检索结果-南通市图书馆

Iodoacetic acid exposure alters the transcriptome in mouse ovarian antral follicles

Journal of Environmental Sciences 2022年第7期34卷 46-57页

作者： Andressa Gonsioroski Mary Laws Vasiliki E.Mourikes alison neff Jenny Drnevich Michael J.Plewa Jodi A.Flaws Department of Comparative Biosciences University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Roy J.Carver Biotechnology Center University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Department of Crop Sciences and the Safe Global Water Institute University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA

Iodoacetic acid(IAA) is an unregulated water disinfection byproduct that is an ovarian toxicant. However, the mechanisms of action underlying IAA toxicity in ovarian follicles remain unclear. Thus, we determined whether IAA alters gene expression in ovarian follicles in mice. Adult female mice were dosed with water or IAA(10 or 500 mg/L) in the water for 35-40 days. Antral follicles were collected for RNA-sequencing analysis and sera were collected to measure estradiol. RNA-sequencing analysis identified 1063 differentially expressed genes(DEGs) in the 10 and 500 mg/L IAA groups(false discovery rate FDR < 0.1), respectively, compared to controls. Gene Ontology Enrichment analysis showed that DEGs were involved with RNA processing and regulation of angiogenesis(10 mg/L) and the cell cycle and cell division(500 mg/L). Pathway Enrichment analysis showed that DEGs were involved in the phosphatidylinositol 3-kinase and protein kinase B(PI3K-Akt), gonadotropin-releasing hormone(Gn RH), estrogen, and insulin signaling pathways(10 mg/L). Pathway Enrichment analysis showed that DEGs were involved in the oocyte meiosis, Gn RH, and oxytocin signaling pathways(500 mg/L). RNA-sequencing analysis identified 809 DEGs when comparing the 500 and 10 mg/L IAA groups(FDR < 0.1). DEGs were related to ribosome, translation, m RNA processing, oxidative phosphorylation, chromosome, cell cycle, cell division, protein folding, and the oxytocin signaling pathway. Moreover, IAA exposure significantly decreased estradiol levels(500 mg/L) compared to control. This study identified key candidate genes and pathways involved in IAA toxicity and can help to further understand the molecular mechanisms of IAA toxicity in ovarian follicles.

关键词： Disinfection byproducts Iodoacetic acid Ovary Ovarian follicles Steroidogenesis Endocrine disruptors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seroepidemiology of hepatitis A virus in Kuwait

引用

World Journal of Gastroenterology 2009年第1期15卷 102-105页

作者： Jameela Alkhalidi Bader Alenezi Seham Al-mufti Entisar Hussain Haifa Askar Nyingi Kemmer Guy W neff Thuniyan Al-Ghanim GI Center & University of KuwaitPO Box 4077 Safat 13041 Kuwait University of Cincinnati Cincinnati OH 45267-0576 United States

AIM: To fi nd the current seroepidemiology of hepatitis A virus (HAV) in ***: A total of 2851 Kuwaitis applying for new jobs were ***: HAV-positive cases were 28.8%; 59% were males and 41% were females. The highest prevalence was in the Ahmadi area. High prevalence was among the group of non-educated rather than educated parents. This is the fi rst study in Kuwait demonstrating the shifting epidemiology of ***: This study reflects the need of the Kuwaiti population for an HAV vaccine.

关键词： Hepatitis A virus Fulminant Liver Failure Hepatitis A virus vaccine Kuwait

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extrapulmonary sarcoidosis of liver and pancreas: A case report and review of literature

引用

World Journal of Gastroenterology 2007年第17期13卷 2504-2509页

作者： Hermann Harder Markus W Büchler Boris Frhlich Philipp Strbel Frank Bergmann Wolfgang neff Manfred V Singer Department of Medicine Ⅱ (Gastroenterology Hepatology and Infectious Diseases) University Hospital of Heidelberg at Mannheim Germany Department of Surgery University of Heidelberg GermanyFrank Bergmann Institute of Pathology University of Heidelberg Germany Institute of Pathology University Hospital of Heidelberg at Mannheim Germany Institute of Pathology University of HeidelbergGermany Institute of Radiology University Hospital of Heidelberg at Mannheim Germany

Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin, which can involve nearly all organs. In the case of an infrequent gastrointestinal tract involvement in systemic sarcoidosis, granulomas of the liver are most commonly described while isolated pancreatic sarcoid lesions are rarely seen. We report a case of systemic sarcoidosis with exclusive extrapulmonal involvement of the liver and the pancreas in a 71-year- old white man. The diagnosis of liver involvement was confirmed by biopsy. Pancreatic surgery was needed because preoperative evaluation could not exclude pancreatic cancer and for biliary decompression. An extensive literature review of systemic sarcoidosis, focusing on reported cases with unusual presentation of sarcoidosis in the liver and the pancreas, its diagnosis, treatment, and prognosis was made.

