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journal of Pharmacy and Pharmacology 2014年第10期2卷 621-626页

作者： jeannie L. Poon allison C. Brenner Michael j. Brenner Veterans Affairs Ann Arbor Healthcare System Ann Arbor 48105 MI USA

Objective： To assess whether adherence to amiodarone monitoring differed pre- and post-amiodarone restriction template and implementation of the pharmacist-managed clinic. Design： This was a retrospective chart review study. Setting： A large, academically-affiliated Veteran Affairs Healthcare System providing primary and tertiary care. Patients： 580 patients were identified as having an active prescription for amiodarone for at least 60 days from january l, 2009 to August 31, 2013 and receiving primary care at the VAAHS （Veterans Affairs Ann Arbor Healthcare System）. Results： Nearly all patients had TSH and LFTs at baseline regardless of study group. Significant associations between baseline rates for CXR, ECG, PFT, and opbthalmologic exams were found, with higher rates in the clinic and template arms compared to usual care. Similar patterns for all monitoring outcome rates were also found for both the 6- and 12-month measures. Conclusions： Patients on amiodarone who are followed by a pharmacist-managed clinic or where a restricted ordering template was used had increased compliance with amiodarone monitoring guidelines compared to usual care. Use of a restricted template may be a reasonable option in place of a pharmacist-managed service.

关键词： Amiodarone pharmacist-managed monitoring Veterans Affairs usual care electronic template.

Re: Errors in Zhao et al(2015), Impact of enteral nutrition on energy metabolism in patients with Crohn's disease

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World journal of Gastroenterology 2016年第9期22卷 2867-2868页

作者： Kathryn A Kaiser Brandon j George david B allison Office of Energetics School of Public Health University of Alabama at Birmingham

We report invalidating errors related to the statistical approach in the analysis and data inconsistencies in a published single cohort study of patients with Crohn's disease. We provide corrected calculations from the available data and request that a corrected analysis be provided by the authors. These errors should be corrected.

关键词： statistical error differences in nominal significance data inconsistency

Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis

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World journal of Orthopedics 2022年第7期13卷 631-643页

作者： Ian S Hong allison j Rao Tyler L CarlLee joshua D Meade Daniel j Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor james E Fleischli Bryan Michael Saltzman Department of Orthopedic Surgery Atrium Health Musculoskeletal InstituteCharlotteNC 28207United States Department of Sports Medicine Orthocarolina Research InstituteCharlotteNC 28207United States Department of Orthopedic Surgery Columbia University Irving Medical CenterNew York CityNY 10032United States Department of Orthopaedic Surgery Carolinas Medical CenterCharlotteNC 28207United States Department of Orthopedic Surgery OrthoCarolina Sports Medicine CenterCharlotteNC 28207United States

BACKGROUND Rotator cuff pathology is a very common source of shoulder ***,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar *** management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of *** To evaluate if a relationship exists between outcomes of RCR in the setting of *** This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between *** were stratified based on rotator cuff tear size and glenohumeral osteoarthritis *** were paired 1:1 with patients without glenohumeral *** included had a minimum two year *** of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were *** A total of 142 patients were *** number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without *** rotator cuff repair,both groups showed favorable patientreported *** Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis.

关键词： Rotator cuff repair Rotator cuff tear Glenohumeral osteoarthritis Shoulder Arthroscopic Outcomes

Plasma-polymerized pericyte patches improve healing of murine wounds through increased angiogenesis and reduced inflammation

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Regenerative Biomaterials 2021年第4期8卷 21-32页

作者： Hannah M.Thomas Parinaz Ahangar Robert Fitridge Giles T.S.Kirby Stuart j.Mills allison j.Cowin Future Industries Institute University of South AustraliaMawson Lakes SA 5095Australia Cell Therapy Manufacturing Cooperative Research Centre Adelaide SA 5000Australia Faculty of Health and Medical Sciences University of AdelaideAdelaide SA 5005Australia

Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning ***,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte *** polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)*** pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization *** AA surface provided the superior transfer of the cells to de-epidermized *** murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the *** delivery also enhanced angiogenesis through a mechanism independent of VEGF ***,when delivered to wounds,improved healing responses by dampening inflammation and promoting *** of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into ***-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds.

