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Neuroscience & Medicine 2017年第4期8卷 53-67页

作者： Michael Chen amelia russo-neustadt Department of Biological Sciences California State University Los Angeles CA USA

Medications acting as mood stabilizers work by enhancing and maintaining the concentration of circulating synaptic neurotransmitters, which then activate a plethora of various intracellular signal transduction and second messenger cascades. Previously, we showed that two of these cascades, the PI-3K and MAPK pathways, are activated by cross-talk with the protein kinase A cAMP cascade and by brain-derived neurotrophic factor (BDNF), an immediate-early gene whose expression is the result of phosphorylation of the transcription factor, cAMP response element binding protein (CREB). In the current study, we extend these findings to include the protein kinase C (PKC) pathway. Western blotting studies show that application of norepinephrine to cultured hippocampal neurons leads to increased expression of BDNF, phosphorylation of CREB, activation of growth-associated protein-43 (GAP-43) and activation of PKCμ and PKCt538. Because GAP-43 is a putative substrate for PKC, the results of this study lend further support of a G-protein coupled receptor cross-talking to an entirely distinct intracellular pathway that is known to be involved in neuritogenesis.

关键词： BDNF CREB PKD PKC Hippocampus

Kinetics of Norepinephrine- and Serotonin-Induced BDNF Release in Cultured Embryonic Hippocampal Neurons

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Neuroscience & Medicine 2013年第4期4卷 194-207页

作者： Michael Chen amelia russo-neustadt Department of Biological Sciences California State University Los Angeles USA

The primary neurotransmitters targeted by currently used antidepressants, such as duloxetine, venlafaxine and fluoxetine, are serotonin and norepinephrine, which also are released in significant amounts in the central nervous system in response to sympathetic nervous system activation. In cultured hippocampal neurons, we have previously shown that norepinephrine induces increased expression of brain-derived neurotrophic factor (BDNF), the PI-3 K/Akt, MAPK pro-survival pathways, the BDNF receptor, TrkB, a transcription factor, and cyclic AMP response element binding protein (CREB). In the present study, we extend these findings of increased BDNF expression to its kinetics of release into the surrounding media. We also evaluate these two cell survival pathways, TrkB and CREB, in response to application of serotonin and/or norepinephrine. Serotonin elicits an earlier, but brief expression and release of BDNF, whereas norepinephrine elicits a more delayed and sustained release of BDNF. In response to both norepinephrine and 5-HT, the presence of BDNF in lysates and subsequent release into the media is significantly increased out to 4 h, as is PI-3 K/Akt activation. Together, these two neurotransmitters increase BDNF expression and release covering the entire 8 h continuum evaluated. The results of this study provide further evidence for a G protein-coupled receptor and a crosstalk-to-TrkB receptor with transactivation signaling across pathways.

关键词： BDNF CREB Serotonin Norepinephrine Hippocampus Kinetics

A step forward in breeding for ratooning ability in rice

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Molecular Plant 2024年第3期17卷 368-369页

作者： amelia Henry Rice Breeding Innovations Department International Rice Research InstituteLos BanosLagunaPhilippines

Rice ratoon cropping,or the cultivation of tillers that have regrown from existing stem nodes of a harvested crop,is currently a hot topic in agriculture,and record-high ratoon crop yields have been achieved in China(Xu et al.,2021).Although rice ratoon cropping is most appropriate for certain agro-ecosystems with a suitable climate and cropping schedule,it is a promising strategy to simultaneously increase productivity while reducing inputs and *** ratoon cropping may thereby contribute to global food security and agro-ecosystem sustainability.

关键词： breeding cropping thereby

Fractal Fractional Order Operators in Computational Techniques for Mathematical Models in Epidemiology

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1385-1403页

作者： Muhammad Farman Ali Akgül Mir Sajjad Hashemi Liliana Guran amelia Bucur Institue of Mathematics Khwaja Fareed University of Enginnering and Information TechnologyRaheem Yar KhanPakistan Department of Computer Science and Mathematics Lebanese American UniversityBeirutLebanon Department of Mathematics Art and Science FacultySiirt UniversitySiirt56100Turkey Department of Mathematics Mathematics Research CenterNear East UniversityNicosiaTurkey Department of Computer Engineering Biruni UniversityIstanbul34010Turkey Department of Hospitality Services Babes-Bolyai UniversityCluj-Napoca400174Romania Department of Pharmaceutical Sciences Vasile Goldi竤Western University of AradArad310025Romania Department of Mathematics and Informatics Faculty of SciencesLucian Blaga University of SibiuSibiu550012Romania Department of Electronics and Communication Engineering Saveetha School of EngineeringSIMATSChennaiTamilnaduIndia

