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synthesis of some New Bisindole Derivatives and Their Biological Activity

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International Journal of Organic Chemistry 2016年第4期6卷 187-191页

作者： amal s. Yanni Chemistry Department Faculty of Science Assiut University Assiut Egypt

Pyrrolidines are well known for their versatile pharmacological activities such as antimicrobial [1] [2] [3] [4], antitumor [5], anti HIV [6], anticonvulsant [7] [8], human melanocortin-4 receptor agonists [9], etc. Moreover, indole nucleus is an important element of many natural and synthetic molecules that covers some of the relevant and recent achievement in the biological, chemical and pharmaceutical activity of important indole derivatives [10]. In view of these observations, the intention is directed to synthesize some new bisindole derivatives of expected biological interest.

关键词： synthesis Bisindoletetrones Cycloaddition Antimicrobial Activity

Maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring;An Egyptian case-control study

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Genes & Diseases 2019年第2期6卷 193-200页

作者： Wesam A.Mokhtar amal Fawzy Reem M.Allam Rania M.Amer Mona s.Hamed Pediatric Department Faculty of MedicineZagazig UniversityEgypt Medical Biochemistry Department Faculty of MedicineZagazig UniversityEgypt Clinical Pathology Department Faculty of MedicineZagazig UniversityEgypt Medical Microbiology and Immunology Department Faculty of MedicineZagazig UniversityEgypt Public Health and Community Medicine Faculty of MedicineZagazig UniversityEgypt

Vitamin D&vitamin D receptor(VDR)signaling play a very crucial role in early embryonic heart *** construct this case-control study to investigate the association between maternal serum vitamin D level&VDR gene Fok1 polymorphism and risk of congenital heart defects(CHD)in *** mothers who had term neonates with CHD were considered as *** age-comparable healthy mothers who had neonates without CHD were contemplated as *** serum 25 hydroxyvitamin D[25(OH)D]level was tested using *** VDR gene Fok1 polymorphism was analyzed using PCR-based *** was a significant decrease in maternal vitamin D level(P=0.002)and a significant increase in vitamin D deficient status(P=0.007)among cases when compared to *** gene Fok1 genotypes distribution frequency were in accordance with Hardy Weinberg equilibrium(HW)among controls.A significant increase in VDR gene Fok1 F/f&f/f genotypes and f allele were observed in cases compared to controls with estimated odds ratio(95%confidence interval)&P-value of 3(1e8)&P=0.006,11(1e97)&P=0.01 and 3(2e6)&P=0.001 *** was a significant decrease in maternal vitamin D level in neonates with cyanotic CHD(P=0.000)compared to those with a cyanotic CHD while there was no significant difference in VDR Fok1 genotype(P=0.18)&allele(P=0.05)distribution between two *** concluded that maternal vitamin D deficiency and VDR gene Fok1 F/f,f/f genotype and f allele were associated with increased risk of CHD in offspring.

关键词： Congenital heart disease FoK1 polymorphism Vitamin D Vitamin D receptor gene Maternal vitamin D

Entropy Bayesian Analysis for the Generalized Inverse Exponential Distribution Based on URRss

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Computers, Materials & Continua 2021年第12期69卷 3795-3811页

作者： Amer I.Al-Omari amal s.Hassan Heba F.Nagy Ayed R.A.Al-Anzi Loai Alzoubi Faculty of science Department of MathematicsAl al-Bayt UniversityMafraq25113Jordan Faculty of Graduate studies for statistical Research Cairo UniversityGiza12613Egypt Department of Mathematics College of Science and Human Studies at Hotat SudairMajmaah UniversityMajmaah11952Saudia Arabia

This paper deals with the Bayesian estimation of shannon entropy for the generalized inverse exponential *** that the observed samples are taken from the upper record ranked set sampling(URRss)and upper record values(URV)*** of Bayesian estimators are derived depending on a gamma prior distribution considering the squared error,linear exponential and precautionary loss functions,in addition,we obtain Bayesian credible *** random-walk Metropolis-Hastings algorithm is handled to generate Markov chain Monte Carlo samples from the posterior ***,the behavior of the estimates is examined at various record *** output of the study shows that the entropy Bayesian estimates under URRss are more convenient than the other estimates under URV in the majority of the ***,the entropy Bayesian estimates perform well as the number of records *** obtained results validate the usefulness and efficiency of the URV *** data is analyzed for more clarifying purposes which validate the theoretical results.

