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Renin angiotensin system in liver diseases: Friend or foe?

World Journal of Gastroenterology 2017年第19期23卷 3396-3406页

作者： Ana Cristina Simoes e Silva aline S Miranda Natália P Rocha Antonio L Teixeira Department of Pediatrics Faculty of MedicineFederal University of Minas Gerais Interdisciplinary Laboratory of Medical Investigation Faculty of MedicineUFMG Laboratory of Neurobiology Department of MorphologyInstitute of Biological SciencesUFMG Neuropsychiatry Program Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolUniversity of Texas Health Science Center at Houston

In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?*** this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two *** first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver *** this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal *** therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed.

关键词： Renin angiotensin system Angiotensin Ⅱ Angiotensin-(1-7) Hepatic cirrhosis Liver fibrosis Hepatorenal syndrome

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Haemochromatosis revisited

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World Journal of Hepatology 2022年第11期14卷 1931-1939页

作者： aline Morgan Alvarenga Pierre Brissot Paulo Caleb Junior Lima Santos Department of Pharmacology-Escola Paulista de Medicina Universidade Federal de São PauloSão Paulo 04044-020Brazil University of Rennes1 Rennes 35065France

Haemochromatosis is a genetic disease caused by hepcidin deficiency,responsible for an increase in intestinal iron *** is associated with homozygosity for the HFE ***282Tyr ***,rare cases of haemochromatosis(non-HFE haemochromatosis)can also be caused by path-ogenic variants in other genes(such as HJV,HAMP,TFR2 and SLC40A1).A working group of the International Society for the Study of Iron in Biology and Medicine(BIOIRON Society)has concluded that the classification based in different molecular subtypes is difficult to be adopted in clinical practice and has proposed a new classification approaching clinical questions and molecular *** aim of the present review is to provide an update on classification,pathophysiology and therapeutic recommendations.

关键词： Haemochromatosis Iron overload HFE Molecular diagnosis Hepcidin

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Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs

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World Journal of Gastroenterology 2014年第6期20卷 1424-1437页

作者： aline Cristina Targa Cadamuro Ana Flávia Teixeira Rossi Nathália Maciel Maniezzo Ana Elizabete Silva Department of Biology UNESP-So Paulo State University Campus So José do Rio Preto

Helicobacter pylori(H. pylori) infection is the most common bacterial infection worldwide. Persistent infection of the gastric mucosa leads to inflammatory processes and may remain silent for decades or progress causing more severe diseases, such as gastric adenocarcinoma. The clinical consequences of H. pylori infection are determined by multiple factors, including host genetic predisposition, gene regulation, environmental factors and heterogeneity of H. pylori virulence factors. After decades of studies of this successful relationship between pathogen and human host, various mechanisms have been elucidated. In this review, we have made an introduction on H. pylori infection and its virulence factors, and focused mainly on modulation of host immune response triggered by bacteria, changes in the pattern of gene expression in H. pylori-infected gastric mucosa, with activation of gene transcription involved in defense mechanisms, inflammatory and immunological response, cell proliferation and apoptosis. We also highlighted the role of bacteria eradication on gene expression levels. In addition, we addressed the recent involvement of different microRNAs in precancerous lesions, gastric cancer, and inflammatory processes induced by bacteria. New discoveries in this field may allow a better understanding of the role of major factors involved in the pathogenic mechanisms of H. pylori.

关键词： Helicobacter pylori Inflammation Virulence factors Immune response Gastric lesions Gastric cancer Gene expression MicroRNAs

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FactSage Thermodynamic Database for Steelmaking Refractory Research

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China's Refractories 2015年第1期24卷 15-21页

作者： In-Ho JUNG Marie-aline VAN ENDE Mun-Kyu CHO Zhanmin CAO Mining and Materials Engineering McGill University Research Institute of Industrial Science and Technology School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

Thermodynamic databases are very useful to analyze the complex chemical reactions happening in high temperature material processes. An accurate thermodynamic database based on physically sound thermodynamic models can provide thermodynamic calculations of useful phase diagrams and comprehensive chemical reactions related to refractory corrosion in steelmaking processes. In this study,the FactS age thermodynamic database,one of the most comprehensive thermodynamic databases for oxide systems among other commercial software,is reviewed in particular for the steelmaking refractory research,and several applications to refractory corrosion are presented.

关键词： thermodynamic database CALPHAD FactSage phase diagram corrosion steelmaking

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Audiovisual translation : subtitling /

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2007年

作者： Jorge Díaz Cintas & aline Remael.

