)were comparatively lower in patients taking D-chiro-inositol as compared to metformin group(14.17±0.42;19.88±1.01;2.61±0.04).HbA1c(3.71±0.08)with P<0.05 was found to be decreased more in metformin group as compared to patients taking D-chiro-inositol(4.90±0.09).A positive correlation was found between HbAlc and LH in metformin,&HbAlc and FSH in D-chiro-inositol groups,***:The results indicate that D-chiro-inositol shows better results in reducing clinical variables involved in causing PCOS as compared to metformin whereas metformin has better glycemic control in PCOS patients.

关键词： PCOS Metformin D-chiro-inositol HbA1c Correlation

Changes in gene expression in liver tissue from patients with fulminant hepatitis E

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World Journal of Gastroenterology 2015年第26期21卷 8032-8042页

作者： Anshu Naik amit Goel Vinita Agrawal Aditya N Sarangi Nanda Chhavi Vineeta singh Shahid Jameel Rakesh Aggarwal Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences Department of Pathology Sanjay Gandhi Postgraduate Institute of Medical Sciences Sandor Proteomics Pvt Ltd Virology Group International Centre for Genetic Engineering and Biotechnology

AIM: To study host gene expression and numberof immune cells in liver tissues from patients with fulminant hepatitis E(FH-E).METHODS: Microarray-based expression profiling was done using Illumina Human WG-6_v3_Bead Chip arrays on post-mortem liver tissue from 5 patients with FH-E,and compared with similar tissue from 6 patients with fulminant hepatitis B(FH-B; disease controls) and normal liver tissue from 6 *** expression was defined as ≥ 2.0-fold change with Benjamini-Hochberg false discovery rate below 0.05 using t-test in liver tissue from FH-B and FH-E,than healthy liver *** some genes that showed differential expression in FH-E,microarray data were validated using quantitative reverse transcription *** expressed gene lists were then subjected to "Gene Ontology" analysis for biological processes,and pathway analysis using Bio Carta database on the DAVID *** addition,tissue sections were stained for CD4+,CD8+ and CD56+ cells using indirect immunohistochemistry; cells staining positive for each of these markers were counted and compared between ***: Compared to normal livers,those from patients with FH-E and FH-B showed differential expression of 3377 entities(up-regulated 1703,downregulated 1674) and 2572 entities(up 1164,down 1408),*** included 2142(up 896,down 1246) entities that were common between the two sets; most of these belonged to metabolic,hemostatic and complement pathways,which are active in normal *** expression data from livers of patients with FH-E but not those of FH-B showed activation of several immune response pathways,particularly those involving cytotoxic T *** fold-change values of m RNA for selected genes in livers from FH-E than in normal liver tissue determined using quantitative reverse transcription PCR showed excellent concordance with microarray *** immunohistochemistry,CD8+ T cells showed an increase in liver biopsies from both FH-E [median

关键词： Cytotoxic T cells Gene expression HepatitisE Hepatitis E virus Immune response Liver biopsy Microarray Natural killer cells Pathogenesis

Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation

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BIOCELL 2022年第12期46卷 2645-2657页

作者： POOJA JAISWAL VERSHA TRIPATHI ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA singh JANESH KUMAR HEM CHANDRA JHA RAJESH SHARMA amit KUMAR DIXIT HAMENDRA singh PARMAR School of Biotechnology Devi Ahilya UniversityIndore452001India Laboratory of Membrane Protein Biology National Centre for Cell SciencePune411007India Department of Biosciences and Biomedical Engineering Indian Institute of TechnologyIndore452020India Department of Biotechnology IPS AcademyIndore452012India School of Pharmacy Devi Ahilya UniversityIndore452001India Central Council for Research in Ayurvedic Sciences Kolkata263645India

Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in *** the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell *** have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate *** study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were *** with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned *** changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and ***-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT ***,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg *** response was in the order of:sitagliptin>vildagliptin>ex

关键词： Sitagliptin Vildagliptin Exendin-4 Apoptosis Migration Viability Chemo-sensitivity Mitochondrial biogenesis

Structural and optical properties of green emitting Y_(2)SiO_(5):Tb^(3+) and Gd_(2)SiO_(5):Tb^(3+) nanoparticles for modern lighting applications

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Rare Metals 2021年第11期40卷 3289-3298页

作者： Sitender singh Devender singh Department of Chemistry Maharshi Dayanand UniversityRohtak 124001India

The optical and structural properties of Tb^(3+)-doped yttrium and gadolinium oxyorthosilicate(Y_(2)SiO_(5) and Gd_(2)SiO_(5)) phosphors were *** samples were synthesized via sol-gel combustion method using organic *** phase purity and structural properties of the samples were determined via combined approach of powder X-ray diffraction,Fourier transformation infrared(FTIR) and transmission electron microscopy(TEM).X-ray measurements revel monoclinic crystal lattice with P_(21/c) symmetry for both M_(2)SiO_(5)(pure host) and M_(2)SiO_(5):Tb^(3+)(doped) silicates,irrespective of the nature of metal(Y or Gd),presence or absence of Tb^(3+)in lattice and change in calcination temperature up to 1050℃.FTIR analysis was applied to confirm the bonding of prepared *** appearance of bands corresponding to SiO_(4) tetrahedra(880-1020 cm^(-1)) suggest the layered structure and support the diffraction *** micrographs confirm the synthesis of spherical nanoparticles with filled morphology,narrow size distribution and slightly agglomerated crystallites of the *** elemental composition of prepared materials was determined using energy dispersive X-ray *** spectra show peaks only for elements assimilated within the host *** photoluminescence(PL) emission spectra of Tb^(3+)-doped samples show ^(5)D_(4)→^(7)F_(J)(J=3-6) transitions under 254 *** dominant peak at 544 nm for ^(5)D_(4)→^(7)F_(5) transition is responsible for the emission of green light on ultraviolet-visible excitation in both the Tb^(3+)-doped host *** to advantageous properties like intense PL and high crystallinity,these nanophosphors could possess potential applications in the mercury free lighting sources and optoelectronic devices.

