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Bacteriocin-like inhibitory substance (BLIS) activity of Streptococcus macedonicus MBF10-2 and its synergistic action in combination with antibiotics

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1140-1145页

作者： Sharon Edith Grazia Sumayyah Sumayyah Fakhri Subhana Haiti Muhamad Sahlan Nicholas C.K. Heng amarila malik Pharmaceutical Microbiology and Biotechnology Research Group Faculty of PharmacyUniversitas IndonesiaUI Campus DepokDepok 16424Indonesia Division of Bioprocess Engineering Faculty of EngineeringUniversitas IndonesiaUI Campus DepokDepok 16424Indonesia research centre for biomedical engineering faculty of engineering universitas indonesiaui campus depok Sir John Walsh Research Institute Faculty of DentistryUniversity of OtagoP.O. Box 56Dunedin 9054New Zealand

Objective: To characterize the bacteriocin-like inhibitory-substances(BLIS) activity of Streptococcus macedonicus MBF10-2 [named BLIS(MBF10-2)], a bacteriocinogenic strain isolated from an Indonesian tofu ***: BLIS(MBF10-2) was obtained by culturing the bacterium, and standard deferred antagonism assays were used to demonstrate its activity. The antibacterial testing of fractions collected by filtration using 3–30 kDa cut-off membrane sizes were carried out by performing well diffusion ***: The growth of Micrococcus luteus, Streptococcus pyogenes, Lactococcus lactis,Leuconostoc mesenteroides and Weissella confusa were inhibited by BLIS(MBF10-2).Interestingly, BLIS-containing fractions obtained from sequential application on ultrafiltration membranes indicated that this bacterium Streptococcus macedonicus MBF10-2 could produces at least two antimicrobial peptides activities, one of which is likely to be a lantibiotic peptide. Potential synergistic activity against certain Gram-positive(but not Gram-negative) species when partnered with antibiotics(ampicillin, tetracycline or kanamycin) were ***: Combination of some BLIS(MBF10-2) active fractions with antibiotics(ampicillin, tetracycline or kanamycin) could demonstrate synergistic activities against certain Gram-positive species.

关键词： Bacteriocin-like inhibitory substance Deferred antagonism assay Lantibiotic Protein fractionation Streptococcus macedonicus Well diffusion assay

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