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Effects of Hydro-alcoholic Extract of Launaea acanthodes on Serum Gonadotropin and Testosterone Levels and the Structure of Seminiferous Tubules in Hyperglycemic Rats

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Chinese Journal of Integrative Medicine 2016年第3期22卷 207-213页

作者： ameneh mohammadi Morteza Behnam-Rassouli Zeinab Momeni Naser Mahdavi-Shahri Department of Biology Faculty of ScienceFredowsi University of Mashhad

Objective： To investigate the effects of hydro-alcoholic extract of Launaea acanthodes, a blood glucose lowering plant in folk medicine of Iran, on the structure of seminiferous tubules and serum gonadotropin and testosterone levels in hyperglycemic rats. Methods： Twenty-four Wistar rats were randomly allocated into 4 groups （n=6）： control, streptozotocin （STZ）, STZ ＋ insulin [STZ ＋ Ins, 5 IU/（kg·day）], and STZ ＋ Launaea acanthodes extract [STZ ＋ Ext, 150 mg/（kg·day）]. Blood samples were collected at the 2nd and 4th weeks for detection of testosterone, follicle stimulating hormone （FSH） and luteinizing hormone （LH） with enzyme-linked immuno sorbent assay （ELISA）, and the dght testes of rats were removed at the 7th week for the evaluation of diameter and wall thickness of seminiferous tubules and number of Leydig cells using unbiased stereological techniques. Results： in comparison with the control group, at the 2nd week FSH （0.45 vs 0.03, 0.02, 0.02 lUlL in STZ, STZ ＋ Ins and STZ ＋ Ext groups, respectively） and LH （1.02 vs 0.37, 0.2, 0.29 IU/L） showed significant decreases （all P〈0.05） and testosterone （4.2 vs 8.37, 7.78, 11.8 ng/mL） showed a remarkable increase （all P〈0.05）. The levels of these hormones became closer in the STZ ＋ Ext and the STZ ＋ Ins groups to the control at the 4th week. A significant decrease in diameter and wall thickness of seminiferous tubules and number of Leydig cells were observed in the STZ group as compared with the control （P〈0.01）. Conclusions： Administration of Launaea extract demonstrated a beneficial impact on the protection of testis from pathogenic and degenerative effects of hyperglycemia which may be partly due to its potential antioxidative effects.

关键词： hyperglycemia Launaea acanthodes testis gonadotropins testosterone rat

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Cost-effectiveness analysis of tele-retinopathy of prematurity screening in Iran

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 560-566页

作者： Seyed-Farzad mohammadi ameneh Rahban Sahel Darabeigi Nastaran Salimi Afsar Farahani Alireza Lashay Cyrus Alinia Translational Ophthalmology Research Center Farabi Eye HospitalTehran University of Medical SciencesTehran ***Iran Department of Health Management and Economics School of Public HealthUrmia University of Medical SciencesUrmia 571478334Iran

AIM:To conduct a cost-utility analysis of the teleretinopathy of prematurity(ROP)screening program against no ***:A decision tree model was developed to identify and treat the infants with threshold ROP through the tele-screening system compared with no screening program from the societal *** used the quality adjusted life years(QALY)index to measure the scenarios’effectiveness,which was discounted for the future years by *** hundred twenty-six randomly selected newborns with ROP required treatment were investigated to extract the treatment *** considered the direct medical and non-medical costs in cost calculations analysed by the bottom-up *** figures of the model’s inputs were calculated using the Monte Carlo simulation that generated 1000 random iteration of the data,and a one-way sensitivity analysis was performed on the model to cope with the potential ***:The total and per capita needed the budget to establish a tele-ROP screening system were estimated at over 1.5 million and 35.13 USD,*** total cost of identifying and treating an ROP case in tele-screening and no screening strategies were obtained as 108.72 and 63.52 USD,respectively,and their lifetime discounted QALY gained were calculated as 15.39 and 15.11,***,incremental cost-effectiveness ratio(ICER)of tele-screening strategy against the competitive strategy was achieved as 161.43 ***:Tele-ROP screening program is one of the most cost-effective interventions in the Iranian health system and has a high priority to receive a budget for implementation.

关键词： cost-utility analysis incremental cost-effectiveness ratio quality adjusted life years tele-retinopathy of prematurity

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