关键词： Structural Optical Silicates Luminescence Optoelectronic

Robust Optimal H_∞ Control for Uncertain 2-D Discrete State-Delayed Systems Described by the General Model

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Journal of Signal and Information Processing 2016年第2期7卷 78-114页

作者： Arun Kumar singh amit Dhawan Department of Electronics and Communication Engineering Motilal Nehru National Institute of Technology Allahabad India

This paper investigates the problem of robust optimal H∞ control for uncertain two-dimensional (2-D) discrete state-delayed systems described by the general model (GM) with norm-bounded uncertainties. A sufficient condition for the existence of g-suboptimal robust H∞ state feedback controllers is established, based on linear matrix inequality (LMI) approach. Moreover, a convex optimization problem is developed to design a robust optimal state feedback controller which minimizes the H∞ noise attenuation level of the resulting closed-loop system. Finally, two illustrative examples are given to demonstrate the effectiveness of the proposed method.

关键词： 2-D Discrete Systems General Model H∞ Control Linear Matrix Inequality State Feedback Uncertain System

Genetics of severe combined immunodeficiency

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Genes & Diseases 2020年第1期7卷 52-61页

作者： Rajni Kumrah Pandiarajan Vignesh Pratap Patra Ankita singh Gummadi Anjani Poonam Saini Madhubala Sharma Anit Kaur amit Rawat Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Severe Combined Immunodeficiency(SCID)is an inherited group of rare,lifethreatening disorders due to the defect in T cell development and *** manifestations are characterised by recurrent and severe bacterial,viral,and fungal opportunistic infections that start from early infancy *** stem cell transplantation(HSCT)is the treatment of *** pattern of inheritance of SCID may be X-linked or autosomal *** the diagnosis of SCID is usually established by flow cytometry-based tests,genetic diagnosis is often needed for genetic counselling,prognostication,and modification of pre-transplant chemotherapeutic *** review aims to highlight the genetic aspects of SCID.

关键词： Adenosine deaminase Flow cytometry Genetics Newborn screening Severe combined immunodeficiency

Utilization of alkali-activated copper slag as binder in concrete

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Frontiers of Structural and Civil Engineering 2021年第3期15卷 773-780页

作者： Jagmeet singh S P singh Department of Civil Engineering Dr.B R Ambedkar National Institute of TechnologyJalandhar144011India

This study was focused on developing concrete using alkali-activated copper slag(AACS)as a *** properties of alkali-activated copper slag concrete(AACSC)were compared with portland cement concrete(PCC).Different AACSC mixes were prepared with varying Na_(2)O dosage(6%and 8%of the binder by weight)and curing *** products in AACSC were retrieved using Fourier-transform infrared spectroscopy(FTIR)and X-ray powder diffraction(XRD)*** test results indicate that the workability of AACSC was lesser than that of *** AACSC mix with 6%Na_(2)O dosage has exhibited similar mechanical properties as that of *** mechanical properties of AACSC were higher than PCC when 8%of Na_(2)O dosage was *** curing was effective to upgrade the strength properties of AACSC at an early age of curing,but at a later age mechanical properties of ambient cured and heat-cured AACSC were *** hydration products of AACSC were not identified in XRD patterns,whereas,in FTIR spectra of AACSC some alkali-activated reaction products were *** AACSC mixes were found to be more sustainable than *** has been concluded that AACSC can be produced similarly to that of PCC and ambient curing is sufficient.

关键词： binder concrete mechanical properties mineralogy workability

MHD free convective flow past semi-infinite vertical permeable wall

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Applied Mathematics and Mechanics(English Edition) 2012年第9期33卷 1207-1222页

作者： R.K.singh A.K.singh Department of Mathematics Banaras Hindu University

In this paper, the basic equations governing the flow and heat transfer of an incompressible viscous and electrically conducting fluid past a semi-infinite vertical per- meable plate in the form of partial differential equations are reduced to a set of non-linear ordinary differential equations by applying a suitable similarity transformation. Approx- imate solutions of the transformed equations are obtained by employing the perturbation method for two cases, i.e., small and large values of the suction parameter. From the numerical evaluations of the solution, it can be seen that the velocity field at any point decreases as the values of the magnetic and suction parameters increase. The effect of the magnetic parameter is to increase the thermM boundary layer. It is also found that the velocity and temperature fields decrease with the increase in the sink parameter.

关键词： magnetohydrodynamics (MHD) suction source/sink Prandtl number permeability boundary layer