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PI3K/AKT signaling pathway as a critical regulator of Cisplatin response in tumor cells

Oncology Research 2021年第4期29卷 235-250页

作者： ZAHRA NASRPOUR NAVAEI GHAZALEH KHALILI-TANHA amir sadra zangouei MOHAMMAD REZA ABBASZADEGAN MEYSAM MOGHBELI Department of Medical Genetics and Molecular Medicine School of MedicineMashhad University of Medical SciencesMashhadIran Student Research Committee Faculty of MedicineMashhad University of Medical SciencesMashhadIran Medical Genetics Research Center Mashhad University of Medical SciencesMashhadIran

Chemotherapy is one of the main therapeutic modalities for cancer ***(CDDP),as one of theﬁrst-line drugs,is of great importance in the chemotherapy of various ***,a signiﬁcant percentage of cancer patients are resistant to CDDP *** to the CDDP side effects on normal tissues,the diagnosis of CDDP resistance is required to suggest the most efﬁcient therapeutic strategies for cancer *** molecular mechanisms and signaling pathways are associated with CDDP *** PI3K/AKT signaling pathway has a pivotal role in the transmission of extracellular signals into the cells to regulate various pathophysiological processes such as cell proliferation,migration,and drug *** the present review,we summarized all of the studies which have been reported on the role of PI3K/AKT pathway in regulation of CDDP *** was shown that the PI3K/AKT pathway is mainly involved in CDDP response in lung,ovarian,and gastrointestinal *** was also observed that the non-coding RNAs have a key role in CDDP response by regulation of PI3K/AKT *** review paves the way for suggesting a PI3K/AKT-related panel marker for the prediction of CDDP response in different cancer patients.

关键词： PI3K/AKT Cancer Chemoresistance Cisplatin Chemotherapy

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Studying the particle size ratio effect on granular mixing in a vertically vibrated bed of two particle types

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Particuology 2020年第6期18卷 100-111页

作者： amir Menbari Kamyar Hashemnia School of Mechanical Engineering Shiraz UniversityMolla Sadra St.ShirazIran

The uniform mixing of solids is important in many industries,such as the pharmaceutical,food,petrochemical and chemical *** numerically investigated the effect of particle size ratio on the mixing of bisized particles in a quasi-two-dimensional vibrationally fluidized *** granular bin ary mixtures comprised spherical particles with different size ***-dimensional discrete-element simulations agreed with previous experimental *** and diffusive mechanisms occurred Keywords:Discrete-element modeling Fluidization Granular media Mixing Particle size ratio Vibration within the vibrated *** particle size had no significant influence on convective mixing,whereas the diffusive mechanism strengthened for large size *** average particle velocity was larger in a mixture of large size *** stronger diffusive motion and larger average particle velocity caused the particles to mix faster for large size *** final mixing index decreased with size ratio because of the difference between the size and number of small and large particles.

关键词： Discrete-element modeling Fluidization Granular media Mixing Particle size ratio Vibration

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