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Chinese Journal of Cancer 2015年第3期34卷 115-120页

作者： Rishil J Kathawala Yi-Jun Wang Suneet Shukla Yun-Kai Zhang Saeed Alqahtani amal kaddoumi Suresh V Ambudkar Charles R Ashby Jr Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John's University Laboratory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of Health Department of Basic Pharmaceutical Sciences College of PharmacyThe University of Louisiana

Introduction:ATP-binding cassette subfamily B member 1(ABCB1) and subfamily C member 10(ABCCIO) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of *** is a novel taxane that differs from paclitaxel by its lower affinity for ATP-binding cassette(ABC) ***:We determined the effects of cabazitaxel,a novel tubulin-binding taxane,and paclitaxel on paclitaxelresistant,ABCB1-overexpressing KB-C2 and LLC-MDR1-WT cells and paclitaxel-resistant,ABCC10-overexpressing HEK293/ABCC10 cells by calculating the degree of drug resistance and measuring ATPase activity of the ABCB1 ***:Decreased resistance to cabazitaxel compared with paclitaxel was observed in KB-C2,LLC-MDR1-WT,and HEK293/ABCC10 ***,cabazitaxel had low efficacy,whereas paclitaxel had high efficacy in stimulating the ATPase activity of ABCB1,indicating a direct interaction of both drugs with the ***:ABCB1 and ABCC10 are not primary resistance factors for cabazitaxel compared with paclitaxel,suggesting that cabazitaxel may have a low affinity for these efflux transporters.

关键词： ATP酶活性阻力家族会员亚科 HEK293 化疗药物紫杉醇

Quaternionic Monge–Ampère Measure on Pluripolar Set

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1431-1457页

作者： Hichame amal Saïd ASSERDA Fadoua BOUKHARI Department of Mathematics Laboratory LaREAMIRegional Centre of Trades of Education and TrainingKenitraMorocco Ibn Tofail University Faculty of SciencesDepartment of MathematicsPO 242 KenitraMorroco

In this paper, we prove that in a hyperconvex domain Ω in H^(n), if a non-negative Borel measure is dominated by a quaternionic Monge–Ampère measure, then it is a quaternionic Monge–Ampère measure of a function i... 详细信息

关键词： Quaternion space Monge-Amp`ere operator plurisubharmonic function

Perceived stress among staff in Saudi Arabian dental colleges before and after an accreditation process: A cross-sectional study

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World Journal of Clinical Cases 2024年第4期12卷 758-765页

作者： amal S Shaiban Department of Restorative Dental Science College of DentistryKing Khalid UniversityAbha 61471Saudi Arabia

BACKGROUND Accreditation processes are extensively employed to guarantee the quality of higher education ***,this process can potentially generate a stressful atmosphere for staff,thus impacting their ability to perform optimally under *** To examine the knowledge of the National Commission for Academic Assessment and Accreditation(NCAAA)and its effects on perceived stress among dental college staff before and after the program accreditation *** The present cross-sectional questionnaire-based study included 300 employees from three dental *** same employees had to fill out the questionnaire 1 mo after the NCAAA *** Approximately 51.33%of the included employees believed that NCAAA is essential to attract quality students to join the program before and after the program.A total of 44.67%felt that their stress was high before,and 31.33%had low stress levels before and after *** findings were statistically significant(P≤0.05).CONCLUSION NCAAA raised the prestige of the institution and specific programmes and increased prospects to attract better students,staff,and money,according to the *** addition to their needed teaching,research,and other service responsibilities,this work requires a tremendous amount of faculty effort and may cause them stress.

关键词： National Commission for Academic Assessment and Accreditation Accreditation process Perceived stress Staff

Development of sustainable thermal insulation based on bio-polyester filled with date pits

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Journal of Bioresources and Bioproducts 2024年第1期9卷 74-89页

作者： amal Mlhem Thomas Teklebrhan Evenezer Bokuretsion Basim Abu-Jdayil Chemical&Petroleum Engineering Department United Arab Emirates UniversityPO Box 15551United Arab Emirates National Water and Energy Center United Arab Emirates UniversityPO Box 15551United Arab Emirates

Date palm pit(DPP)-filled poly(-hydroxybutyrate)(PHB)composites were prepared,evaluated,and characterized to determine their thermal insulation *** conductivity values ranged between 0.086 and 0.100 W/(m·K).At a maximum filler concentration(50%(w)),the specific heat capacity and thermal diffusivity were 1183 J/(kg·K)and 0.0689 mm^(2)/s,*** DPP increased the thermal stability,and the highest compressive strength obtained was 80 MPa at 30%filler *** PHB-DPP composites exhibited promising water absorption(less than 6%)and tensile strength(6-14 MPa).Date-pit-based PHB composites could be used in sustainable building engineering and cleaner production.

