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Development of new ionic gelation strategy： Towards the preparation of new monodisperse and stable hyaluronic acid/ β-cyclodextrin-grafted chitosan nanoparticles as drug delivery carriers for doxorubicin

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Frontiers of Materials Science 2018年第1期12卷 83-94页

作者： amina ben mihoub Boubakeur SAIDAT Youssef BAL Celine FROCHOT Regis VANDERESSE Samir ACHERAR Laboratoire de Chimie Physique Macromoleculaire (LCPM) Universite de Lorraine-CNRS UMR 7375 1 Rue Grandville BP 2045154001 Nancy Cedex France Laboratory of Physical Chemistry of Materials (LPCM) Faculty of Sciences (UATL) BP 37G Laghouat 03000 Algeria Laboratory of Biomaterials & Transport Phenomena (LBTP) Quartier Ain D'Heb 26000 Medea Algeria Department of Chemistry Faculty of Sciences University Saed Dahleb of Blida (USDB) route de Soumae 09000 Blida Algeria Laboratoire Reactions et Genie des Procedes (LRGP) Universite de Lorraine-CNRS UMR 7274 1 Rue Grandville BP 20451 54001 Nancy Cedex France

In the present study, β-cyclodextrin-grafted chitosan nanoparticles （β-CD- g-CS NPs） were prepared using a new ionic gelation strategy involving a synergistic effect of NaCI （150 mmol/L）, 4-（2-hydroxyethyl）-1-piperazineethanesulfonic acid （HEPES, 10 mmol/L）, and water bath sonication. This new strategy afforded smaller and more monodisperse β-CD-g-CS NPs vs. the classical ionic gelation method. New HA8β-CD-g-CS NPs were also prepared using the above-mentioned strategy by adding hyaluronic acid （HA） to the β-CD-g-CS copolymer at different weight ratios until the ZP values conversion. The best result was obtained with the weight ratio of w（HA）：w（β-CD-g-CS） = 2：1 and furnished new spherical and smooth HA/β-CD-g-CS NPs. Furthermore, the stability of β- CD-g-CS NPs and HA/β-CD-g-CS NPs at 4℃ in physiological medium （pH 7.4） was compared for 3 weeks period and showed that HA/β-CD-g-CS NPs were more stable all maintaining their monodispersity and high negative ZP values compared to β-CD-g-CS NPs. Finally, preliminary study of HA/β-CD-g-CS NPs as carrier for the controlled release of the anticancer drug doxorubicin was investigated. These new HA/β-CD-g-CS NPs can potentially be used as drug delivery and targeting systems for cancer treatment.

关键词： β-cyclodextrin-grafted chitosan hyaluronic acid ionic gelation drugdelivery physicochemical parameters control

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Case Report and Clinical Management of a Case of Osteogenesis Imperfecta Detected in the Prenatal Period

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 996-1002页

作者： amina Chaieb Oumayma ben Rejeb Samar Knaz Yasmine ben Ali Syrine Chelly Safia Ernez Mouna Derouiche Department of Gynecology and Obstetrics Farhat Hached University Hospital Sousse Tunisia Faculty of Medicine Ibn Al Jazzar University of Sousse Sousse Tunisia

Osteogenesis imperfecta is a hereditary disease characterized by bone fragility due to a defect in type I collagen synthesis. The diagnosis is typically suspected based on suggestive ultrasound findings and confirmed through genetic studies. We present a case of osteogenesis imperfecta suspected during obstetrical ultrasound at 19 weeks’ gestation, which was later confirmed radiographically through computed tomography. Due to the severity of the condition, therapeutic termination of pregnancy was indicated.

关键词： Osteogenesis Imperfecta Ultrasound Screening Antenatal Diagnosis

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Case Report and Clinical Management of a Case of Osteogenesis Imperfecta Detected in the Prenatal Period

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2024年第7期 996页

作者： amina Chaieb Oumayma ben Rejeb Samar Knaz Yasmine ben Ali Syrine Chelly Safia Ernez Mouna Derouiche

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Effects of the hydro-ethanolic extract of Marrubium vulgare in female rats

