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Does orthotics use improve comfort,speed,and injury rate during running?A randomised control trial

World Journal of Orthopedics 2023年第5期14卷 348-361页

作者： alice e fortune Jonathan M G Sims George Ampat School of Medicine University of LiverpoolLiverpool L693GEUnited Kingdom Research Unit Talita Cumi Ltd.SouthportPR83NSUnited Kingdom School of Medicine University of LiverpoolLiverpool L693GEMerseysideUnited Kingdom

BACKGROUND Running is a hugely popular ***,running-related injury(RRI)rates are high,particularly amongst amateur and recreational *** ways to reduce RRI rates and maximise comfort and performance for runners is *** regarding whether orthotics can successfully improve these parameters is limited and *** research is required to provide runners with clearer guidance on the usefulness of *** To investigate the effect of Aetrex Orthotics on comfort,speed and RRI rates during recreational *** One hundred and six recreational runners were recruited on a voluntary basis via running clubs and social media pages and randomised into either the intervention or control *** in the intervention group ran with Aetrex L700 Speed Orthotics inserted in their usual running shoes,whilst participants in the control group ran in their usual running shoes with no *** study ran for an 8-wk *** provided data relating to running comfort,distance,and time during weeks *** provided data relating to any RRIs they sustained during all 8 *** distance and time were used to calculate running speed in miles per hour(mph).For each outcome variable,95%confidence intervals and P values were calculated to assess the statistical significance between the *** comfort and speed data,univariate multi-level analysis was performed,and for outcome variables with significant between group differences,multi-level multivariate analysis was performed to evaluate any confounding effects of gender and *** Ninety-four participants were included in the final analysis(drop-out rate=11%).Comfort and speed from 940 runs and 978 injury data reports were *** who ran with orthotics reported,on average,speeds 0.30 mph faster(P=0.20)and comfort scores 1.27 points higher(P≤0.001)than participants who ran with no *** were also 2.22 times less

关键词： Running Foot orthoses Running related injuries Pain Patient comfort Athletic performance

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Does orthotics use improve comfort,speed and injury rate during running?Preliminary analysis of a randomised control trial

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World Journal of Orthopedics 2022年第7期13卷 652-661页

作者： alice e fortune Jonathan M G Sims Samantha J Rhodes George Ampat School of Medicine University of LiverpoolLiverpool L693GEUnited Kingdom Research Unit Talita Cumi LtdSouthport PR83NSUnited Kingdom

BACKGROUND evidence regarding the effectiveness of using orthotics in improving comfort,increasing running speed and helping to reduce injury rate during running is limited and *** the increasing popularity of running is the increasing rate of running-related injuries(RRIs).Further research into whether orthotics could be used to help reduce RRIs would be highly beneficial for those ***,there is a need to clarify whether orthotics use increases comfort during running and helps improve running *** To investigate whether running with Aetrex Orthotics improves comfort and performance and reduces injury whilst *** Runners were recruited on a voluntary basis if they were 18 or older with no serious health conditions,ongoing foot pain or deformity,previous foot surgery in their lifetime or any surgery in the past 6 *** were randomly assigned to either an intervention group or a control *** participants were asked to complete runs and provide quantitative data regarding comfort during running,running time and distance,and any RRIs over an 8-wk study *** in the intervention group ran with Aetrex L700 Speed Orthotics,whilst participants in the control group ran without *** than the addition of orthotics for participants in the intervention group,all participants were asked to run as they usually *** report presents preliminary data from the first 47 participants recruited for this *** speed was calculated from running distance and time and given in miles per *** each outcome variable,the mean for each group,effect size and 95%confidence interval were calculated,and a t-test was performed to determine if between-group differences were statistically *** Data for all three primary outcomes was provided from a total of 254 runs by the 23 participants in the intervention group and a total of 289 runs by the 24 participants in the control ***

关键词： Running Foot orthoses Running related injuries Pain Patient comfort Athletic performance

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Use of orthotics with orthotic sandals versus the sole use of orthotics for plantar fasciitis:Randomised controlled trial

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世界骨科杂志:英文版 2023年第9期14卷 707-719页

作者： Portia Amoako-Tawiah Holly Love Jaida Chacko Madathilethu Jessica LaCourse alice e fortune Jonathan M G Sims George Ampat School of Medicine University of LiverpoolMerseysideLiverpool L693GEUnited Kingdom Urology Royal Stoke University HospitalStaffordshireStoke ST46QGUnited Kingdom Research Unit Talita Cumi Ltd.MerseysideSouthport PR83NSUnited Kingdom

