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Infectious causation of chronic disease:Examining the relationship between Giardia lamblia infection and irritable bowel syndrome

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World Journal of Gastroenterology 2007年第34期13卷 4574-4578页

作者： Alice S Penrose Eden v Wells allison E Aiello Preventive Medicine University of Michigan Ann Arbor MI 48109-2029 United States Michigan Department of Community Health Lansing MI United States Department of Epidemiology University of Michigan Ann Arbor MI 48109-2029 United States

AIM: To evaluate whether a higher prevalence of Giardia lamblia infection is associated with an increase in irritable bowel syndrome (IBS) prescriptions at the county level in Michigan. METHODS: The Michigan Disease Surveillance System (MDSS) was used to ascertain both the numbers of Giardia lamblia infections as well as the total number of foodborne illnesses per population by county in Michigan during 2005. This was compared with Blue Cross Blue Shield (BCBS) of Michigan numbers of drug prescriptions for IBS per one thousand members per county in 2005. These data were also analyzed for associations with per capita income by county and the number of refugees entering each county in 2005. RESULTS: There were a total of 786 confirmed cases of Giardia lamblia reported to MDSS in 2005. During the same time period, the number of prescriptions for IBS varied from 0.5 per 1000 members up to 6.0 per 1000 members per month. There was no trend towards higher numbers of IBS prescriptions in the counties with more Giardia lamblia infections. Per capita income was not associated with either IBS prescriptions or Giardiasis. There was a significant linear association between the number of refugees entering each county, and the number of Giardia lamblia cases per 100 000 population. CONCLUSION: In this ecological study, there was no association found between BCBS prescriptions for IBS and Giardia lamblia infections in Michigan counties. Our findings may have been influenced by the disparate number of refugees admitted per county.

关键词： Foodborne Gastrointestinal Giardia lamblia Irritable bowel syndrome Parasite Prescription Refugees

ILLUMINATION AND EXPOSITION OF A CONvEX n-DIMENSIONAL BODY DEPENDING ON ITS SHARPNESS

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Acta Mathematica Scientia 2002年第2期22卷 189-198页

作者： Boris v. Dekster Mathematics, Mount allison University, Sackville, N.B. EOA 3C0, Canada Mathematics Mount Allison University Sackville N.B. E0A 3C0 Canada

A convex n-body C is said to be exposable to a set D of a few directions if there is a linear transformation L : En → En such that L(C) arid each body isometric to L(C) is illuminated by D. Denote by En the minimum integer such that each C is exposable to a (fixed) set D of cardinality En. An upper bound for En is established here.

关键词： Covering illumination Hadwiger conjecture

心脏磁共振评估肾素-血管紧张素-醛固酮系统的心血管相互作用：动脉粥样硬化的多种族研究

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中华高血压杂志(中英文) 2024年第6期32卷 600-600页

作者： varadarajan v Marques MD venkatesh BA allison M Ostovaneh MR Yoneyama K Donekal S Shah Rv Murthy vL Wu CO Tracy RP Ouyang P Rochitte EC Bluemke DA Lima JAC 袁源练桂丽

小型研究已描述了肾素-血管紧张素-醛固酮系统在心血管系统中的作用。该研究旨在探讨醛固酮和血浆肾素活性（plasma renin activity,PRA）与心血管结构和功能的关系。方法：研究者评估在2003-2005年进行醛固酮和PRA检测，并在2010年接...

小型研究已描述了肾素-血管紧张素-醛固酮系统在心血管系统中的作用。该研究旨在探讨醛固酮和血浆肾素活性（plasma renin activity,PRA）与心血管结构和功能的关系。方法：研究者评估在2003-2005年进行醛固酮和PRA检测，并在2010年接受心脏磁共振检查的动脉粥样硬化多种族研究参与者的随机样本。排除服用血管紧张素转换酶抑制药或血管紧张素受体阻滞药的参与者。结果：醛固酮组615例，平均年龄（61.6±8.9）岁；肾素组580例，平均年龄（61.5±8.8）岁，两组女性占比均约50%。

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Poriferan chitin as a template for hydrothermal zirconia deposition

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Frontiers of Materials Science 2013年第3期7卷 248-260页

作者： Marcin WYSOKOWSKI Mykhaylo MOTYLENKO vasilii v. BAZHENOv Dawid STAWSKI lroslav PETRENKO Andre EHRLICH Thomas BEHM Zoran KLJAJIC allison L. STELLING Teofil JESIONOWSKI Hermann EHRLICH Institute of Chemical Technology and Engineering Poznan University of Technology 60965 Poznan Poland Institute of Materials Science TU Bergakademie Freiberg D-09599 Freiberg Germany Institute of Experimental Physics TU Bergakademie Freiberg 09599 Freiberg Germany Department of Commodity and Material Sciences and Textile Metrology Technical University of Lodz 90924 Lodz Poland Institut fur Eisenund Stahltechnologie TU Bergakademie Freiberg 09599 Freiberg Germany Institute of Mineralogy TU Bergakademie Freiberg 09599 Freiberg Germany Institute of Marine Biology University of Montenegro 85330 Kotor Montenegro Department of Mechanical Engineering and Materials Science Duke University 27708 Durham NC USA

