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Formation of DNA Strand Breaks in Peripheral Lymphocytes of Rats After Exposure to Natural Sunlight

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Biomedical and Environmental Sciences 2012年第2期25卷 245-249页

作者： Dorival Mendes RODRIGUES-JUNIOR Ana amélia de CARVALHO MELO Benedito Borges da SILVA Pedro Vitor LOPES-COSTA Department of Biology Federal University of Piaui-TeresinaPiauiBrazil Department of Gynecology Federal University of Piaui-TeresinaPiauiBrazil

Objective This paper aims to evaluate the genotoxicity in peripheral blood lymphocytes of rats after exposure to sunlight at different time points of day in a tropical region of Brazil（5oS,42oW）.Materials and Methods Thirty Wistar-Hannover rats,three months old,were randomly divided into three groups of 10 animals each：Group I [control,without exposure to ultraviolet（UV） radiation],Group II（exposed to sunlight during 08：00 *** 10：00 a.m.）,and Group III（exposed to sunlight during 10：00 *** 12：00 a.m.）.After a week of exposure,peripheral blood samples were taken from the tail of these animals to prepare smears on two slides per *** 24 h after exposure to sunlight in Group III,a new collection was obtained to observe the repair *** alkaline comet assay was used in this study to evaluate the genotoxic activity of sunlight（P0.05）.Results There was no statistical difference between Group I and II（P=0.672）.On the other hand,the exposure to sunlight in Group III showed genotoxic action in comparison to the other groups（P0.0001）.Also,there was no significant repair in Group III R（P=0.407）.Conclusion This study has shown a genotoxic potential of sunlight（UVA-B） in lymphocytes of mammals from 10：00 *** 12：00 a.m.,due to a higher intensity of UV in this tropical region.

关键词： Comet assay DNA damage Rats Sunlight Ultraviolet radiation

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Gewachse der Seele

Gewachse der Seele

Impact of enhanced recovery pathways on safety and efficacy of hip and knee arthroplasty:A systematic review and meta-analysis

作者： Herausgeber/editor Wilhelm-Hack-Museum Ludwigshafen am Rhein

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World Journal of Orthopedics 2022年第3期13卷 307-328页

作者： Marion JLF Heymans Nanne P Kort Barbara am Snoeker Martijn GM Schotanus Zuyderland Academy Zuyderland Medical CenterSittard 6155 NHNetherlands Department of Orthopedic Surgery CortoclinicsSchijndel 5482 WNNetherlands Department of Clinical Epidemiology Biostatistics and BioinformaticsAmsterdam Medical CenterUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Orthopaedic Surgery and Traumatology Zuyderland Medical CenterSittard-Geleen 6162 BGLimburgNetherlands Care and Public Health Research Institute Maastricht University Medical CentreFaculty of HealthMedicine&Life SciencesMaastricht 6229 ERLimburgNetherlands

BACKGROUND Over the past decades,clinical pathways(CPs)for hip and knee arthroplasty have been strongly and continuously evolved based on scientific evidence and *** The present systematic review,including meta-analysis,aimed to compare the safety and efficacy of enhanced recovery pathways(ERP)with regular pathways for patients with hip and/or knee *** A literature search in healthcare databases(Embase,PubMed,Cochrane Library,CINAHL,and Web of Science)was conducted from inception up to June *** randomized controlled trials as well as observational studies comparing ERP,based on novel evidence,with regular or standard pathways,prescribing care as usual for hip and/or knee arthroplasty,were *** effect of both CPs was assessed for(serious)adverse events[(S)AEs],readmission rate,length of hospital stay(LoS),clinician-derived clinical outcomes,patient reported outcome measures(PROMs),and financial *** possible,a meta-analysis was *** case of considerable heterogeneity among studies,a qualitative analysis was *** Forty studies were eligible for data extraction,34 in meta-analysis and 40 in qualitative *** total sample size consisted of more than 2 million patients undergoing hip or knee arthroplasty,with a mean age of 66 years and with 60%of *** methodological quality of the included studies ranged from average to *** ERP had lower(S)AEs[relative risk(RR):0.9,95%confidence interval(CI):0.8-1]and readmission rates(RR:0.8,95%CI:0.7-1),and reduced LoS[median days 6.5(0.3-9.5)],and showed similar or improved outcomes for functional recovery and PROMs compared to regular *** analyses for readmission presented a statistically significant difference in the enhanced recovery pathway in favor of knee arthroplasties(P=0.01).ERP were reported to be cost effective,and the cost reduction varied largely between studies(€109 and$20573).The overall outcomes of all studies reported

