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Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice

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World Journal of Hepatology 2015年第24期7卷 2551-2558页

作者： Simone Coghetto Acedo Cintia Rabelo e Paiva Caria érica Martins Ferreira Gotardo José Aires Pereira José Pedrazzoli Marcelo Lima Ribeiro Alessandra Gambero Clinical Pharmacology and Gastroenterology Unit Sao Francisco University Medical School

AIM:To study pentoxifylline effects in liver and adipose tissue inflammation in obese mice induced by high-fat diet(HFD).METHODS: Male swiss mice(6-wk old) were fed a highfat diet(HFD; 60% kcal from fat) or AIN-93(control diet; 15% kcal from fat) for 12 wk and received pentoxifylline intraperitoneally(100 mg/kg per day) for the last 14 d. Glucose homeostasis was evaluated by measurements of basal glucose blood levels and insulin tolerance test two days before the end of the protocol. Final body weight was assessed. Epididymal adipose tissue was collected and weighted for adiposity evaluation. Liver and adipose tissue biopsies were homogenized in solubilization buffer and cytokines were measured in supernatant by enzyme immunoassay or multiplex kit, respectively. Hepatic histopathologic analyses were performed in sections of paraformaldehyde-fixed, paraffin-embedded liver specimens stained with hematoxylin-eosin by an independent pathologist. Steatosis(macrovesicular and microvesicular), ballooning degeneration and inflammation were histopathologically determined. Triglycerides measurements were performed after lipid extraction in liver tissue. RESULTS: Pentoxifylline treatment reduced microsteatosis and tumor necrosis factor(TNF)-α in liver(156.3 ± 17.2 and 62.6 ± 7.6 pg/mL of TNF-α for non-treated and treated obese mice, respectively; P aminotransferase levels were also reduced(23.2 ± 6.9 and 12.1 ± 1.6 U/L for nontreated and treated obese mice, respectively; P < 0.05) but had no effect on glucose homeostasis. In obese adipose tissue, pentoxifylline reduced TNF-α(106.1 ± 17.6 and 51.1 ± 9.6 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) and interleukin-6(340.8 ± 51.3 and 166.6 ± 22.5 pg/mL for non-treated and treated obese mice, respectively; P < 0.05) levels; however, leptin(8.1 ± 0.7 and 23.1 ± 2.9 ng/mL for non-treated and treated lean mice, respectively; P < 0.05) and plasminogen activator inhibitor-1(600.2 ± 32.3

关键词： Pentoxifylline Steatosis Obesity Adipose tissue Adipokine Tumor necrosis factor-α

Identification and evaluation of enzymatic ability of fungal endophytes from Citrofortunella microcarpa(Bunge)Wijnands

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Studies in Fungi 2021年第1期6卷 460-468页

作者： Reyes RDC Parayao am Waing KGD Department of Biological Sciences College of ScienceCentral Luzon State University3120 Science City of MuñozNueva EcijaPhilippines

Citrofortunella microcarpa locally known as“kalamansi”belongs to the family Rutaceae is one of the most important marketable fruit crops grown in the *** from being a fruit crop,the plant also houses various endophytic microorganisms which exhibit various symbiotic ***,this study isolated fungal endophytes from *** stem and leaves and were identified culturally and *** identities of the fungal species were confirmed using ITS1 and ITS4 *** identified fungal endophytes were tested for their ability to produce fungal enzymes such as amylase,cellulase,laccase and *** 11 fungal endophytes were isolated from stem and leaves of *** namely,Colletotrichum fructicola,Colletorichum gloeosporioides,Colletotrichum siamense,Fusarium oxysporum,Lasiodiplodia theobromae,Nigrospora oryzae,Nigrospora rubi,Nodulisporium indicum,Phomopsis azadirachtae,Phyllosticta capitalensis,and an unidentified species under the Order *** the identified endophytic fungal species showed production of *** the cellulose assay,four species namely ***,***,***,and the unidentified species had potential for cellulose *** oxysporum and *** were found to be producers of ***,only the unidentified species showed extracellular protease activity.

关键词： enzymes extracellular ITS primers Pleosporales

Review on Partial Discharge Detection Techniques Related to High Voltage Power Equipment Using Different Sensors

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Photonic Sensors 2014年第4期4卷 325-337页

作者： MM YAACOB MA ALSAEDI JR RASHED am DAKHIL SF ATYAH Institute of High Voltage and High Current Faculty of Electrical Engineering Universiti Teknologi Malaysia Department of Electrical Engineering College of Engineering Misan University Iraq

When operating an equipment or a power system at the high voltage, problems associated with partial discharge （PD） can be tracked down to electromagnetic emission, acoustic emission or chemical reactions such as the formation of ozone and nitrous oxide gases. The high voltage equipment and high voltage installation owners have come to terms with the need for conditions monitoring the^process of PD in the equipments such as power transformers, gas insulated substations （GIS）, and cable installations. This paper reviews the available PD detection methods （involving high voltage equipment） such as electrical detection, chemical detection, acoustic detection, and optical detection. Advantages and disadvantages of each method have been explored and compared. The review suggests that optical detection techniques provide many advantages in the consideration of accuracy and suitability for the applications when compared to other techniques.

