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Satellite-enabled enviromics to enhance crop improvement

Molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende Lee Hickey Cibele H.amaral Lucas L.Peixoto Gustavo E.Marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil TheCROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(LiDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

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Starch Orodispersible Film Loaded with Melatonin for Human Supplementation

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Journal of Renewable Materials 2024年第7期12卷 1343-1354页

作者： Fabio Tamanini Tatiane Zucchini de Souza Creusa Sayuri Tahara amaral Antônio JoséFelix Carvalho Eliane Trovatti Department of Health and Biological Sciences University of Araraquara(UNIARA)São Paulo14801-340Brazil Department of Materials Engineering São Carlos School of EngineeringUniversity of São PauloSão Paulo13563-120Brazil

An innovative pharmaceutical form for administering melatonin,based on starch orodispersibleﬁlm(ODF),was designed and *** composition of the ODF included starch as the polymer matrix,the active drug melatonin,and a ***,a natural hormone produced by the pineal gland in the brain,can be absorbed by passive diffusion across the mucous membrane,resulting in improved bioavailability when compared to conventional oral *** study shows a simple and efﬁcient method for preparing melatonin-loaded orodispersibleﬁlms with a physically stable and commercially viable matrix,suitable for use in the pharmaceutical ***ﬁlms were prepared by treating the starch with microwave irradiation,followed by plasticization with glycerol,melatonin loading and drying by solvent *** tests showed theﬁlms’robustness,with a modulus of approximately 97 MPa,indicating good handling *** uptake analysis showed fast water absorption,reaching about 150%within 2 min,indicating its fast oral disintegration *** tests in artiﬁcial saliva and dissolution studies indicated the release of the drug in min-utes,indicating the potential properties of theﬁlm for oral drug *** the best of our knowledge,there is no melatonin ODF based on starch described in the literature.

关键词： Starch orodispersibleﬁlm melatonin drug delivery

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Analysing vaccine efficacy evaluated in phase 3 clinical trials carried out during outbreaks

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Infectious Disease Modelling 2024年第4期9卷 1027-1044页

作者： Francisco Antonio Bezerra Coutinho Marcos Amaku Fernanda Castro Boulos Jose Alfredo de Sousa Moreira Joao Italo DiasFranca Julio Antonio do amaral Eliana Nogueira Castro de Barros Claudio Jose Struchiner Esper Jorge Kallas Eduardo Massad School of Medicine University of Sao PauloBrazil Instituto Butantan Sao PauloBrazil School of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil

In this paper we examine several definitions of vaccine efficacy(VE)that we found in the literature,for diseases that express themselves in outbreaks,that is,when the force of infection grows in time,reaches a maximum and then *** fact that the disease occurs in outbreaks results in several problems that we *** propose a mathematical model that allows the calculation of VE for several *** trials usually needs a large number of volunteers that must be ***,all volunteers should be enrolled in approximately the same time,but this is generally impossible for logistic reasons and they are enrolled in a fashion that can be replaced by a continuous density function(for example,a Gaussian function).The outbreak can also be replaced by a continuous density function,and the use of these density functions simplifies the ***,for example Gaussian functions,one of the problems one can immediately notice is that the peak of the two curves do not occur at the same *** model allows us to conclude:First,the calculated vaccine efficacy decreases when the force of infection increases;Second,the calculated vaccine efficacy decreases when the gap between the peak in the force of infection and the peak in the enrollment rate increases;Third,different trial protocols can be simulated with this model;different vaccine efficacy definitions can be calculated and in our simulations,all result are approximately the *** final,and perhaps most important conclusion of our model,is that vaccine efficacy calculated during outbreaks must be carefully examined and the best way we can suggest to overcome this problem is to stratify the enrolled volunteer's in a cohort-by-cohort basis and do the survival analysis for each cohort,or apply the Cox proportional hazards model for each cohort.

关键词： Vaccine efficacy Clinical trials Mathematical models Simulations Covid-19

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Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson Siewe Fodjo Olivia Kamoen Luis-Jorge amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

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Evaluation of the effectiveness of horizontal subsurface flow constructed wetlands for different media

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Journal of Environmental Sciences 2010年第6期22卷 820-825页

作者： Antonio Albuquerque José Oliveira Sabrina Semitela Leonor amaral Department of Civil Engineering and Architecture and C-MADE University of Beira Interior Municipality of Penamacor Department of Sciences and Environmental Engineering Faculty of Sciences and TechnologyNew University of Lisbon

Two media bed （gravel and Filtralite NR） were tested in a mesocosm to evaluate the removal of organic matter （as chemical oxygen demand （COD））, ammonia （NH4-N）, nitrite, nitrate and solid matter （as total suspended solids （TSS）） for a synthetic wastewater （acetate-based） and a domestic wastewater. The use of Filtralite allowed average removal rates （6--16.8 g COD/（m^2·day）, 0.8-1.1 g NH4-N/（m^2·day） and 3.1 g TSS/（m^2·day）） and removal efficiencies （65%-93%, 57%-85% and 78% for COD, NH4-N and TSS, respectively）, higher than that observed in the experiments with gravel. The applied loads of COD, ammonia, nitrate and TSS seem to influence the respective removal rates but only for the treatment of domestic wastewater with nigher correlation coefficients for Filtralite. Regardless the type of media bed and the type of wastewater, nitrate was completely removed for nitrogen loading rates up to 1.3 g NO3-N/（m^2·day）. There was no evidence of the influence of nitrate loads on the removal of organic matter.

