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Foraging, feeding, and physiological stress responses of wild wood mice to increased illumination and common genet cues

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Current Zoology 2018年第4期64卷 409-417页

作者： alvaro navarro-castilla Isabel BARJA Mario DíAZ Department of Biology Faculty of Sciences Universidad Autónoma de Madrid C/Darwin 2 Campus Universitario de Cantolanco Madrid 28049 Spain Department of Biogeography and Global Change Museo Nacional de Ciencias Naturales CSIC Madrid 28006 Spain

In nature, animals are exposed to a broad range of threats imposed by predators, which may strongly influence the ecology of prey species directly or indirectly by affecting their behavior via fear of predation. Here, we studied wood mice Apodemus sylvaticus behavioral and physiological responses to simulated predation risk. Risk avoidance was analyzed by live trapping with control traps and traps treated with feces of common genet Genetta genetta （direct cue of risk） under new moon nights and following by simulated full moon conditions （indirect cue）. The time devoted to foraging behavior and capture time were analyzed by video recording mice activity around traps. Food intake was calculated based on the amount of bait remaining in each trap. Fecal cortico- sterone metabolites （FCMs） were measured by enzyme-immunoassay as indicators of physio- logical stress responses. Fewer wood mice were captured during full moon, yet only non-breeding adult males clearly avoided common genet odor. Mice were captured sooner at night during the simulated full moon conditions and later in predator-treated traps. Foraging activity was lower when individuals faced predator＇s feces, but neither food intake nor FCM levels were affected by predation risk cues. Direct and indirect cues of predation risk selectively affected wood mice behavior, although behavioral responses seem to be modulated by different costs-benefit balances related to the individual＇s perception of risk. The lack of physiological responses to predation risk cues suggests that wood mice did not perceive them as reliable stressors or the response was too small or transient to be measured by FCM.

关键词： common genet fecal predator cues feeding foraging moonlight predator avoidance

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Validation of ERA5-Land temperature and relative humidity on four Peruvian glaciers using on-glacier observations

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Journal of Mountain Science 2022年第7期19卷 1849-1873页

作者： BONSHOMS Martí UBEDA Jose LIGUORI Giovanni KORNER Philipp navarro alvaro CRUZ Rolando Departamento de Geografía Universidad Complutense de MadridMadrid 28040Spain Guías de Espeleología y Montana Torremocha del Jarama 28189Spain Department of Physics and Astronomy University of BolognaBologna 40127Italy School of Earth Atmosphere and EnvironmentMonash UniversityMelbourne 3800Australia Institute of Hydrology and Meteorology Technische Universitat DresdenDresden 01737Germany ESRI-Espana Madrid 28037Spain Area de Evaluación de Glaciares y Lagunas.Autoridad Nacional del Agua Huaraz 02002Peru

Weather and climate conditions drive the evolution of tropical glaciers which play an important role as water reservoirs for Peruvian inhabitants in the arid coast and semi-arid Andean *** scarcity of long-term high-quality observations over Peruvian glaciers has motivated the extensive use of reanalysis data to describe the climatic evolution of these ***,the representativeness and uncertainties of these reanalysis products over these glaciers are still poorly *** study evaluates the ability of the ERA-Land reanalysis(ERAL)to reproduce hourly and monthly 2 m air temperature and relative humidity(T2m and Rh2m,respectively)over several Peruvian *** compared the ERAL with data from four on-glacier automatic weather stations(AWS),whose hourly time series were completed with nearby stations,for the period January 2017 to December *** indicates a better performance of the reanalysis for T2m(r>0.80)than for Rh2m(~0.4

关键词： ERA5 Land Tropical glaciers Temperature Relative humidity Peru Validation

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Monoclonal antibodies and aptamers:The future therapeutics for Alzheimer’s disease

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2795-2814页

作者： alvaro Barrera-Ocampo Facultad de Ingenierıa Diseno y Ciencias AplicadasDepartamento de Ciencias Farmaceuticas y QuimicasGrupo NaturaUniversidad IcesiCali 760031Colombia

Alzheimer’s disease(AD)is considered the most common and prevalent form of dementia of adult-onset with characteristic progressive impairment in cognition and *** cure for AD has not been found yet and the treatments available until recently were only *** of multidisciplinary approaches and efforts made by pharmaceutical companies,it was only in the past two years that new drugs were approved for the treatment of the *** beta(Aβ)immunotherapy is at the core of this therapy,which is one of the most innovative approaches looking to change the course of *** technology is based on synthetic peptides or monoclonal antibodies(mAb)to reduce Ab levels in the brain and slow down the advance of ***,this article reviews the state of the art about AD neuropathogenesis,the traditional pharmacologic treatment,as well as the modern active and passive immunization describing approved drugs,and drug prototypes currently under investigation in different clinical *** addition,future perspectives on immunotherapeutic strategies for AD and the rise of the aptamer technology as a non-immunogenic alternative to curb the disease progression are discussed.

