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Variable change in renal function by hypertonic saline

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World journal of Critical Care Medicine 2014年第2期3卷 61-67页

作者： jesse j Corry Panayiotis Varelas Tamer Abdelhak Stacey Morris Marlisa Hawley allison Hawkins Michelle jankowski Department of Neurology Henry Ford Hospital Department of Neurosurgery Henry Ford Hospital Department of Biostatistics Henry Ford Hospital

AIM: To investigate the effects of hypertonic saline in the neurocritical care ***: We retrospectively reviewed our hospital's use of hypertonic saline(HS) since March of 2005, and prospectively since October 2010. Comparisons were made between admission diagnoses, creatinine change(Cr), and HS formulation(3% Na Cl, 3% Na Cl/sodium acetate mix, and 23.4% Na Cl) to patients receiving normal saline or lactated ringers. The patients(n = 1329) of the retrospective portion were identified. The data presented represents the first 230 patients with data. RESULTS: Significant differences in Acute Physiology and Chronic Health Evaluation Ⅱ scores and GlasgowComa Scale scores occurred between different saline formulations. No significant correlation of Cl- or Na+ with Cr, nor with saline types, occurred. When dichotomized by diagnosis, significant correlations appear. Traumatic brain injury(TBI) patients demonstrated moderate correlation between Na+ and Cr of 0.45. Stroke patients demonstrated weak correlations between Na+ and Cr, and Cl- and Cr(0.19 for both). Patients receiving HS and not diagnosed with intracerebral hemorrhage, stroke, subarachnoid hemorrhage, or TBI demonstrated a weak but significant correlation between Cl- and Cr at ***: Cr directly correlates with Na+ or Cl- in stroke, Na+ in TBI, and Cl- in other populations. Prospective comparison of HS and renal function is needed.

关键词： Hypertonic saline solution Sodium chloride Acute kidney injury Cerebral edema Critical care

Uncovering the immunological repertoire of the carpet shell clam Ruditapes decussatus through a transcriptomic-based approach

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Aquaculture and Fisheries 2019年第1期4卷 37-42页

作者： Frederico M.Batista allison M.Churcher Manuel Manchado Alexandra Leitao Deborah M.Power Centro de Cieencias do Mar(CCMAR) Universidade do AlgarveCampus de Gambelas8005-139 FaroPortugal Instituto Portugues do Mar e da Atmosfera Estaçao Experimental de Moluscicultura de TaviraPortugal Department of Biosciences College of ScienceSwansea UniversitySwanseaSA28PPWalesUnited Kingdom IFAPA Centro El Toruno Junta de AndalucíaCamino Tiro Pichon sn11500 El Puerto de Santa MaríaCadizSpain Environmental Science Center(ESC) Qatar UniversityP.O.Box 2713 DohaQatar

The grooved carpet-shell clam Ruditapes decussatus is native to the Northern Atlantic and Mediterranean Sea and has a high commercial *** is one of the main native bivalve species cultured in *** main objective of the present study was to gain further insights into the immunological repertoire of *** through a transcriptomic *** mantle samples of eight *** individuals were sequenced using Illumina platform.A total of 67132 contigs with more than 800 bp were *** annotation of these contigs revealed 146 immune-related *** gene families in which the highest number of immune-related genes was observed were:C1q domain-containing proteins(63),tumor necrosis factors(15)and toll-like receptors(TLRs,10).A total of 5359 putative single nucleotide polymorphisms(SNPs)were identified in the 146 immune-related *** density of SNPs ranged between 0.04 and 7.92 SNPs/100 *** highest and the lowest SNP density were observed in genes of the C1q domain-containing protein *** to the importance of TLRs in innate immunity,we focused our attention on these membrane *** TLRs were identified based on protein domain *** analysis revealed that *** TLRs were diverse and only 3 showed orthology with TLRs of known immune functions in other bivalve ***,our analysis suggests that lineage restricted-expansions of TLRs occurred in all mollusc taxa analysed including in venerids.