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 154-158页

作者： Rim Aouni Mossadok ben Attia Mohamed Habib Jaafoura amina Bibi-Derbel Mustapha Haouari Faculty of Sciences of Bizerte Department of life Sciences7021 JarzounaUniversity of Carthage INNTA SURVEN Research Laboratory(Monitoring and nutritional epidemiology in Tunisia) Laboratoire Biomonitoring of the Environment Faculty of Sciences of Bizerte.7021 JarzounaUniversity of Carthage Orthopedic InstituteMohamed Kassab Laboratory of Cyto-Morphology and Anatomy Pathologic National Institute of Nutrition and Food technology Clinical laboratory of biochemistry Ecole Superior of Science and Technology of Health of Tunis University of Tunis El Manar

Objective:To evaluate the effects of ethanol–water(80:20) extract of Marrubium vulgare(***) on the hematological parameters,macroscopic and histological aspects of the uterus and fetus in non-pregnant and pregnant ***:Female rats were divided into 4 equal groups(n = 9),group N(normal rats) and group G(pregnant rats) considered as control groups,group NE(normal rats treated with the ethanol–water(80:20,v/v) extract of ***) and group GE(pregnant rats treated with the extract).The ethanol–water(80:20) plant extract was administered in a single daily dose 1 g/kg at the morning,during 19 *** the 19 day of the experiment,animals were sacrificed,the uterus and fetuses were removed for the morphological and histological studies and the blood was collected in EDTA tubes for the measurement of hematological parameters with the use of an automate ‘HORIBA ABX Micros 60 Hematology Analyzer'.Results:Our results showed,in group NE and GE,a significant decrease on hematological parameters:red blood cells(NE:18.6%;GE:38.4%),hematocrit(NE:13.8%;GE:20.4%),hemoglobin(NE:12.1%;GE:8.3%) and mean corpuscular volume(NE:6.4%;GE:2%) with P more less a ***,the extract of *** caused a significant decrease on the mean implantations of fetuses(82.5%,P<0.001) and their size(47.2%,P< 0.01).As for the macroscopic and histological appearance of uterus,our data showed no change in normal treated *** contrast,the treated pregnant rats showed a severe histological change characterized by the existence of location of stopped ***,it was also found in the uterus of these rat lyses placental and embryo ***:All these results support the hypothesis of an abortifacient effect of ***.

关键词： Vegetal extract Abortificiant effect Hematological parameters Fetuses Uterus Histology

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Prenatal exposure to the fluoride containing psychiatric drug fluoxetine and anti-oxidative alterations in the neonatal rat brain

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BIOCELL 2019年第2期43卷 65-71页

作者： RAMESA SHAFI BHAT amina EL GEZEERY ABIR ben BACHAN MONA AWAD ALONAZI LEENA SALEH ALSUHAIBANI AFAF EL-ANSARY Biochemistry Department College of ScienceKing Saud University Human Genetic Department Medical Research instituteAlexandria UniversityEgypt Central Laboratory Female Centre for Scientific and Medical StudiesKing Saud UniversitySaudi Arabia Medicinal Chemistry Department National Research CentreDokkiCairoEgypt

Fluoride is a key ingredient of many psychiatric drugs like fluoxetine(Prozac■Fluoxetine■).Pregnant women frequently use this drug as they suffer from depression and anxiety disorders during this *** is able to reach the fetus through the placenta and passes to the newborn through *** the present study,female Wistar rats were treated with 5,10,and 20 mg/L fluoxetine(containing 94% fluorides)from pregnancy day 10 to day *** delivery,the levels of the enzymatic antioxidants in the brain of their offspring at postnatal day 2 were *** results showed that,in all fluoxetine exposed groups compared with the control group,there was a significant decrease(P0.05)in the activity of malondialdehyde and creatine *** results suggest that fluoxetine may be a developmental neurotoxicant due to presence of fluoride hence must be used carefully during pregnancy.

关键词： Antidepressant Brain Neonate Prozac Oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 720-726页

作者： amina Hoceini Nihel Klouche Khelil Ilhem ben-Yelles Amine Mesli Sara Ziouani Lotfi Ghellai Nadia Aissaoui Fatima Nas Mounia Arab Laboratory of Applied Microbiology in Food Biomedical and Environment Department of Biology Faculty of Nature and Life University of Tlemcen Laboratory of Experimental Surgery Dental Surgery Department Faculty of Medicine University of Tlemcen Laboratory of Applied Molecular Biology and Immunology Department of Biology University of Tlemcen

