检索结果-南通市图书馆

Nano Research 2022年第6期15卷 5705-5711页

作者： Wei-Xing Chen Nikolay V.Tkachenko alvaro muñoz-castro Alexander I.Boldyrev Zhong-Ming Sun State Key Laboratory of Elemento-Organic Chemistry Tianjin Key Lab of Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin 300350China Department of Chemistry and Biochemistry Utah State University0300 Old Main HillLoganUT 84322-0300USA Grupo de Química Inorgánicay Materiales Moleculares Facultad de IngenieriaUniversidad Autonoma de ChileEl Llano SubercaseauxSantiago 2801Chile

In this work,we report the synthesis and characterization of two novel Ru-containing Zintl clusters:[Sn_(19){Ru(COD)(en)}_(2)]^(4−)and[Sn_(20){Ru(COD)}_(2)]^(6−).The synthesized compounds not only expand the family of Ru-Sn cluster systems but also shed light on the structure of heterometallic complexes in a previously unknown range of tin *** single-crystal X-ray diffraction(XRD)analysis reveals the dimeric nature of the *** different assembly patterns of the formal[Sn(η^(3)-Sn_(9))]monomer were observed:the dimerization through the vertex fusion process and the direct dimerization through the formation of 2c–2e Sn–Snσ*** both clusters,the density functional theory calculations reveal the locallyσ-aromatic nature of the[Sn(η^(3)-Sn_(9))]monomer resulting in two independent magnetic shielding *** believe that our findings will help the community to further explore the fascinating chemistry of polystannide clusters.

关键词： heterometallic clusters aromaticity polystannide ruthenium Zintl anion

[As_(3)M(As_(3)Pb_(3))]^(3−)(M=Nb,Ta):Ternary Heterometallic Clusters with Early Transition Metal Atoms and Aromatic[Pb_(3)]^(2−)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第7期39卷 1953-1957页

作者： Cong-Cong Shu Lei Qiao alvaro muñoz-castro Zhong-Ming Sun Tianjin Key Lab for Rare Earth Materials and Applications State Key Laboratory of Elemento-Organic ChemistrySchool of Materials Science and EngineeringNankai UniversityTianjin300350 China Grupo de Química Inorgánicay Materiales Moleculares Facultad de IngenieriaUniversidad Autonoma de ChileEl Llano SubercaseauxSantiago2801 Chile

Main observation and conclusion Two ternary clusters,[As_(3)Nb(As_(3)Pb_(3))]^(3−)1 and[As_(3)Ta(As_(3)Pb_(3))]^(3−)2,were directly extracted from“K_(8)NbPbAs_(5)”and“K_(8)TaPbAs_(5)”intermetallic solid in the presence of ethylenediamine and 2.2.2-crypt,*** 1 and 2,comprising an electron-poor early transition metal-atom Nb or Ta coordinated to a As3 triangle and a bowl-like As_(3)Pb_(3).

关键词： Cluster compounds Aromaticity Zintl anions DFT calculation Sandwich structure

Monoclonal antibodies and aptamers:The future therapeutics for Alzheimer’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第7期14卷 2795-2814页

作者： alvaro Barrera-Ocampo Facultad de Ingenierıa Diseno y Ciencias AplicadasDepartamento de Ciencias Farmaceuticas y QuimicasGrupo NaturaUniversidad IcesiCali 760031Colombia

Alzheimer’s disease(AD)is considered the most common and prevalent form of dementia of adult-onset with characteristic progressive impairment in cognition and *** cure for AD has not been found yet and the treatments available until recently were only *** of multidisciplinary approaches and efforts made by pharmaceutical companies,it was only in the past two years that new drugs were approved for the treatment of the *** beta(Ab)immunotherapy is at the core of this therapy,which is one of the most innovative approaches looking to change the course of *** technology is based on synthetic peptides or monoclonal antibodies(mAb)to reduce Ab levels in the brain and slow down the advance of ***,this article reviews the state of the art about AD neuropathogenesis,the traditional pharmacologic treatment,as well as the modern active and passive immunization describing approved drugs,and drug prototypes currently under investigation in different clinical *** addition,future perspectives on immunotherapeutic strategies for AD and the rise of the aptamer technology as a non-immunogenic alternative to curb the disease progression are discussed.

