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Acta Pharmacologica Sinica 2006年第4期27卷 469-476页

作者： Tsung-hsing LEE allan m concejero Departments of Anesthesiology Departments of Surgery Kaohsiung Chang Gung Memorial HospitalTaipeiChina

Aim:Liver fibrosis represents a process of healing and scarring in response tochronic liver *** therapies for liver fibrosis are ***-10（IL-10）is a cytokine that downregulates pro-inflarnmatory responses and has amodulatory effect on hepatic *** aim of this study was to investi-gate whether electroporative IL-10 gene therapy has an hepatic fibrolytic effect ***:Hepatic fibrosis was induced by administering carbon tetrachlo-ride（CCl4）for 10 weeks in *** human IL-10 expression plasmid was deliv-ered via electroporation after hepatic fibrosis was ***,reverse transcription polymerase chain reaction（RT-PCR）,immunoblotting,andgelatin zymography were used to investigate the possible mechanisms of actionof ***:Human IL-10 gene therapy reversed CCl4-induced liver fibrosisin ***-PCR revealed that IL-10 gene therapy attenuated liver TGF-β1,col-lagen α1,fibronectin,and cell adhesion molecule mRNA *** transfer,both the activation of(x-smooth muscle actin and cyclooxygenase-2were significantly ***,IL-10 significantly inhibited matrixmetalloproteinase-2（mmP-2）and tissue inhibitors of matrix metalloproteinase（TImP）activation after ***:We demonstrated that IL-10gene therapy attenuated CCl4-induced liver fibrosis in ***-10 preventedupregulated fibrogenic and pro-inflammatory gene *** collagenolyticeffect may be attributed to mmP and TImP ***-10 gene therapy maybe an effective therapeutic modality against liver fibrosis with potential clinicaluse.

关键词： interleukin-10 gene therapy liver cirrhosis gelatinase A tissue inhibitor of metalloproteinases cyclooxygenase 2

Early post-operative complications in living donor liver transplantation:prevention,detection and management

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Hepatobiliary & Pancreatic Diseases International 2007年第4期6卷 345-347页

作者： allan m. concejero Liver Transplantation Program Department of SurgeryChang Gung Memorial HospitalKaohsiung Medical Centerand Chang Gung University College of MedicineTaiwanChina

Living donor liver transplantation (LDLT) is now performed with high rates of success due to judicious recipient and donor selection,careful preoperative planning, excellent anesthesia management, and prompt detection and treatment of complications. The indications for LDLT for adult and pediatric recipients should be the same as for deceased donor liver transplantation. Early postoperative complications are often defined as complications occurring within the first 3 months

关键词： Early post-operative complications in living donor liver transplantation PVT

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Left-sided gallbladder:Its clinical significance and imaging presentations

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World Journal of Gastroenterology 2007年第47期13卷 6404-6409页

作者： Sheng-Lung Hsu Tai-Yi Chen Tung-Liang Huang Cheuk-Kwan Sun allan m concejero Leo Leung-Chit Tsang Yu-Fan Cheng Department of Diagnostic Radiology Chang Gung Memorial Hospital - Kaohsiung Medical Center Chang Gung University College of Medicine Kaohsiung Taiwan China Department of Surgery Chang Gung Memorial Hospital - Kaohsiung Medical Center Chang Gung University College of Medicine Kaohsiung Taiwan China

AIm: To assess the importance of preoperative diagnosis and presentation of left-sided gallbladder using ultrasound (US),CT and angiography. mETHODS: Retrospective review of 1482 patients who underwent enhanced CT scanning was performed. Left-sided gallbladder was diagnosed if a right-sided ligamentum teres was present. The image presentations on US,CT and angiography were also reviewed. RESULTS: Left-sided gallbladder was diagnosed in nine patients. The associated abnormalities on CT imaging included portal vein anomalies,absence of umbilical portion of the portal vein in the left lobe of the liver,club-shaped portal vein in the right lobe of the liver,and difficulty in identifying segment Ⅳ. Angiography in six of nine patients demonstrated abnormal portal venous system (trifurcation type in four of six patients). The main hepatic arteries followed the portal veins in all six patients. The segment Ⅳ artery was identified in four of six patients using angiography,although segment Ⅳ was difficult to define on CT imaging. Hepatectomy was performed in three patients with concomitant liver tumor and the diagnosis of left-sided gallbladder was confirmed intraoperatively. CONCLUSION: Left-sided gallbladder is an important clinical entity in hepatectomy due to its associated portal venous and biliary anomalies. It should be considered in US,CT and angiography images that demonstrate no definite segment Ⅳ,absence of umbilical portion of the portal vein in the left lobe,and club-shaped right anterior portal vein.

