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Am.rican Journal of Analytical Chem.stry 2023年第9期14卷 378-389页

作者： Waleed Alhussaini Ezzeldeen Ghanem.m.gd Alsahly amani Kurdi Em.n Alharbi Im.dul Islam.m.jed Aljeraisy Departm.nt of Pharm.ceutical Analysis King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences Ministry of the National Guard—Health Affairs Riyadh Saudi Arabia Research Office King Abdullah International Medical Research Center King Saud bin Abdulaziz University for Health Sciences Ministry of the National Guard—Health Affairs Riyadh Saudi Arabia

A sensitive, accurate and robust Liquid Chrom.tography Tandem.m.ss Spectrom.try m.thod has been developed and validated to m.asure voriconazole trough levels in hum.n plasm.. The plasm. sam.les were m.xed with fluconazole as an Internal Standard and directed to protein precipitation and drug extraction. An aliquot of 1 μl was injected into the chrom.tographic system.and separated by the Acquity BEH C18 colum. at a flow rate of 0.30 m./m.n in a gradient m.bile phase consisting of acetonitrile, Ultrapure water (UPW), m.thanol and form.c acid. Voriconazole was detected by a Triple Quadrupole Detector (TQD) operating on m.ltiple Reaction m.nitoring (m.m. and a positive ion m.de Electrospray ionization (ESI) Q1 m.ss: 350.1 m.z, Q3 m.ss: 281.1 m.z. m.thod linearity of the calibration curve (0.10 - 8.00 μg/m.) indicated a correlation coefficient r ≥ 0.99. The intra and inter-assay accuracy was within 85% - 115% and the intra and inter-assay precision was ≤5.76%. Voriconazole recovery percentage was between 97.69 - 119.62%. The m.thod was successively applied in routine voriconazole TDm.

关键词： Voriconazole Hum.n Plasm. Liquid Chrom.tography Tandem.m.ss Spectrom.try Therapeutic Drug m.nitoring

Astragalus kahiricus根提取物对乙醇诱导的大鼠肝细胞凋亡的肝保护作用(英文)

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中国天然药物 2013年第4期11卷 354-361页

作者： Rasha m.Allam.Dina A.Selim.Asser I.Ghoneim.m.ham.d m.Radwan Salwa m.Nofal amani E.Khalifa Ola A.Sharaf Soad m.Toaim. Aya m.Asaad Nadia A.El-Sebakhy Pharm.cology Departm.nt Medical DivisionNational Research CenterGizaEgypt Departm.nt of Pharm.cognosy Faculty of PharmacyThe University of AlexandriaAlexandria 21521Egypt Departm.nt of Pharm.cology and Toxicology Faculty of PharmacyDamanhour UniversityDamanhourEgypt Departm.nt of Pharm.cology & Therapeutics Faculty of PharmacyBeirut Arab UniversityBeirutLebanon National Center for Natural Products Research School of PharmacyThe University of MississippiUniversity 38677 MSUSA Departm.nt of Pharm.cology and Toxicology Faculty of PharmacyAin Shams UniversityCairoEgypt

The hepatoprotective activity of the ethanol extract of Astragalus kahiricus(Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very prom.sing hepatoprotective actions through different *** extract counteracted the ethanol-induced liver enzym.s leakage and glutathione *** addition,it dem.nstrated anti-apoptotic effects against caspase-3 activation and DNA fragm.ntation that were confirm.d by liver histopathological ***,the phytochem.cal study of this extract led to the isolation of four cycloartane-type triterpenes identified as astrasieversianin II(1),astram.m.rannin II(2),astrasieversianin XIV(3),and cycloastragenol(4).The structures of these isolates were established by HRESI-m. and 1D and 2D Nm. *** antim.crobial,antim.larial,and cytotoxic activities of the isolates were further evaluated,but none of them.showed any activity.

关键词：实验药理学药理病理作用天然药物

Hypoglycem.c and antioxidant activities of Caesalpinia ferrea m.rtius leaf extract in streptozotocininduced diabetic rats

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Asian Pacific Journal of Tropical Biom.dicine 2015年第6期5卷 460-470页

作者： Sherien Kam.l Hassan Nerm.n m.ham.ed El-Sam.ad Am.ia m.m.ouh m.usa m.ha Hashim.m.ham.ed Abd el Razik Hussein Farrag amani Nassir Eldin Hashim.Victoria Werner Ulrike Lindequist m.hm.ud Abd El-m.ein Nawwar Departem.nt of Biochem.stry National Research CentreCairo Egypt Departem.nt of Pathology National Research CentreCairo Egypt Departem.nt of Phytochem.stry and Plant System.tics National Research CentreCairo Egypt Institute of Pharm.cy Pharmaceutical Biology Ernst-Moritz-Arndt-Universitt GreifswaldD-17487 Greifswald Germany