关键词： Green construction material Sustainable thermal insulator Date pit Polyhydroxybutyrate

A Deep Learning Approach for Landmines Detection Based on Airborne Magnetometry Imaging and Edge Computing

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2117-2137页

作者： Ahmed Barnawi Krishan Kumar Neeraj Kumar Bander Alzahrani amal Almansour Faculty of Computing and Information Technology King Abdulaziz UniversityJeddahSaudi Arabia Department of Computer Science and Engineering Thapar Institute of Engineering and TechnologyDeemed to be UniversityPatialaIndia

Landmines continue to pose an ongoing threat in various regions around the world,with countless buried landmines affecting numerous human *** detonation of these landmines results in thousands of casualties reported worldwide ***,there is a pressing need to employ diverse landmine detection techniques for their *** effective approach for landmine detection is UAV(Unmanned Aerial Vehicle)based AirborneMagnetometry,which identifies magnetic anomalies in the local terrestrial magnetic *** can generate a contour plot or heat map that visually represents the magnetic field *** the effectiveness of this approach,landmine removal remains a challenging and resource-intensive task,fraughtwith *** computing,on the other hand,can play a crucial role in critical drone monitoring applications like landmine *** processing data locally on a nearby edge server,edge computing can reduce communication latency and bandwidth requirements,allowing real-time analysis of magnetic field *** enables faster decision-making and more efficient landmine detection,potentially saving lives and minimizing the risks involved in the ***,edge computing can provide enhanced security and privacy by keeping sensitive data close to the source,reducing the chances of data exposure during *** paper introduces the MAGnetometry Imaging based Classification System(MAGICS),a fully automated UAV-based system designed for landmine and buried object detection and *** have developed an efficient deep learning-based strategy for automatic image classification using magnetometry dataset *** simulating the proposal in various network scenarios,we have successfully detected landmine signatures present in themagnetometry *** trained models exhibit significant performance improvements,achieving a maximum mean average precision value of 97.8%.

关键词： CNN deep learning landmine detection magnetometer mean average precision UAV

Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

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Nano-Micro Letters 2024年第6期16卷 127-179页

作者： amal George Kurian Rajendra K.Singh Varsha Sagar Jung‑Hwan Lee Hae‑Won Kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

The Impact of Network Topologies and Radio Duty Cycle Mechanisms on the RPL Routing Protocol Power Consumption

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Computers, Materials & Continua 2024年第5期79卷 1835-1854页

作者： amal Hkiri Hamzah Faraj Omar Ben Bahri Mouna Karmani Sami Alqurashi Mohsen Machhout Physic Department Electronics and Micro-Electronics LaboratoryFaculty of Sciences of MonastirMonastir5000Tunisia Department of Science and Technology College of RanyahTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

The Internet of Things(IoT)has witnessed a significant surge in adoption,particularly through the utilization of Wireless Sensor Networks(WSNs),which comprise small internet-connected *** deployments span various environments and offer a multitude of ***,the widespread use of battery-powered devices introduces challenges due to their limited hardware resources and communication *** response to this,the Internet Engineering Task Force(IETF)has developed the IPv6 Routing Protocol for Low-power and Lossy Networks(RPL)to address the unique requirements of such *** the critical role of RPL in maintaining high performance,this paper proposes a novel approach to optimizing power ***,it introduces a developed sensor motes topology integrated with a Radio Duty Cycling(RDC)mechanism aimed at minimizing power *** rigorous analysis,the paper evaluates the power efficiency of this approach through several simulations conducted across different network topologies,including random,linear,tree,and elliptical ***,three distinct RDC mechanisms—CXMAC,ContikiMAC,and NullRDC—are investigated to assess their impact on power *** findings of the study,based on a comprehensive and deep analysis of the simulated results,highlight the efficiency of ContikiMAC in power *** research contributes valuable insights into enhancing the energy efficiency of RPL-based IoT networks,ultimately facilitating their widespread deployment and usability in diverse environments.

