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Liposomal Iron for Iron Deficiency Anemia in Women of Reproductive Age: Review of Current Evidence

Open Journal of Obstetrics and Gynecology 2018年第11期8卷 993-1005页

作者： Parag Biniwale Bhaskar Pal Tripura Sundari Gorakh Mandrupkar Nikhil Datar Amandeep Singh Khurana amit qamra Salman Motlekar Rishi Jain Department of Obstetrics & Gynecology Biniwale Clinic Pune India Department of Obstetrics & Gynecology Apollo Gleneagles Hospital Ltd. Kolkata India Department of Obstetrics & Gynecology Krishna Institute of Medical Sciences Secunderabad India Department of Obstetrics & Gynecology Mandrupkar Clinic Islampur India Department of Obstetrics & Gynecology Cloudnine Hospital Mumbai India Department of Medical Affairs Wockhardt Limited Mumbai India

Iron deficiency anemia is the most frequent nutritional deficiency disorder. Conventionally administered oral iron is associated with gastrointestinal intolerance that affects the outcomes and compliance. Liposomal iron is associated with increased absorption without causing significant adverse effects. In this review, we have discussed the technology of liposomal iron preparation, mechanisms of its absorption and clinical evidence on its utility in iron deficiency states in pregnant and non-pregnant women. Based on the available evidence, we compared liposomal iron to conventional oral iron. Encapsulation of micronized iron in liposomes is associated with lesser exposure to gastric contents, lesser interaction with food contents, no exposure to different digestive juices, targeted delivery of iron and allows lower doses to be administered in lieu of direct absorption without need for protein carriers. The available evidence suggests that liposomal iron significantly increases hemoglobin, ferritin levels in pregnant women as well as in women with iron deficiency.

关键词： Liposomal Iron Microencapsulated Micronized Iron Deficiency Anemia Pregnancy

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Heme Iron Polypeptide in Iron Deficiency Anemia of Pregnancy: Current Evidence

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Open Journal of Obstetrics and Gynecology 2017年第4期7卷 420-431页

作者： Bhaskar Pal Hemant Deshpande Tripura Sundari Parag Biniwale Kamlesh Shah Sugandh Goel Amandeep Singh Khurana amit qamra Salman Motlekar Hanmant Barkate Department of Obstetrics & Gynecology Apollo Gleneagles Hospital Ltd. Kolkata India Department of Obstetrics & Gynecology Dr D.Y. Patil Medical College & Hospital Pune India Department of Obstetrics & Gynecology Krishna Institute of Medical Sciences Secunderabad India Department of Obstetrics & Gynecology Biniwale Clinic Pune India Department of Obstetrics & Gynecology Sahyadri Hospital Karad India Department of Medical Affairs Wockhardt Limited Mumbai India

Iron deficiency is the most common nutritional deficiency leading to anemia in pregnancy. Conventionally, non-heme form of iron salts has been the mainstay of treatment. However, patient compliance is an important concern with existing oral iron therapy due to gastrointestinal side effects. Heme iron, a better bioavailable and tolerable form of iron can be suitable form of iron for supplementation in pregnancy. Evidence suggests its utility in pregnancy for treatment of iron deficiency anemia with benefits extending to postpartum period. Effective transfer across placenta to fetus further supports its utility in pregnancy. This review discusses in details the absorption kinetics along with clinical evidence on efficacy, safety, and tolerability of heme-iron supplementation in iron deficiency anemia of pregnancy.

关键词： Heme Iron Pregnancy Iron Absorption Iron Deficiency Anemia

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Real World Evidence of Safety and Effectiveness of Combination of Vitamin E and <i>Fraxinus excelsior</i>in Treatment of Indian Patients with Nonalcoholic Fatty Liver Disease

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Open Journal of Gastroenterology 2020年第1期10卷 14-22页

作者： Virukalpatti Gopalratnam Mohan Prasad Prashant Rahate Husain Bohri Jyoti Ranjan Mahapatra Ashish Mungantiwar Priyanka Srivastava Nirali Bhatt Dhavalkumar Patel Soumen Roy amit qamra VGM Gastro Centre Singanallur Coimbatore Tamil Nadu India SevenStar Hospital Nagpur Maharashtra India Premium Digestive Diesase Liver and Endoscopy Clinic Nashik Maharashtra India Apollo Clinic Salt Lake City Kolkata West Bengal India R & D and Clinical Trials Department Macleods Pharmaceuticals Ltd. Mumbai Maharashtra India Medical Affairs Department Macleods Pharmaceuticals Ltd. Mumbai Maharashtra India

Introduction: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease ranging from liver steatosis to nonalcoholic steatohepatitis (NASH). Besides lifestyle modifications, Vitamin E (800 IU/day) is generally recommended for NASH. Vitamin E monotherapy is not sufficient for the multifaceted disease like NALFD. The combination of Vitamin E 400IU and Fraxinus excelsior 500 mg twice daily was found to be better than vitamin E 400 IU twice daily in improving the lipid profile and liver function parameters in patients with NAFLD. We conducted a study to assess safety and effectiveness of Vitamin E plus Fraxinus excelsior in Indian patients with NAFLD in real-world settings. Patients and Methods: This was a non-interventional study in NAFLD patients with varying grades of steatosis conducted by 234 physicians across India from January 2018 to August 2018. Patients received combination of Vitamin E (400 IU) and Fraxinus excelsior (500 mg) soft gelatin capsules twice daily after meals for 12 weeks. Effectiveness of the treatment was assessed at visit 2 (6 weeks) and visit 3 (12 weeks, end of study) from baseline. The parameters for assessment included severity of liver steatosis, liver function parameters and the global assessment of safety and effectiveness. Results: A total of 1114 patients were included in the study. At baseline, majority of the patients (71.18%) had Grade II liver steatosis followed by 21.01% and 7.81% patients who had Grade III and Grade I liver steatosis, respectively. After 12 weeks of treatment with vitamin E and Fraxinus excelsior combination, 21% patients had no steatosis, 58.79% patients were in Grade 1 steatosis, 19.57% in grade II steatosis and only 0.63% patients in Grade III steatosis. The mean percentage reduction in aspartate aminotransferase (AST) level at week 6 and week 12 from baseline was 24.92% and 43.79%, respectively. Similarly, the mean percentage reduction in alanine aminotransferase (ALT) level at week 6 and week 12 fr

关键词： NAFLD NASH Vitamin E Fraxinus excelsior Real Life India

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