Objective: To evaluate the antidiabetic and antioxidant ef ects of aqueous ethanolic extract of Caesalpinia ferrea(C. ferrea) leaf in norm.l and streptozotocin(STZ) induced diabetic ***: m.le Sprague-Dawley rats divided into 6 groups of 6 rats each were assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal adm.nistration of STZ(65 m./kg body weight). C. ferrea extract at the doses of 250 and 500 m./kg body weight was orally adm.nistered to both diabetic and non-diabetic anim.ls for a period of 30 days. After com.letion of experim.ntal duration serum. liver and pancreas were used for evaluating biochem.cal and histopathological ***: Oral adm.nistration of C. ferrea leaf extract significantly reduced elevated serum.glucose, α-am.lase, liver function levels and signii cantly increased serum.insulin, total protein and body weight as well as im.roved lipid proi le due to diabetes. Furtherm.re, the treatm.nt resulted in a m.rked increase in glutathione peroxidase, superoxide dism.tase, catalase and reduced glutathione, and dim.nished levels of lipid peroxidation in liver and pancreas of diabetic rats. Histopathological studies dem.nstrated the reduction in the pancreas and liver dam.ge and coni rm.d the biochem.cal i ***: From.the present study, it can be concluded that the C. ferrea leaf extract ef ectively im.roved hyperglycaem.a while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. Hence, it can be used in the m.nagem.nt of diabetes m.llitus.

关键词： Caesalpinia ferrea Diabetes Streptozotocin Hypoglycem.a Antioxidant m.rkers Histopathology

Study of Varietal Influence Post Conservation on Biochem.cal and Sensory Qualities of Attiékéand Boiled Cassava (m.nihot esculenta Crantz)

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Agricultural Sciences 2016年第3期7卷 127-136页

作者： Pierre m.rtial Thierry Akely Yves Djina Brou Roger Konan Kady Irie Lucien Patrice Kouam. N’guessan Georges amani Laboratoire de Biochim.e Alim.ntaire Technologie de Produits Tropicaux UFR STA UNA Abidjan Cote d’Ivoire Section Sciences de la vie et de la Terre Sciences et Technologie ENS Abidjan Cote d’Ivoire Laboratoire d’Enzym.logie et Catalyse Enzym.tique UFR STA UNA Abidjan Cote d’Ivoire

Cassava root is shortly preserved after harvesting due to its tanning and rapid physiological decom.osition. Consequently, the com.ercial value is reduced and the craving of its finishes products. With an aim.of im.roving physiological quality, post harvest food value “the effects of bleaching and conservation in silo-pits were evaluated. Four (04) varieties of cassava: Bocou1, Bocou2, Bocou3 and Yavo were collected fresh and healthy in 13 m.nths of m.turity. They were subjected to a bleaching (65°C /15 - 30 s) followed by a kinetic conservation (7 days of intervals) in silo-pit (1 × 0.6 × 0.5 m.. Results show that Bocou2 variety has the high proteins content (2.64% ± 0.01%), followed by hydrocyanic acid (8.21 ± 0.01 m./100 g) and total carotenoids (26.7 μg/100 g). The conservation influences positively the protein content, reducing sugars content, the dries m.tter content and the total phenolic com.ounds for all the varieties excluded Bocou2 variety whose protein content drops. As regard of the fat contents, a weak increase is observed. The sensory analysis reveals that the boiled cassava of the Yavo variety is m.re appreciated followed by Bocou1 variety. Concerning the Attiéké, Bocou3 variety gives the m.re appreciated dish followed by the Yavo variety. In conclusion, the silo-pit conservation after bleaching im.roves the physiological quality of the cassava and the sensory taste even during 14 days. This study has a huge im.act of reducing the post harvests losses and increases the com.ercial value of cassava in the world.

关键词： Cassava Atttieke Boiled Post Conservation Silo-Pit Case Sensory Quality

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煤层甲烷井选用性脱水装置

国外油田工程 1996年第12期12卷 29-31页

作者： m.amani 陈立华 H.C.Juvkam.Wold 中原油田经济技术信息中心

本文论述了液压气泵适用于煤层甲烷井的各个生产阶段。介绍了液压气泵脱水用于煤层甲烷井的开采所具有的几项操作优点。当评估脱水经济效益时。应当首先考虑液压气泵脱水装置。

关键词：煤层甲烷井液压气泵脱水装置天然气

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煤层甲烷井选用性脱水装置

石油石化节能与计量 1996年第12期 29-31页

作者： m.amani,陈立华,H．C．Juvkam.Wold 中原油田经济技术信息中心

关键词：煤层甲烷井液压气泵脱水装置现场试验

Sedim.ntary Inputs and m.rphology Characterization of the Bottom.Agropastoral Lake of Nafoun (North Ivory Coast)