关键词： Ab Monoclonal antibody DNA aptamers Cognitive impairment Alzheimer’s disease Clinical trials Immunotherapy Machine learning

Smoothed particle hydrodynamics based numerical study of hydroplaning considering permeability characteristics of runway surface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第3期18卷 319-333页

作者： Yang YANG Xingyi ZHU Denis JELAGIN alvaro GUARIN Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 200092China Auto Engineering Research Institute BYD Auto Industry Company LimitedShenzhen 518118China Department of Civil and Architectural Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

The presence of water films on a runway surface presents a risk to the landing of *** tire of the aircraft is separated from the runway due to a hydrodynamic force exerted through the water film,a phenomenon called *** a lot of numerical investigations into hydroplaning have been conducted,only a few have considered the impact of the runway ***,computational problems,such as excessive distortion and computing efficiency decay,may arise with such numerical models when dealing with the thin water *** paper presents a numerical model comprising of the tire,water film,and the interaction with the runway,applying a mathematical model using the smoothed particle hydrodynamics and finite element(SPH-FE)*** material properties and geometric features of the tire model were included in the model framework and water film thicknesses from 0.75 mm to 7.5 mm were used in the numerical ***,this work investigated the impacts of both surface texture and the runway *** interaction between tire rubber and the rough runway was analyzed in terms of frictional force between the two *** SPH-FE model was validated with an empirical equation proposed by the National Aeronautics and Space Administration(NASA).Then the computational efficiency of the model was compared with the traditional coupled Eulerian-Lagrangian(CEL)*** on the SPH-FE model,four types of the runway(Flat,SMA-13,AC-13,and OGFC-13)were *** simulation of the asphalt runway shows that the SMA-13,AC-13,and OGFC-13 do not present a hydroplaning risk when the runway permeability coefficient exceeds 6%.

关键词： SPH-FE approach hydroplaning numerical simulation surface texture runway surface reconstruction

multiple scales method for analyzing a forced damped rotational pendulum oscillatorwithgallows

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第5期76卷 58-67页

作者： Haifa A Alyousef alvaro H Salas B M Alotaibi S A El-Tantawy Department of Physics College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia Department of Mathematics and Statistics Universidad Nacional de ColombiaFIZMAKO Research GroupColombia Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt Research Center for Physics(RCP) Department of PhysicsFaculty of Science and ArtsAl-MikhwahAl-Baha UniversityAl-Baha 1988Saudi Arabia

This study reports the analytical solution for a generalized rotational pendulum system with gallows and periodic excited *** multiple scales method(MSM)is applied to solve the proposed *** types of rotational pendulum oscillators are studied and talked about in *** include the forced damped rotating pendulum oscillator with gallows,the damped standard simple pendulum oscillator,and the damped rotating pendulum oscillator without *** MSM first-order approximations for all the cases mentioned are derived in *** obtained results are illustrated with concrete numerical *** first-order MSM approximations are compared to the fourth-order Runge-Kutta(RK4)numerical ***,the maximum error is estimated for the first-order approximations obtained through the MSM,compared to the numerical approximations obtained by the RK4 ***,we conducted a comparative analysis of the outcomes obtained by the used method(MSM)and He-MSM to ascertain their respective levels of *** proposed method can be applied to analyze many strong nonlinear oscillatory equations.

关键词： rotational pendulum system multiple scales method approximate solution damped oscillations forced pendulum with gallows he-multiple scales method

Real-World Evidence in Localized Pancreatic: Coping with Uncertainty in Unselected Populations

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2024年第4期15卷 164-178页

作者： María I. Pamies Ramón Diana Ibarra Anguita Paula Rodríguez Payá alvaro muñoz Abad David Sánchez García María Valero Revert Beatriz Grau Mirete Mariano Martínez Marín Alicia Calero Amaro Lorena Rodríguez Cazalla Javier Gallego Plazas Medical Oncology Department Elche University Hospital Elche (Alicante) Spain General Surgery Department Elche University Hospital Elche (Alicante) Spain General Surgery Department Vega Baja Hospital Orihuela (Alicante) Spain