New fractional operators, the COVID-19 model has been studied in this paper. By using different numericaltechniques and the time fractional parameters, the mechanical characteristics of the fractional order model areidentified. The uniqueness and existence have been established. Themodel’sUlam-Hyers stability analysis has beenfound. In order to justify the theoretical results, numerical simulations are carried out for the presented methodin the range of fractional order to show the implications of fractional and fractal *** applied very effectivenumerical techniques to obtain the solutions of themodel and simulations. Also, we present conditions of existencefor a solution to the proposed epidemicmodel and to calculate the reproduction number in certain state conditionsof the analyzed dynamic system. COVID-19 fractional order model for the case of Wuhan, China, is offered foranalysis with simulations in order to determine the possible efficacy of Coronavirus disease transmission in theCommunity. For this reason, we employed the COVID-19 fractal fractional derivative model in the example ofWuhan, China, with the given beginning conditions. In conclusion, again the mathematical models with fractionaloperators can facilitate the improvement of decision-making for measures to be taken in the management of anepidemic situation.

关键词： COVID-19 model fractal-fractional operator Ulam-Hyers stability existence and uniqueness numerical simulation

Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

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Molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.Escaray amelia Felipo-Benavent Cristian J.Antonelli Begona Balaguer Maria Pilar Lopez-Gresa Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value *** polyxenous nature and pathogenic success are due to its ability to perceive host signals in its *** this study,we found that laticifer cells of Euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of vast structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results provide an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： Euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

Changes in Adipose Tissue and Circulating Concentrations of Persistent Organic Pollutants in Midlife Women

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Environment & Health 2024年第4期2卷 243-252页

作者： amelia Grant-Alfieri Amila Devasurendra Stuart Batterman Carrie Karvonen-Gutierrez Sung Kyun Park Department of Environmental Health Sciences University of Michigan School of Public HealthAnn ArborMichigan 48109United States Department of Epidemiology University of Michigan School of Public HealthAnn ArborMichigan 48109United States

Polychlorinated biphenyls(PCBs)and organochlorine pesticides(OCPs)are persistent organic pollutants(POPs)that bioaccumulate in adipose *** investigated the relationship between change in central adiposity and changes in circulating concentrations of POPs over a 12-year period during the *** concentrations of 34 PCBs and 19 OCPs were measured at four time points(1999/2000,2002/03,2005/06,2009/11)in a cohort of midlife women,the Study of Women’s Health Across the *** mixed models were used to test the association between a change in waist circumference and a change in serum POP ***-five women contributed 181 PCB ***-nine women contributed 151 OCP *** adjustment for covariates(study site,race and ethnicity,age at baseline,parity),a one-inch(2.54 cm)increase in the change in waist circumference between visits was associated with a 4.9%decrease in the change in serum concentration of PCB 194(95%CI:−8.0%,−1.6%).No associations were observed for other PCB congeners or the presence of *** increase in the difference in waist circumference over time was not associated with a change in the difference in serum concentrations of PCBs and OCPs except for PCB 194,possibly due to the high lipophilicity.

关键词： persistent organic pollutants PCBs pesticides adipose tissue women midlife

Impact of COVID-19 on Safety Performance for Motorcycles: Pre-and during-Pandemic Conditions

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Journal of Transportation Technologies 2024年第3期14卷 390-401页

作者： Hongyun Chen amelia Lawson Charles Hurda Madalyn Smith Tate Grant Civil Engineering Department Embry-Riddle Aeronautical University Daytona Beach FL USA

Florida has the highest number of motorcycle fatalities in the United States and contains the second largest population of registered motorcycles. The COVID-19 pandemic influenced the roads, traffic, and driving behavior in the continental United States. Motorcycle crashes decreased during the COVID-19 years (2020 and 2021) while the fatality rates increased. The purpose of this study is to 1) investigate motorcycle crashes before and during the Pandemic period to understand the impacts on motorcycle safety and contributing factors to the crash severity levels;2) develop the crash predictive model for different degrees of severity in motorcycle crashes in Florida. Florida statewide crash data were collected. T tests have been conducted to compare the contributing factors between two periods. The injury severities are significantly different among all five levels between those during normal period and the Pandemic period. A crash predictive model has been developed to determine the facts to injury severity levels for motorcycle crashes. A total of eight variables are found to significantly increase the injury severity levels for motorcycle crashes during the Pandemic period.