关键词： Systemic Sarcoidosis Extrapulmonary Liver Pancreas

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anatomy and physiology of the palatine tonsils, adenoids, and lingual tonsils

引用

World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第10期7卷 155-160页

作者： Alexandra Arambula Jason RBrown Laura neff Department of Otolaryngology-Head and Neck Surgery University of KansasKansas CityKSUSA Division of Pediatric Otolaryngology Children's Mercy Hospital and ClinicsKansas CityMOUSA Department of Surgery-University of Missouri-Kansas City School of Medicine Kansas CityMOUSA

Objective::This review aims to discuss the basic anatomy and physiology of the palatine and pharyngeal tonsils,with reference to how this foundational understanding may affect patient management and surgical procedures in these regions of the upper ***::A literature search was performed using PubMed and Google Scholar using the MeSH terms tonsils,adenoids,anatomy,physiology,and *** sources were excluded if they were abstracts only,non-English language,or non-human ***-five sources were included in this *** and conclusions::The pharyngeal and palatine tonsils are compact yet physiologically complex mucosa-associated lymphoid tissues that make up a portion of Waldeyer’s *** part of the mucosal immune system,these structures function in exogenous antigen sampling and stimulation of immune *** immune activation and/or regulation can lead to a myriad of pathologies,with adenotonsillar hypertrophy,chronic tonsillitis/adenoiditis,and recurrent otitis media among the most commonly encountered conditions by *** the pathophysiology of these conditions is still incompletely understood,current evidence and future investigations may reveal patterns amenable to targeted medical *** medical management fails,tonsillectomy and/or adenoidectomy may be indicated for patient *** routine procedures,the execution of tonsil and/or adenoid removal requires a thorough understanding of the anatomy of these lymphoepithelial organs so as to minimize the risk for rare serious complications that can occur.

关键词： Anatomy of tonsils Adenoids Waldeyer’s ring

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Upper arm length along with mid-upper arm circumference to enhance wasting prevalence estimation and diagnosis:sensitivity and specificity in 6-59-months old children

引用

Family Medicine and Community Health 2021年第2期9卷 24-30页

作者： Mouhamed Barro Mohamed Daouda Baro Djibril Cisse Noel Zagre Thierno Ba Shanti neff Baro Yacouba Diagana Nutrition and development association NouakchottMauritania Nutrition UNICEFNouakchottMauritania UNICEF West and Central Africa Regional Office DakarSenegal Ministry of Health NouakchottMauritania Independent Consultant in Biostatistics ParisFrance University of Nouakchott NouakchottMauritania

Objective To evaluate the added value of the use of upper arm length(UAL)along with mid-upper arm circumference(MUAC)to diagnose and estimate the prevalence of wasting in comparison to current WHO standard and other MUAC-based *** UAL and usual anthropometric measurements were collected during a national cross-sectional nutritional *** were classified into three upper arm length groups(UALGs):UALG1,UALG2 and UALG3 according to the following UAL limits:≤150,151-180 and≥181 mm,*** operating characteristic curves were used to determine the best MUAC cut-off for each group using weight-for height Z-score(WHZ)as a reference *** prevalence,sensitivity and specificity of all diagnostic methods were *** This study was conducted in *** National representative sample of children from 6 to 59 months *** In total,12590 children were included in the *** prevalence was 16.1%,5.0%and 12.5%when diagnosed by WHZ<−2,MUAC<125 mm and MUAC-UALG methods,*** the MUAC-UALG method increased the sensitivity for wasting diagnosis from 17.98%with MUAC<125 mm to 39.43%with *** specificity decreased from 97.49%with MUAC<125 mm to 92.71%with *** MUAC-height Z score and MUAC<138 mm,sensitivity was 26.04%and 69.76%and specificity were 97.40%and 75.64%*** This alternative method using MUAC tape to measure UAL increases the wasting diagnosis accuracy and allows for a better estimation of wasting *** method could be used as a potential alternative method for quick surveys in emergency settings such as Corona virus disease 2019 context.

关键词： diagnosis estimation Upper

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

挤压锭DMC多铸次除气过滤法

引用

轻金属 1992年第7期 59-63,47页

作者： David V.neff 张发明

0 前言为满足今日市场的需要,人们提高了生产高质量产品的能力,因而使得80年代的铝产量获得了持续稳定的大幅度增长。当今使用的一些产品如航空航天材料、电子封装材料。

关键词：轻金属挤压锭除气过滤装置

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

烃类储集层的递增可采层厚度模拟

引用

地球物理学进展 1991年第2期6卷 103-114页

作者： Dennis B.neff 赵明

本文在做理论地震图的过程中,系统地使用了岩石物理性质参数(如孔隙度、页岩体积、水的饱和度等).因此一维褶积模型或合成地震图提供了更多的关于烃类储集层的地震波波形信息。这种模拟技术的应用,即IPT模拟技术(递增可采层厚度模拟Incr... 详细信息