Background: Localized pancreatic cancer, including resectable (R), borderline resectable (BR) and locally advanced unresectable disease (LAU), is considered in clinical guidelines for diverse treatment options based on clinical trials in selected populations. Hence, exploring with real world evidence (RWE) clinicians’ preferences for treatment options and their results seems pertinent. Methods: In a set of consecutive patients with localized pancreatic cancer assisted in a third level hospital from January 2013 to December 2022, medical records, symptoms, diagnostic process, distribution between subtypes, and treatment plans, with safety and efficacy results, were assessed. Results: A total of 152 patients with localized disease were included (43.4% R, 21.0% BR, 33.6% LAU). The population characteristics exemplified differences between daily practice and clinical trials. Tumor location and symptoms were as expected. Treatment plan was conditioned by PS or comorbidities in 23.0% of patients. In patients with R disease, surgery followed by different adjuvant chemotherapy (CT) regimes was the antineoplastic treatment of choice (64.8%) with efficacy results (OS 37.5 months;95% CI 18.4 - 56.7), in the range of contemporary standards. The common use of neoadjuvant CT for BR disease (94.4%), with surgery in 50% of them, and its results (OS 30.8 months;95% CI 10.5 - 51.2) reflected current controversies of treatment recommendations and evolution in this scenario. Paliative CT with or without radiotherapy was the standard specific treatment in LAU disease (95.1%) with survival results (PFS: 10.8 months;95% CI 8.8 - 12.7. OS: 20.3 months;95% CI 13.5 - 27.2) that justify the distinct character and the specific study of this entity. Conclusion: RWE for localized pancreatic cancer aroused from the analysis of this population confirms the distinct nature of patients assisted in daily practice, as well as mirrors the complexity of decision making in clinical assumptions in which a

关键词： Real-World Evidence Localized Pancreatic Cancer

Pancreatic neuroendocrine tumors:Are tumors smaller than 2 cm truly indolent?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1756-1762页

作者： Sergio Hoyos Pablo Posada-Moreno Natalia Guzman-Arango Romario Chanci-Drago Jaime Chavez alvaro Andrés-Duarte Santiago Salazar-Ochoa Hepatobilary and Liver Transplant Unit Hospital Pablo Tobon Uribe and Gastrohepathology Group Universidad de AntioquiaMedellin 050034AntioquiaColombia Department of General Surgery Universidad Pontificia BolivarianaMedellín 050034AntioquiaColombia

BACKGROUND Pancreatic neuroendocrine tumors(PNETs)are relatively rare but rank as the second most common pancreatic *** can be functional,causing early metabolic disturbances due to hormone secretion,or non-functional and diagnosed later based on tumor size-related *** diagnoses of PNETs under 2 cm in size have sparked debates about their management;some practitioners advocate for surgical removal and others suggest observation due to the tumors’lower potential for ***,it is unclear whether managing these small tumors expectantly is truly *** To evaluate poor prognostic factors in PNETs based on tumor size(>2 cm or<2 cm)in surgically treated *** This cohort study included 64 patients with PNETs who underwent surgical resection between 2006 and 2019 at a high-complexity reference hospital in Medellín,*** assess patient survival,quarterly follow-ups were conducted during the first year after surgery,followed by semi-annual con-sultations at the hospital's hepatobiliary surgery *** variables were described using absolute and relative frequencies,and quantitative variables were expressed using measures of central tendency and their corresponding measures of *** The presence of lymph node involvement,neural involvement,and lymphovascular invasion were all associated with an increased risk of mortality,with hazard ratios of 5.68(95%CI:1.26–25.61,P=0.024),6.44(95%CI:1.43–28.93,P=0.015),and 24.87(95%CI:2.98–207.19,P=0.003),*** involvement and lymphovascular invasion were present in tumors smaller than 2 cm in diameter and those larger than 2 cm in *** recurrence rates between the two tumor groups were furthermore similar:18.2%for tumors smaller than 2 cm and 21.4%for tumors larger than 2 *** survival was additionally comparable between the two tumor *** Tumor size does not dictate prognosis;lymph node and lymphovascular involvement a

关键词： Neuroendocrine tumor Pancreatic neoplasm Pancreas Pancreatic neuroendocrine neoplasm Pancreatic neuroendocrine tumors