关键词： media bed constructed wetlands pollutants removal rates

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Recent advances on quasi-solid-state electrolytes for supercapacitors

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Journal of Energy Chemistry 2022年第4期31卷 697-717页

作者： Murilo M.amaral Raissa Venâncio Alfredo C.Peterlevitz Hudson Zanin Advanced Energy Storage Division Center for Innovation on New EnergiesCarbon Sci-Tech Labs and Manufacturing GroupSchool of Electrical and Computer EngineeringUniversity of CampinasCampinasSP 13083-852Brazil

Solid-state and quasi-solid-state electrolytes have been attracting the scientific community’s attention in the last decade. These electrolytes provide significant advantages, such as the absence of leakage and separators for devices and safety for users. They also allow the assembly of stretchable and bendable supercapacitors. Comparing solid-state to quasi-solid-states, the last provides the most significant energy and power densities due to the better ionic conductivity. Our goal here is to present recent advances on quasisolid-state electrolytes, including gel-polymer electrolytes. We reviewed the most recent literature on quasi-solid-state electrolytes with different solvents for supercapacitors. Organic quasi-solid-state electrolytes need greater attention once they reach an excellent working voltage window greater than 2.5 ***, aqueous-based solid-state electrolytes have a restricted voltage window to less than 2 V. On the other hand, they are easier to handle, provide greater ionic conductivity and capacitance. Recent water-in-salt polymer-electrolytes have shown stability as great as 2 V encouraging further development in aqueous-based quasi-solid-state electrolytes. Moreover, hydrophilic conductive polymers have great commercial appeal for bendable devices. Thus, these electrolytes can be employed in flexible and bendable devices, favoring the improvement of portable electronics and wearable devices(376 references were evaluated and summarized here).

关键词： Quasi-solid-state electrolyte Gel-polymer electrolyte Flexible supercapacitor Wearables

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Uncertainty in sap flow of Brazilian mahogany determined by the heat ratio method

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Journal of Forestry Research 2021年第4期32卷 1457-1466页

作者： Alisson Macendo amaral Frederico Antonio Loureiro Soares Lucas Melo Vellame Marconi Batista Teixeira Federal Institute North of Minas Gerais(IFNMG) Campus ArinosMG-202 RoadKm 407ArinosMinas Gerais 38.680-000Brazil Federal Institute of Goiano(IF Goiano) Campus Rio VerdeSul Goiana RoadMailbox 66Rio VerdeGoiás 75.901-970Brazil Center for Agricultural Sciences Biological and EnvironmentalDepartment of Water Engineering and SoilFederal University of Bahia Reconcavo(UFRB)Rui Barbosa Street710Cruz das AlmasBahia 44380-000Brazil

The tropical arboreal species Brazilian mahogany(Swietenia macrophylla) is very important economically and ecologically,for which understanding ecophysiological variables such as sap flow will improve understanding of the species and its *** paper aims to measure uncertainties(U) involved in the application of the heat ratio method for determining sap flow in Brazilian mahogany using sets of heating probes and thermometers installed on plants of 18 months of age,cultivated in Yellow Latosol,under a weighing lysimeter and located in a protected *** uncertainty in sap flow was calculated as the combination of uncertainty in the thermal diffusivity(U_(k)),conductive section(U_(Sc)) and corrected sap velocity(U_(Vc)).U_(k) had greater weight in determining the flow of sap in Brazilian mahogany,when compared to U_(Sc) and U_(Vc).The thermal diffusivity during the cycle,or period evaluated,must be adjusted to improve the accuracy of the heat ratio method because the sap flow overestimated transpiration by 15.0%.When soil water was optimal In addition,the vapor pressure deficit linearly and indirectly influenced the SF with a difference of 14.6%.

关键词： Heat pulse Diffusivity Reliability Transpiration Vapor pressure deficit

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Yield of surgery in solid pseudopapillary neoplasms of the pancreas: A case series and literature review

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 589-599页

作者： Flávio Silano Ricardo Bandeira de Melo amaral Rodolfo Carvalho Santana Vanessa Costa Neves JoséCelso Ardengh Paulo Cezar Galvão do amaral Digestive Surgery Hospital São Rafael/Rede D’OrSalvador 40285000BahiaBrazil Department of Surgery of the Upper Digestive System São Rafael Hospital/Rede D’Or Hospital GroupSalvador 41253-190BahiaBrazil Surgery and Anatomy Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto-Universidade de São PauloSão Paulo 04611-000São PauloBrazil Endoscopy Service Hospital 9 de JulhoSão Paulo 04611-000São PauloBrazil Imaging and Diagnosis Escola Paulista de Medicina-São Paulo Federal UniversitySão Paulo 04611-000SPBrazil

