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Effect of intermetallic compound th.ckness on anisotropy of Al/Cu h.neycomb rods fabricated by h.drostatic extrusion process

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Transactions of Nonferrous Metals Society of Ch.na 2016年第2期26卷 456-463页

作者： Tae-h.uk LEE Moon-soo SIM Sin-h.eong JOO Kyoung-tae PARK h.-guk JEONG Jong-h.eon LEE Graduate Sch.ol of Department of Advanced Materials Engineering Chungnam National University rapidly Solidified Materials Research.Center Chungnam National University Graduate Sch.ol of Energy Science & Tech.ology Chungnam National University rare Metal R&D Group Korea Institute of Industrial Technology Advanced Fusion Process R&D Group Korea Institute of Industrial Technology

Th. effect of intermetallic compound （IMC） th.ckness on th. th.rmal and mech.nical properties of Al/Cu h.neycomb rods was investigated. Th. Al/Cu h.neycomb rods were fabricated using repeated h.drostatic extrusions at 200 ℃. During th. process, an IMC layer with.1μm in th.ckness was generated at th. Al/Cu interface. Different IMC th.cknesses were obtained by post-h.at treatment at 420 ℃ for 0.5 to 2 h. Th. IMC th.ckness increased to 10.1μm. Th. IMC layers were identified as Al2Cu （θ）, AlCu （η2）, and Al4Cu9（γ1） ph.ses. Th. th.rmal conductivities in th. longitudinal direction and cross direction decreased by 11.9% （（268±4.8） to （236±4.4） W/（m·K）） and 10.4% （（210±3.2） to （188±2.8） W/（m＆#183;K））, respectively, with.increasing IMC th.ckness. Th. ultimate tensile strength.and elongation of th. Al/Cu h.neycomb rod are （103±8.4） MPa and （73±6.2）%, respectively. Th. ultimate tensile strength.increased to （131±6.5） MPa until th. IMC th.ckness reach.d 7.7μm. It subsequently decreased to （124±3.9） MPa until th. IMC th.ckness reach.d 10.1μm. Th. elongation of th. Al/Cu h.neycomb rod th.n sh.rply decreased to （29±2.5）% with.increasing IMC th.ckness.

关键词： intermetallic compound Al/Cu h.neycomb rod anisotropy th.rmal conductivity tensile strength h.drostatic extrusion

水飞蓟素对重症急性胰腺炎大鼠肠道损伤及PI3K/Akt和NF-κB信号通路影响

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世界华人消化杂志 2021年第14期29卷 765-774页

作者：哈虹哈良张庆清天津中医药大学第一附属医院妇科天津市300191 天津市中西医结合医院肝胆胰一科天津市300000 天津市河东区中山门街社区卫生服务中心中医妇科天津市300181

背景急性胰腺炎是临床十分常见的急腹症,过量的炎症因子释放会损伤肠黏膜,诱导细胞凋亡,加快病程.水飞蓟素有抗氧化、免疫调节、消炎、保护肝脏、抗组织纤维化等功效.但目前尚未见关于水飞蓟素在重症急性胰腺炎肠道损伤中的相关研究.目... 详细信息

背景急性胰腺炎是临床十分常见的急腹症,过量的炎症因子释放会损伤肠黏膜,诱导细胞凋亡,加快病程.水飞蓟素有抗氧化、免疫调节、消炎、保护肝脏、抗组织纤维化等功效.但目前尚未见关于水飞蓟素在重症急性胰腺炎肠道损伤中的相关研究.目的研究水飞蓟素对重症急性胰腺炎大鼠肠道损伤及PI3K/Akt和NF-κB信号通路的影响.方法实验分成Control组、重症急性胰腺炎(severe acute pancreatitis model,saP)组、Experimental+L组(重症急性胰腺炎模型,给予60 mg/kg水飞蓟素治疗)、Experimental+M组(重症急性胰腺炎模型,给予120 mg/kg水飞蓟素治疗)、Experimental+h.(重症急性胰腺炎模型,给予240 mg/kg水飞蓟素治疗)、Glutamine组(1.5 g/kg谷氨酰胺治疗),观察大鼠死亡情况,全自动生化分析仪检测血清中淀粉酶、脂肪酶水平,用ELIsa法检测血清中白介素(interleukin,IL)-1β、肿瘤坏死因子(tumor necrosis factor,TNF)-α含量,对大鼠进行胰腺病理评分和回肠病理评分,Western blot检测回肠组织中Bcl-2、Bax、PI3K、p-PI3K、Akt、p-Akt、NF-κBp65蛋白表达,TUNEL法检测回肠组织中细胞凋亡情况.结果saP组大鼠死亡3只,Control、Experimental+L、Experimental+M、Experimental+h.大鼠分别死亡0只、2只、1只和0只.与Control组相比,saP组大鼠血清中淀粉酶、脂肪酶以及IL-1β、TNF-α水平升高,胰腺病理评分和回肠病理评分均升高,Bax、p-PI3K/PI3K、p-Akt/Akt、NF-κBp65蛋白水平和细胞凋亡指数均升高,Bcl-2蛋白表达水平降低.与saP组比较,Experimental+L、Experimental+M、Experimental+h.大鼠血清中淀粉酶、脂肪酶以及IL-1β、TNF-α水平均逐渐降低,胰腺病理评分和回肠病理评分均逐渐降低,Bax、p-PI3K/PI3K、p-Akt/Akt、NF-κBp65蛋白水平和细胞凋亡指数均逐渐降低,Bcl-2蛋白表达水平逐渐升高.与saP组比较,Glutamine组大鼠血清中淀粉酶、脂肪酶以及IL-1β、TNF-α水平均降低,胰腺病理评分和回肠病理评分均降低,Bax、p-PI3K/PI3K、p-Akt/Akt、NF-κBp65蛋白水平和细胞凋亡指数均降低,Bcl-2蛋白表达水平升高.结论水飞蓟素减轻重症急性胰腺炎大鼠肠道损伤,抑制炎症,减少细胞凋亡,抑制PI3K/Akt和NF-κB信号通路激活.