本文在做理论地震图的过程中,系统地使用了岩石物理性质参数(如孔隙度、页岩体积、水的饱和度等).因此一维褶积模型或合成地震图提供了更多的关于烃类储集层的地震波波形信息。这种模拟技术的应用,即IPT模拟技术(递增可采层厚度模拟Incremenal Pay Thickness modeling),已经对墨西哥湾几种近海地震响应振幅异常提供了有价值的解释。通过在积分中引入岩石物性,地震波形响应和预期的烃类可采层厚度的比较结果已经推广到用于包括对总可采层厚度、可采层有效曝度、可采层有效孔隙地层厚度和含烃量等的估计。对这些一维合成数据很容易进行二维显示,二维显示常常表现出合成数据与真实的地震资料之间的非正常波形关系。异常的观测波形响应包括复调谐曲线;甚至在不能分辨的薄储集层中的特征等时线测量结果;以及烃-流体界面的在地震波形中引起的极值变化。尽管IPT模拟的例子给出了对烃类储集层的地震响应的可变性和不唯一性,但如果恰当选择相对于可采层厚度的振幅-等时线IPT模拟即对应于总可采层厚度、可采层有效厚度、可采层有效孔隙地层厚度或含烃量的波峰、波谷和平均振幅,则它们常常显示出地震资料对可采层厚度有良好预测性。

关键词：储集层地震波形地层厚度岩石物理性质岩石物性有效厚度合成数据合成地震图地震资料等时线

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

油气储层的递增产层厚度模拟

引用

国外油气勘探 1991年第1期 53-63页

作者： Dennis B.neff 徐焱东

当把物性资料(孔隙度、页岩体积百分比、水饱和度等)系统的综合到产生地震记录的过程中时,一维褶积模型或合成地震记录可以提供关于油气储层地震波形特点的更多信息。从现在开始,将该模拟技术叫做递增产层厚度模拟(简写成IPT)技术,这种... 详细信息

当把物性资料(孔隙度、页岩体积百分比、水饱和度等)系统的综合到产生地震记录的过程中时,一维褶积模型或合成地震记录可以提供关于油气储层地震波形特点的更多信息。从现在开始,将该模拟技术叫做递增产层厚度模拟(简写成IPT)技术,这种模拟技术提供了有关墨西哥湾近海区若干个振幅异常的地震响应的有价值的认识。通过与物性资料进行综合,地震波形响应与预计的储层产层厚度之间的对比可以扩展到估算产层总厚度、产层净厚度、产层净孔隙厚度和地层油气。这些一维合成数据很容易转换成二维显示,二维显示常常表现出合成记录和实际地震资料之间较好的波形对比。观测到的异常波形响应包括复合调谐曲线;甚至是在不可分辨的薄储层时的有特征的等时差测量值;油气一流体接触面的地震响应的急剧变化。如果对振幅-等时差与产层厚度的关系(即峰振幅值、谷振幅值或平均振幅值与产层总厚度、产层厚度、产层纯孔隙厚度或地层内油气的关系)进行了适当的选择的活,则IPT模拟实例常常表明用地震资料可以较好地预测产层厚度,尽管这些实例表现出碳氢储层的地震响应的可变性和非唯一性。

关键词： IPT 模拟合成地震记录声波测井曲线密度测井曲线

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

用正演模拟做砂岩和碳酸盐岩储层的振幅图分析

引用

国外油气勘探 1995年第4期7卷 474-486页

作者： Dennis B.neff 刘传虎胜利石油管理局物探公司研究所

地震振幅图可供烃类储层分析这一事实已在世界范围内用于碎屑岩和碳酸盐岩储层的研究通过采用一种基于岩石物性的、称之为递增产层厚度(IPT)模拟的正演模拟方法,时5种岩石类型定量地分析了地震振幅与岩性、孔隙度、油气孔隙流体饱和度... 详细信息

地震振幅图可供烃类储层分析这一事实已在世界范围内用于碎屑岩和碳酸盐岩储层的研究通过采用一种基于岩石物性的、称之为递增产层厚度(IPT)模拟的正演模拟方法,时5种岩石类型定量地分析了地震振幅与岩性、孔隙度、油气孔隙流体饱和度、分层几何形态和储层厚度之间的相互作用。研究结果辨识出三种常见的调谐曲线形状(凹形的、凸状的和双线性的),他们基本上取决于岩性模型类型和储层的平均有效孔隙度。虽然每种类型模型由振幅图获得的产层和孔隙度预测值的可靠性不同,但全部分析结果表明有一个有限的厚度范围,在这个范围内由振幅数据能成功地预测有效孔隙厚度或油气孔隙体积。研究结果证明,在振幅图能被正确地解释之前需要做系统的正演模拟。

关键词：模拟砂岩碳酸盐岩振幅地震勘探储集层

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论述延长空气预热器使用寿命的方法步骤

引用

锅炉技术 1989年第7期20卷 17-20页

作者： J.Thomas neff 田安平 C-E预热器公司山东电力职工大学

由于空气预热器是整个电站运行工作的组成部分,在研究延长电站使用寿命的同时也必须把它考虑进去。本文论述:在延长回转再生式空气预热器使用寿命时,应遵循的主要方法步骤。

关键词：电站空气预热器使用寿命

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：