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Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

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Research 2024年第1期2023卷 763-778页

作者： Qing Liu Qiaoyun Long Jiayu Zhao Wenjie Wu Zexin Lin Wei Sun Ping Gu Tuo Deng Kerry Martin Loomes Donghai Wu alice P.S.Kong Jingying Zhou Alfred S.Cheng Hannah Xiaoyan Hui School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina China-New Zealand Joint Laboratory on Biomedicine and Health Chinese Academy of SciencesGuangzhouChina Department of Endocrinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of Diabetes Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina School of Biological Sciences and Maurice Wilkins Centre University of AucklandAucklandNew Zealand Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Adipose browning has demonstrated therapeutic potentials in several ***,by conducting transcriptomic profiling at the single-cell and single-nucleus resolution,we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue(iWAT)at thermoneutrality or chronic cold *** major nonimmune cells within the iWAT,including adipose stem and progenitor cells(ASPCs),mature adipocytes,endothelial cells,Schwann cells,and smooth muscle cells,were recovered,allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown *** findings also unravel the existence of subpopulations in mature adipocytes,ASPCs,and endothelial cells,as well as new insights on their interconversion and reprogramming in response to *** adipocyte subpopulation competent of major histocompatibility complex class Ⅱ(MHCⅡ)antigen presentation is ***,a subcluster of ASPC with CD74 expression was identified as the precursor of this MHCⅡ^(+)*** adipocytes are transdifferented from preexisting lipid generating adipocytes,which exhibit developmental trajectory from de novo differentiation of amphiregulin cells(Aregs).Two distinct immune-like endothelial subpopulations are present in iWAT and are responsive to *** data reveal fundamental changes during cold-evoked adipose browning.

关键词： evoked programming generating

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Management of Severely Malnourished Children Aged 6 - 59 Months Hospitalized in the Pediatric Ward of Kayanza Hospital/Burundi

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Open Journal of Pediatrics 2024年第1期14卷 11-21页

作者： Michel Baseka Jonathan Niyukuri alice Ndayishimiye Sedki Az-Eddine Vestine Ntakarutimana Department of Health Nutrition Doctoral School University of Burundi Bujumbura Burundi Food Science and Technology Research Center (CRSTA) Department of Food Science and Technology (STA) Faculty of Agronomy and Bioengineering (FABI) University of Burundi Bujumbura Burundi East African Institute of Nutritional Sciences Bujumbura Burundi Faculty of Medicine University of Burundi Bujumbura Burundi Department of Biology Semlalia Faculty of Science Cadi Ayyad University Marrakech Morocco Centre de recherche en sciences naturelles et environnementales Faculty of Science University of Burundi Bujumbura Burundi

The implementation of WHO guidelines has significantly reduced hospital mortality due to severe malnutrition. Nevertheless, severe acute malnutrition in children under five remains a major public health problem in all low-income countries and is little studied. The study aimed to assess the nutritional status and quality of management of severe acute malnutrition in children aged 06 to 59 months hospitalized in the pediatric ward of Kayanza Hospital. This is a prospective study with descriptive and analytical aims over 6 months from February 10 to July 9, 2023. All children aged 6 to 59 months admitted for severe acute malnutrition are included in this study. The results show that the most affected age group is 12 to 23 months (42.55%). Marasmus is the most common clinical form, at 70.2%. Housewives and mothers from rural areas are the most affected, with rates ranging from 69.14% to 91.49%. The study shows that the reasons for consultation are respectively: edema (29.78%), diarrhea (26.59%), vomiting (19.14%), and fever (14.89%). Dehydration and hypothermia were the main complications observed in 45.74% and 22.34% respectively. Medical treatment was provided by antibiotics (44.68%), artesunate (31.91%), and resomal (21.27%). Nutritional treatment consisted of F75 100% milk and F100 100% milk. Pathologies observed were: anemia 38.29%, malaria 37.23%, urinary tract infection 12.7%, measles 11.7%. The national protocol for integrated management of acute malnutrition (PCIMA) was followed. This study shows that 72.3% of children were successfully treated, with 9.5% dropping out and dying, and 8.5% not responding. We found that malnutrition remains a public health problem, affecting mostly children aged 12 to 24 months. The main complications or pathologies associated with malnutrition are diarrhea, malaria, and fever, and the majority of children suffer from marasmus.