来源：畅想之星图书光盘版（南... 评论

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Immune checkpoint inhibitor-induced colitis:A comprehensive review

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World Journal of Clinical Cases 2019年第4期7卷 405-418页

作者： Aniruddh Som Rohan Mandaliya Dana Alsaadi Maham Farshidpour aline Charabaty Nidhi Malhotra Mark C Mattar Department of Internal Medicine Medstar Washington Hospital Center Department of Gastroenterology MedStar Georgetown University Hospital Department of Internal Medicine MedStar Georgetown University Hospital Department of Internal Medicine MedStar Union Memorial Hospital and Good Samaritan Hospital Department of Gastroenterology Sibley Memorial Hospital Department of Gastroenterology MedStar Washington Hospital Center

Immune checkpoint inhibitors(ICIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen-4, programmed cell death protein-1, and its ligand programmed death-ligand *** have revolutionized the treatment of a variety of malignancies. However,many immune-related adverse events have also been described which mainly occurs as the immune system becomes less suppressed, affecting various organs including the gastrointestinal tract and causing diarrhea and colitis. The incidence of immune-mediated colitis(IMC) ranges from 1%-25% depending on the type of ICI and if used in combination. Endoscopically and histologically there is a significant overlap between IMC and inflammatory bowel disease,however more neutrophilic inflammation without chronic inflammation is usually present in IMC. Corticosteroids are recommended for grade 2 or more severe colitis while holding the immunotherapy. About one third to two thirds of patients are steroid refractory and benefit from infliximab. Recently vedolizumab has been found to be efficacious in steroid and infliximab refractory cases. While in grade 4 colitis, the immunotherapy is permanently discontinued, the decision is controversial in grade 3 colitis.

关键词： Immune checkpoint inhibitors Immune-related adverse events Cytotoxic Tlymphocyte-associated antigen 4 Programmed cell death protein 1 Programmed deathligand 1 Immune-mediated colitis

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Nutrition and exercise can attenuate inflammatory and psychobiological changes in hypoxia?

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 86-90页

作者： aline Venticinque Caris Wanessa Ysis Valdir de Aquino Lemos Ricardo Bottura Ronaldo Vagner Thomatieli dos Santos Department of Psychobiology Federal University of Sao Paulo(UNIFESP)SantosBrazil Department of Bioscience Federal University of Sao Paulo(UNIFESP)SantosBrazil

Exposure to hypoxia causes damage in several physiological systems, whose tissues are dependent on the O2 supply. Recently, there has been growing attention on the immunosuppressive and inflammatory potential of the hypoxia, including stimulation, nuclear factor kappa B pathway in macrophages and Th2 response from lymphocytes. These changes may result in transient immunosuppression and happen at the same time to worsening of cognition and other psychobiological aspects. Furthermore, exercise and nutrition, especially glutamine supplementation may provide important role, not pharmacological partially reversing the effects of hypoxia. In fact, recent studies show that moderate exercise can improve cognition in people exposed to hypoxia while the exercise associated with glutamine supplementation can reverse the increase in inflammatory markers and the Th1/Th2 balance. This review aims to bring the light of the discussion about nonpharmacological ways to prevent the effects of hypoxia on the connection between the immune system and the central nervous system.

关键词： Physical exercise High altitude Inflammation Cognition Glutamine

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Application of Multi-Temporal MODIS NDVI Data to Assess Practiced Maize Calendars in Rwanda

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Journal of Resources and Ecology 2018年第3期9卷 273-280页

作者： MUGABOWINDEKWE Maurice MUYIZERE aline LI Fadong QIAO Yunfeng RWANYIZIRI Gaspard Centre for Geographic Information Systems and Remote Sensing College of Science and Technology University of Rwanda 3900 Kigali Rwanda Department of Environmental Management Bright Green Nature Ltd 2916 Kigali Rwanda Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China College of Resources and Environment University of Chinese Academy of Sciences Beijing 100190 China Department of Geography and Urban Planning College of Science and Technology University of Rwanda 3900 Kigali Rwanda

Crop calendar is an important tool providing relevant information on crops cycles in a specific area for effective agricultural management. Crop calendars vary in different areas given dissimilarities in agro-ecosystems＇ characteristics. This research used multi-temporal MODIS NDVI stratification to assess differences in practiced maize crop calendars in various areas of Rwanda. Four（4） sample NDVI strata dominated by agriculture were purposively chosen, and 433 local farmers were randomly selected from the strata for interviews. The collected information helped to know about their maize planting as well as harvesting dates in order to generate maize calendars per NDVI strata. The generated crop calendars were later classified using k-means unsupervised classification, and produced 4 groupings of practiced maize calendars irrespective of NDVI strata. ANOVA results revealed significant differences between both the generated maize crop calendars by NDVI strata and the practiced crop calendars irrespective of NDVI strata, at p = 0.05. Moreover, chi-square tests and t-tests revealed not only a significant relationship between maize calendars and number of crop growing seasons, but also a significant relationship between maize calendars and NDVI strata, at p = 0.05. Finally, findings of this research contrasted the present conviction that there exist a single general maize calendar all over the country. Instead, the results were in accordance with the fact that Rwanda agro-ecosystems differ from East to West in terms of, mainly, altitude and rainfall patterns variations.