Chitin is a thermostable biopolymer found in various inorganic-organic skeletal structures of numerous invertebrates including sponges （Porifera）. The occurrence of chitin within calcium- and silica-based biominerals in organisms living in extreme natural conditions has inspired development of new （extreme biomimetic） synthesis route of chitin-based hybrid materials in vitro. Here, we show for the first time that 3D-a-chitin scaffolds isolated from skeletons of the marine sponge Aplysina aerophoba can be effectively mineralized under hydrothermal conditions （150℃） using ammonium zirconium（Iv） carbonate as a precursor of zirconia. Obtained chitin-ZrO2 hybrid materials were characterized by FT-IR, SEM, HRTEM, as well as light and confocal laser microscopy. We suggest that formation of chitin-ZrO2 hybrids occurs due to hydrogen bonds between chitin and ZrO2.

关键词： chitin biocomposite zirconia hydrothermal synthesis ammonium zirco-nium carbonate

PRISMS-Fatigue computational framework for fatigue analysis in polycrystalline metals and alloys

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npj Computational Materials 2021年第1期7卷 349-360页

作者： Mohammadreza Yaghoobi Krzysztof S.Stopka Aaditya Lakshmanan veera Sundararaghavan John E.allison David L.McDowell Materials Science and Engineering University of MichiganAnn ArborMIUSA Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGAUSA Aerospace Engineering University of MichiganAnn ArborMIUSA School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGAUSA

The PRISMS-Fatigue open-source framework for simulation-based analysis of microstructural influences on fatigue resistance for polycrystalline metals and alloys is presented *** framework uses the crystal plasticity finite element method as its microstructure analysis tool and provides a highly efficient,scalable,flexible,and easy-to-use ICME community *** PRISMS-Fatigue framework is linked to different open-source software to instantiate microstructures,compute the material response,and assess fatigue indicator *** performance of PRISMS-Fatigue is benchmarked against a similar framework implemented using *** indicate that the multilevel parallelism scheme of PRISMS-Fatigue is more efficient and scalable than ABAQUS for large-scale fatigue *** performance and flexibility of this framework is demonstrated with various examples that assess the driving force for fatigue crack formation of microstructures with different crystallographic textures,grain morphologies,and grain numbers,and under different multiaxial strain states,strain magnitudes,and boundary conditions.

关键词： fatigue alloys grain

压铸过程中铸件-铸型界面换热系数与铸件凝固速率的关系

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金属学报 2009年第1期45卷 102-106页

作者：郭志鹏熊守美 Mei Li John allison 清华大学机械工程系先进成形制造教育部重点实验室北京100084 Research ＆ Advanced Engineering Department Scientific Research Laboratory Ford Motor Company Dearborn MI 48121 USA

在实际压铸实验的基础上,求解了铸件-铸型界面换热系数h与铸件凝固速率v的关系.结果表明,二者呈线性变化关系:h=k_(h-v)·v+ω(其中,斜率k_(h-v)为铸型初始表面温度及铸件厚度的函数,ω为常数);通过线性拟合确定k_(h-v)和ω值,从而确立... 详细信息

在实际压铸实验的基础上,求解了铸件-铸型界面换热系数h与铸件凝固速率v的关系.结果表明,二者呈线性变化关系:h=k_(h-v)·v+ω(其中,斜率k_(h-v)为铸型初始表面温度及铸件厚度的函数,ω为常数);通过线性拟合确定k_(h-v)和ω值,从而确立换热系数与铸件凝固速率的关系.这种关系同时适用于镁合金AM50和铝合金ADC12.