关键词： Severe Acute Malnutrition Child Burundi

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Exploring fs-laser irradiation damage subthreshold behavior of dielectric mirrors via electrical measurements

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High Power Laser Science and Engineering 2024年第2期12卷 24-32页

作者： Petrisor Gabriel Bleotu Radu Udrea alice Dumitru Olivier Uteza Maria-Diana Mihai Dan Gh Matei Daniel Ursescu Stefan Irimiciuc Valentin Craciun Extreme Light Infrastructure-Nuclear Physics(ELI-NP) Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)MagureleRomania Doctoral School of Physics University of BucharestMagureleRomania LULI-CNRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Apel Laser IlfovRomania Aix-Marseille University CNRSLP3 UMR 7341MarseilleFrance Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH) MagureleRomania University Politehnica of Bucharest BucharestRomania National Institute for Lasers Plasma and Radiation Physics MagureleRomania

With ultrafast laser systems reaching presently 10 PW peak power or operating at high repetition rates,research towards ensuring the long-term,trouble-free performance of all laser-exposed optical components is *** work is focused on providing insight into the optical material behavior at fluences below the standardized laser-induced damage threshold(LIDT)value by implementing a simultaneous dual analysis of surface emitted particles using a Langmuir probe(LP)and the target current(TC).HfO_(2) and ZrO_(2) thin films deposited on fused silica substrates by pulsed laser deposition at various O_(2) pressures for defect and stoichiometry control were irradiated by Gaussian,ultrashort laser pulses(800 nm,10 Hz,70 fs)in a wide range of *** TC and LP collected signals were in good agreement with the existing theoretical description of laser–matter interaction at an ultrashort time *** approach for an in situ LIDT monitoring system provides measurable signals for below-threshold irradiation conditions that indicate the endurance limit of the optical surfaces in the single-shot energy scanning *** LIDT value extracted from the LP-TC system is in line with the multipulse statistical analysis done with ISO 21254-2:2011(E).The implementation of the LP and TC as on-shot diagnostic tools for optical components will have a significant impact on the reliability of next-generation ultrafast and high-power laser systems.

关键词： HfO_(2) in situ detection Langmuir probe laser-induced damage threshold target current ZrO_(2)

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护你周全

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初中生 2024年第6期 28-29页

作者： alice(赏析) 不详

埃利安娜出生于瑞士,是一名创作型女歌手。她从小学习弹钢琴,有良好的乐感和表演基础。2012年,埃利安娜参加瑞士选秀节目,获得年度冠军后顺利成为一名职业音乐人,在全球拥有众多乐迷。她的嗓音优美、轻盈而富有力量。

关键词：选秀节目女歌手弹钢琴安娜表演基础瑞士一名

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我的毕业典礼

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光明少年 2024年第7期 52-54页

作者： alice Xie

我叫alice Xie,中文名字谢海跃。在美国,我们被称为ABC,即“American Born Chinese”,意为“在美国出生的中国人”。今年,我迎来了人生中的一个重要时刻——11岁的我,刚刚小学毕业。美国小学共六年,第一年是学前班,五年级是小学的最后...

我叫alice Xie,中文名字谢海跃。在美国,我们被称为ABC,即“American Born Chinese”,意为“在美国出生的中国人”。今年,我迎来了人生中的一个重要时刻——11岁的我,刚刚小学毕业。美国小学共六年,第一年是学前班,五年级是小学的最后一年。毕业典礼是学校每年的盛事,更是我们小学生涯中非常值得纪念的仪式,所有五年级的学生都盼着这一天的到来。

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Microbiological Quality of Cyperus esculentus L. Products Sold in Ouagadougou and Bobo Dioulasso (Burkina Faso)

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Open Journal of Applied Sciences 2024年第3期14卷 635-642页

作者： Zénabou Semdé Passinguemsin alice Sonia Tiendrebeogo Bahanla Edwige Oboulbiga Charles Parkouda Hagrétou Sawadogo Lingani Laboratoire des Sciences et Technologies des Aliments et Nutrition Département technologie alimentaire IRSAT CNRST Ouagadougou Burkina Faso

This study aimed to assess the microbiological quality of tiger nut (Cyperus esculentus L.) products sold in Ouagadougou and Bobo Dioulasso. The microbial load of tubers and tiger nut milk was determined using ISO 4833-1 (2003) standard (total mesophilic aerobic flora), NF ISO 7954 (1998) standard (yeasts and molds), and ISO 4832 (2006) standard (total coliforms, thermotolerant coliforms). The results showed that tiger nut tubers had an average microbial load between 4.86 ± 7.03 × 106 UFC/g and 1.82 ± 2.30 × 107 UFC/g for total mesophilic aerobic flora, from 4.34 ± 10.6 × 105 UFC/g to 3.52 ± 4.54 × 106 UFC/g for yeasts and molds, from 2.23 ± 2.25 × 105 UFC/g to 1.41 ± 2.16 × 105 UFC/g for total coliforms and from 1.83 ± 2.03 × 105 UFC/g to 7.0 ± 10.8 × 104 CFU/g for thermotolerant coliforms. For tiger nut milk samples, the average microbial load varied from 3.48 ± 2.98 × 106 CFU/g to 2.80 ± 5.69 × 107 CFU/g for total mesophilic aerobic flora, from 5.00 ± 7.21 × 104 CFU/g to 1.88 ± 3.31 × 105 CFU/g for yeasts and molds, from 4.58 ± 10.4 × 104 CFU/g to 6.31 ± 9.17 × 105 CFU/g for total coliforms and 7.00 ± 7.00 × 103 CFU/g to 2.87 ± 5.86 × 105 CFU/g for thermotolerant coliforms. This study revealed that the tubers and tiger nut milk sold in Ouagadougou and Bobo Dioulasso had a high microbial load which could lead to the degradation of these products and food poisoning for consumers.