关键词： Motorcycle Crash Pandemic Injury Severity Contributing Factors

Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi

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Biosafety and Health 2024年第1期6卷 12-20页

作者： Shuang Zhao amelia Siqi Huang Weibo Zhang Lili Ren Hexiang Wang Jianbin Wang Xinyang Shao Guanbo Wang Institute of Agri-Food Processing and Nutrition Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBejing 100097China Bejing Key Laboratory of Fruits and Vegetable Storage and Processing Key Laboratory of Vegetable Postharvest ProcessingMinistry of AgricultureBejing 100097China Dalton Academy The Affliated High School of Peking UniversityBeijing 100190China NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory National Institute of Pathogen BiologyBejing 100730China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China College of Biological Sciences China Agricultural UniversityBejing 100193China School of Life Sciences Tsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Institute for Cell Analysis Shenzhen Bay LaboratoryShenzhen 518132China

The coronavirus disease of 2019(COVID‐19),a global pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),can result in severe health *** addition to physical preventative measures,pharmaceutical intervention is also *** natural products from medicinal fungi have shown promise as potential antiviral drugs and may serve as a source of effective components with antiviral activity against SARS‐CoV‐2 and other *** this study,we developed a workflow that integrates viral infection inhibition assays at both cellular and molecular levels,as well as molecular separation and characterization,to screen and identify natural products with antiviral *** this workflow,we screened 167 extracts extracted from 36 medicinal fungi using optimized extraction *** assessed the antiviral effects of these extracts by measuring their ability to inhibit SARS‐CoV‐2 infection and receptor binding domain‐human angiotensin‐converting enzyme 2(RBD‐hACE2)binding in *** charge‐and size‐based characterization of the active compounds through filtration and chromatographic fractionation,mass spectrometry characterization of the fractionated compounds revealed that the active components are polysaccharides and determined their monosaccharide residue *** findings provide new insights into the antiviral potential of natural products and their screening strategies and may contribute to the development of effective antiviral therapeutics against COVID‐19 and other diseases.

关键词： Medicinal fungi Natural products Antiviral activity COVID‐19 Polysaccharides

The Dallas Donation after Circulatory Death Transplantation Summit:expanding donation after circulatory death procedures through process improvement,broader utilization,and innovation

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 824-836,I0009页

作者： Michele Finotti Anji Wall Anthony D’Alessandro Gary Schwartz Chris Sonnenday David Goldberg Ashish Shah Peter Friend Jeff P.Orlowski Greg McKenna Steve Newton Brad Adams William C.Chapman Amit Mathur Marwan Abouljoud Tim Pruett amelia Hessheimer James F.Trotter Sumeet K.Asrani Giuliano Testa Simmons Transplant Institute Baylor University Medical CenterDallasTXUSA Hepatobiliary and General Surgery Unit Regional Hospital TrevisoDISCOGUniversity of PaduaPaduaItaly Division of Transplantation Department of SurgeryUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA Department of Thoracic Surgery and Lung Transplantation Baylor University Medical CenterCenter for Advanced Heart and Lung DiseaseDallasTXUSA Department of Surgery University of MichiganAnn ArborMIUSA Division of Digestive Health and Liver Diseases Department of MedicineUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Cardio-Thoracic Surgery Vanderbilt University Medical CenterNashvilleTNUSA Nuffield Department of Surgical Sciences University of OxfordOxfordUK LifeShare Transplant Donor Services of Oklahoma Oklahoma CityOKUSA Administration Baylor University Medical CenterDallasTXUSA Southwest Transplant Alliance DallasTXUSA Department of Surgery/Transplantation Washington UniversitySt.LouisMOUSA Division of Transplant Surgery Department of SurgeryMayo Clinic ArizonaAlix School of MedicinePhoenixAZUSA Divisions of Transplant and Hepatobiliary Surgery Henry Ford HospitalDetroitMIUSA Department of Surgery University of MinnesotaMinneapolisMNUSA General and Digestive Surgery Hospital Universitario La PazIdiPAZMadridSpain