关键词： NDVI data stratification crop calendar maize growing season Rwanda

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Salvage anastomosis in free PAP-flap breast reconstruction:What about free flap neovascularization?

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第4期5卷 178-181页

作者： Michael Hepp aline Berners Christine Deconinck Genevieve Pirson Maxime Servaes Philippe Fosseprez Department of Plastic Reconstructive and Aesthetic SurgeryCHU UCL NamurNamur 5000Belgium

Since the emergence of microsurgery in reconstructive surgery, free flaps have become a key tool in the management of patients with breast cancer. One such flap is the profunda artery perforator(PAP) flap. To date,there is no scientific consensus on whether voluminous free flaps remain dependent on their vascular pedicle throughout their lifespan. Therefore, the pedicle should always be carefully protected during revision *** this article, we review the case of a middle-aged woman who suffered a pedicle transection needing reanastomosis during revision surgery six months after free-flap breast reconstruction. A 52-year-old woman who noticed a firm nodule in her right breast and armpit was referred to our department for surgical management. The Caucasian woman presented with no significant medical history or symptoms at the first consultation. Ultrasound-guided biopsy confirmed an invasive grade Ⅲ lobular carcinoma. Following staging,the patient underwent neoadjuvant chemotherapy before a right mastectomy with a complete homolateral axillary lymph node dissection and postoperative radiotherapy. One year after completing radiotherapy, free flap reconstruction with a PAP flap was performed, and six months later, revision surgery was required to enhance the volume of the reconstructed breast with a tissue expander and later an implant. Unfortunately,pedicle transection occurred during revision surgery, causing complete devascularization of the flap, which was confirmed by intraoperative Indocyanine Green imaging. The authors elected to perform salvage reanastomosis during the surgery. In keeping with the author’s 23-year experience with free flaps, the vascular pedicle should always be preserved in voluminous free flaps, as neovascularization alone may not ensure whole flap survival. The authors suggest always attempting re-anastomosis if vessels are compromised during revision surgery.

关键词： Free flap Autonomy Vascular pedicle Revascularization PAP flap Microsurgery

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Analysing the impact of migration on HIV/AIDS cases using epidemiological modelling to guide policy makers

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Infectious Disease Modelling 2022年第1期7卷 252-261页

作者： Ofosuhene O.Apenteng Prince P.Osei Noor Azina Ismail aline Chiabai Division for Global Surveillance Research Group for Genomic EpidemiologyNational Food InstituteTechnical University of DenmarkKongens LyngbyDenmark School of Mathematics and Statistics Carleton UniversityCanada Department of Statistics University of HaifaIsrael Department of Applied Statistics Faculty of Economics and AdministrationUniversity of MalayaKuala LumpurMalaysia Basque Centre for Climate Change(BC3) LeioaSpain

In this paper,we present the impact of migration on the spread of HIV and AIDS cases.A simple model for HIV and AIDS that incorporates migration and addresses its contributions to the spread of HIV and AIDS cases was *** model was calibrated to HIV and AIDS incidence data from *** explore the use of Markov chain Monte Carlo(MCMC)simulation method to estimate uncertainty in all the unknown parameters incorporated in our proposed *** the migrant population,1.5572e-01 were susceptible to HIV transmission,which constituted 67,801 migrants.A proportion of migrants,6.3773e-04,were estimated to be HIV infected,constituting 278 *** were 72(per 10,000)migrants estimated to have had AIDS,representing a proportion of *** result suggests that the disease-free steady state was unstable since the estimated basic reproduction number R0 was 2.0906 and 2.3322 for the models without and with migration,*** is not a good indicator from the public health point of view,as the aim is to stabilize the epidemic at the disease-free *** advantage of introduction of migration to the simple model validated the true R0 and the transmission rate b associated with HIV and AIDS epidemic disease in *** also indicates an approximately 12 percentage points increase in the rate of HIV infection with migration.

关键词： Migration Mathematical transmission modeling HIV/AIDS Parameter estimation Basic reproduction number

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