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Discussion of“optimal reinsurance designs based on risk measures:a review”by Jun Cai and Yichun Chi

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Statistical Theory and Related Fields 2020年第1期4卷 23-25页

作者： ambrose Lo Department of Statistics and Actuarial Science The University of IowaIowa CityIAUSA

The academic community should be indebted to Professors Jun Cai and Yichun Chi for their meticulously written review paper(referred to as Cai&Chi,in press in what follows)on optimal reinsurance,which summarises and sy... 详细信息

关键词： academic Cai insurance

Digital surgery for gastroenterological diseases

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World Journal of Gastroenterology 2021年第42期27卷 7240-7246页

作者： Niall Philip Hardy Ronan ambrose Cahill UCD Centre for Precision Surgery University College DublinDublin D07 Y9AWIreland

Advances in machine learning,computer vision and artificial intelligence methods,in combination with those in processing and cloud computing capability,portend the advent of true decision support during interventions in real-time and soon perhaps in automated surgical *** capability,deployed alongside technology intraoperatively,is termed digital surgery and can be delivered without the need for high-end capital robotic *** area close to clinical usefulness right now harnesses advances in near infrared endolaparoscopy and fluorescence guidance for tissue characterisation through the use of biophysics-inspired *** represents a potential synergistic methodology for the deep learning methods currently advancing in ophthalmology,radiology,and recently gastroenterology via *** databanks of more general surgical videos are created,greater analytic insights can be derived across the operative spectrum of gastroenterological disease and operations(including instrumentation and operative step sequencing and recognition,followed over time by surgeon and instrument performance assessment)and linked to value-based ***,issues of legality,ethics and even morality need consideration,as do the limiting effects of monopolies,cartels and isolated data ***,the role of the surgeon,surgical societies and healthcare institutions in this evolving field needs active deliberation,as the default risks relegation to bystander or passive *** editorial provides insight into this accelerating field by illuminating the nearfuture and next decade evolutionary steps towards widespread clinical integration for patient and societal benefit.

关键词： Digital surgery Artificial intelligence Gastrointestinal disease Biophysics Deep learning Fluorescence-guided surgery

Thermal ablation of metastatic disease to the musculoskeletal system

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 36-48页

作者： Erwin Xia ambrose J.Huang Department of Radiology Division of Musculoskeletal Imaging and InterventionMassachusetts General HospitalBostonMA 02114USA

A variety of indications have been published regarding the use of percutaneous thermal ablation for treating tumors of the musculoskeletal system,including bone and soft tissue lesions,benign and malignant lesions,and primary and metastatic *** the appropriately selected patient,the advantages of percutaneous thermal ablation include decreased morbidity,decreased cost,and shorter hospitalization stays compared to *** number of different thermal ablation modalities is increasing,and each modality has its advantages and *** directly comparing the effectiveness of the various thermal ablation modalities are sparse,however,so the choice of ablation modality often depends on availability,user preference,and local *** the list of uses for percutaneous thermal ablation is ever-expanding,in this article,we will discuss the two most well-established indications,which are palliation of pain attributed to bone and soft tissue metastases and local control of oligometastatic *** clinical trials have shown percutaneous thermal ablation to be an effective method of palliating pain due to bone and soft tissue metastases and of achieving local control in the setting of oligometastatic disease with low rates of complication.

关键词： Musculoskeletal intervention radiofrequency ablation cryoablation image-guided metastatic disease

Bariatric and endo-bariatric interventions for diabetes:What is the current evidence?

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World Journal of Diabetes 2024年第11期15卷 2255-2263页

作者： Sunetra Mondal Vanessa ambrose Fistus Joseph M Pappachan Department of Endocrinology NRS Medical College and HospitalKolkata 700014West BengalIndia Department of Medicine Royal Preston HospitalLancashire Teaching Hospitals NHS TrustPreston PR29HTLancashireUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTLancashireUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal UniversityManipal 576104India