关键词： Left-sided gallbladder Angiography Computed tomography Ultrasound

macro-regenerative nodules in biliary atresia:CT/mRI findings and their pathological relations

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World Journal of Gastroenterology 2008年第28期14卷 4529-4534页

作者： Jiun-Lung Liang Yu-Fan Cheng allan m concejero Tung-Liang Huang Tai-Yi Chen Leo Leung-Chit Tsang Hsin-You Ou Departments of Diagnostic Radiology Chang Gung Memorial HospitalKaohsiung Medical Center and Chang Gung University College of Medicine Kaohsiung 83305 Taiwan China Departments of Surgery Chang Gung Memorial Hospital-Kaohsiung Medical Center and Chang Gung University College of Medicine Kaohsiung 83305 Taiwan China

AIm: To describe the radiological findings of a macro-regenerative nodule (mRN) in the liver of pre-transplantation biliary atresia (BA) patients and to correlate it with histological findings. mETHODS: Between August 1990 and November 2007, 144 BA patients underwent liver transplantation (LT) at our institution. The pre-transplantation computer tomograghy (CT) and magnetic resonance imaging (mRI) findings were reviewed and correlated with the post-transplantation pathological findings. RESULTS: Nine tumor lesions in 7 patients were diagnosed in explanted livers. The post-transplantation pathological findings showed that all the lesions were mRNs without malignant features. No small nodule was detected by either mRI or CT. Of the 8 detectable lesions, 6 (75%) were in the central part of the liver, 5 (63%) were larger than 5 cm, 5 (63%) had intra- tumor tubular structures, 3 (38%) showed enhancing fibrous septa, 3 (38%) had arterial enhancement in CT, one (13%) showed enhancement in mRI, and one (13%) had internal calcifications. CONCLUSION: Although varied in radiological appearance, mRN can be differentiated from hepatocellular carcinoma (HCC) in most of BA patients awaiting LT. The presence of an arterial-enhancingnodule does not imply that LT is withheld solely on the basis of presumed malignancy by imaging studies. Liver biopsy may be required in aid of diagnostic imaging to exclude malignancy.

关键词： Biliary atresia macro-regenerative nodule Liver neoplasm Liver transplantation Computed tomography magnetic resonance imaging

Complete portal vein occlusion after cyanoacrylate sclerotherapy in biliary atresia treated by living donor liver transplantation with intraoperative portal vein stenting via segment 4 portal vein stump

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Hepatobiliary Surgery and Nutrition 2018年第4期7卷 313-316页

作者： Chao-Long Chen Yu-Fan Cheng Hsin-You Ou Chee-Chien Yong Tsan-Shiun Lin Shih-Ho Wang Chih-Che Lin allan m.concejero Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiungTaiwan Liver Transplantation Center Department of Diagnostic RadiologyKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiungTaiwan Department of Surgery University of the Philippines College of MedicineManilaPhilippines

IntroductionLiving donor liver transplantation(LDLT)is a durable treatment for end-stage liver disease due to biliary atresia(BA)with excellent graft and patient survivals as shown in our previous study(1).Vascular complications are a major cause of graft failure in LDLT,particularly in children,where size disparity between donor and recipient vessels is often unavoidable.