Quantum-mechanical effects in photoluminescence from thin crystalline gold films

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第4期13卷 783-794页

作者： Alan R.Bowman alvaro Rodríguez Echarri Fatemeh Kiani Fadil Iyikanat Ted V.Tsoulos Joel D.Cox Ravishankar Sundararaman F.Javier García de Abajo Giulia Tagliabue Laboratory of Nanoscience for Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICFO–Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Born-Institut BerlinGermany. POLIMA–Center for Polariton-driven Light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute for Advanced Study University of Southern DenmarkOdense MDenmark. Department of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. Department of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana de Recerca i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique source of insight into hot carrier processes in metals,including those in plasmonic nanostructures used for sensing and energy ***,being weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly debated,and its potential for unraveling nanoscale carrier dynamics largely ***,we reveal quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold ***,we present experimental evidence,supported by first-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission from electron/hole recombination)when exciting in the interband *** model allows us to identify changes to the measured gold luminescence due to quantum-mechanical effects as the gold film thickness is ***,such effects are observable in the luminescence signal from flakes up to 40 nm in thickness,associated with the out-of-plane discreteness of the electronic band structure near the Fermi *** qualitatively reproduce the observations with first-principles modeling,thus establishing a unified description of luminescence in gold monocrystalline flakes and enabling its widespread application as a probe of carrier dynamics and light-matter interactions in this *** study paves the way for future explorations of hot carriers and charge-transfer dynamics in a multitude of material systems.

关键词： luminescence quantum crystalline

Docking MOF crystals on graphene support for highly selective electrocatalytic peroxide production

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第1期15卷 145-152页

作者： Xiaofeng Huang Peter Oleynikov Hailong He alvaro Mayoral Linqin mu Feng Lin Yue-Biao Zhang School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Chemistry Virginia TechBlacksburgVA 24061USA

Tailoring the reaction kinetics is the central theme of designer electrocatalysts,which enables the selective conversion of abundant and inert atmospheric species into useful *** we show a supporting effect in tuning the electrocatalytic kinetics of oxygen reduction reaction(ORR)from four-electron to two-electron mechanism by docking metalloporphyrin-based metal-organic frameworks(MOFs)crystals on graphene support,leading to highly selective peroxide production with faradaic efficiency as high as 93.4%.A magic angle of 38.1°tilting for the co-facial alignment was uncovered by electron diffraction tomography,which is attributed to the maximization of n-n interaction for mitigating the lattice and symmetry mismatch between MOF and *** facilitated electron migration and oxygen chemisorption could be ascribed to the supportive effect of graphene that disperses of the electron state of the active center,and ultimately regulates rate-determining step.

关键词： metal-organic frameworks nanocomposites support effect oxygen reduction reaction peroxide selectivity

Risk Stratification in Obstetrics: An Integrated Approach to Maternal Health

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Obstetrics and Gynecology 2024年第6期14卷 903-910页

作者： Taina Crespo Mendonca Bianca Beatriz Soares dos Reis Júlia Cruz Coelho Antônio de Oliveira Battistini Pestana Vitória Carolina Barreto Negri alvaro Augusto Trigo Department of Medicine University of Franca Franca Brazil

Introduction: Prenatal care is crucial for maternal and fetal health, highlighting the importance of obstetric risk stratification. This enables personalized care, avoiding unnecessary interventions and reducing costs. Conditions such as first trimester bleeding, spontaneous abortion, gestational trophoblastic disease, and ectopic pregnancy require specific approaches. Early identification of these complications is vital, especially in urgent and emergency obstetric cases, which demand immediate hospital attention. Objective: Comprehensive review of first trimester pathologies and gestational hypertension, focusing on obstetric risks and personalized prenatal management. Methods: Literature review on bleeding and gestational hypertension. Results: The study provides a detailed analysis of pathologies associated with first trimester uterine bleeding and hypertensive disorders, focusing on obstetric risk stratification. The main causes of maternal and fetal mortality are hypertensive disorders, hemorrhages, infections, childbirth complications, and abortion. Spontaneous abortion is common, with different classifications, ranging from threatened to missed abortion. Infected abortion is a severe complication. Brazil has restrictive abortion laws, but many unsafe abortions occur, resulting in high public health costs. Pharmacological treatment with misoprostol is a safe option. Other pathologies include gestational trophoblastic disease, ectopic pregnancy, and placenta previa. Preeclampsia and eclampsia are severe conditions requiring immediate treatment to avoid complications. Conclusion: Early identification and management of obstetric risk factors, such as uterine bleeding, are essential for positive maternal and fetal outcomes. A multidisciplinary approach is fundamental.

关键词： Obstetrics Emergencies Hypertension Pregnancy-Induced Uterine Hemorrhage Pregnancy Trimester First