BACKGROUND Plantar fasciitis(PF)affects around 10%of the *** orthotics with arch support has been shown to provide symptom relief in PF by decreasing the repetitive stress sustained by the plantar ***,prefabricated orthotics are only effective when shoes are worn,meaning the foot may be left unsupported when it is impractical to wear *** orthotic sandals in conjunction with prefabricated orthotics may increase PF symptom relief,as they can be worn inside the home,extending the period in which the foot is *** To compare the combined use of prefabricated orthotics and orthotic sandals vs the sole use of prefabricated orthotics in the treatment of *** 98 participants with PF were randomised into two *** intervention group received the Aetrex L420 Compete orthotics and the Aetrex L3000 Maui Flips(orthotic sandals),whilst the control group received the Aetrex L420 Compete orthotics *** pain was assessed both by the numerical rating scale(NRS)and the pain sub-scale of the foot health status questionnaire(FHSQ).Foot functionality was measured using the function sub-scale of the *** change was measured using the global rating of change scale(GROC).ReSULTS Foot pain scores measured both by NRS and FHSQ pain sub-scale showed statistically significant reductions in foot pain in both groups(Peported statistically significant improvements(Peasured by the FHSQ function subscale and improvement of symptoms as measured by the GROC ***-group analysis showed that the intervention group with the combined use of orthotics and orthotic sandals scored better on all four outcome measures as compared to the control group with the sole use of ***,the between-group analysis only reached statistical significance on the NRS pain score(Ped use of prefabricated orthotics and orthotic sandals provides a greater d

关键词： Plantar fasciitis Foot diseases Musculoskeletal pain Foot orthoses

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A Theoretically Grounded Question Answering Data Set for evaluating Machine Common Sense

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Data Intelligence 2024年第1期6卷 1-28页

作者： Henrique Santos Ke Shen alice M.Mulvehill Mayank Kejriwal Deborah L.McGuinness Rensselaer Polytechnic Institute Troy NY Information Sciences Institute Marina del Rey CA

Achieving machine common sense has been a longstanding problem within Artificial *** far,benchmark data sets that are grounded in a theory of common sense and can be used to conduct rigorous,semantic evaluations of common sense reasoning(CSR)systems have been *** expectation of the AI community is that neuro-symbolic reasoners can help bridge this gap towards more dependable systems with common *** propose a novel benchmark,called Theoretically Grounded common sense Reasoning(TG-CSR),modeled as a set of question answering instances,with each instance grounded in a semantic category of common sense,such as space,time,and *** benchmark is few-shot i.e.,only a few training and validation examples are provided in the public release to avoid the possibility of *** from recent evaluations suggest that TG-CSR is challenging even for state-of-the-art statistical *** to its semantic rigor,this benchmark can be used to evaluate the common sense reasoning capabilities of neuro-symbolic systems.

关键词： reasoning Intelligence instance

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Percutaneous decannulation of extracorporeal membrane oxygenation using MANTA device:A real-world single-center experience

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World Journal of Cardiology 2024年第10期16卷 574-579页

作者： Ioannis Milioglou alice Qian Pedro Rafael Vieira de Oliveira Salerno Gabriel Tensol Rodrigues Pereira Luis Augusto Palma Dallan Kelsey e Gray Michael Morrison Yasir Abu-Omar Mohammad eldiasty Cristian Baeza Department of Cardiology University Hospitals Cleveland Medical CenterClevelandOH 44106United States Department of Surgery University Hospitals Cleveland Medical Center and Case Western Reserve University School of MedicineClevelandOH 44106United States

BACKGROUND The MANTA vascular closure device(VCD)represents a novel approach to achieving hemostasis after large-bore femoral access *** clinical studies have evaluated the efficacy of the MANTA device across a range of patient populations undergoing different ***,there is still a paucity of data available concerning the use of MANTA devices in aiding the decannulation of venoarterial extracorporeal membrane oxygenation(VAeCMO).AIM To present our single-center experience of utilizing the MANTA VCD in patients undergoing this *** This single-center study included all patients undergoing percutaneous decannulation of femoral VA-eCMO using the MANTA plug-based VCD between January 2021 and October 2023 at University Hospitals Cleveland Medical *** criteria were adult patients who required prolonged(>24 hours)hemodynamic support with *** included all-cause mortality,hemostasis,bleeding,limb ischemia,and site *** This is a retrospective cohort study of 19 patients with a mean age of 56.8 *** of them were males with a mean body mass index of *** most common extracorporeal membrane oxygenation indication was acute coronary syndrome complicated by cardiogenic shock at 36.8%.The mean length of intensive care unit stay for these patients was 18.8±8.42 *** out of 19 patients survived to *** MANTA device was successfully deployed in 19 patients,with 10 procedures conducted at the bedside and 9 in an operating room *** hemostasis was achieved within 5 minutes of MANTA deployment in 17 out of 19 *** 2 patients manual compression after Manta deployment was required to achieve adequate ***,acute lower extremity ischemia was noted in two patients,necessitating endovascular *** infections were reported at the site of MANTA *** Overall,based on our experience and that of other centers,the MANTA VCD