关键词： Hip arthroplasty Knee arthroplasty Joint arthroplasty Clinical pathway Enhanced recovery pathway Systematic review Meta-analysis

An immunoglobulin Y that specifically binds to an in silico-predicted unique epitope of Zika virus non-structural 1 antigen

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Asian Pacific Journal of Tropical Medicine 2022年第1期15卷 35-43页

作者： Leonardo A.Guevarra Jr Scott Dean P.De Sagon Treena rica D.Teh Maria Katrina Diana MCruz Nikki Cyrill C.Capistrano Austine James Z.Stamaria Laarni Grace M.Corales Leslie Michelle M.Dalmacio Department of Biochemistry and Molecular Biology College of MedicineUniversity of the Philippines ManilaPhilippines Department of Biochemistry Faculty of PharmacyUniversity of Santo TomasPhilippines Research Center for Natural and Applied Sciences University of Santo TomasPhilippines

Objective:To identify unique immunogenic epitopes of Zika virus non-structural 1(NS1)antigen and produce immunoglobulin Y(IgY)for potential use in he diagnosis of of Zika virus ***:Immunogenic epitopes were identified using in silico B-cell epitope prediction.A synthetic peptide analog of the predicted epitope was used to induce antipeptide IgY production in hens which was purified using affinity *** of purified IgY and its binding specificity were performed by gel electrophoresis and ELISA,***:Out of the nine continuous epitopes identified,the sequence at position 193-208(LKVREDYSLECDPAVI)was selected and used to produce anti-peptide *** produced IgY was found to bind to the synthetic analog of the Zika virus NS1 immunogenic epitope but not to other flaviviruses and random peptides from other ***:In this study,we identified an immunogenic epitope unique to Zika virus that can be used to develop a serodiagnostic tool that specifically detect Zika virus infection.

关键词： Immunoglobulin Y IgY B-cell epitope prediction Flavivirus Non-structural 1 antigen Zika virus

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希区柯克论导演方法

电影文学 2002年第5期 70-71页

作者： am

一般人都认为,电影导演只是在摄影棚里,让演员们遵循他的意图去表演。而我不是这样的导演,我有自己的一套工作方法,并且总是在拍摄之前构思好整个计划。有时候,那仅仅是一个未成型的故事,或者是一个吸引人的开端,和一些模糊的情节,到中... 详细信息

一般人都认为,电影导演只是在摄影棚里,让演员们遵循他的意图去表演。而我不是这样的导演,我有自己的一套工作方法,并且总是在拍摄之前构思好整个计划。有时候,那仅仅是一个未成型的故事,或者是一个吸引人的开端,和一些模糊的情节,到中间的部分,加上追逐和历险的场面。有了一个初步的框架之后,要寻找相应的故事内容;或者可以先有素材,然后理出一个线索。在拍摄一部影片之前,我会写出分镜头剧本,在拍摄过程中严格执行剧本中的要求。我把创作分镜头剧本看得同实际拍摄一样重要,但是,后期的剪辑工作不一定要导演亲自把握。大部分电影导演都把剪辑看得非常重要,他们认为一部电影是最后剪出来的。其实,如果剧本设计得十分精确的话,拍摄时再严格把关,最后的剪辑工作就变得简单了。

关键词：导演分镜头剧本摄影机摄影设备演员观众

Catechins Green Tea GMB4 Clone Increases mRNA of ABCA1 through LXR Signaling in Cultured Macrophage Exposed OX-LDL

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Food and Nutrition Sciences 2019年第9期10卷 1179-1190页

作者： Erna Susanti Retty Ratnawati Aulanni’am Aulanni’am Achmad Rudijanto Pharmacy and Food Analysis Academy “Putra Indonesia Malang” Malang Indonesia Doctoral Program of Biomedical Science Medical Faculty Brawijaya University Malang Indonesia

