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Clinical importance of serum procalcitonin in ulcerative colitis patients

World Journal of Gastroenterology 2014年第42期20卷 15941-15942页

作者： Ergenekon Karagoz alpaslan tanoglu Department of Infectious Diseases and Clinical Microbiology GATA Haydarpasa Training Hospital Department of Gastroenterology GATA Haydarpasa Training Hospital

We have read with interest the recently published article entitled “Clinical significance of serum procalcitonin in patients with ulcerative colitis” by Koido et al. They aimed to investigate the association of procalcitonin with ulcerative colitis (UC) activity. They concluded that elevated procalcitonin levels were significantly correlated with UC activity. We would like to thank the authors for their comprehensive contribution.

关键词： Procalcitonin Ulcerative colitis Clinical significance Disease activity Remission phase

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Is the neutrophil to lymphocyte ratio associated with liver fibrosis in patients with chronic hepatitis B?

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World Journal of Gastroenterology 2015年第18期21卷 5575-5581页

作者： Murat Kekilli alpaslan tanoglu Yusuf Serdar Sakin Mevlut Kurt Serkan Ocal Sait Bagci Department of Gastroenterology Hitit University Corum Training and Research Hospital Department of Gastroenterology GATA Haydarpasa Training Hospital Department of Gastroenterology Gulhane Military Medical Academy School of Medicine Department of Gastroenterology Abant ?zzet Baysal Faculty of Medicine Training and Research Hospital

AIM: To determine the association between the neutrophil to lymphocyte(N/L) ratio and the degree of liver fibrosis in patients with chronic hepatitis B(CHB) infection. METHODS: Between December 2011 and February 2013, 129 consecutive CHB patients who were admitted to the study hospitals for histological evaluation of chronic hepatitis B-related liver fibrosis were included in this retrospective study. The patients were divided into two groups based on the fibrosis score: individuals with a fibrosis score of F0 or F1 were included in the "no/minimal liver fibrosis" group, whereas patients with a fibrosis score of F2, F3, or F4 were included in the "advanced liver fibrosis" group. The Statistical Package for Social Sciences 18.0 for Windows was used to analyze the data. A P value of < 0.05 was accepted as statistically ***: Three experienced and blinded pathologists evaluated the fibrotic status and inflammatory activity of 129 liver biopsy samples from the CHB patients. Following histopathological examination, the "no/minimal fibrosis" group included 79 individuals, while the "advanced fibrosis" group included 50 individuals. Mean(N/L) ratio levels were notably lower in patients with advanced fibrosis when compared with patients with no/minimal fibrosis. The mean value of the aspartate aminotransferase-platelet ratio index was markedly higher in cases with advanced fibrosis compared to those with no/minimal ***: Reduced levels of the peripheral blood N/L ratio were found to give high sensitivity, specificity and predictive values in CHB patients with significant fibrosis. The prominent finding of our research suggests that the N/L ratio can be used as a novel noninvasive marker of fibrosis in patients with CHB.

关键词： Chronic hepatitis B Liver fibrosis Neutrophil to lymphocyte ratio Fibrotic stage Inflammatory activity Non-invasive marker

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Healing Effects of Omalizumab in a Patient with Cholinergic Urticaria Associated Severe Dyspeptic Complaints

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Chinese Medical Journal 2015年第11期128卷 1559-1560页

作者： Ali Kutlu alpaslan tanoglu Sami Ozturk Department of Immunologv and Allerqy GATA Haydarpasa Training Hospital 34668 Uskudar Istanbul Turkey Department of Gastroenterology GATA Haydarpasa Training Hospital 34668 Uskudar Istanbul Turkey

To the Editor： Cholinergic urticaria （CU） is a type of physical urticaria characterized by a number of short-lasting, highly pruritic weals. The underlying pathological mechanism of CU is not fully understood. Omalizumab is a humanized, monoclonal IgG anti-lgE antibody that binds specifically to circulating lgE molecules, thus interrupting the allergic cascade, The efficacy of anti-lgE treatment has been shown in many disorders with complex and unclear etiology, comprising physical urticarias, chronic idiopathic urticaria, angioedema and eosinophil-associated gastrointestinal disorders.

关键词：抗体单克隆免疫球蛋白E 免疫球蛋白G 铜血管性水肿胰岛素荨麻疹

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