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Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin

World Journal of Gastroenterology 2011年第33期17卷 3836-3841页

作者： Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena am amer Basel al-Ramadi Sherif M Karam Department of Physiology Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Biology Faculty of ScienceUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Anatomy Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates Department of Microbiology and Immunology Faculty of Medicine and Health SciencesUAE UniversityAl AinPO Box 17666United Arab Emirates

AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)***:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic *** label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before *** stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU ***:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day *** ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined *** analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by *** mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin ***:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation.

关键词： Gastrointestinal cell proliferation Gastrointestinal mucosal damage Ghrelin

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Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage

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World Journal of Gastroenterology 2006年第35期12卷 5692-5698页

作者： MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri am amer N Morad A Bener Department of Gastroenterology and Hepatology Hamad Medical Corporation Doha Qatar Department of Immunology Hamad Medical Corporation Doha Qatar Department of Haematology Hamad Medical Corporation Doha Qatar Department of Histopathology Hamad Medical Corporation Doha Qatar Department of Medical Statistics and Epidemiology Hamad Medical Corporation Doha Qatar

AIM： To evaluate pegylated interferon alpha2a （PegIFN-α2a） in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS： A total of 73 nafve patients （61 with history of bilharziasis） with compensated chronic HCV genotype 4 were enrolled into： group A （38 patients） who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B （35 patients） received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS： Significant improvement in both end of treatment response （ETR）（P 〈 0.002） and sustained response （SR）（P 〈 0.05） was noted with pegylated interferon, where ETR was achieved in 29 （76.3%） and 14 patients （40%） in both groups respectively, and 25 patients in group A （65.8%） and 9 （25.7%） in group B could retain negative viraemia by the end of follow up period. Sustained virological response （SVR） showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR （P 〈 0.001）, but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis （grade 3 and 4） with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response between bilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect, both drugs were comparable. CONCLUSION： PegIFN-~2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation.

关键词： Hepatitis C virus Genotype 4 Pegasys Bilharziasis

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Optimal Coordination of Transportable Power Sources and Repair Crews for Service Restoration of Distribution Networks Considering Uncertainty of Traffic Congestion

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 189-201页

作者： Zhao Shi Yan Xu Dunjian Xie Shiwei Xie amer M.Y.M.Ghias Nanyang Technological University Singapore the School of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China

This paper proposes a new method for service restoration of distribution network with the support of transportable power sources(TPSs)and repair crews(RCs).Firstly,a coupling model of distribution networks and vehicle routing of TPSs and RCs is proposed,where the TPSs serve as emergency power supply sources,and the RCs are used to repair the faulted *** the uncertainty of traffic congestion,the probability distribution of the travel time spent on each road is derived based on the Nesterov user equilibrium model,and a two-stage stochastic program is formulated to determine the optimal routings of TPSs and *** efficiently solve the proposed stochastic mixed-integer linear program(MILP),a two-phase scenario reduction method is then developed to scale down the problem size,and an adaptive progressive hedging algorithm is used for an efficient *** effectiveness of the proposed methods and algorithms has been illustrated in a modified IEEE 33-bus system.

关键词： Service restoration distribution network traffic uncertainty transportable power source repair crew stochastic program

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An Electrical Impedance Imaging System Towards Edge Intelligence for Non-Destructive Testing of Concrete

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Tsinghua Science and Technology 2024年第3期29卷 883-896页

作者： Abolfazl Roshanpanah Mahdi Abbasi Hani Attar Ayman amer Mohammad R.Khosravi Ahmed A.Solyman Department of Electrical Engineering Islamic Azad UniversityScience and Research BranceTehran ***Iran Department of Computer Engineering Bu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Department of Computer Engineering Persian Gulf UniversityBushehr ***Iran Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNişantaşıUniversityIstanbul 34398Turkey

In the construction industry,to prevent accidents,non-destructive tests are necessary and *** impedance tomography is a new technology in non-invasive imaging in which the image of the inner part of conductive bodies is reconstructed by the arrays of external electrodes that are connected on the periphery of the *** equipment is cheap,fast,and edge *** this imaging method,the image of electrical conductivity distribution(or its opposite;electrical impedance)of the internal parts of the target object is *** image reconstruction process is performed by injecting a precise electric current to the peripheral boundaries of the object,measuring the peripheral voltages induced from it and processing the collected *** an electrical impedance tomography system,the voltages measured in the peripheral boundaries have a non-linear equation with the electrical conductivity *** paper presents a cheap Electrical Impedance Tomography(EIT)instrument for detecting impurities in the concrete.A voltage-controlled current source,a micro-controller,a set of multiplexers,a set of electrodes,and a personal computer constitute the structure of the *** conducted tests on concrete with impurities show that the designed EIT system can reveal impurities with a good accuracy in a reasonable time.