Inhibition of atherogenesis through inhibition of lipid metabolism has not been explored while other inhibitions through inflammation, endothelial dysfunction and free radicals have done. Inhibition of atherogenesis via inhibition of lipid metabolism can be done through the mechanism of Reverse Cholesterol Transport (RCT). Signaling pathways that play a role in this mechanism is LXR signaling. LXR activation by an LXR agonist led increasing cholesterol efflux. Catechins based on bioinformatics study showed as a potent candidate LXR agonists that can be used as an inhibitor of atherogenesis. This study aims to prove that the administration Catechins green tea Clone GMB4 can prevent atherosclerosis through increasing mechanism cholesterol efflux from macrophage by taking effect of ABCA1, ABCG1, SRB1 gene expression in cultured macrophages were exposed ox-LDL. Long-term goals of the outcome of the research are the use of Catechins Green Tea Clones GMB4 as an inhibitor of atherogenesis so that it can be used as a complementary therapy for the treatment of atherosclerosis and cardiovascular diseases. The research is divided into 5 groups, namely the culture of macrophages without exposed ox-LDL, culture exposed ox-LDL and groups of Catechins dose I, II, III. In vitro study showed that administration of Catechins increases mRNA of ABCA1, whereas mRNA ABCG1 and SRB1 decreased at all three doses given. The result of protein profilling was identified a protein with a molecular weight of 70 kDa by SDS-PGE with silver staining.

关键词： Atherogenesis Catechins ABCA1 ABCG1 Dan SRB1 Cultured Macrophage

Management of fistula-in-ano: An introduction

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World Journal of Gastroenterology 2011年第28期17卷 3271-3271页

作者： am El-Tawil Department of Surgery University Hospital BirminghamEast CorridorGround Floor

Peri-anal fistulae are a worldwide health problem that can affect any person *** management of these fistulae is not free from *** and fecal incontinence are the most common complications after *** cumulative personal surgical experience in managing cases with anal fistulae is significantly considered as necessary for obtaining better results with minimal adverse effects after *** purpose for conducting this survey is to facilitate better outcome after surgical interventions in idiopathic anal fistulae’ cases.

关键词： Peri-anal fistulae Surgery Fecal incontinence Recurrence Complications

Adult intussusception caused by cystic lymphangioma of the colon:A rare case report

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World Journal of Gastroenterology 2006年第13期12卷 2130-2132页

作者： Tae Oh Kim Jung Hyun Lee Gwang Ha Kim Jeong Heo Dae Hwan Kang Geun am Song Mong Cho Division of Gastroenterology Department of Internal Medicine College of MedicinePusan National University College of MedicineBusanKorea

We experienced a case of intussusception caused by cystic lymphangioma of the colon in a 32 years old female who was admitted to our hospital for the chief complaint of bloody stool. In the colonoscopic examination, cystic mass with stalk which had smooth mucosal surface was noted at the descending colon. Abdominal ultrasonography and computed tomography revealed left colon intussusception with a multilocular cystic tumor as a leading point. Emergent operation was performed. On the histopathologic examination, the cystically dilated spaces lined by endothelium and septated by fibrous septa were present. The pathological diagnosis was cystic lymphangioma of the colon. Although intussusception due to lymphangioma in an adult are rare, it should be taken into consideration that it is possible diagnosis.

关键词： Cystic lymphangioma of the colon Adult intussusception

Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage

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World Journal of Gastroenterology 2006年第35期12卷 5692-5698页

作者： MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri am amer N Morad A Bener Department of Gastroenterology and Hepatology Hamad Medical Corporation Doha Qatar Department of Immunology Hamad Medical Corporation Doha Qatar Department of Haematology Hamad Medical Corporation Doha Qatar Department of Histopathology Hamad Medical Corporation Doha Qatar Department of Medical Statistics and Epidemiology Hamad Medical Corporation Doha Qatar

AIM： To evaluate pegylated interferon alpha2a （PegIFN-α2a） in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS： A total of 73 nafve patients （61 with history of bilharziasis） with compensated chronic HCV genotype 4 were enrolled into： group A （38 patients） who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B （35 patients） received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS： Significant improvement in both end of treatment response （ETR）（P 〈 0.002） and sustained response （SR）（P 〈 0.05） was noted with pegylated interferon, where ETR was achieved in 29 （76.3%） and 14 patients （40%） in both groups respectively, and 25 patients in group A （65.8%） and 9 （25.7%） in group B could retain negative viraemia by the end of follow up period. Sustained virological response （SVR） showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR （P 〈 0.001）, but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis （grade 3 and 4） with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response between bilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect, both drugs were comparable. CONCLUSION： PegIFN-~2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation.

关键词： Hepatitis C virus Genotype 4 Pegasys Bilharziasis