关键词： Cyperus esculentus L. Tiger Nut Tubers Tiger Nut Milk Microbiological Quality

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多层次营销迷局

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商业周刊（中文版） 2024年第8期 64-71页

作者： alice KANTOR MICHAEL KENNEDY(插图) 不详

IM Academy向年轻的投资者承诺可以让他们快速致富许多会员反而失望了,甚至失去一切当帕特里斯·雷查兹(Patrice Rechards)走进鹿特丹的这个体育场时,流行歌曲响起,闪光灯令人眼花缭乱,她能感觉到身体里流尚着一股神明之力。她在阿姆斯... 详细信息

IM Academy向年轻的投资者承诺可以让他们快速致富许多会员反而失望了,甚至失去一切当帕特里斯·雷查兹(Patrice Rechards)走进鹿特丹的这个体育场时,流行歌曲响起,闪光灯令人眼花缭乱,她能感觉到身体里流尚着一股神明之力。她在阿姆斯特丹的一个相对贫穷且笃信宗教的家庭长大,是苏里南和荷兰混血,她一直都知道自已有更高的目标。但是,直到她发现了IMAcademy,她才明白这个目标到底是什么。自三个月前加人这个金融教育平台以来,这位26岁的女孩已经学会了如何交易期权、加密货币、股票和外汇,所有这些都是为了追求致富一一很快,她将与其他人分享这些课程。去年春天,她和来自欧洲各地的其他1.5万名年轻的IM会员一起完成了朝圣之旅,在为期三天的会议上亲眼见到了他们的导师克里斯·特里(Chris Terry),他正是IM的首席执行官。

关键词：首席执行官阿姆斯特丹期权苏里南营销闪光灯多层次

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Percutaneous decannulation of extracorporeal membrane oxygenation using MANTA device:A real-world single-center experience

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World Journal of Cardiology 2024年第10期16卷 574-579页

作者： Ioannis Milioglou alice Qian Pedro Rafael Vieira de Oliveira Salerno Gabriel Tensol Rodrigues Pereira Luis Augusto Palma Dallan Kelsey E Gray Michael Morrison Yasir Abu-Omar Mohammad Eldiasty Cristian Baeza Department of Cardiology University Hospitals Cleveland Medical CenterClevelandOH 44106United States Department of Surgery University Hospitals Cleveland Medical Center and Case Western Reserve University School of MedicineClevelandOH 44106United States

BACKGROUND The MANTA vascular closure device(VCD)represents a novel approach to achieving hemostasis after large-bore femoral access *** clinical studies have evaluated the efficacy of the MANTA device across a range of patient populations undergoing different ***,there is still a paucity of data available concerning the use of MANTA devices in aiding the decannulation of venoarterial extracorporeal membrane oxygenation(VAECMO).AIM To present our single-center experience of utilizing the MANTA VCD in patients undergoing this *** This single-center study included all patients undergoing percutaneous decannulation of femoral VA-ECMO using the MANTA plug-based VCD between January 2021 and October 2023 at University Hospitals Cleveland Medical *** criteria were adult patients who required prolonged(>24 hours)hemodynamic support with *** included all-cause mortality,hemostasis,bleeding,limb ischemia,and site *** This is a retrospective cohort study of 19 patients with a mean age of 56.8 *** of them were males with a mean body mass index of *** most common extracorporeal membrane oxygenation indication was acute coronary syndrome complicated by cardiogenic shock at 36.8%.The mean length of intensive care unit stay for these patients was 18.8±8.42 *** out of 19 patients survived to *** MANTA device was successfully deployed in 19 patients,with 10 procedures conducted at the bedside and 9 in an operating room *** hemostasis was achieved within 5 minutes of MANTA deployment in 17 out of 19 *** 2 patients manual compression after Manta deployment was required to achieve adequate ***,acute lower extremity ischemia was noted in two patients,necessitating endovascular *** infections were reported at the site of MANTA *** Overall,based on our experience and that of other centers,the MANTA VCD