关键词： Ruditapes decussatus Transcriptome Immune genes Toll-like receptors

豇豆退绿斑驳病毒(CCMV)突变体的混合侵染研究

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植物病理学报 2002年第1期32卷 59-64页

作者：杨普云 RichardF.allison 中国农业大学植物病理系，北京100094 DepartmentofBotanyandPlantPathology CollegeofNaturalScienceMichiganStateUniversityEastLansingMI48824USA

本研究采用 PCR点突变的方法 ,对豇豆退绿斑驳病毒 (CCMV) RNA3的 c DNA克隆进行突变 ,突变体 TP7是在外壳蛋白基因之前突变形成一个独特的 Sal I酶切点 ;TP8是在 3a基因之前突变形成一个独特的 Bam H I酶切点 ;AG 1是在外壳蛋白基因之... 详细信息

本研究采用 PCR点突变的方法 ,对豇豆退绿斑驳病毒 (CCMV) RNA3的 c DNA克隆进行突变 ,突变体 TP7是在外壳蛋白基因之前突变形成一个独特的 Sal I酶切点 ;TP8是在 3a基因之前突变形成一个独特的 Bam H I酶切点 ;AG 1是在外壳蛋白基因之后突变形成一个独特的 Not I酶切点。TP7、TP8、AG1体外转录产物分别与 CCMV RNA1、RNA2的 c DNA克隆的体外转录产物混和后接种豇豆 ,结果表明 ,接种后第 6 d TP7植株首先表现出症状 ,9d后 TP8、AG1和野生型 CCMV接种的植株表现出症状 ,TP7的症状发展最快。采用 TP7、TP8、AG1接种 2 0 d的毒源植株 ,按 TP7+ TP8、TP7+ AG1、TP8+ AG1等量混合汁液接种豇豆 ,接种 2 0 d,通过 RT- PCR分析接种植物 ,在 TP7+ TP8和 TP7+ AG1混合侵染中 ,TP7在混合侵染中占优势 ,在 TP8+ AG1的混合侵染中 ,TP8和 AG1的种群十分接近。

关键词：豇豆退绿斑驳病毒混合侵染突变体 RNA病毒

The Ecdysone and Notch Pathways Synergistically Regulate Cut at the Dorsal-Ventral Boundary in Drosophila Wing Discs

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journal of Genetics and Genomics 2016年第4期43卷 179-186页

作者： Dongyu jia jamal Bryant allison jevitt Gabriel Calvin Wu-Min Deng Department of Biological Science Florida State University

Metazoan development requires coordination of signaling pathways to regulate patterns of gene *** Drosophila,the wing imaginal disc provides an excellent model for the study of how signaling pathways interact to regulate pattern *** determination of the dorsal-ventral（DV） boundary of the wing disc depends on the Notch pathway,which is activated along the DV boundary and induces the expression of the homeobox transcription factor,***,we show that Broad（Br）,a zinc-finger transcription factor,is also involved in regulating Cut expression in the DV boundary ***,Br expression is not regulated by Notch signaling in wing discs,while ecdysone signaling is the upstream signal that induces Br for Cut ***,we find that the ecdysone-Br cascade upregulates cut-lacZ expression,a reporter containing a 2.7 kb cut enhancer region,implying that ecdysone signaling,similar to Notch,regulates cut at the transcriptional ***,our findings reveal that the Notch and ecdysone signaling pathways synergistically regulate Cut expression for proper DV boundary formation in the wing ***,we show br promotes Delta,a Notch ligand,near the DV boundary to suppress aberrant high Notch activity,indicating further interaction between the two pathways for DV patterning of the wing disc.

关键词： Ecdysone Notch Broad Cut Drosophila Wing disc Dorsal-ventral boundary

AFM Observation of GaN Grown on Different Substrates at Low Temperatures

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journal of Beijing Institute of Technology 1999年第2期8卷 19-26页

作者：曹传宝 ATTOLINI G fornari R PELOSI C 北京理工大学材料科学研究中心国家研究院电磁材料研究所

Aim To study the relationship between the substrate temperature and the morphology and properties of GaN. Methods\ Applying the hydride chemical vapor deposition method, GaN films were deposited on different kinds of substrates, including sapphire, Si(111),Si(100),GaAs and GaP(111) both on the P face and the Ga face. The growth was performed at low temperatures of below 700℃. XRD, Hall measurement, cathodoluminescence (CL) and atomic force microscopy (AFM) were used to characterise the film properties. Results\ It was found that the temperature and the nature of substrate materials influence the layer morphology. Conclusion\ The analysis shows that no apparent relationship exists between the optical properties and layer morphology.

关键词： gallium nitride atomic force microscopy(AFM) crystal growth hydride vapour phase epitaxy(HVPE)

An Investigation of the Self-Assembly of Meso-Tetra（4-Sulfonatophenyl）porphyrin

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An Investigation of the Self-Assembly of Meso-Tetra（4-Sulfo...