关键词： non-destructive testing system concrete electrical impedance tomography

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Heating-Cooling Monitoring and Power Consumption Forecasting Using LSTM for Energy-Efficient Smart Management of Buildings: A Computational Intelligence Solution for Smart Homes

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Tsinghua Science and Technology 2024年第1期29卷 143-157页

作者： Omid Akbarzadeh Sahand Hamzehei Hani Attar Ayman amer Nazanin Fasihihour Mohammad R.Khosravi Ahmed A.Solyman Department of Electronics and Telecommunications Politecnico di TorinoTurin 10129Italy Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262799China Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNisantası UniversityIstanbul 25370The Republic of Turkiye

Energy management in smart homes is one of the most critical problems for the Quality of Life(QoL)and preserving energy *** of the relevant issues in this subject is environmental contamination,which threatens the world's *** computing-enabled Artificial Intelligence(Al)algorithms can provide impactful solutions to this *** research proposes using one of the Recurrent Neural Network(RNN)algorithms known as Long Short-Term Memory(LSTM)to comprehend how it is feasible to perform the cloud/fog/edge-enabled prediction of the building's *** parameters of power electricity,power heating,power cooling,and total power in an office/home in cold-climate cities are considered as our features in the *** on the collected data,we evaluate the LSTM approach for forecasting parameters for the next year to predict energy consumption and online monitoring of the model's performance under various *** implementing the Al predictive algorithm,several existing tools are *** results have been generated through simulations,and we find them promisingforfutureapplications.

关键词： design-builder Besos smart cities smart building neural network Long Short-Term Memory(LSTM)

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Unique presentation of neonatal liver failure:A case report

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World Journal of Clinical Pediatrics 2024年第2期13卷 221-226页

作者： Eman Al Atrash amer Azaz Samar Said Mohammad Miqdady Department of Pediatrics Division of Pediatric GastroenterologySheikh Khalifa Medical CityAbu Dhabi 971United Arab Emirates Department of Pathology Mayo ClinicRochesterMN 55905United States

BACKGROUND Acute fulminant liver failure rarely occurs in the neonatal *** etiologies include viral infection(15%),metabolic/genetic disease(10%),hematologic disorders(15%),and ischemic injury(5%).Gestational alloimmune liver disease usually manifests as severe neonatal liver failure,with extensive hepatic and extrahepatic iron overload,sparing the reticuloendothelial *** liver failure is a rare cause of liver failure where a patient presents with liver failure in the neonatal period with no hepatocytes in liver *** SUMMARY A 5-week-old male presented with *** examination revealed an alert but deeply icteric *** data demonstrated direct hyperbilirubinemia,a severely deranged coagulation profile,normal transaminase,and normal *** resonance imaging of the abdomen was suggestive of perinatal *** biopsy showed histiocytic infiltration with an absence of *** hemosiderin deposition was identified in a buccal mucosa *** Neonatal liver failure in the absence of hepatocellular regeneration potentially reflects an acquired or inborn defect in the regulation of hepatic regeneration.

关键词： Liver Hyperbilirubinemia Le foie vide Neonatal hemochromatosis Case report

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Using IoT to Smart Security Door System with Face Tracking Camera

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Intelligent Information Management 2024年第4期16卷 157-175页

作者： amer Nizar AbuAli College of Computer Science and Engineering Information Systems Department Taibah University Medina KSA

Security is a serious concern, whether it may be the security of assets, data and human life. Providing humans with security and safety for their belongings and items is an important need. A smart lock door project/ with different types of methods for entry, like fingerprint and authentication PIN code is suggested with an unnoticeable face tracking camera capturing a photo in case of error data entry. It is to be controlled via the user’s smartphone using Blynk with the implementation of IoT. This technology is made with two microcontrollers. ESP32 is used to control the solenoid lock, fingerprint sensor and keypad. ESP32-Cam is used to capture a photo and send it to the owner’s smartphone to be viewed on Telegram application. Many conclusions are extracted from system results, as well as suggested ideas for future work.