关键词：压铸界面换热系数凝固速率镁合金AM50 铝合金ADC12

Post-COvID recovery and renewal through whole-of-society resilience in cities

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Journal of Safety Science and Resilience 2022年第3期3卷 222-228页

作者： Andrew G.McClelland Roisin Jordan Szymon Parzniewski Duncan shaw Nat O’Grady David Powell Alliance Manchester Business School University of ManchesterManchester M139PLUK Alliance Manchester Business School Humanitarian&Conflict Response InstituteUniversity of ManchesterManchester M139PLUK Humanitarian&Conflict Response Institute University of ManchesterManchester M139PLUK

This paper explores and extends understanding of the role and significance of whole-of-society resilience pro-grammes that support cities when dealing with complex crises,like the COvID-19 *** the complexity of whole-of-society resilience as different actors locally shape it,we ask the question:How can collab-oration between formal and informal resilience practices help to enhance resilience across the‘whole-of-society’?We answer this question by reviewing the importance of whole-of-society resilience and its complexity in a city’s governance of the COvID-19 *** argue that the necessity of renewing approaches to building lo-cal resilience capabilities across the whole-of-society requires synchronisation across and between formal and informal approaches-that is,“bottom-up”and governmental initiatives-to meet the diverse needs of ***,we detail two recent practice-orientated initiatives that have taken a renewal approach to building resilience through the involvement of whole-of-society in planning recovery from COvID-19 using in-ternational standard ISO/TS 22393;and a new initiative called the National Consortium for Societal Resilience[UK+].Finally,we signpost a set of critical questions for whole-of-society resilience practice.

关键词： Whole-of-society resilience Crisis Recovery Renewal Cities,COvID-19

Memories of Donald ***:Mentor and seismologist extraordinaire

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Earthquake Science 2022年第1期35卷 19-21页

作者： allison Bent Natural Resources Canada 7 Observatory Cres. OttawaOntario K1A 0Y3Canada

I grew up in one of the most aseismic regions of the planet but decided as a child that I wanted to be a *** all the naysayers who claimed that no one really did that for a living and who told me I should choose something sensible like neurosurgery or engineering,I showed up at the Caltech Seismo Lab in the summer of 1985.I arrived equipped with the right skills but,as I quickly learned,no real knowledge of the breadth of seis-mological *** day one I made the usual rounds of the faculty and soon thereafter began working on a project relocating earthquakes of a swarm in the Coso region.

关键词： planet something equipped

Mechanism of the Rpn13-induced activation of Uch37

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Protein & Cell 2014年第8期5卷 616-630页

作者： Lianying Jiao Songying Ouyang Neil shaw Gaojie Song Yingang Feng Fengfeng Niu Weicheng Qiu Hongtao Zhu Li-Wei Hung Xiaobing Zuo v. Eleonora Shtykova Ping Zhu Yu-Hui Dong Ruxiang Xu Zhi-Jie Liu National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China iHuman Institute ShanghaiTech University Shanghai 201210 China Shandong Provincial Key Laboratory ofEnergy-Genetics Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of Sciences Qingdao 266101 China Physics Division 'Los Alamos National Laboratory Los Alamos NM 87545 USA X-ray Science Division Argonne National Laboratory 9700 South Cass Avenue Argonne IL 60439 USA Institute of Crystallography~ Russian Academy of Sciences 59 Leninsky Pr. 117333 Moscow Russian Federation Center for Multi-disciplinary Research Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049China Department of Nerosurgery The Military General Hospital of Beijing PLA Beijing 100700 China

Uch37 is a de-ubiquitinating enzyme that is activated by Rpn13 and involved in the proteasomal degradation of proteins. The full-length Uch37 was shown to exhibit low iso-peptidase activity and is thought to be auto-inhibited. Structural comparisons revealed that within a homo- dimer of Uch37, each of the catalytic domains was blocking the other＇s ubiquitin （Ub）-binding site. This blockage likely prevented Ub from entering the active site of Uch37 and might form the basis of auto-inhibition. To understand the mode of auto-inhibition clearly and shed light on the activation mechanism of Uch37 by Rpn13, we investigated the Uch37-Rpn13 complex using a combi- nation of mutagenesis, biochemical, NMR, and small- angle X-ray scattering （SAXS） techniques. Our results also proved that Uch37 oligomerized in solution and had very low activity against the fluorogenic substrate ubi- quitin-7-amino-4-methylcoumarin （Ub-AMC） of de-ubiq- uitinating enzymes. Uch37AHb＇Hc＇KEKE, a truncation removal of the C-terminal extension region （residues 256- 329） converted oligomeric Uch37 into a monomeric form that exhibited iso-peptidase activity comparable to that of a truncation-containing the Uch37 catalytic domain only. We also demonstrated that Rpn13C （Rpn13 residues 270- 407） could disrupt the oligomerization of Uch37 by sequestering Uch37 and forming a Uch37-Rpn13 com- plex. Uch37 was activated in such a complex, exhibiting 12-fold-higher activity than Uch37 alone. Time-resolved SAXS （TR-SAXS） and FRET experiments supported the proposed mode of auto-inhibition and the activation mechanism of Uch37 by Rpn13. Rpn13 activated Uch37 by forming a 1：1 stoichiometric complex in which the active site of Uch37 was accessible to Ub.

关键词： Uch37-Rpn13 complex de-ubiquitination,SAXS analysis oligomerization iso-peptidase