关键词： shannon entropy generalized inverse exponential distribution Bayesian estimators loss function ranked set sampling markov chain

Recent advances in flexible batteries:From materials to applications

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Nano Research 2023年第4期16卷 4821-4854页

作者： Fuwei Xiang Fang Cheng Yongjiang sun Xiaoping Yang Wen Lu Rose amal Liming Dai College of Chemical science and Engineering Yunnan UniversityKunming 650091China Institute of Energy storage Technologies Yunnan UniversityKunming 650091China Australian Carbon Materials Centre(A-CMC) School of Chemical EngineeringUniversity of New South WalesSydneyNSW 2052Australia

Along with the rapid development of flexible and wearable electronic devices,there have been a strong demand for flexible power sources,which has in turn triggered considerable efforts on the research and development of flexible *** ideal flexible battery would have not only just high electrochemical performance but also excellent mechanical ***,battery constituent components,chemistry systems,device configurations,and practical applications are all pivotal aspects that should be thoroughly ***,we systematically and comprehensively review the fundamentals and recent progresses of flexible batteries in terms of these important ***,we first discuss the requirements for constituent components,including the current collector,electrolyte,and separator,in flexible *** then elucidate battery chemistry systems that have been studied for various flexible batteries,including lithium-ion batteries,non-lithium-ion batteries,and high-energy metal *** is followed by discussions on the device configurations for flexible batteries,including onedimensional fiber-shaped,two-dimensional film-shaped,and three-dimensional structural ***,we summarize recent efforts in exploring practical applications for flexible *** challenges and future opportunities for the research and development of flexible batteries are also discussed.

关键词： flexible batteries flexible power sources wearable electronics electrochemistries battery applications

Dietary effects of A zolla pinnata combined with exogenous digestive enzyme(Digestin^(TM)) on growth and nutrients utilization of freshwater prawn, Macrobrachium rosenbergii(de Man 1879)

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Journal of Oceanology and Limnology 2018年第4期36卷 1434-1441页

作者： GODA Ashraf sAAD amal HANAFY Mohamed sHARAWY Zaki EL-HAROUN Ehab Aquaculture Division National Institute of Oceanography and Fisheries (NIOF) Institute of Oceanology Chinese Academy of Sciences Division of Aquaculture College of Agriculture Food Science and Sustainable Systems Kentucky State University

The present study was conducted to evaluate the effect of either individual or combined wheat bran(WB) replacement with Azolla pinnata supplemented with Digestin^(TM) in the diet of freshwater prawn, Macrobrachium rosenbergii Postlarvae(PL) on growth performance, nutrient utilization, chemical body composition and survival(%). Experimental diets were a wheat bran-soybean based diet with no Azolla and Digestin^(TM)(control, T_1), and diets containing 17% Azolla supplemented with Digestin^(TM) 0%(T_2), 1%(T_3), 2%(T_4) and 3%(T 5). Each experimental diet was allocated into three tanks(6 m^3/tank) fed for 12 wks. Each tank was subdivided into three equal pens by nets(2 m^3) and stoked with 84 PL/m^2. The experimental diets were readily consumed by prawns PLs where both high growth and good feed efficiency were achieved for all diets. The results showed that the diets containing A. pinnata supplemented with Digestin? at the level up to 3% have the higher growth and better nutrient utilization than the control diet. No differences were observed for moisture and protein content among the experimental diets. However, the highest protein content was observed on prawns fed on diets T_1 and T 5 respectively, while the lowest value was recorded for T_4 diet. The results also show that prawn PLs fed the diets contain A. pinnata and supplemented with Digestin^(TM) recorded the highest values of body lipid content compared to the control diet. Feed efficiency and economic conversion rate(ECR) values show that economic performance and the cost-effectiveness of the A. pinnata supplemented with up to 3% Digestin^(TM) recorded the highest net return, and therefore it is recommended for prawn, M. rosenbergii PL's. These results are clearly indicating that A. pinnata have a good potential for use in prawn diets at reasonable levels than other conventional diets.