Objective: To compare oral hygiene practices, education and social background, food intake and oral malodor of Algerian adults suffering from dental caries with normal controls, and to determine and compare the bacterial composition of the supragingival plaques from the above-mentioned ***: Participants completed a questionnaire and were clinically examined for dental caries using decayed, missing and filled teeth index according to the criteria laid down by the World Health Organization. Supragingival plaque samples were collected from 50 caries-free adults(CF) and 50 caries-active adults(CA). Standard procedures of culture and identification of aerobic and anaerobic bacteria were used. Data were analyzed using Chi-square ***: A total of 117 bacterial strains were isolated from supragingival plaques in CF group subjects, 76(64.96%) of them belonged to 9 aerobic genera, and 41(35.04%) to 9anaerobic genera(P < 0.05). While in the second group, 199 strains were isolated, 119(59.80%) of the strains belonged to 10 aerobic genera and 80(40.20%) to 10 anaerobic bacteria(P < 0.05). Streptococcus mutans, Enterococcus faecium, Aerococcus viridans,Actinomyces meyeri, Lactobacillus acidophilus and Eubacterium limosum showed a significantly higher prevalence in the CA group(P < 0.05). The findings revealed that CA group had a high sugar intake(80%). A significantly higher frequency of tooth brushing(P < 0.000) and a significantly less self-reported oral malodor(P < 0.000) and tooth pain(P < 0.000) were found in CF group, while there was no association of socioeconomic levels and intake of meal snacks with dental ***: This study confirms the association of some aciduric bacteria with caries formation, and a direct association of sugar intake and cultural level with dental ***, oral hygiene practices minimize the prevalence of tooth decay.

关键词： Supragingival plaque Caries-free Caries-active Bacterial composition Algerian adults Cultural level Food intake

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Complete pathologic response after chemoradiotherapy in a patient with rectal squamous cell carcinoma： a case report

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Cancer Biology & Medicine 2017年第4期14卷 414-417页

作者： Zaied Sonia Daldoul Amira Bhiri Hanene Ammar Nouha Khechine Wiem Toumi Omar Abbes Ibtissem ben Salem amina Njima Manel Mhabrech Houda Department of Medical Oncology Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia Department of Surgery Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia Department of Radiology El Omrane University Hospital of Monastir Monastir 5000 Tunisia Department of Pathological Anatomy Fattouma Bourguiba University Hospital of Monastir Monastir 5000 Tunisia

Squamous cell carcinoma(SCC)of the rectum is a rare disease.A 59-year-old man presented with SCC of the middle rectum located 10 cm from the *** stage of the tumor was revealed to be T3N+*** patient received a combined treatment with cisplatin and fluorouracil in concomitance with external radiation *** then underwent an anterior resection of the *** postoperative histopathological findings classified the tumor as yp T0N0 with cancer-free margins and lymph *** of SCC remains very challenging,and the acquisition of more consistent data is needed.

关键词： Squamous cell carcinoma rectal neoplasm surgery colonoscopy

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The Dynamics and Control of the Fractional Forms of Some Rational Chaotic Maps

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Journal of Systems Science & Complexity 2020年第3期33卷 584-603页

作者： OUANNAS Adel KHENNAOUI amina-Aicha benDOUKHA Samir WANG Zhen PHAM Viet-Thanh Laboratory of Mathematics Informatics and Systems(LAMIS)University of Larbi TebessiTebessa 12002Algeria Department of Mathematics and Computer Sciences University of Larbi Ben M'hidiOum El BouaghiAlgeria Department of Electrical Engineering College of EngineeringYanbuTaibah UniversitySaudi Arabia Shaanxi Engineering Research Center of Controllable Neutron Source School of ScienceXijing UniversityXi'an 710123China Faculty of Electrical and Electronic Engineering Phenikaa Institute for Advanced Study(PIAS)Phenikaa UniversityYen NghiaHa Dong districtHanoi 100000Vietnam Phenikaa Research and Technology Institute(PRATI) A&A Green Phoenix Group167 Hoang NganHanoi 100000Vietnam

This paper proposes three fractional discrete chaotic systems based on the Rulkov,Chang,and Zeraoulia–Sprott rational *** dynamics of the proposed maps are investigated by means of phase plots and bifurcations *** stabilization schemes are proposed for each of the three maps and the convergence of the states is established by using the Lyapunov ***,a combination synchronization scheme is proposed whereby a combination of the fractional Rulkov and Chang maps is synchronized to the fractional Zeraoulia-Sprott *** results are used to confirm the findings of the paper.