关键词： Aβ Monoclonal antibody DNA aptamers Cognitive impairment Alzheimer’s disease Clinical trials Immunotherapy Machine learning

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ALPPS versus portal vein embolization for hepatitis B virus-associated hepatocellular carcinoma: a delicate balance between volume and morbidity

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 284-286页

作者： Victor Lopez-Lopez Kohei Miura Asuncion Lopez-Conesa Roberto Brusadin alvaro navarro Ricardo Robles-Campos Department of General Visceral and Transplantation SurgeryClinic and University Hospital Virgen de La ArrixacaIMIB-ARRIXACAEl PalmarMurciaSpain Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental SciencesNiigataJapan

We have read with great interest the recent study published by Li et al.,entitled“Associating liver partition and portal vein ligation for staged hepatectomy versus sequential transarterial chemoembolization and portal vein embolization in staged hepatectomy for HBV-related hepatocellular carcinoma:a randomized comparative study”(1).

关键词： Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) portal vein embolization(PVE) hepatocellular carcinoma(HCC) Hepatitis B

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Simultaneous pars plana vitrectomy,panretinal photocoagulation,cryotherapy,and Ahmed valve implantation for neovascular glaucoma

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1396-1401页

作者： Carolina Bernal-Morales Marina Dotti-Boada alvaro Olate-Perez Manuel J.navarro-Angulo Laura Pelegrín Marc Figueras-Roca Institut Clínic d’Oftalmologia(ICOF) Hospital ClínicBarcelona 08028Spain August Pi i Sunyer Biomedical Research Institute(IDIBAPS) Barcelona 08028Spain

AIM:To describe and evaluate the efficacy of Ahmed glaucoma valve implantation(AGV)combined with pars plana vitrectomy(PPV)in a single surgical act for the treatment of advanced neovascular glaucoma(NVG).METHODS:Retrospective observational case series included 51 eyes from 50 patients with severe NVG treated with PPV,AGV,and panretinal photocoagulation and/or cryotherapy in a single surgical act during a 13-year period(2005-2018).Preoperative,intraoperative and postoperative data at day 1 and months 1,3,6,21,and 24 were systematically *** of surgical success was stablished at IOP between 6 and 21 mm Hg with or without topical ***:Main indications for surgery were NVG secondary to proliferative diabetic retinopathy(39.2%)and central retinal vein occlusion(37.3%).Mean(±SD)preoperative IOP was 42.0±11.2 mm Hg decreasing to 15.5±7.1 mm Hg at 12 mo and 15.8±9.1 mm Hg at 24 mo of follow *** incidence of success of IOP control was 76.0%at first postoperative month,reaching 88.3%at 6 *** of successful IOP control at long term was 74.4%at 12 mo and 71.4%at 24 *** evisceration for unsuccessful NVG management was required in 1 case(2.0%).CONCLUSION:Combination of AGV implantation and PPV in a single act may be a suitable option for severe forms of NVG in a case-by-case basis for effective IOP control and a complete panretinal photocoagulation.

关键词： neovascular glaucoma Ahmed valve pars plana vitrectomy panretinal photocoagulation cryotherapy

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Smoothed particle hydrodynamics based numerical study of hydroplaning considering permeability characteristics of runway surface

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 319-333页

作者： Yang YANG Xingyi ZHU Denis JELAGIN alvaro GUARIN Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 200092China Auto Engineering Research Institute BYD Auto Industry Company LimitedShenzhen 518118China Department of Civil and Architectural Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

The presence of water films on a runway surface presents a risk to the landing of *** tire of the aircraft is separated from the runway due to a hydrodynamic force exerted through the water film,a phenomenon called *** a lot of numerical investigations into hydroplaning have been conducted,only a few have considered the impact of the runway ***,computational problems,such as excessive distortion and computing efficiency decay,may arise with such numerical models when dealing with the thin water *** paper presents a numerical model comprising of the tire,water film,and the interaction with the runway,applying a mathematical model using the smoothed particle hydrodynamics and finite element(SPH-FE)*** material properties and geometric features of the tire model were included in the model framework and water film thicknesses from 0.75 mm to 7.5 mm were used in the numerical ***,this work investigated the impacts of both surface texture and the runway *** interaction between tire rubber and the rough runway was analyzed in terms of frictional force between the two *** SPH-FE model was validated with an empirical equation proposed by the National Aeronautics and Space Administration(NASA).Then the computational efficiency of the model was compared with the traditional coupled Eulerian-Lagrangian(CEL)*** on the SPH-FE model,four types of the runway(Flat,SMA-13,AC-13,and OGFC-13)were *** simulation of the asphalt runway shows that the SMA-13,AC-13,and OGFC-13 do not present a hydroplaning risk when the runway permeability coefficient exceeds 6%.