关键词： PD detection methods power transformer high voltage equipments

High resolution manometric findings in patients with Chagas' disease esophagopathy

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 110-112页

作者： Luciana C Silva Fernando PP Vicentine Fernando am Herbella Department of Surgery Escola Paulista de MedicinaFederal University of Sao PauloSao PauloBrazil

Objective:To describe high resolution manometry features of a population of symptomatic- patients with Chagas’ disease esophagopathy(CDE).Methods:Sixteen symptomatic dysphagic patients with CDE[mean age(54.81±13.43) years,10 women]were included in this *** patients underwent a high resolution ***:Mean lower esophageal sphincter(LES) extension was(3.02±1.17) cm with a mean basal pressure of(15.25±7.00) *** pressure was(14.31±9.19) *** was found in all 16 *** with minimal esophageal pressurization(type I) was present in 25%of patients and achalasia with esophageal compression(type 2) in 75%,according to the Chicago *** esophageal sphincter(UES) mean basal pressure was(97.96±54.22) mmHg with a residual pressure of(12.95±6.42) ***:Our results show that LES was hypotensive or normotensive in the majority of the *** relaxation was found in a minority of our *** was seen in 100%of *** had impaired relaxation in a significant number of patients. Further clinical study is needed to investigate whether manometric features can predict outcomes following the studies of idiopathic achalasia..

关键词： Achalasia Chagas disease High resolution manometry

Soil Macrofaunal Communities are Heterogeneous in Heathlands with Different Grazing Intensity

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Pedosphere 2015年第4期25卷 524-533页

作者： Jean-Franois PONGE Sandrine SALMON amélie BENOIST Jean-Jacques GEOFFROY Muséum National d’Histoire Naturelle CNRS UMR 7179 4 avenue du Petit Chteau 91800 Brunoy (France) Muséum National d’Histoire Naturelle CNRS UMR 7204 4 avenue du Petit Chteau 91800 Brunoy (France)

Moderate grazing by cattle increases the heterogeneity of soil and vegetation. This has been suggested as an ecologically sustainable mean of managing natural environments endangered by tree encroachment, such as heathlands. Our study was performed to test the impact of grazing intensity on soil macroinvertebrate communities in heterogeneous landscapes in a private property eligible to the Natura 2000 European Network of Special Protection Areas within the Brenne Natural Regional Park （Indre, ~rance）. We sampled macroinvertebrates along a broken line crossing 5 different land-use types, from pasture to pine forest, passing through a besom heath （Erica scoparia） heathland at 3 levels of cattle pressure. We hypothesized that： i） litter-dwelling （mostly arthropods and mollusks） and soil-dwelling macroinvertebrates （mostly earthworms） would respond in an opposite manner to various grazing intensities, and ii） intermediate cattle pressure （pastured heath） would increase soil and community heterogeneity. The results supported the first hypothesis, which was explained by land-use impacts mediated by soil properties. However, our results supported only partly the second hypothesis since maximum dissimilarity （whether in the composition of soil macroinvertebrate communities or in soil features） was observed in only one out of the two pastured heaths where cattle pressure was intermediate.

关键词： besom heath cattle grazing heterogeneity land-use types soil macroinvertebrates

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马达加斯加孔子学院汉语教材使用与对策研究

马达加斯加孔子学院汉语教材使用与对策研究

作者：李芊（NAHARISOA rica）燕山大学

学位级别：硕士

自2008年,马达加斯加设立第一所孔子学院以来,汉语教学与学习受到马达加斯加人的广泛关注。马达加斯加汉语学习者日益增多,与此同时,马达加斯加对汉语教材的需求日益提升。汉语教学面临着教材方面的巨大挑战,特别是,选择与马达加斯加汉... 详细信息