关键词： extracorporeal membrane oxygenation MANTA Decannulation Hemostasis Ischemia

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exploring fs-laser irradiation damage subthreshold behavior of dielectric mirrors via electrical measurements

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High Power Laser Science and engineering 2024年第2期12卷 24-32页

作者： Petrisor Gabriel Bleotu Radu Udrea alice Dumitru Olivier Uteza Maria-Diana Mihai Dan Gh Matei Daniel Ursescu Stefan Irimiciuc Valentin Craciun extreme Light Infrastructure-Nuclear Physics(eLI-NP) Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering(IFIN-HH)MagureleRomania Doctoral School of Physics University of BucharestMagureleRomania LULI-CNRS CEAUniversite SorbonneEcole PolytechniqueInstitut Polytechnique de ParisPalaiseau CEDEXFrance Apel Laser IlfovRomania Aix-Marseille University CNRSLP3 UMR 7341MarseilleFrance Horia Hulubei National Institute for R&D in Physics and Nuclear engineering(IFIN-HH) MagureleRomania University Politehnica of Bucharest BucharestRomania National Institute for Lasers Plasma and Radiation Physics MagureleRomania

With ultrafast laser systems reaching presently 10 PW peak power or operating at high repetition rates,research towards ensuring the long-term,trouble-free performance of all laser-exposed optical components is *** work is focused on providing insight into the optical material behavior at fluences below the standardized laser-induced damage threshold(LIDT)value by implementing a simultaneous dual analysis of surface emitted particles using a Langmuir probe(LP)and the target current(TC).HfO_(2) and ZrO_(2) thin films deposited on fused silica substrates by pulsed laser deposition at various O_(2) pressures for defect and stoichiometry control were irradiated by Gaussian,ultrashort laser pulses(800 nm,10 Hz,70 fs)in a wide range of *** TC and LP collected signals were in good agreement with the existing theoretical description of laser–matter interaction at an ultrashort time *** approach for an in situ LIDT monitoring system provides measurable signals for below-threshold irradiation conditions that indicate the endurance limit of the optical surfaces in the single-shot energy scanning *** LIDT value extracted from the LP-TC system is in line with the multipulse statistical analysis done with ISO 21254-2:2011(e).The implementation of the LP and TC as on-shot diagnostic tools for optical components will have a significant impact on the reliability of next-generation ultrafast and high-power laser systems.

关键词： HfO_(2) in situ detection Langmuir probe laser-induced damage threshold target current ZrO_(2)

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Infectious causation of chronic disease:examining the relationship between Giardia lamblia infection and irritable bowel syndrome

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World Journal of Gastroenterology 2007年第34期13卷 4574-4578页

作者： alice S Penrose eden V Wells Allison e Aiello Preventive Medicine University of Michigan Ann Arbor MI 48109-2029 United States Michigan Department of Community Health Lansing MI United States Department of epidemiology University of Michigan Ann Arbor MI 48109-2029 United States

AIM: To evaluate whether a higher prevalence of Giardia lamblia infection is associated with an increase in irritable bowel syndrome (IBS) prescriptions at the county level in Michigan. MeTHODS: The Michigan Disease Surveillance System (MDSS) was used to ascertain both the numbers of Giardia lamblia infections as well as the total number of foodborne illnesses per population by county in Michigan during 2005. This was compared with Blue Cross Blue Shield (BCBS) of Michigan numbers of drug prescriptions for IBS per one thousand members per county in 2005. These data were also analyzed for associations with per capita income by county and the number of refugees entering each county in 2005. ReSULTS: There were a total of 786 confirmed cases of Giardia lamblia reported to MDSS in 2005. During the same time period, the number of prescriptions for IBS varied from 0.5 per 1000 members up to 6.0 per 1000 members per month. There was no trend towards higher numbers of IBS prescriptions in the counties with more Giardia lamblia infections. Per capita income was not associated with either IBS prescriptions or Giardiasis. There was a significant linear association between the number of refugees entering each county, and the number of Giardia lamblia cases per 100 000 population. CONCLUSION: In this ecological study, there was no association found between BCBS prescriptions for IBS and Giardia lamblia infections in Michigan counties. Our findings may have been influenced by the disparate number of refugees admitted per county.