BACKGROUND Solid pseudopapillary neoplasms(SPN)of the pancreas represents approximately 2%of non-endocrine tumors of the *** is described in the literature as a rare and predominant tumor in young *** To report a case series with SPN and analyzing clinical,surgical,anatomopathological characteristics,as well as the prognosis and review of *** Retrospective analysis of patients undergoing surgery,with histological diagnosis of SPN between 1998 and 2018,using standardized and prospectively completed forms,performed at the Surgery Service of the Upper Digestive System at Hospital São Rafael/Rede D’Or in *** of literature through a database search in MEDLINE/PubMed of retrospective *** Fourteen female patients with the average age of 31.6 years(range min-max)were *** patients(85.7%)were asymptomatic,being an incidental diagnosis or due to screening for other *** patient had abdominal pain due to gastric compression and another patient had *** 14 patients were staged with computerized tomography or magnetic resonance *** had evidence of *** 8 patients(57.1%),the tumor was in the tail and *** average size was 6.7 cm(range min-18).The type of surgery was according to the anatomical location of the *** was no lymph node *** two cases,vascular resection with the use of a prosthesis was required for *** surgical margins were *** all cases,postoperative immunohistochemistry confirmed that it was a solid pseudo-papillary neoplasia of the *** has been no disease recurrence in any case so *** The tumors had a benign,indolent and histopathological behavior compatible with the *** surgery is recommended in all cases.

关键词： Frantz tumor Malignancy Solid pseudo-papillary tumor Surgical treatment Survival Pancreas

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Population structure of Araucaria angustifolia under distinct forest protection status:implications for management and conservation

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林业研究:英文版 2023年第5期34卷 1437-1446页

作者： Vinicius Costa Cysneiros Allan Libanio Pelissari Sylvio Pellico Netto Sebastiao do amaral Machado Afonso Figueiredo Filho Departamento de Agricultura Biodiversidade e FlorestasUniversidade Federal de Santa Catarina-UFSCRodovia Ulysses GaboardiKm 03CuritibanosSC 89520-000Brazil Departamento de Ciencias Florestais Universidade Federal do Paraná-UFPRAv.Prof.Lothario Meissner632CuritibaPR 80210-170Brazil Departamento de Engenharia Florestal Universidade Estadual do Centro-Oeste-UNICENTROPR-153Km 7IratiPR 84500-000Brazil

Araucaria angustifolia is the dominant coniferous species in Brazil,a long-lived pioneer species and a supplier of valuable timber and non-timber products,which gives it key-species *** study examines how *** population structure affects the stand structure,and whether these relationships differ between protected and unprotected *** study was carried out on two protection status forests(national forest and urban forest)in a region of Atlantic mixed forest in ParanáState,southern *** coefficient and the Weibull shape parameter described the population structure and its effects on species diversity and biomass *** diameter distribution differed significantly between forests,with unbalanced structure in both,although regeneration was more abundant in the protected *** positively affected aboveground biomass whereas shape negatively affected it and species *** relationships differed between protected and unprotected *** effect of *** populations on stand structure was conditioned on protection ***-growth populations may have lower diversity and biomass stock even supporting large ***,old-growth forests,can lead to wood loss through mortality,senescence,and declining populations,representing the waste of a valuable timber *** findings provide useful knowledge for forest management,species conservation,and the carbon market.

关键词： Key species Diameter distribution Weibull shape parameter Aboveground biomass

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Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration

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Cellular & Molecular Immunology 2019年第10期16卷 833-834页

作者： Joao Moura Joao Rodrigues Marta Gonçalves Claudia amaral Margarida Lima Eugenia Carvalho Center for Neuroscience and Cell Biology(CNC) University of CoimbraCoimbraPortugal INEB-Instituto Nacional de Engenharia Biomedica University of PortoPortoPortugal I3S-Instituto de Investigaçao e Inovaçao em Saude University of PortoPortoPortugal Department of Hematology Hospital de Santo Antonio(HSA)Centro Hospitalar Universitario do Porto(CHUP)PortoPortugal Unidade Multidisciplinar de Investigaçao Biomedica(UMIB/ICBAS/UP) PortoPortugal Department of Endocrinology Hospital de Santo Antonio(HSA)Centro Hospitalar Universitário do Porto(CHUP)PortoPortugal Department of Geriatrics University of Arkansas for Medical Sciences(UAMS)and Arkansas Children’s Hospital Research Institute(ACHRI)Little RockArkansas 72202USA

Diabetes is a growing epidemic due to the systematic increase in overweight and obesity,and chronic diabetic foot ulcers(DFUs)are the most debilitating and costly complication of *** is still essential for DFU care,but early detection is limited because we do not have a good DFU ***,we report the preliminary results of a large longitudinal study to test the effectiveness of the use of T-cell phenotype and TCR repertoire diversity as DFU *** results show that the ratio of effector/naïve T-cells and the number of TCR expansions are valuable biomarkers of DFU prognosis.

关键词： diabetic chronic obesity

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