自2008年,马达加斯加设立第一所孔子学院以来,汉语教学与学习受到马达加斯加人的广泛关注。马达加斯加汉语学习者日益增多,与此同时,马达加斯加对汉语教材的需求日益提升。汉语教学面临着教材方面的巨大挑战,特别是,选择与马达加斯加汉语学习者适配的汉语教材。然而,对于马达加斯加孔子学院汉语教材编写和使用情况的研究却比较少。主要研究目的是马达加斯加孔子学院现用汉语教材是否能够满足学生汉语学习和教师汉语教学的需求。主要研究问题是:(1)马达加斯加师生对现用汉语教材的满意度如何?(2)从马达加斯加师生的角度来看,汉语教材有哪些不足之处?(3)马达加斯加师生对汉语教材内容有什么需求?(4)如何解决马达加斯加孔子学院现用汉语教材中的问题?为回答以上四个研究问题,我们使用问卷调查收集数据、并使用IBM Statistic SPSS 26和Nvivo 11 plus软件分析定量数据和定性数据。结果表明:教材没有引起学生学习汉语的兴趣,汉语教材不符合学生的需求,教材内容不符合马达加斯加的日常生活、民俗和文化,教材四个语言技能的练习不足,学生对课本的外观也不满意。然而,学生对课本中的词汇和语法难度感到满意。此外,教师认为结构、语法和词汇难度适合马达加斯加汉语学习者;以及缺少教师手册、四个语言技能区分不明确。基于定量数据分析,发现马达加斯加汉语教材奇缺,资源不足。汉语教材的针对性原则、科学性原则、实用性原则有待完善,教材缺乏趣味性原则和目标原则适应。通过定性数据分析,认为教材应该反映马达加斯加国情、风俗文化、当代化马达加斯加生活等。提出如下建议:(1)为解决中文教材资源匮乏问题,建议中马两国出版社合作,编写一本马达加斯加本土化汉语教材。(2)改编或修订现用教材。(3)改进马达加斯加汉语教材编写内容,用马达加斯加语注释,内容编排与情景设置体现中马两国经济、文化特点、时代性和现实性。(4)教材编写应重视网络辅助资源建设,充分利用现代科技,搭建资源共享平台。(5)组织中马教师开展教材研讨,等等。

关键词：马达加斯加孔子学院汉语教材调查分析现存问题对策

Evaluation of angiosuppressive activity of Pleurotus florida on developing chick embryo using chorioallantoic membrane assay

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Studies in Fungi 2021年第1期6卷 334-341页

作者： Zacarias RC Kalaw SP De Leon am Department of Biological Sciences College of ScienceCentral Luzon State UniversityScience City of MuñozNueva EcijaPhilippines Center for Tropical Mushroom Research and Development College of ScienceCentral Luzon State UniversityScience City of MuñozNueva EcijaPhilippines

Angiogenesis is the proliferation of new blood vessels that enable the normal embryonic development and may also induce growth of numerous pathologies like tumor growth and cancer *** assays were used for both pro and anti-angiogenic *** study evaluated the angiosuppressive activity of Pleurotus florida on the developing chick embryo using chorioallantoic membrane(Cam)assay and used destructive sampling into four different treatment concentrations and a *** result revealed a decrease in the number of blood vessels branch points formed after 24,48,and 72 hours at higher treatment concentrations(0.50%and 1%).Statistical analysis showed that 24 hours and 48 hours of exposure to various concentrations have no significant ***,after 72 hours of exposure,the mean blood vessel branch points formed showed a significant difference among the treatment means between the highest concentration of ***(1%)and the control treatment(sterile water).In terms of the percentage of angiosuppressive activity of *** with the greatest angiogenic effect,which was the 1%*** treatment concentration possesses 35.69%and 36.85%angiosuppressive rate after 48 and 72 hours of exposure ***,this study showed that *** lyophilized hot water extract exhibits angiosuppressive activity on the developing chick embryo using chorioallantoic membrane assay and is concentration and time exposure dependent.

关键词： angiogenesis blood vessels destructive sampling embryonic development pathologies

Routine utilization of machine perfusion in liver transplantation:Ready for prime time?

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World Journal of Gastroenterology 2024年第11期30卷 1488-1493页

作者： Alessandro Parente Keyue Sun Philipp Dutkowski am James Shapiro Andrea Schlegel Department of Surgery Division of TransplantationUniversity of Alberta HospitalEdmonton T6G 2B7Canada Immunity and Inflammation Lerner Research InstituteClevelandOH 44195United States Swiss Hepato-Pancreato-Biliary Center Department of Visceral and Transplantation SurgeryUniversity Hospital ZurichZurich 8091Switzerland Immunity and Inflammation Digestive Disease and Surgery InstituteClevelandOH 44195United States

The last decade has been notable for increasing high-quality research and dramatic improvement in outcomes with dynamic liver *** evidence from numerous randomized controlled trials has been pooled by meta-analyses,providing the highest available evidence on the protective effect of machine perfusion(MP)over static cold storage in liver transplantation(LT).Based on a protective effect with less complications and improved graft survival,the field has seen a paradigm shift in organ *** editorial focuses on the role of MP in LT and how it could become the new“gold standard”.Strong collaborative efforts are needed to explore its effects on long-term outcomes.

关键词： Liver transplantation Machine perfusion Viability assessment Hypothermic oxygenated perfusion Normothermic machine perfusion

Descentralization and Citizens Participation

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技术经济与管理研究 2000年第5期 11-14页

作者：ＲｕｂéｎＡｍéｒｉｃｏＭａｒｔí