Science and exploration in the high interior of East Antarctica in the twentieth century

2013年全国高分子学术论文报告会

作者： javoris Hollingswortha allison j.Richardb Graca H.Vicenteb Paul Russob Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Polymer Physics Department of Chemistry and Macromolecular Studies Group Louisiana State University

＜正＞The self-assembly of meso-tetra（4-sulfonatophenyl）porphyrin（H 2 TPPS 4 - ） in aqueous solutions was investigated as a function of pH,concentration,time,ionic strength,and solution preparation（either from dilution of a freshly prepared 2mM stock or by direct preparation of μM solution concentrations） using a combination of complementary analytical ***-vis and

关键词： water-soluble porphyrin aggregation SAXS AUC cryo-TEM

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Advances in Polar Science 2016年第2期27卷 65-77页

作者： Irina Gan David Drewry Ian allison Vladimir Kotlyakov Antarctic Climate and Ecosystems Cooperative Research Centre HobartAustralia University of Hull HullUK Institute of Geography Russian Academy of SciencesMoscowRussia

The highest part of the East Antarctic Ice Sheet, more than 4000 m above sea level, has been an area that has seen a considerable scientific research effort undertaken by the Chinese National Antarctic Research Expedition, and its international collaborators, since january 2005. That includes the establishment of the most remote Of the Chinese Antarctic stations, Kunlun, at Dome A in 2009. However, the exploration and mapping of this region had been commenced many decades earlier, most notably by inland traverses of the Union of Soviet Socialist Republics during the 1957-1958 International Geophysical Year 0GY） and later; and the extensive surveys of Antarctic surface and sub-ice topography by airborne radio-echo sounding made by the US National Science Foundation-Scott Polar Research Institute-Technical University of Denmark （NSF-SPRI-TUD） in the late-1960s and the 1970s. Here we provide a history of the activities and achievements of these earlier programs. Recent topographic maps of the ice sheet surface in the Dome A region, produced using Chinese GPS data and satellite altimetry, have shown the maps compiled from the earlier data were remarkably accurate.

关键词： East Antarctica Dome A Gamburtsev Mountains traverse sub-glacial mapping seismic radio-echosounding (RES)

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弹性波层析成像技术检测活立木腐朽

林业科学 2008年第5期44卷 109-114页

作者：梁善庆王喜平蔡智勇 Robert j．Ross R．Bruce allison 傅峰中国林业科学研究院木材工业研究所北京100091 美国农业部林务局林产品实验室麦迪逊53726-2398 美国威斯康星州艾里森树木保护中心维罗纳53593

介绍弹性波层析成像技术应用于活立木内部缺陷检测的研究现状,阐述弹性波的产生、传播途径和成像原理,总结该技术在应用中出现的问题。并使用弹性波层析成像技术对美国林务局纳西比特营地脂松活立木进行检测。结果表明:弹性波层析成像... 详细信息

介绍弹性波层析成像技术应用于活立木内部缺陷检测的研究现状,阐述弹性波的产生、传播途径和成像原理,总结该技术在应用中出现的问题。并使用弹性波层析成像技术对美国林务局纳西比特营地脂松活立木进行检测。结果表明:弹性波层析成像技术能够模拟出不规则树干形状并以二维图像方式直观地显示立木腐朽部位、程度、大小及形状等情况。基于此方法发展的设备,具有检测方便、有效、实用性强等特点。

关键词：弹性波层析成像技术无损检测活立木腐朽

Traumatic brain injury induced by exposure to blast overpressure via ear canal

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Neural Regeneration Research 2022年第1期17卷 115-121页

作者： Yang Ou Brad AClifton jinghui Li David Sandlin Na Li Li Wu Chunming Zhang Tianwen Chen jun Huang Yue Yu jerome allison Fan Fan Richard jRoman james Shaffery Wu Zhou Yi Pang Hong Zhu Departmant of Otolaryngology and Head Neck Surgery Department of Neurobiology and Anatomical Sciences MD Program School of Medicine Graduate Program in Neuroscience Department of Pediatrics Department of Pharmacology and Toxicology Department of Psychiatry and Human Behavior University of Mississippi Medical CenterJacksonMSUSA Kunming Medical University KunmingYunnan ProvinceChina Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina

Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian *** ears are most often damaged following exposure to *** there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear *** present study investigated whether exposure to blasts directed through the ear canal causes brain injury in LongEvans *** were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain injury was evaluated by histological and behavioral outcomes at multiple *** exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of *** blast-induced injury was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive ***,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast *** results suggest that the unprotected ear canal provides a locus for blast waves to cause *** study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019).

关键词： anxiety blast ear ear protection learning memory microglia neuroinflammation neuron rat traumatic brain injury