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Prevalence of Dyslipidemia among Patients Received at the Biochemistry Unit of the Charles de Gaulle Pediatric University Hospital in Ouagadougou

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Advances in Biological Chemistry 2024年第1期14卷 16-26页

作者： Fabienne Marie Soudre Arnaud Kouraogo alice kiba Ollo Da Mahutin Benoîte Hounhoui Diema Nadia Karama Seraphine Mano Denis Claude Drabo Augustin Kyetega Raoul Karfo Elie Kabre Jean Sakande Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso Charles de Gaulle Pediatric University Hospital Ouagadougou Burkina Faso Health Sciences Institute Nazi BONI University Bobo Dioulasso Burkina Faso Biochemistry Unit Sourou Sanou University Hospital Bobo Dioulasso Burkina Faso Tengandogo University Hospital Ouagadougou Burkina Faso Faculty of Health Sciences Saint Thomas d’Aquin University Ouagadougou Burkina Faso Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso National Agency for Environmental Food Labor and Health Product Safety Ouagadougou Burkina Faso

Introduction: Cardiovascular disease represents a major public health burden worldwide. Research and management of risk factors contribute to the prevention of these diseases. The aim of this study was to assess the prevalence of dyslipidemia in the biochemistry unit of the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) in Ouagadougou. Material and Methods: This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients of all ages who performed a lipid panel in the CHUP-CDG biochemistry unit during the study period have been included. Results: A total of 2872 patients have been included. The mean age of the study population was 27.72 ± 19.51 years and the M/F sex ratio was 0.81. Among the patients, 22.84% had at least one dyslipidemia. The prevalences of hypercholesterolemia, hypo-HDL cholesterolemia and hyper-LDL cholesterolemia were 11.57%, 49.19% and 57.50% respectively. Hypertriglyceridemia and mixed hyperlipidemia were present in 9.04% and 2.08% of patients. Hypercholesterolemia was significantly more frequent in the female sex (p = 0.0077);hyper-LDL cholesterolemia (p = 0.0255) and mixed hyperlipidemia (p Conclusion: The relatively high prevalence of dyslipidemia in the study indicates a worrying situation. It would therefore appear essential to extend the search for risk factors nationwide, particularly those that can be modified, in order to reduce morbidity and mortality linked to cardiovascular disease.

关键词： Dyslipidemia Lipid Profile Lipid Abnormalities Prevalence Burkina Faso

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Abnormalities of Serum Protein Fractions in Hemodialysis Patients with Chronic Renal Failure at Ouagadougou, Burkina Faso

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Advances in Biological Chemistry 2022年第6期12卷 196-206页

作者： Arnaud Kouraogo Fabienne Soudre alice kiba Raoul Karfo Ollo Da Emmanuel Zongo Elie Kabre Jean Sakande Biochemistry Laboratory of Souro Sanou Teaching Hospital Nazi Boni University Bobo-Dioulasso Burkina Faso Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso

Introduction: The main objective of this study was to investigate abnormalities of serum protein fractions in hemodialysis patients with chronic renal failure (CRF) in Ouagadougou, Burkina Faso. Methods: This was a descriptive cross-sectional study of 48 hemodialysis patients with chronic renal failure (CRF) recruited at the Yalgado Ouedraogo Teaching Hospital (YO-TH), and 48 controls declared fit to donate blood by the Regional Blood Transfusion Center (RBTC) of Ouagadougou. Urea, creatinine, uric acid, and serum proteins were measured on the ARCHITECT C4000 equipment (ABOTT®), while the separating of the different protein fractions was performed on the Helena SAS 3 & 4 automated system. Results: A total of 96 individuals were included in the study. Protein levels were on average higher in controls (75.19 ± 6.56 g/L) than in hemodialysis patients (71.44 ± 12.33 g/L). Low blood albumin was significantly associated with the CRF hemodialysis groups compared to controls (p Conclusion: Serum protein electrophoresis is rapidly feasible and low cost. In hemodialysis CKD patients, it can be used to guide therapeutic management and predict morbidity and mortality related to variations in the various protein fractions.