Despite a significant increase in utilization over the past decade,the number of donation after circulatory death(DCD)organs that are procured and transplanted in the United States(US)remains well below its *** is still room for expansion,as utilizing DCD organs to the fullest extent is currently the most viable solution to the persistent mismatch between supply and demand in *** convened a multidisciplinary transplantation summit to examine various aspects of DCD,with faculty members from around the world with clinical and academic interest in DCD donation and transplantation,including abdominal and cardiothoracic surgeons,organ procurement organization directors,hepatologists,and *** conference focused on identifying barriers to DCD organ utilization and strategies to overcome these *** divide the barriers to DCD utilization into three mains categories:(Ⅰ)policy and process variation;(II)logistical and transportation challenges;and(Ⅲ)higher risk perceptions related to DCD *** each barrier,we proposed a variety of solutions,providing an overview of the status of DCD donation in the US and suggestions on how to increase the use of *** is a specific focus on ex situ machine perfusion,normothermic regional perfusion,and other opportunities to expand DCD utilization without negatively impacting recipient outcomes.

关键词： Donation after circulatory death donation(DCD donation) marginal graft donor pool machine perfusion(MP)

Overview of dyslipidemia and metabolic syndrome in myeloproliferative neoplasms

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World Journal of Clinical Oncology 2024年第6期15卷 717-729页

作者： Mihnea-Alexandru Găman Bahadar Singh Srichawla Yong-Feng Chen Poulami Roy Arkadeep Dhali Ahmed Nahian Muhammad Romail Manan Vincent Kipkorir Richard Christian Suteja Lakshmi Venkata Simhachalam Kutikuppala amelia Maria Găman Camelia Cristina Diaconu Faculty of Medicine “Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Department of Hematology Center of Hematolog Department of Cellular and Molecular Pathology Stefan S Nicolau Institute of VirologyRomanian AcademyBucharest 030304Romania Department of Neurology University of Massachusetts Chan Medical SchoolWorcesterMA 01655United States Department of Basic Medical Sciences School of Medicine of Taizhou UniversityTaizhou UniversityTaizhou 318000Zhejiang ProvinceChina Department of Medicine North Bengal Medical College and HospitalWest Bengal 734012India Academic Department of Gastroenterology Sheffield Teaching Hospitals NHS Foundation TrustSheffield S57AUUnited Kingdom Lecom at Seton Hill GreensburgPA 15601United States Faculty of Medicine Services HospitalLahore 54000Pakistan Department of Human Anatomy and Physiology University of NairobiNairobi 00100Kenya Faculty of Medicine Udayana UniversityDenpasarBali 80361Indonesia Department of General Surgery Dr.NTR University of Health SciencesVijayawada 520008Andhra PradeshIndia Department of Pathophysiology University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Clinic of Hematology Filantropia City HospitalCraiova 200143Romania Department of Internal Medicine Faculty of Medicine“Carol Davila”University of Medicine and PharmacyBucharest 050474Romania Internal Medicine Clinic Clinical Emergency Hospital of BucharestBucharest 105402Romania

Myeloproliferative neoplasms(MPNs)occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral *** suffering from MPNs display a high burden of cardiovascular risk factors,and thrombotic events are often the cause of death in this population of ***,we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia,metabolic syndrome,and MPNs,with a special focus on cardio-vascular risk,atherosclerosis,and thrombotic ***,we investigate the impact of dyslipidemia and metabolic syndrome on the occurrence and survival of thrombosis in MPN patients,as well as the management of dyslipidemia in MPNs,and the impact of MPN treatment on serum lipid concentrations,particularly as side/adverse effects reported in the context of clinical trials.

关键词： Polycythemia vera Essential thrombocythemia Myelofibrosis Cardiovascular disease Hypercholesterolemia Hypertriglyceridemia Obesity Diabetes Inflammation Oxidative stress