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Safety, Tolerability and Anti-Diarrhoeal Activity of “Diarra”, a Preparation of Medicinal Plants Used in Ivorian Traditional Medicine

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Pharmacology & Pharmacy 2023年第10期14卷 428-440页

作者： Kouakou Etienne Effo Yacouba Adebo Adehouni Gbongué Eric Tia amenan geneviève irié-n’guessan n’Doua Gisèle Kouakou Siransy Department of Pharmacology Clinical and Therapeutic Pharmacy Faculty of Pharmaceutical and Biological Sciences University of Félix Houphou&#235t-Boigny Abidjan C&#244te d’Ivoire

Background: “Diarra”, a traditional herbal remedy made from five (5) medicinal plants, might be endowed with anti-diarrhoeal properties according to its owner. However, scientific evidence of its safety, tolerability and activity has not been established. Objective: This study aimed to assess the safety, tolerability and anti-diarrhoeal activity of “Diarra” in experimental rats. Materials and Methods: Safety was assessed by acute (OECD 423) and sub-acute (OECD 407) toxicity studies at doses of 5, 10 and 20 mg/kg. Clinical tolerability was assessed for 28 days. On day 29, a blood sample was taken to evaluate biological tolerability. The anti-diarrhoeal activity was investigated in a castor oil-induced diarrhoea model. Rats were given the remedy at doses of 5, 10 and 20 mg/kg and then castor oil 1 hour later. They were observed for 4 hours and diarrhoeal stools were collected. The Percentage of diarrhoeal inhibition was calculated. Results: A single dose of “Diarra” at a dose of 2000 mg/kg did not induce any lethality, behavioural or weight change in rats for 14 days. When administered once daily for 28 days, “Diarra” did not cause lethality or significant behavioural disorders or significant weight loss in rats. no biological disorders were observed. The treatment of rats with “Diarra” at doses of 5 mg/kg, 10 mg/kg and 20 mg/kg in a single administration inhibited the occurrence of diarrhoeal stools. The respective percentages of inhibition were 60%, 50% and 62%, similar to those of loperamide at a dose of 2 mg/kg (68%). Conclusion: “Diarra” has an anti-diarrheal activity in rats. It is also safe to use this remedy as such.

关键词： Safety Tolerability Antidiarrheal Diarra Traditional Medicine

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Safety, Tolerability and Anti-Diarrhoeal Activity of “Diarra”, a Preparation of Medicinal Plants Used in Ivorian Traditional Medicine

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Pharmacology & Pharmacy（药理与制药） 2023年第10期

作者： Kouakou Etienne Effo Yacouba Adebo Adehouni Gbongué Eric Tia amenan geneviève irié-n’guessan n’Doua Gisèle Kouakou Siransy

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Isolation and Spasmolytic Evaluation of new Alkaloids from Dichrostachys cinerea (L.) Wight et Arn. (Fabaceae)

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Pharmacology & Pharmacy 2013年第9期4卷 684-688页

作者： amenan genevieve n’guessan-irie Joel Dade Pierre Champy n’doua Gisele Siransy-Kouakou veronique Leblais Chimie des Substances naturelles CNRS UMR 8076 BioCISChatenay-MalabryFrance Laboratoire de Pharmacologie et Physiologie UFR Sciences Pharmaceutiques et BiologiquesUniversiteFelix Houphouet-BoignyAbidjanRepublique de Cote d’Ivoire Facultede Pharmacie UniversiteParis-Sud 11Chatenay-MalabryFrance InSERM UMR-S 769 Chatenay-MalabryFrance

Dichrostachys cinerea (L.) Wight et Arn. (Fabaceae) root bark is used in Ivorian Traditional Medicine to treat asthma, which is a respiratory disorder characterized by inflammation and the restriction of tracheal muscles obstructing the air circulation. The tracheal relaxant effect of a crude aqueous-alcoholic extract of the plant root bark was previously shown. For the present study, alkaloids were isolated from the same extract and investigated ex vivo in C57Bl/6j mice isolated trachea contracted with carbachol 1 μM, in comparison with a reference bronchodilatator, i.e. salbutamol. Two extraction procedures allowed isolating 2 Alkaloids that monodimensional and bi-dimensional nuclear magnetic resonance (nMR) and mass specters allowed identifying a pyrolidine structure type nucleus with a long bi-hydroxyled alkyl chain. Alkaloid 1, carrier of a sugar, is a glycoside of Alkaloid 2. Both alkaloids induced similar spasmolytic effects, but Alkaloid 1 was more effective than Alkaloid 2 at 9 × 10-6 M (p nd 9 × 10-5 M (p nduced its spasmolytic effect in a different way, and its maximal effect Emax (less than 30%) was obtained at 9 × 10-6 M, while Emax of both alkaloids (100%) was obtained at 3 × 10-4 M.

关键词： Alkaloids Isolated Plant Spasmolytic Asthma

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