关键词： Extracorporeal membrane oxygenation MANTA Decannulation Hemostasis Ischemia

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草地贪夜蛾对新入侵地区蝙蝠超声波胁迫的行为反应和转录组分析

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生态学报 2024年

作者：石林云张亚宁江廷磊杨采青孙成 alice Catherine Hughes 张爱兵首都师范大学生命科学学院东北师范大学吉林省动物资源保护与利用重点实验室香港大学生物科学学院

草地贪夜蛾Spodoptera frugiperda是一种极具破坏性的入侵物种，对粮食作物构成重大威胁。蝙蝠是鳞翅目昆虫的重要天敌之一，控制着鳞翅目昆虫的生存和数量。为探究草地贪夜蛾在到达新的入侵地区后，是否以及如何对入侵地的食虫蝙蝠发... 详细信息

草地贪夜蛾Spodoptera frugiperda是一种极具破坏性的入侵物种，对粮食作物构成重大威胁。蝙蝠是鳞翅目昆虫的重要天敌之一，控制着鳞翅目昆虫的生存和数量。为探究草地贪夜蛾在到达新的入侵地区后，是否以及如何对入侵地的食虫蝙蝠发出的超声波做出响应，本研究首先观察并记录了草地贪夜蛾在暴露于入侵地蝙蝠超声波前后的行为变化，然后以正常环境中的成虫作为对照，对暴露于蝙蝠超声0.5、3、12、24、48小时和72小时的一日龄雄性草地贪夜蛾转录组进行比较分析。转录组的综合分析为研究蝙蝠超声信号对草地贪夜蛾产生的分子变化提供有价值的信息。行为结果表明，在草地贪夜蛾听觉范围内的入侵地蝙蝠超声波可以显著降低蛾类的行为活动，表明这些信号可能在成虫的行为中起着至关重要的作用。转录组分析表明，蝙蝠超声胁迫诱导了草地贪夜蛾体内广泛的基因表达变化，与对照组相比，不同时长的超声刺激下共鉴定出2389个显著上调基因和2491个显著下调基因，将在多个时间点均显著上调或下调的521个基因定义为草地贪夜蛾对蝙蝠超声响应的关键基因。对这些关键基因的GO和KEGG富集分析进一步揭示了蝙蝠超声胁迫对草地贪夜蛾的不同影响过程，结果显示215个上调基因与神经信号传递、声音感知、听觉受体细胞发育、氧化应激和恐惧反应等过程高度相关，306个下调基因主要富集在各种能量代谢途径和生物合成过程中。通过qRT-PCR实验验证了转录组分析结果的可靠性。本研究为草地贪夜蛾应对蝙蝠超声胁迫的生物学和分子机制提供了新的见解，并为今后开发更有效、更环保的方法控制鳞翅目害虫提供更多依据。

关键词：草地贪夜蛾入侵物种超声波胁迫行为活动转录组

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Amniotic Band Syndrome at the Van Norman Clinic in Burundi: A Case Series

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Surgical Science 2024年第3期15卷 118-124页

作者： alice Ndayishimiye Hélène Bukuru Déogratias Niyungeko Anne Marie Nikuze Sylvestre Bazikamwe Jean Claude Mbonicura Gilbert Ndayizeye Department of Pediatrics Kamenge University Hospital Center Bujumbura Burundi Department of Obstetrics and Gynecology Kamenge University Hospital Center Bujumbura Burundi General Surgery Department Kamenge University Hospital Center Bujumbura Burundi Orthopaedy Department Kamenge University Hospital Center Bujumbura Burundi

Amniotic band syndrome is an acquired embryo-fetopathy. It is rare and is characterized by malformations mainly affecting the limbs but also the skull, face and thoraco-abdominal axis. Its etiopathogenesis remains poorly understood. Its diagnosis is essentially clinical and is classically based on the existence of signs such as furrows, amputations and pseudosyndactyly. To show the importance of antenatal diagnosis in resource-limited countries, we report the case of two newborns, one premature at 31 weeks and the other at term, in whom amniotic band syndrome was discovered incidentally at birth. It involved an amputation of the right leg for both cases. The premature baby was born in a context of neonatal sepsis and will succumb to the latter while the 2nd case was released from the hospital alive. Imaging examinations to search for probable congenital malformations could only be carried out for the 2nd case and no accessible congenital malformation had been identified. And as management of the disease, only psychological support to the parents was provided for the 2 cases. The antenatal discovery of a case of amniotic band syndrome in countries with low technical capacity such as Burundi should push clinicians to think in time about treatment options.

关键词： Amniotic Band Syndrome Embryo-Fetopathies Antenatal Diagnosis Limbs

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