关键词： Azolla meal enzymes growth performance economic analysis feed efficiency

On chaotic properties of new semidynamical systems of Lasota type in two spaces

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International Journal of Biomathematics 2018年第5期11卷 201-215页

作者： Habeeb Kareem Abdullah amal Khalaf Haydar Yaqoob All Hussein Department of Mathematics Faculty of Education for Girls University of Kufa Najaf Iraq

The present study is concerned with construct two new semidynamical systems which are generated by two partial differential equations of Lasota type. In addition, this study discusses the asymptotic properties： strong stability, exponential stability, periodic points, the density of periodic points, transitivity and chaos in two spaces： Lp space and Lp space.

关键词： Initial value problems for linear first-order equations stability periodic solutions chaotic dynamics.

Power Inverted Topp–Leone Distribution in Acceptance sampling Plans

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Computers, Materials & Continua 2021年第4期67卷 991-1011页

作者： Tahani A.Abushal amal s.Hassan Ahmed R.El-saeed said G.Nassr Faculty of science Umm AL-Qura UniversityMakkah Al Mukarramah715Saudi Arabia Faculty of Graduate studies for statistical Research Cairo UniversityGiza12613Egypt Obour High Institute for Management&Information Al-Sharqua44516Egypt Faculty of Business Administration Sinai UniversityAl-Arish45511Egypt

We introduce a new two-parameter model related to the inverted Topp–Leone distribution called the power inverted Topp–Leone(PITL)*** properties of the PITL distribution are stated;including;quantile measures,moments,moment generating function,probability weighted moments,Bonferroni and Lorenz curve,stochastic ordering,incomplete moments,residual life function,and entropy *** sampling plans are developed for the PITL distribution,when the life test is truncated at a pre-specified *** truncation time is assumed to be the median lifetime of the PITL distribution with pre-specified *** minimum sample size necessary to ensure the specified life test is obtained under a given consumer’s *** results for given consumer’s risk,parameters of the PITL distribution and the truncation time are *** estimation of the model parameters is argued using maximum likelihood,least squares,weighted least squares,maximum product of spacing and Bayesian methods.A simulation study is confirmed to evaluate and compare the behavior of different *** real data applications are afforded in order to examine the flexibility of the proposed model compared with some others *** results show that the power inverted Topp–Leone distribution is the best according to the model selection criteria than other competitive models.

关键词： Inverted Topp-Leone distribution acceptance sampling plans maximum likelihood estimators weighted least squares estimators Bayesian estimators

＂RADIOTRANsCRIPTOMICs＂： A synergy of imaging and transcriptomics in clinical assess- ment

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Frontiers of Electrical and Electronic Engineering in China 2016年第1期4卷 1-12页

作者： amal Katrib William Hsu Alex Bui Yi Xing Department of Microbiology Immunology and Molecular Genetics University of California Los Angeles Los Angeles CA_ 90095 USA Department of Radiological sciences University of California Los Angeles Los Angeles CA 90095 USA

Recent advances in quantitative imaging and ＂omics＂ technology have generated a wealth of mineable biological ＂big data＂. With the push towards a P4 ＂predictive, preventive, personalized, and participatory＂ approach to medicine, researchers began integrating complementary tools to further tune existing diagnostic and therapeutic models. The field of radiogenomics has long pioneered such multidisciplinary investigations in neuroscience and oncology, correlating genotypic and phenotypic signatures to study structural and functional changes in relation to altered molecular behavior. Given the innate dynamic nature of complex disorders and the role of environmental and epigenetic factors in pathogenesis, the transcriptome can further elucidate serial modifications undetected at the genome level. We therefore propose ＂radiotranscriptomics＂ as a new member of the P4 medicine initiative, combining transcriptome information, including gene expression and isoform variation, and quantitative image annotations.

关键词： quantitative imaging transcriptomics RNA-seq genomics image genomics radiogenomics systems biology precision medicine

Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and skin Regeneration

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Nano-Micro Letters 2024年第6期16卷 127-179页

作者： amal George Kurian Rajendra K.singh Varsha sagar Jung‑Hwan Lee Hae‑Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROs scavenging Anti-inflammation skin regeneration