关键词： pericytes cell therapy wound healing plasma polymerization advanced surfaces

An Investigation of the Self-Assembly of Meso-Tetra（4-Sulfonatophenyl）porphyrin

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An Investigation of the Self-Assembly of Meso-Tetra（4-Sulfo...

Traumatic brain injury induced by exposure to blast overpressure via ear canal

2013年全国高分子学术论文报告会

作者： javoris Hollingswortha allison j.Richardb Graca H.Vicenteb Paul Russob Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Polymer Physics Department of Chemistry and Macromolecular Studies Group Louisiana State University

＜正＞The self-assembly of meso-tetra（4-sulfonatophenyl）porphyrin（H 2 TPPS 4 - ） in aqueous solutions was investigated as a function of pH,concentration,time,ionic strength,and solution preparation（either from dilution of a freshly prepared 2mM stock or by direct preparation of μM solution concentrations） using a combination of complementary analytical ***-vis and

关键词： water-soluble porphyrin aggregation SAXS AUC cryo-TEM

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Neural Regeneration Research 2022年第1期17卷 115-121页

作者： Yang Ou Brad AClifton jinghui Li David Sandlin Na Li Li Wu Chunming Zhang Tianwen Chen jun Huang Yue Yu jerome allison Fan Fan Richard jRoman james Shaffery Wu Zhou Yi Pang Hong Zhu Departmant of Otolaryngology and Head Neck Surgery Department of Neurobiology and Anatomical Sciences MD Program School of Medicine Graduate Program in Neuroscience Department of Pediatrics Department of Pharmacology and Toxicology Department of Psychiatry and Human Behavior University of Mississippi Medical CenterJacksonMSUSA Kunming Medical University KunmingYunnan ProvinceChina Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina

Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian *** ears are most often damaged following exposure to *** there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear *** present study investigated whether exposure to blasts directed through the ear canal causes brain injury in LongEvans *** were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain injury was evaluated by histological and behavioral outcomes at multiple *** exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of *** blast-induced injury was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive ***,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast *** results suggest that the unprotected ear canal provides a locus for blast waves to cause *** study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019).

关键词： anxiety blast ear ear protection learning memory microglia neuroinflammation neuron rat traumatic brain injury

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弹性波层析成像技术检测活立木腐朽

林业科学 2008年第5期44卷 109-114页

作者：梁善庆王喜平蔡智勇 Robert j．Ross R．Bruce allison 傅峰中国林业科学研究院木材工业研究所北京100091 美国农业部林务局林产品实验室麦迪逊53726-2398 美国威斯康星州艾里森树木保护中心维罗纳53593

介绍弹性波层析成像技术应用于活立木内部缺陷检测的研究现状,阐述弹性波的产生、传播途径和成像原理,总结该技术在应用中出现的问题。并使用弹性波层析成像技术对美国林务局纳西比特营地脂松活立木进行检测。结果表明:弹性波层析成像... 详细信息

介绍弹性波层析成像技术应用于活立木内部缺陷检测的研究现状,阐述弹性波的产生、传播途径和成像原理,总结该技术在应用中出现的问题。并使用弹性波层析成像技术对美国林务局纳西比特营地脂松活立木进行检测。结果表明:弹性波层析成像技术能够模拟出不规则树干形状并以二维图像方式直观地显示立木腐朽部位、程度、大小及形状等情况。基于此方法发展的设备,具有检测方便、有效、实用性强等特点。

关键词：弹性波层析成像技术无损检测活立木腐朽

PLGA nanodepots co-encapsulating prostratin and anti-CD25 enhance primary natural killer cell antiviral and antitumor function

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Nano Research 2020年第3期13卷 736-744页

作者： Elizabeth E.Sweeney Preethi B.Balakrishnan allison B.Powell Allan Bowen Indra Sarabia Rachel A.Burga R.Brad jones Alberto Bosque C.Russell Y.Cruz Rohan Fernandes The George Washington Cancer Center The George Washington UniversityWashingtonDC20052USA Center for Cancer and Immunology Research Children’s National Health SystemWashingtonDC20010USA Department of Microbiology Immunologyand Tropical MedicineThe George Washington UniversityWashingtonDC20052USA Infectious Disease Division Weill Cornell Medical CollegeNew YorkNY10065USA View author publications Department of Medicine The George Washington UniversityWashingtonDC20052USA