关键词： liver donor biliary

Concentrations and sources of an emerging pollutant, decabromodiphenylethane (DBDPE), in sewage sludge for land application

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Journal of Environmental Sciences 2012年第3期24卷 558-563页

作者： De la Torre A concejero m A martínez m A Persistent Organic Pollutant Group Environment Department CIEMAT Avd. Complutense 22 Madrid 28040 Spain

The presence of an emerging brominated flame retardant, decabromodiphenylethane （DBDPE）, has been confirmed in Spanish sewage sludge. Thirty one samples from different urban wastewater treatment plants （WWTPs） were analyzed for this brominated flame retardant. DBDPE was positively identified and quantified in all samples at lower concentrations （47.0 ± 29.7 ng/g dry weight （dw）; mean ± SD） than those obtained for decabromodiphenyl ether （BDE-209）（290 ± 236 ng/g dw; mean ± SD） in a previous study. Influence of the WWTP characteristics in the pollutant levels was evaluated. No significant correlations were obtained between DBDPE concentrations and the population or sewage sludge production rate associated with the plants, neither wastewater treatment method. Sources of DBDPE in the sludge were also evaluated. Data indicate a common origin for DBDPE and BDE-209, which may be related to leaching processes during the use and disposal of consumer products containing these chemicals. Nevertheless, DBDPE contents are not influenced by industrial activities, which suggests that the infusion of DBDPE commercial mixture is not a source of this chemical into the environment, and indicates that the use of DBDPE in the Spanish industry is still low compared to deca-BDE.

关键词： decabromodiphenylethane polybrominated diphenyl ethers wastewater treatment plants sewage sludge

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich allan D.Levi James D.Guest miller School of medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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RABL-regulated pathways： a new tale in sperm function

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Asian Journal of Andrology 2013年第1期15卷 87-88页

作者： Charles m allan ANZAC Research Institute Concord Hospital Universityof Sydney Sydney NSW 2139 Australia

mammalian sperm have a specialized motile flagellum to provide the unidirectional propulsion required to achieve fertilisation of the egg. Defective flagella development and/or function is a significant cause of reduced sperm motility （asthenospermia） and male infertility. Over the past decade, a growing number of distinct proteins with crucial roles in sperm flagella have been identified by genetic loss-offunction approaches in mice, in which the deliberately engineered or spontaneous mutation of individual genes have lead to anomalies in sperm tail assembly,

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The skeleton gets a （reproductive） life

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Asian Journal of Andrology 2011年第5期13卷 651-652页

作者： Charles m allan David l Handelsman ANZAC Research Institute Concord Hospital Universityof Sydney Sydney NSW 2139 Australia

To most well-informed scientists who do not work on bone, the idea that bones determine anything other than your posture and location for the miseries of arthritis would come as quite a surprise. It would be like imagining that the walls of our home played something more than a passive role in the complexities of the lives conducted within. Yet something precisely as radical as that is what Karsenty and his colleagues boldly imagined,1 and then provocatively established in a series of studies over the past decade.20steocalcin （OCN） is a vitamin K- dependent peptide hormone secreted by the bone-formine osteoblasts.

关键词： reproductive David J Handelsman

IRX14 and IRX14-LIKE, Two Glycosyl Transferases Involved in Glucuronoxylan Biosynthesis and Drought Tolerance in Arabidopsis

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molecular Plant 2010年第5期3卷 834-841页

作者： Brian D. Keppler allan m. Showalter Department of Environmental and Plant Biology Molecular and Cellular Biology Program Ohio University 315 Porter Hall Athens OH 45701-2979 USA

IRX14 and IRX14-LIKE （IRX14L） are two closely related glycosyl transferases in the glycosyl transferase 43 （GT43） family of Arabidopsis. A T-DNA insertion mutant for IRX14 results in comparatively minor changes, such as irregular xylem, while a mutation for IRX14L results in no changes. However, an irx14 and irx14L double mutant severely affects growth and development, with the dwarf plants failing to produce an inflorescence stem. Plants that are homozygous for IRX14 but heterozygous for IRX14L （irx14 irx14L（±）） exhibit an intermediate phenotype, including noticeably smaller leaves, stems, and underdeveloped siliques. Additionally, the T-DNA insertion mutant for IRX14 was found to result in a drought-tolerant phenotype. Carbohydrate analysis of total cell wall extracts revealed a reduction in xylose for the irx14 and irx14 irx14L（±） mutants, consistent with a defect in glucuronoxylan biosynthesis. Immunolocalization of xylan with the Lm10 antibody revealed a loss of xylan in irx14 mutants and a further reduction in the irx14 irx14L（±） mutants. IRX14L likely functions redundantly with IRX14 in glucuronoxylan biosynthesis, with IRX14 having a more important role in the process.

关键词： Abiotic/environmental stress cell walls genetics Arabidopsis irregular xylem xylan.