关键词： SPH-FE approach hydroplaning numerical simulation surface texture runway surface reconstruction

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Implicit large eddy simulation of unsteady cloud cavitation around a plane-convex hydrofoil

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Journal of Hydrodynamics 2015年第6期27卷 815-823页

作者： HIDALGO Victor 罗先武 ESCALER Xavier 季斌 AGUINAGA alvaro Beijing Key Laboratory of CO2 Utilization and Reduction Technology Tsinghua University CDIF Universitat Politècnica de Catalunya School of Power and Mechanical Engineering Wuhan University Mechanical Engineering Department Escuela Politecnica Nacional University

The present paper focuses on the erosive cavitation behavior around a plane convex hydrofoil. The Zwart-Gerber-Belamri cavitation model is implemented in a library form to be used with the OpenFOAM. The implicit large eddy simulation （ILES） is app- lied to analyze the three-dimensional unsteady cavitating flow around a plane convex hydrofoil. The numerical results in the cases under the hydrodynamic conditions, which were experimentally tested at the high speed cavitation tunnel of the l^cole Polytechnique F6d＆ale de Lausanne （EPFL）, clearly show the sheet cavitation development, the shedding and the collapse of vapor clouds. It is noted that the cavitation evolutions including the maximum vapor length, the detachment and the oscillation frequency, are captured fairly well. Furthermore, the pressure pulses due to the cavitation development as well as the complex vortex structures are reasona- bly well predicted. Consequently, it may be concluded that the present numerical method can be used to investigate the unsteady cavitation around hydrofoils with a satisfactory accuracy.

关键词： implicit large eddy simulation (ILES) unsteady partial cavitation Zwart-Gerber-Belamri cavitation model OpenFOAM,Q - criterion

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Sizing and Siting of Battery Energy Storage Systems:A Colombian Case

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Journal of Modern Power Systems and Clean Energy 2022年第3期10卷 700-709页

作者： alvaro Avendano Pena David Romero-Quete Camilo A.Cortes Department of Electrical and Electronics Engineering Universidad Nacional de ColombiaBogotaColombia

This paper presents a mixed-integer linear programming(MILP)formulation for sizing and siting of battery energy storage systems(BESSs).The problem formulation seeks to minimize both operation costs and BESS *** proposed model includes restrictions of the conventional securityconstrained unit commitment problem,a piece-wise linear approximation to model power losses,and a linear model of hydro generation *** proposed model is tested in a 6-bus test system and a 15-bus system representing the Colombian power *** the two studied systems,simulation results show that the reduction of operation costs due to the installation of BESSs compensates the investments,under some of the considered technical cost ***,results show that adequate sizing and siting of BESSs reduce renewable energy curtailment in the Colombian power system with high penetration of fluctuating renewable generation.

关键词： Battery energy storage curtailment sizing and siting renewable energy

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Phenotypic variation in food utilization in an outbreak insect herbivore

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Insect Science 2018年第3期25卷 467-474页

作者： Roberto Quezada-Garcia alvaro Fuentealba Eric Bauce Faculté de Foresterie Géographie et Géomafique Département des Sciences du Bois et de la Forêt Centre d'Etude de la Forêt (CEF) Universite Laval Quebec City Quebec Canada

The effects of nutrition may have subtantial impact on insect evolution by shaping different components of phenotypes. The key to undestanding this evolutionary process is to know how nutritional condition affects additive and nonadditive components of the phenotype. However, this is poorly understood in outbreaking insects. We investigated the additive and nonadditive variation present in food utilization traits in spruce budworm individuals subjected to chronic nutritional stress. A total of 160 full-sib families of spruce budworm （Choristoneurafumiferana Clem.） were raised under laboratory condi- tions, feeding on 2 diets （high and low energy） during 3 generations. Variables tested were pupal mass, consumption rate （RCR）, growth rate （RGR）, approximate digestibility （AD）, the efficiency of conversion of digested food （ECD） and the efficiency of conversion of ingested food （ECI）. Our results show that all traits tested presented a high percentage of nonadditive effects that modulate phenotype expression. We found a significant impact of family × diet interaction on pupal mass, RGR and ECD. Furthermore, these traits exhib- ited the greatest heritability. There was no evidence of presence of maternal effects. The results revealed that food utilization traits may evolve through epigenetics effects, such as phenotypic plasticity. This information can be used by modellers to improve forecast of spruce budworm population dynamics.

关键词： food utilization nutritional stress phenotypic plasticity spruce budworm

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New insights on cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2010年第3期2卷 136-145页

作者： Manuela Gatto Domenico alvaro Division of Gastroenterology Department of Clinical MedicineUniversity of Rome"Sapienza"Polo Pontino

Cholangiocarcinoma(CCA) is a devastating cancer arising from the neoplastic transformation of the biliary *** is characterized by a progressive increase in incidence and *** only curative therapy is radical surgery or liver transplantation but,unfortunately,the majority of patients present with advanced stage disease,which is not amenable to surgical ***,proposed serum and bile biomarkers could help in the screening and surveillance of categories at risk and in diagnosing CCA at an early *** molecular mechanisms triggering neoplastic transformation and growth of biliary epithelium are still undef ined,but signif icant progress has been achieved in the last few *** review deals with the most recent advances on epidemiology,biology,and clinical management of CCA.

关键词： Cholangiocarcinoma Cholangiocytes Growth factors Proliferation Apoptosis

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