关键词： Fractional discrete chaos fractional rational maps stabilization synchronization

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Hidden attractors in a new fractional-order discrete system: Chaos, complexity, entropy, and control

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Chinese Physics B 2020年第5期29卷 174-181页

作者： Adel Ouannas amina Aicha Khennaoui Shaher Momani Viet-Thanh Pham Reyad El-Khazali Laboratory of Mathematics Informatics and Systems(LAMIS)University of Laarbi TebessiTebessa12002Algeria College of Humanities and Sciences Ajman UniversityAjmanUAE Laboratory of Dynamical Systems and Control University of Larbi Ben M’hidiOum El BouaghiAlgeria Department of Mathematics Faculty of ScienceUniversity of JordanAmman 11942Jordan Nonlinear Systems and Applications Faculty of Electrical and Electronics EngineeringTon Duc Thang UniversityHo Chi Minh CityVietnam ECCE Department Khalifa UniversityAbu-Dhabi 127788United Arab Emirates

This paper studies the dynamics of a new fractional-order discrete system based on the Caputo-like difference *** is the first study to explore a three-dimensional fractional-order discrete chaotic system without *** phase portrait,bifurcation diagrams,and largest Lyapunov exponents,it is shown that the proposed fractional-order discrete system exhibits a range of different dynamical ***,different tests are used to confirm the existence of chaos,such as 0-1 test and C0 *** addition,the quantification of the level of chaos in the new fractional-order discrete system is measured by the approximate entropy ***,based on the fractional linearization method,a one-dimensional controller to stabilize the new system is *** results are presented to validate the findings of the paper.

关键词： discrete chaos discrete fractional calculus hidden attractor

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Essential oil of <i>Thymus vulgaris</i>L. and <i>Rosmarinus officinalis</i>L.: Gas chromatography-mass spectrometry analysis, cytotoxicity and antioxidant properties and antibacterial activities against foodborne pathogens

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Natural Science 2013年第6期5卷 729-739页

作者： Hanene Miladi Rihab ben Slama Donia Mili Sami Zouari amina Bakhrouf Emna Ammar Laboratory of Analysis Treatment and Valorisation of Environment Polluants and Products Faculty of Pharmacy Monastir Tunisia Laboratory of Biochemistry Faculty of Medicine Monastir Tunisia Range Ecology Laboratory Arid Land Institute of Medenine Medenine Tunisia UR Study & Management of Urban and Coastal Environments LARSEN—National Engineering School Sfax Tunisia

The essential oil composition of Thymus vulgaris L. and Rosmarinus officinalis L. endemic to France were determined by GC and GC-MS. Oils were assessed for their cytotoxic, antioxidant and antimicrobial activity. 31 and 37 different compounds were identified representing 99.64% and 99.38% of the thyme and rosemary oils respectively, where oxygenated monoterpenes constituted the main chemical class. Thymol (41.33%) and 1.8-cineole (24.10%) were identified as the main constituents of T. vulgaris L. and R. officinalis L., respectively. Essential oils (EOs) of selected plant species were evaluated for their in vitro cytotoxicity against the human lung adenocarcinoma epithelial cell line (A549). Cytotoxicity was measured using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphynyltetra-zolium bromide] colorimetric assay. Dose-dependent studies revealed IC50 of 8.50 ± 0.01 μg/mL and 10.50 ± 0.01 μg/mL after 72 h on the A549 cells for R. officinalis L. and T. vulgaris L., respectively. Antioxidant activity was determined using a quantitative DPPH (1,1-diphenyl- 2-picryl hydrazyl) assay. Thymus and rosemary EOs exhibited effective radical scavenging capacity with 50% inhibitory concentration (IC50) of 437 ± 5.46 μg/mL and 189 ± 2.38 μg/mL respectively and therefore acts as a natural antioxidant agent. The antimicrobial activity of these species has also been studied against several foodborne pathogens and food isolated Salmonella spp. including S. enteritidis of significant importance. According to the results, T. vulgaris L. showed higher bactericidal effect than those from R. officinalis L. These results suggest that the essential oil from T. vulgaris L. and R. officinalis L. have potential to be used as a natural cytotoxic, antioxidant and antimicrobial agent in food processing.

关键词： Thymus vulgaris L. Rosmarinus officinalis L. GC–MS Cytotoxicity Antioxidant Activity Antimicrobial Activity

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