Bariatric interventions have shown the best therapeutic benefits in individuals with *** can be classified into surgical procedures(bariatric/metabolic surgery)and endoscopic *** surgical procedures include sleeve gastrectomy,Roux-en-Y gastric bypass,bilio-pancreatic diversion with or without duodenal switch and Stomach Intestinal Pylorus Sparing *** procedures include intragastric balloons,transpyloric shuttle,endoscopic gastroplasties,aspiration therapy,duodenal mucosal resurfacing,duodeno-jejunal bypass liner,gastro-duodeno-jejunal bypass and incisionless magnetic anastomosis system among ***,these procedures are limited by lack of wide availability,high costs,immediate and long-term complications and poor acceptability in some *** re-gain is a common concern and revisional metabolic surgery is often *** pre-operative evaluation and correction of nutritional deficiencies post-surgery are very *** most appropriate procedure for a person would depend on multiple factors like the intended magnitude of weight-loss,comorbidities and surgical fitness,as well as choice of the ***,glucagon-like insulinotropic peptide-1 receptor agonists(GLP)and the GLP-1/gastric inhibitory polypeptide co-agonist-Tirzepatide have shown remarkable weight loss potential,which is at par with bariatric interventions in some *** far these can help in avoiding invasive bariatric procedures in near future remains to be *** updated and comprehensive clinical review by He et al in the recent issue of World Journal of Diabetes address has addressed the avenues and challenges of currently available bariatric surgeries which will enable clinicians to make better decisions in their practice,including their applicability in special populations like the elderly and pediatric age groups,type 1 diabetes mellitus,and non-diabetics.

关键词： Bariatric surgery Bariatric endoscopy Obesity Type 2 diabetes mellitus Metabolic benefits

Mitotic Spindle Organization by the Preprophase Band

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Molecular Plant 2008年第6期1卷 950-960页

作者： J. Christian ambrose Richard Cyr The Pennsylvania State University Department of Biology The Huck Institutes of the Life Sciences Integrative Biosciences Graduate Degree Program PlantPhysiology Program University Park PA 16802 USA Present address: Department of Botany University of British Columbia Vancouver British Columbia V6T 1Z4 Canada

In higher plants, the preprophase band （PPB） of microtubules （MTs） forecasts the cell division site prior to mitosis and specifies the organization of MTs into a bipolar prophase spindle surrounding the nucleus. However, the mechanisms governing this PPB-dependent establishment of bipolarity are unclear. Here, we present evidence from live cell imaging studies that suggest a role for the MTs bridging the PPB and the prophase nucleus in mediating this function. Results from drug treatments, along with genetic evidence from null kinesin plants, suggest that these MTs contribute to the bipolarity, orientation, and position of the prophase spindle. Specifically, the absence of these bridge MTs is associated with lack of bipolarity, while non-uniform distributions of bridge MTs correlate with prophase spindle migration, deformation, and enhanced bipolarity toward the region of highest bridge MT density. This behavior does not require actomyosin-based forces, and is enhanced by suppressing MT dynamics with taxol. These observations occur during late prophase, and are coincident with the gradual closing of annular spindle poles. Based on these data, we describe a hypothetical mechanism for bridge MT-dependent organization of prophase spindles.

关键词： preprophase band mitosis acentrosomal spindle microtubule kinesin ATK5 cytokinesis.

Phytochemicals, polyphenols content, in vitro antioxidant and antibacterial activities of Albizia coriaria Welw ex. Oliver flowers

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Traditional Medicine Research 2023年第2期8卷 1-6页

作者： Timothy Omara ambrose K.Kiprop Viola J.Kosgei Department of Chemistry and Biochemistry School of Sciences and Aerospace StudiesMoi UniversityP.O.Box 3900-30100EldoretKenya Africa Center of Excellence II in Phytochemicals Textile and Renewable Energy(ACE II PTRE)Moi UniversityP.O.Box 3900-30100EldoretKenya Institute of Chemistry of Renewable Resources Department of ChemistryUniversity of Natural Resources and Life Sciences Vienna3430TullnAustria Testing Department Uganda National Bureau of StandardsBweyogerere Industrial and Business ParkP.O.Box 6329KampalaUganda

Albizia coriaria Welw ***(hereafter ***)is a revered medicinal tree whose organs are used by indigenous African societies for managing various ***,we assessed the secondary metabolites,total polyphenolics,free radical scavenging and antimicrobial activities of *** *** dry powdered sample was extracted serially with ethyl acetate,ethanol and distilled *** of classical phytochemical screening showed that saponins,phenols,alkaloids,flavonoids,tannins and terpenes were the dominant *** highest total polyphenolic content(10.37±0.02 mg QE/g DW and 72.09±0.09 mg GAE/g DW)and free radical scavenging potential(IC50=24.23±0.04 mg/mL)were for the ethyl acetate *** also had a higher bacteriostatic activity than the ethanolic extract against Pseudomonas aeruginosa,Salmonella typhi,Escherichia coli and Staphylococcus aureus with diameters of inhibition ranging from 7.00±0.00 to 22.00±1.73 *** aqueous extract showed no appreciable antibacterial effect on the tested *** is the first report which support the use of floral extracts of this species in the management of ailments in African traditional medicine.