关键词： Security Block Diagram Microcontroller Bluetooth Dual Mode

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Alert Device for Social Distancing

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Communications and Network 2024年第2期16卷 31-50页

作者： amer Nizar AbuAli College of Computer Science and Engineering Taibah University Medina Saudi Arabia

Social distancing among people is vital in minimizing spread of COVID-19 within community and can be effective in flattening the outbreak. This research work focuses on developing a close contact proximity detection system among smartphone users, particularly of COVID-19 patient, using Bluetooth signal to identify and analyze close contact proximity and social distancing from other anonymous smartphone users in their surroundings. Covering a physical space of six feet, a mandatory safety measure in shopping centers, schools, and other crowded areas, is a social solution advocated by World Health Organization (WHO) officials in this COVID-19. Everyone is concerned about their safety in the COVID-19 environment, so we came up with the concept of producing this new equipment. Most of the time, our attention is drawn to those in front of us and to our sides, but we are unable to keep track of those behind us. The major goal of this project is to keep individuals at a safe distance from one another. PIR sensor is used in this proposed work. Why did the World Health Organization (WHO) put 6 feet as a social distancing? When someone coughs or sneezes, small droplets are spread from the cough or sneeze. If you are in close proximity, you can breathe in those droplets, which may contain the COVID-19 virus, according to the World Health Organization. Vanderbilt University infectious disease expert Dr. William Schaffner said the “6 feet distance” rule comes from studies of respiratory physiology. Schaffner explains that even “without a cough or sneeze, the exhaled air mixes with the surrounding air within a distance of 3 to 6 feet, which is known as the breathing zone.” Schaffner continues: “If you are standing 3 to 6 feet away from me, you may inhale droplets that spread through coughing or sneezing. Of course, if I am infected with the virus, these droplets will contain the virus.”

关键词： Social Distancing COVID-19 Pandemic

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High-Performance Flow Classification of Big Data Using Hybrid CPU-GPU Clusters of Cloud Environments

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Tsinghua Science and Technology 2024年第4期29卷 1118-1137页

作者： Azam Fazel-Najafabadi Mahdi Abbasi Hani H.Attar Ayman amer amir Taherkordi Azad Shokrollahi Mohammad R.Khosravi Ahmed A.Solyman Department of Computer Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13132Jordan Department of Informatics University of OsloOslo 0316Norway Department of Computer Science MalmöUniversityMalmö20506Sweden Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 261100China Department of Electrical and Electronics Engineering NişantaşıUniversityIstanbul 34481742Türkiye

The network switches in the data plane of Software Defined Networking (SDN) are empowered by an elementary process, in which enormous number of packets which resemble big volumes of data are classified into specific flows by matching them against a set of dynamic rules. This basic process accelerates the processing of data, so that instead of processing singular packets repeatedly, corresponding actions are performed on corresponding flows of packets. In this paper, first, we address limitations on a typical packet classification algorithm like Tuple Space Search (TSS). Then, we present a set of different scenarios to parallelize it on different parallel processing platforms, including Graphics Processing Units (GPUs), clusters of Central Processing Units (CPUs), and hybrid clusters. Experimental results show that the hybrid cluster provides the best platform for parallelizing packet classification algorithms, which promises the average throughput rate of 4.2 Million packets per second (Mpps). That is, the hybrid cluster produced by the integration of Compute Unified Device Architecture (CUDA), Message Passing Interface (MPI), and OpenMP programming model could classify 0.24 million packets per second more than the GPU cluster scheme. Such a packet classifier satisfies the required processing speed in the programmable network systems that would be used to communicate big medical data.

关键词： OpenMP Compute Unified Device Architecture(CUDA) Message Passing Interface(MPI) packet classification medical data tuple space algorithm Graphics Processing Unit(GPU)cluster

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Pulsed lavage in joint arthroplasty: A systematic review and metaanalysis

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World Journal of Orthopedics 2024年第3期15卷 293-301页

作者： Mohammad Daher Gaby Haykal Marven Aoun Marc Moussallem Ali Ghoul Jean Tarchichi amer Sebaaly Department of Orthopedics Saint Joseph UniversityBeirut 1001Lebanon

BACKGROUND Knee and hip osteoarthritis affects millions of people around the world and is expected to rise even more in frequency as the population *** arthroplasty is the surgical management of choice in these *** ossi-fication and radiolucent lines formation are two frequent problems faced in hip and knee replacements *** studies show that the usage of pulsed lavage may prevent their *** To compare pulsed lavage to standard lavage in joint *** PubMed,Cochrane,and Google Scholar(page 1-20)were searched till December *** comparative studies were *** clinical outcomes evaluated were the heterotopic ossification formation in hip replacements,radiolucent lines formation,and functional knee scores in knee *** Four studies met the inclusion criteria and were included in this *** lavage was shown to reduce the formation of radiolucent lines(P=0.001).However,no difference was seen in the remaining outcomes CONCLUSION Pulsed lavage reduced the formation of radiolucent lines in knee *** difference was seen in the remaining ***,the clinical significance of these radiolucent lines is poorly *** conducted randomized controlled studies and cost-effectivity studies are needed to reinforce these findings.

关键词： Knee arthroplasty Hip arthroplasty Pulsed lavage Syringe lavage Heterotopic ossification Radiolucent lines

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