关键词： Protein Fractions Albumin Globulin Hemodialysis

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Ionic Disorders Observed in Infants with Severe Wasting at the Yalgado Ouedraogo Teaching Hospital and the Charles de Gaulle Pediatric Teaching Hospital in Ouagadougou, Burkina Faso

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Advances in Biological Chemistry 2023年第6期13卷 247-255页

作者： Arnaud Kouraogo Fabienne Soudre Caroline Yonaba Okengo Faouziatou Yagui Angele Kalmogho Ghislaine Yameogo alice kiba Raoul Karfo Ollo Da Emmanuel Zongo Cherileila Thiombiano Fatou Gueye Tall Abdoul Salam Ouédraogo Sanata Bamba Georges Anicet Ouédraogo Elie Kabré Fla Koueta Jean Sakande Biochemistry Laboratory of Souro Sanou Teaching Hospital Nazi Boni University Bobo-Dioulasso Burkina Faso Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso Department of Pharmaceutical Biochemistry Faculty of Medicine Pharmacy and Dentistry Cheikh Anta Diop University Dakar Senegal

Introduction: A higher risk of death is associated with wasting in children if it is not treated properly. The objective of this study was to investigate the ionic disorders observed in infants suffering from severe wasting at Yalgado Ouedraogo Teaching Hospital (YO-TH) and at Charles de Gaulle Pediatric Teaching Hospital (CDG-PTH) in Ouagadougou (Burkina Faso). Methods: This was a retrospective study with a descriptive and analytical aim over the period from January 1, 2016 to December 31, 2020. Results: It concerned infants aged 6 to 24 months hospitalized at YO-TH and at CDG-PTH from Ouagadougou. We included 271 infants. The mean age of the infants was 14.48 ± 5.44 months with 42.07% which was in the age range of [12 - 18] months. On admission to the hospital, the children had an average weight, height and BMI of 6.22 ± 1.32 kg, 0.73 ± 0.07 m and 11.67 ± 1.53 kg/m2. In urban areas 56.46% of children and the main reasons for consultation were fever (88.19%), vomiting (52.80%) and diarrhea (50.20%). Electrolyte disturbances in emaciated infants affected all 8 parameters of the blood ionogram. However, the major disorders were 65.68% hyponatremia, 55.35% hypobicarbonatemia, 41.33% hypoprotidemia and 32.47% hypokalemia in infants aged 6 to 24 months. We found an association between diarrhea and residence with hypokalemia (p = 0.0000) and hypochloremia (p = 0.010), respectively. Conclusion: Severe acute wasting in infants 6 to 24 months of age remains a concern in the hospital setting. The frequency of biochemical disturbances is also high.

关键词： Severe Wasting Emaciation Infants over 6 - 24 Months Blood Ionogram Burkina Faso

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DC-SIGN (CD209) Promoter -336 A/G Polymorphism Is Not Associated with Dengue Fever at Burkina Faso, West Africa

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Journal of Biosciences and Medicines 2023年第1期11卷 175-183页

作者： Fiffou Yougbare Aziz Sidi Aristide Tapsoba Pegdwendé Abel Sorgho Bagora Bayala Lassina Traore Prosper Bado Bapio Valérie Elvira Jean Télesphore Bazie Abdou Azaque Zoure Esther Mah Alima Traore Théodora Mahoukèdè Zohoncon Sessi Frida Tovo Albert Théophane Yonli alice kiba Florencia Wendkuuni Djigma Jacques Simpore Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Université Saint Thomas d’Aquin Ouagadougou Burkina Faso Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Centre National de Transfusion Sanguine (CNTS) Ouagadougou Burkina Faso

Objective: The aim of this study was to characterize the polymorphisms of the DC-SIGN (-336 A/G, rs4804803) gene and their association with the immunopathogenicity of dengue fever in Burkina Faso. Methods: A total of three hundred forty-one subjects, patients of all ages have been included in the study: 208 persons presenting clinical signs of dengue fever which were confirmed by diagnostic and 133 Healthy Controls. Genotyping for the CD209 variant (-336 A/G, rs4804803) was carried out using TaqMan SNP Genotyping Assays. Haplotype frequencies were inferred and compared between the study groups. Results: The percentage of men was 61.88% (211/341) and 38.12% (130/341) for women. The highest frequency of dengue fever (77.42%) was noted in patients with age between 20 to 40 years. Around 1.52% of the study population was positive for HIV, 40.55% were carriers of HBV and 3.83% of HCV. Genotype distribution of the CD209 variant (-336 A/G, rs4804803) was in Hardy-Weinberg equilibrium in both patients and controls. The frequency of allele A was higher than allele G;however, statistical analyses showed that there is no significant difference in genotypes GG, AG and AA in patients and controls. Conclusion: This related no significant association with dengue for the variant of ?336 A/G in the DC-SIGN gene in an Ouagadougou population. However, our results offered the SNP frequencies in a West African population, which might be useful for the study of ethnic groups.

关键词： Dengue Virus CD209 Variant (-336 A/G rs4804803) Burkina Faso

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