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Journal of Water Resource and Protection 2020年第5期12卷 389-400页

作者： Anzoum.nan Kam.gate Yao Blaise Koffi Kouassi Ernest Ahoussi m.chel amani Kouassi Herm.nn Essan Ehui Kouassi Serge Aristide Yao Seydou Diallo Training and Research Unit for Earth Sciences and m.ning Resources Soil Water and Geomaterials Laboratory Université Félix Houphouet-Boigny Abidjan Ivory Coast Departm.nts of Earth Sciences and m.neral Resources Civil Engineering Geosciences and Geographic Sciences Laboratory Yamoussoukro Ivory Coast Environm.ntal Science and m.nagem.nt Training and Research Unit Laboratory Geosciences and Environment Université Nangui Abrogoua Abidjan Ivory Coast

A bathym.tric and sedim.ntological analysis carried out respectively in July 2017 and April 2018 m.de it possible to characterize the sedim.nts and the m.rphology of Lake Nafoun. The sedim.nts of the lake consist of vases, fine to very coarse sands with average particle sizes ranging from.475.67 and 2111 μm. There is a predom.nance of very coarse elem.nts (43.50%). The standard deviation of the lake sand is between 1.21 and 1.86 and is poorly classified. The skewness fluctuates between ?0.06 and 0.41. The sedim.nts were deposited at the bottom.of the lake due to a progressive decline in the flow of water that carried them. m.reover, this study m.de it possible to realize the first bathym.tric chart of Lake Nafoun, 42 years after its im.oundm.nt in 1975.

关键词： Sedim.nts m.rphology Nafoun Lake Bathym.try

Opening a new route to m.ltiport coherent XUV sources via intracavity high-order harm.nic generation

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Light(Science & Applications) 2020年第1期9卷 398-406页

作者： Natsuki Kanda Tom.hiro Im.hoko Koji Yoshida Akihiro Tanabashi Aamani Eilanlou Yasuo Nabekawa Tetsum. Sum.yoshi m.koto Kuwata-Gonokam. Katsum. m.dorikawa RIKEN Center for Advanced Photonics RIKENWakoSaitama 351-0198Japan Photon Science Center The University of TokyoTokyo 113-8656Japan Intstitute for Solid State Physics The University of TokyoKashiwaChiba 277-8581Japan Cyber Laser Inc. WakoSaitama 351-0104Japan Institute for Photon Science and Technology The University of TokyoTokyo 113-0033Japan Departm.nt of Physics The University of TokyoTokyo 113-0033Japan

High-order harm.nic generation(HHG)is currently utilized for developing com.act table-top radiation sources to provide highly coherent extrem. ultraviolet(XUV)and soft X-ray pulses;however,the low repetition rate of fundam.ntal lasers,which is typically in the m.lti-kHz range,restricts the area of application for such HHG-based radiation ***,we dem.nstrate a novel m.thod for realizing a m.z-repetition-rate coherent XUV light source by utilizing intracavity HHG in a m.de-locked oscillator with an Yb:YAG thin disk laser m.dium.and a 100-m.long ring *** have successfully im.lem.nted HHG by introducing two different rare gases into two separate foci and picking up each HH *** to the two different HH beam. generated from.one cavity,this XUV light source will open a new route to perform.ng a tim.-resolved m.asurem.nt with an XUV-pum. and XUV-probe schem. at a m.zrepetition rate with a fem.osecond resolution.

关键词： intracavity coherent repetition

Interest of SAAG in Etiological Diagnosis of Ascites in African Black

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Open Journal of Gastroenterology 2018年第10期8卷 337-347页

作者： Okon Anassi Jean Baptiste Soro Dram.ne Doffou Stanislass Diakite m.m.dou Koné Am.dou Aké Fabrice Thot’o amani Sroboua N’dri N’guessan Hepato-Gastroenterology Departm.nt University Hospital Center Bouaké Ivory Coast Hepato-Gastroenterology Departm.nt University Hospital Center Abidjan Ivory Coast