关键词： bacteriostatic Albizia coriaria DPPH assay traditional medicine oxidative stress

Knowledge of sexually transmitted infections among senior high school adolescents in the Wa Municipality of Ghana

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Global Health Journal 2022年第2期6卷 95-101页

作者： Munawar Harun Koray Augustine Adomah-Afari Damien Punguyire ambrose Naawa Regional Health Directorate Upper West RegionWaGhana School of Public Health University of GhanaAccraGhana

Background:Sexually transmitted infections(STIs)are responsible for a high burden of morbidity and mortality in many developing countries especially among *** are predisposed to STIs because they are more likely to engage in unhealthy ***,these adolescents have limited knowledge of the use and barriers to sexual and reproductive health information and care *** study explored the knowledge of STIs among Senior High School Adolescents in the Wa Municipality of ***:The study designed as a descriptive cross-sectional research.A multistage sampling technique was used to recruit these adolescents for the *** 355 adolescents were selected from senior high schools in the Wa *** statistics and Chi-square test were used to analyze the data,at a significance level ofP<***:The majority of respondents had good knowledge of STIs,with the most common examples of STIs identified as HIV/AIDS(80.8%,287/355)and gonorrhea(73.8%,262/355).The main known signs and symptoms identified were discharges from the penis/vagina(72.4%,257/355),painful urination(71.5%,254/355),and itching,and sores around the genital area(72.7%,258/355).The main sources of information/education of STIs for these adolescents were the school,hospital,internet and *** respondent lived with was found to be significantly associated with knowledge of STI(P<0.001).Conclusion:Many of the respondents had good knowledge of STI,and the school was the most common source of information on STL It is,therefore,important for the Ghana Education Service and the Ghana Health Service to strengthen the School Health Education Programme in second cycle institutions in the Wa ***,especially mothers,should be actively involved in the sexual health education of adolescents.

关键词： Knowledge Sexual transmitted infection Senior high school Adolescent

The Relevance of CARICOM＇s Existence to the Virgin Islands in the Context of Globalization

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Chinese Business Review 2011年第12期10卷 1148-1155页

作者： Dana Lewis-ambrose H. Lavity Stoutt Community College Paraquita Bay Tortola the Virgin Islands

The purpose of this study was to consider the relevance of CARICOM＇s existence to the Virgin Islands （BVI）. Its relevance becomes more significant to the BVI and the Caribbean, by extension, when the globalization phenomenon is applied; a phenomenon that has been in existence for centuries. Overall, the study concluded that even though the BVI remains only an associate member of CARICOM and not of CSME, it still has an interest in the progress of the regional grouping and its trade initiatives. Over the years, CARICOM has been struggling with its identity as a unified grouping. Nonetheless, it was found that in an effort to combat the trade liberalization process, the grouping must find that inner connection to advance its agenda on the global stage. Accordingly, it has been suggested that CARICOM begin to focus on its strengths and opportunities in order for economic development across the region to occur. It has also been recommended that more serious considerations be taken towards the development of a comprehensive regional market for the trading of goods and services, that is, the Caribbean Single Market and Economy （CSME）. To substantiate its findings, the paper used the qualitative research approach, combined with a situation （SWOT） analysis.

关键词： CARICOM qualitative research method SWOT analysis the Virgin Islands

Agricultural development and food security： The way out of crisis

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Journal of Agricultural Science and Technology 2009年第12期3卷 51-62页

作者： Lewis-ambrose Dana Business and Computer Studies Department H. Lavity Stoutt Community College Tortola VGI 1 I0 B VI

The purpose of this study is to elicit how investments in agricultural development and food security would safeguard the Virgin Islands （BVI） and the Caribbean, by extension, from future global crisis. History shows that agriculture played a significant role in the rise of civilization globally and was the main contributor to the Caribbean economy before the 1950＇s. Overall, it was determined that the BVI population, in general, is desirous of more investment opportunities within the agricultural sector, to assist with the alleviation of poverty at the national level, to advance economic development and trade across the region and to make sustainable development more attainable for the Caribbean, as a whole. To do this, agricultural development and food security must become the focal point of the BVI and other Caribbean economies. Accordingly, the paper recommends that investment within the agricultural sector be undertaken more aggressively across the region. The mixed research approach method was used to validate these claims.

关键词： agricultural development Caribbean food security global financial crisis investment mixed research approachmethod