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Evaluating the safety and efficacy of mesenchymal stem cell-derived exosomes for treatment of refractory perianal fistula in IBD patients:clinical trial phaseⅠ

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Gastroenterology Report 2022年第1期10卷 585-593页

作者： Hojjatollah Nazari Foroogh Alborzi Asieh Heirani-Tabasi Alireza Hadizadeh Reza Akbari Asbagh Behnam Behboudi Mohammad Sadegh Fazeli Mojgan Rahimi Mohammad Reza Keramati amir keshvari Alireza Kazemeini Masoud Soleimani Seyed Mohsen Ahmadi Tafti Department of Colorectal Surgery Colorectal Research CenterImam Khomeini Hospital ComplexTehran University of Medical SciencesTehranIran Department of Biomedical Engineering School of Biomedical EngineeringUniversity of Technology SydneySydneyNSWAustralia Department of Gastroenterology Division of GastroenterologyImam Khomeini HospitalSchool of MedicineTehran University of Medical SciencesTehranIran Department of Cardiovascular Surgery Research Center for Advanced Technologies in Cardiovascular MedicineCardiovascular Research InstituteTehran University of Medical SciencesTehranIran Division of Colorectal Surgery Department of SurgeryTehran University of Medical SciencesTehranIran Department of Cell Therapy and Hematology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in MedicineStudent Research CommitteeShahid Beheshti University of Medical SciencesTehranIran

Background:Exosome administration is a novel medical approach that promises excellent immunomodulatory properties without the conventional side effects of current antitumor necrosis factor drugs and *** study aimed to assess the safety and efficacy of usingmesenchymal stemcell(MSC)exosomes to treat refractory fistulas in patients with inflammatory bowel ***:MSCs were derived from the umbilical cords and their exosomes were *** patients with refractory perianal Crohn’s disease fistulas with amedian age of 35 years(range 31–47 years)were enrolled in the *** injections were administered in the operating roomto patients with refractory fistula(fistulas that are irresponsive to anti-tumor necrosis factor-αadministration within 6months).Sixmonths later,a physical examination,face-to-face interviews,andmagnetic resonance imaging were employed to evaluate the therapy responses of ***:The outcomes within 6 months after initiation of therapy showed that four patients had responded to *** patients who received exosome injections exhibited complete healing,while one reported no improvement and active discharge from the fistula *** addition,five patients(100%)reported neither systemic nor local adverse ***:Injection of exosomes extracted from MSCs demonstrates safety and a satisfactory therapeutic effect,as evidenced in this and other studies,and may play a significant role in the future treatment of gastrointestinal fistulas.

关键词： IBD exosome Crohn’s disease MSCs fistula

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伊朗护士关于家庭护理伦理问题的质性研究

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International Journal of Nursing Sciences 2022年第3期9卷 364-372页

作者： Masoume Arab Mohsen Shahriari amir Keshavarzian Abbas Abbaszadeh Mahrokh keshvari School of Nursing and Midwifery Isfahan University of Medical SciencesIsfahanIran Department of Medicine Sari BranchIslamic Azad UniversitySariIran Nursing and Midwifery Care Research Center Adult Health Nursing DepartmentSchool of Nursing and MidwiferyIsfahan University of Medical SciencesIsfahanIran Department of Medical Ethics&Philosophy of Medicine School of MedicineShiraz University of Medical SciencesShirazIran Department of Medical Ethics Isfahan University of Medical SciencesIsfahanIran School of Nursing and Midwifery Shahid Beheshti University of Medical SciencesTehranIran Nursing and Midwifery Care Research Center School of Nursing and Midwifery Department of Community Health Nursing Isfahan University of Medical SciencesIsfahanIran

目的鉴于院外护理服务的重要性,家庭护理的出现,以及护理实践中伦理框架的需求,本研究旨在探讨护士对家庭护理中伦理问题的看法和体验。方法采用面对面个人访谈收集资料。2020年,通过目的性抽样方法选取在伊朗4个城市的家庭护理中心中... 详细信息

目的鉴于院外护理服务的重要性,家庭护理的出现,以及护理实践中伦理框架的需求,本研究旨在探讨护士对家庭护理中伦理问题的看法和体验。方法采用面对面个人访谈收集资料。2020年,通过目的性抽样方法选取在伊朗4个城市的家庭护理中心中工作的20名护士进行访谈,了解他们在家庭护理过程中关于伦理问题的看法和体验。基于内容分析法,应用Granehei和Lundman方法对资料进行分析。结果本研究共提取编码416个。基于相似性对编码进行合并,提取出7个主题和16个子主题。主题包括对职业身份的感知、尊重患者的自主权、尊重隐私、建立人际交往、维护相互安全、遵守公平性原则和文化-宗教能力。子主题包括责任、专业发展及专业间互动、在家庭护理中保持专业性、提供整体性和艺术性的护理、尊重患者隐私、尊重护士隐私、信息保密、尊重服务对象的选择、诚实告知、富有同情心的互动、平衡权力地位、维护患者安全、维护护士安全、公平性的建立、尊重家庭宗教信仰,以及注重文化敏感性。结论研究参与者表示由于在家庭护理中涉及患者隐私,与在医院环境中的护理实践相比,家庭护理中对于护士职业身份的认知、隐私、家庭互动的管理、相互安全和文化-宗教能力等伦理问题显得尤为重要。

关键词：伦理学,护理家庭护理(专业) 护士定性研究

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