Purpose: To show the interest of the serum.ascites concentration gradient in album.n (SAAG) in the etiological diagnosis of ascites in African black. m.teriel and m.thods: This was a m.nocentric observational and analytical study perform.d on patients over 15 years old and hospitalized in the Hepato-Gastroenterology departm.nt of Cocody from.January 1st, 2010 to m.rch 31st, 2017 for ascites. The cytology and chem.stry of the ascites fluid and the protidogram.were perform.d. The m.in outcom. m.asure was the prediction of portal hypertension (PHT) or non-portal hypertension related causes of ascites from.SAAG. Results: The hospital prevalence of ascites was 11%. There were 82 wom.n (46.9%) and 93 m.n (53.1%) with a sex ratio (m.F) of 1.1. SAAG was low in 68.6% of cases and high in 31.4% of cases. The m.st com.on etiologies were post-viral cirrhosis (74%), HCC (16.60%) and peritoneal tuberculosis (13.7%) respectively. In the case of high SAAG, 91% of ascites related to PHT were observed, but also 77.5% of a low SAAG corresponded to ascites related to PHT (p = 0.024) with Se = 35% Sp = 84% and accuracy = 44%. All patients with peritoneal tuberculosis had a SAAG low of less than 1.1 g/dl significantly (p = 0.002). SAAG had a diagnostic perform.nce of 89% in peritoneal tuberculosis at the cutoff value of ?1.24 g/dl (AUROC = 0.91, Se = 96%, Sp = 86%) while in post viral hepatitis cirrhosis at a threshold of 0.58 g/dl the diagnostic perform.nce was 60% (AUROC = 0.69, Se = 53%, Sp = 79%). Conclusion: The sim.le technical SAAG, allowing to distinguish the ascites linked to the PHT and the ascites not bound to the PHT, can be used like a m.thod of diagnosis of the etiologies of the ascites especially in the peritoneal tuberculosis in the African countries low incom..

关键词： SAAG Ascites Peritoneal Tuberculosis Cirrhosis PHT

Optim.zation of a m.thod for the Sim.ltaneous Determ.nation of Phloroglucinol and Trim.thylphloroglucinol by High Perform.nce Liquid Chrom.tography in Routine Use in a Pharm.ceutical Industry in Abidjan

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Open Journal of Optim.zation 2023年第2期12卷 11-24页

作者： Jean-Kisito Kouam. m.riette Désirée Yéhé Claude Bérenger Ngalem. Ngantchouko amani Germ.in Brou Carine Nina Ablé Aya m.lissa Diane Kouadio Bi Gogoua Désiré Vagny Vincent De Paul Ovi Christophe N’cho Am.n Gildas Kom.nan Gbassi National Public Health Laboratory (NPHL) Food Control Service Abidjan Ivory Coast Departm.nt of Analytical Sciences and Public Health Training and Research Unit (UFR) of Pharmaceutical and Biological Sciences Félix Houphou&#235t Boigny University Abidjan Ivory Coast Higher Institute of Health Sciences of the University of the m.untains (Udm. Bangangté Cameroon

In order to provide the population with safe, effective and good quality m.dicines, the pharm.ceutical industries, before releasing batches of their products into the pharm.ceutical circuit, put in place internal dosage m.thods to control the quality of these products. The present study consisted in optim.zing a m.thod for the sim.ltaneous determ.nation of Phloroglucinol (PHG) and Trim.thylphloroglucinol (TPH) by high perform.nce liquid chrom.tography (HPLC) routinely used in a pharm.ceutical industry located in a township in Abidjan (Ivory Coast). The basic chrom.tographic conditions were those routinely used for the determ.nation of these two m.lecules: m.bile phase: acetonitrile/water (60/40), stationary phase (C18 BDS Hypersil 250 m. * 4.6 m. - 5 μm., detection wavelength (265 nm., flow rate, injection volum. and run tim. configured at the equipm.nt level were respectively 1 m./m.n, 10 μL and 8 m.n. The m.thod of preparation of the analytes (PHG and TPHG) was also applied by the pharm.ceutical industry. The application of these different param.ters at the equipm.nt level m.de it possible to determ.ne a chrom.togram.which highlights three chrom.tographic peaks with respective retention tim.s (RT) of 0.773 m.n (unidentified com.ound), 2.275 m.n (PHG) and 7.269 m.n for an analysis tim. of 8 m.n with a better resolution of the peaks and baseline. The progressive optim.zation of different param.ters such as the stationary phase (C18 Ym. 150 m. * 4.6 m. - 3 μm., the proportion of the m.bile phase: acetonitrile/water (80/20), the flow rate im.elled by the pum. (0.8 m./m.n) and the m.dification of the analyte preparation m.de (sam. am.unt of PHG and TPHG in a 50 m. volum.tric flask) resulted in a final chrom.togram.that highlighted two chrom.tographic peaks at the respective RT of 2.391 m.n (PHG) and 3.735 m.n (TPHG) at a run tim. of 6 m.n. The chrom.tographic conditions that led to the final chrom.togram.can be used routinely by the pharm.ceutical industry for the dete

关键词： PHG TPHG Pharm.ceutical Industry Chrom.tographic Profile Chrom.tographic Peak