关键词： WSN IoT radio duty cycles topologies

The Value of Tocotrienols in the Prevention and Treatment of Cancer

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The Value of Tocotrienols in the Prevention and Treatment of...

RPL-Based IoT Networks under Decreased Rank Attack:Performance Analysis in Static and Mobile Environments

作者： Paul W.Sylvester amal kaddoumi Sami Nazzal Khalid A.El Sayed College of Pharmacy University of Louisiana at MonroeMonroeLouisiana

Tocopherols and tocotrienols represent the 2 subgroups that make up the vitamin E family of compounds, but only tocotrienols display potent anticancer *** in vitro experimental evidence has been very promising,oral supplementation of tocotrienols in animal and human studies has produced inconsistent results. However,recent studies have now clarified the reasons for these discrepancies observed between in vitro and in vivo *** absorption of tocotrienols into the circulation is mediated in large part by carrier transporter

关键词： tocotrienols breast cancer intestinal absorption lipid nanoparticles tocotrienol analogues

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Computers, Materials & Continua 2024年第1期78卷 227-247页

作者： amal Hkiri Mouna Karmani Omar Ben Bahri Ahmed Mohammed Murayr Fawaz Hassan Alasmari Mohsen Machhout Physic Department Electronics and Micro-Electronics LaboratoryFaculty of Sciences of MonastirMonastir5000Tunisia Department of Science and Technology College of RanyahTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

The RPL(IPv6 Routing Protocol for Low-Power and Lossy Networks)protocol is essential for efficient communi-cation within the Internet of Things(IoT)*** its significance,RPL’s susceptibility to attacks remains a *** paper presents a comprehensive simulation-based analysis of the RPL protocol’s vulnerability to the decreased rank attack in both static andmobilenetwork *** employ the Random Direction Mobility Model(RDM)for mobile scenarios within the Cooja *** systematic evaluation focuses on critical performance metrics,including Packet Delivery Ratio(PDR),Average End to End Delay(AE2ED),throughput,Expected Transmission Count(ETX),and Average Power Consumption(APC).Our findings illuminate the disruptive impact of this attack on the routing hierarchy,resulting in decreased PDR and throughput,increased AE2ED,ETX,and *** results underscore the urgent need for robust security measures to protect RPL-based IoT ***,our study emphasizes the exacerbated impact of the attack in mobile scenarios,highlighting the evolving security requirements of IoT networks.

关键词： RPL decreased rank attacks mobility random direction model

Improving Prediction of Chronic Kidney Disease Using KNN Imputed SMOTE Features and TrioNet Model

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3513-3534页

作者： Nazik Alturki Abdulaziz Altamimi Muhammad Umer Oumaima Saidani amal Alshardan Shtwai Alsubai Marwan Omar Imran Ashraf Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department College of Computer Science and Engineering University of Hafr Al-BatinHafarAl-Batin39524Saudi Arabia Department of Computer Science&Information Technology The Islamia University of BahawalpurP.O.Box 63100BahawalpurPakistan Department of Computer Science College of Computer Engineering and SciencesPrince Sattam bin Abdulaziz UniversityP.O.Box 151Al-Kharj11942Saudi Arabia Information Technology and Management Illinois Institute of TechnologyChicagoIL 60616-3793USA Information and Communication Engineering Yeungnam UniversityGyeongsan38541Korea

Chronic kidney disease(CKD)is a major health concern today,requiring early and accurate *** learning has emerged as a powerful tool for disease detection,and medical professionals are increasingly using ML classifier algorithms to identify CKD *** study explores the application of advanced machine learning techniques on a CKD dataset obtained from the University of California,UC Irvine Machine Learning *** research introduces TrioNet,an ensemble model combining extreme gradient boosting,random forest,and extra tree classifier,which excels in providing highly accurate predictions for ***,K nearest neighbor(KNN)imputer is utilized to deal withmissing values while synthetic minority oversampling(SMOTE)is used for class-imbalance *** ascertain the efficacy of the proposed model,a comprehensive comparative analysis is conducted with various machine learning *** proposed TrioNet using KNN imputer and SMOTE outperformed other models with 98.97%accuracy for *** in-depth analysis demonstrates the model’s capabilities and underscores its potential as a valuable tool in the diagnosis of CKD.

关键词： Precisionmedicine chronic kidney disease detection SMOTE missing values healthcare KNNimputer ensemble learning