Natural killer(NK)cells are attractive effector cells of the innate immune system against human immunodeficiency virus(HIV)and ***,NK cell therapies are limited by the fact that target cells evade NK cells,for example,in latent reservoirs(in HIV)or through upregulation of inhibitory signals(in cancer).To address this limitation,we describe a biodegradable nanoparticlebased“priming”approach to enhance the cytotoxic efficacy of peripheral blood mononuclear cell-derived NK *** present poly(lactic-co-glycolic acid)(PLGA)nanodepots(NDs)that co-encapsulate prostratin,a latency-reversing agent,and anti-CD25(aCD25),a cell surface binding antibody,to enhance primary NK cell function against HIV and *** utilize a nanoemulsion synthesis scheme to encapsulate both prostratin and aCD25 within the PLGA NDs(termed Pro-aCD25-NDs).Physicochemical characterization studies of the NDs demonstrated that our synthesis scheme resulted in stable and monodisperse *** NDs successfully released both active prostratin and anti-CD25,and with controllable release *** Pro-aCD25-NDs were administered in an in vitro model of latent HIV and acute T cell leukemia using j-Lat 10.6 cells,the NDs were observed to prime j-Lat cells resulting in significantly increased NK cell-mediated cytotoxicity compared to free prostratin plus anti-CD25,and other *** findings demonstrate the feasibility of using our Pro-aCD25-NDs to prime target cells for enhancing the cytotoxicity of NK cells as antiviral or antitumor agents.

关键词： poly(lactic-co-glycolic acid)(PLGA)nanodepots natural killer(NK)cells human immunodeficiency virus(HIV) cancer latency-reversing agent antibody

制作高速GaAs场效应晶体管用的微细光刻技术

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微纳电子技术 1987年第1期 46-54页

作者： j.F.allison 江泽流

本文论述了用来制作高速GaAs金属-半导体场效应晶体管(MESFET)的源、漏和栅电极的微细光刻技术。用剥离法和常规光刻制备了MESFET的源和漏电极,并叙述了用斜角蒸发形成亚微米栅长的工艺过程。还详述了用电子束刻蚀技术进行栅极的描绘乖... 详细信息

本文论述了用来制作高速GaAs金属-半导体场效应晶体管(MESFET)的源、漏和栅电极的微细光刻技术。用剥离法和常规光刻制备了MESFET的源和漏电极,并叙述了用斜角蒸发形成亚微米栅长的工艺过程。还详述了用电子束刻蚀技术进行栅极的描绘乖抗蚀剂剖面的控制。提供了在制作GaAs场效应晶体管(FET)和微波单片集成电路(MMIC)过程中,应用这些工艺技术实例的有关数据。

关键词：场效应晶体管单极晶体管场效应器件抗蚀剂 GaAs 光刻技术栅长 MESFET 栅极栅电极钻蚀电子束光刻电子束加工光学光刻欧姆接触

Housing Environment Affects Baseline Anxiety in Zebrafish

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journal of Behavioral and Brain Science 2017年第11期7卷 520-531页

作者： Bhavana Movva jacob W. Guerrant Maxwell j. jentsch allison N. Ogren julie L. Mustard Norbert W. Seidler Laboratory of Neurobiology and Zebrafish Behavior Research Division of Basic Sciences Kansas City University of Medicine and Biosciences Kansas City Missouri USA

Neuroscience researchers that wish to address compelling questions in psychopharmacology would benefit from the use of zebrafish, which have a behavioral repertoire that is rich and complex and that reflects many fundamental processes in humans, such as those that evoke anxiety. Zebrafish behavior is easily quantified in diverse test environments, but it is important to consider the conditions used to house the fish, prior to the behavioral testing, when designing experiments. Studies show that fish housed at high densities exhibit elevated cortisol levels as compared with fish housed at lower densities. The literature is less clear about the behavioral consequences of housing and handling. We examined the effects of housing (group versus paired) on several behavioral parameters. We observed that group-housed fish exhibited an anxious phenotype as evidenced by tank diving and meandering. Other more general indicators of movement and spatial navigation were unaffected by housing. This study focused on two specific housing environments, and the results support the need for continued research in this area to further elucidate the contributions of housing and handling on the subtleties of zebrafish behavioral markers.

关键词： Zebrafish Behavior Anxiety Behavioral Phenotype Animal Model