关键词： Foodborne Gastrointestinal Giardia lamblia Irritable bowel syndrome Parasite Prescription Refugees

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Finite Line-transitive Linear Spaces:Theory and Search Strategies

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Acta Mathematica Sinica,english Series 2009年第9期25卷 1399-1436页

作者： Anton BeTTeN Anne DeLANDTSHeeR Maska LAW alice C. NIeMeYeR Cheryl e. PRAeGeR Shenglin ZHOU Colorado State University Department of Mathematics Fort Collins CO 80523 U.S.A. Universite Libre de Bruxelles Facultd des Sciences appliquges CP165J11 av. F.D. Roosevelt 50 B 1050 Brussels Belgium The University of Western Australia School of Mathematics and Statistics 35 Stirling Highway Crawley 6009 Australia Department of Mathematics South China University of Technology Guangzhou 510641 China

The paper summarises existing theory and classifications for finite line-transitive linear spaces, develops the theory further, and organises it in a way that enables its effective application. The starting point is a theorem of Camina and the fifth author that identifies three kinds of line-transitive automorphism groups of linear spaces. In two of these cases the group may be imprimitive on points, that is, the group leaves invariant a nontrivial partition of the point set. In the first of these cases the group is almost simple with point-transitive simple socle, and may or may not be point-primitive, while in the second case the group has a non-trivial point-intransitive normal subgroup and hence is definitely point-imprimitive. The theory presented here focuses on point-imprimitive groups. As a non-trivial application a classification is given of the point-imprimitive, line-transitive groups, and the corresponding linear spaces, for which the greatest common divisor gcd（k, v - 1） ≤ 8, where v is the number of points, and k is the line size. Motivation for this classification comes from a result of Weidong Fang and Huffing Li in 1993, that there are only finitely many non-trivial point-imprimitive, linetransitive linear spaces for a given value of gcd（k, v - 1）. The classification strengthens the classification by Camina and Mischke under the much stronger restriction k ≤ 8： no additional examples arise. The paper provides the backbone for future computer-based classifications of point-imprimitive, line- transitive linear spaces with small parameters. Several suggestions for further investigations are made.

关键词： linear space line-transitive automorphism group combinatorial design combinatorial search algorithm

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Finding the Mid-Path

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Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 83-99页

作者： alice e. Fischer Department of Computer Science, University of New Haven,West Haven CT 06516,USA Department of Computer Science University of New Haven West Haven USA

Computers have changed nearly every aspect of life in this world. Invented roughly fifty years ago, they now form the infrastructure on which government, business, and global communications rest. As our reliance on computers increases, so does the number and complexity of the applications and the number and quality of trained professionals that will be needed to support further progress. The United States already faces personnel shortages in some computer related jobs, including university teaching. In the face of this evident and increasing need, we must think clearly about out expectations for computing professionals of all sorts and the way they are trained. In the forty years that I have been in the field, the focus in industry has changed from programming to software development. A gulf is growing between the skills that students build at a university and the needs of industry. This paper examines the nature and extent of the problem and suggests a variety of ways to address it

关键词： curriculum gap internship professional competence professional training

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Synaptic alterations as a common phase in neurological and neurodevelopmental diseases: JNK is a key mediator in synaptic changes

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Neural Regeneration Research 2023年第3期18卷 531-532页

作者： Clara alice Musi Carlo Bonadonna Tiziana Borsello Department of Pharmacological and Biomolecular Sciences Universitàdegli Studi di MilanoMilanoItaly Mario Negri Insitute for Pharmacolgical Research-IRCCS MilanoItaly

Brain synapses play a key role in neuronal communication:this“conversation”is at the basis of all brain activities and synaptic dysfunction leads to brain *** study the modulators of this crucial synaptic function and we here present the evidence supporting the c-Jun N-terminal kinase(JNK)pathway as a pivotal actor in this scenario.

关键词： alterations diseases neurological

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