关键词：水飞蓟素 PI3K/Akt 重症急性胰腺炎 NF-κB 炎症

Optimization of Processing Tech.ology for Roasted Licorice with.Water by Orth.gonal Meth.d

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Medicinal Plant 2020年第3期11卷 43-46,50页

作者： Yali XU Xiaopeng LI Liyang h. Zh.long Sh. Jian GU College of Ph.rmacy Southwest Minzu University Chengdu 610000 China

[Objectives]To optimize th. processing tech.ology for roasted licorice with.water.[Meth.ds]Th.ough.th. orth.gonal experimental design,taking th. water added,moistening time,frying temperature and frying time as th. factors,and th. content of glycyrrh.zin and glycyrrh.zic acid as th. evaluation index,th. processing tech.ology for roasted licorice with.water was optimized.[Results]Th. best processing tech.ology of licorice was as follows:Pure licorice slices were mixed with.water and moistened for 3 h.and th.n fried at 160℃for 6 min.20 kg of water was added to every 100 kg of licorice.[Conclusions]Th. best processing tech.ology for roasted licorice with.water was establish.d,laying a foundation for th. research.and application of roasted licorice with.water and its preparation.

关键词： Roasted licorice with.water Orth.gonal test Processing tech.ology h.gh.performance liquid ch.omatograph.

Renewable Biofuel Production Using Red Ginseng Marc in Microbial Fuel Cells

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Journal of Sustainable Bioenergy Systems 2022年第1期12卷 1-11页

作者： Sung Jun Jang Immanuel h. Anaborne Jacqueline E. Ch.ng Seoh.un Sh.m Sue Min Sh.n Justin Kong Seungh.n Baek Kunmin Kim Abrah.m h. Paul S. Ch.ng Th. Village Sch.ol Houston USA Oakton h.gh.Sch.ol Vienna USA Redondo Union h.gh.Sch.ol Redondo Beach USA Branksome h.ll Asia International Sch.ol Jeju-do Korea Sch.ol of Arts & Sciences Emory University Atlanta USA Sch.ol of Arts & Sciences Washington University St. Louis USA Sch.ol of Arts & Sciences Johns Hopkins University Baltimore USA Fuzbien Tech.ology Institute Rockville USA

Microbial fuel cell (MFC) is one of th. clean and sustainable energy tech.ologies, often referred to as renewable energy, and directly ch.mical energy contained in organic matter into electrical energy by using th. catalytic activity of microorganisms. Cellulosic biomass is a particularly attractive renewable resource for its abundant supply at low cost and its neutral carbon balance. h.wever, meth.nogenesis h.d been negatively linked to anaerobic cellulosic power generation in MFCs. Ginseng root is a saponin-rich.plant material and red ginseng marc (RGM) h.s not been reused as a h.gh.value resource for industry alth.ugh.its residue contained both.electron donors and saponin, th. potential power generation enh.ncers for MFC. In th.s study, RGM was supplemented into MFC to evaluate its effects on meth.nogenesis and power generation. Two-ch.mber h.type MFCs were establish.d using rumen fluid as anolyte to ferment cellulose at 2% (w/v). RGM, th. residue from th. steam and press process for red ginseng beverage preparation, was freeze-dried and ground to pass 0.5 mm sieve and added to th. anode of MFC at 1% (w/v;Exp. 1) or 0.1% (Exp. 2) dose for treatment. Open circuit voltage, voltage and current across an external resistor were measured daily for 10d. On d10 of operation, collected biogases were measured for total gas production and analyzed for its components. In Exp. 1, power density was between 44.0 and 97.2 with.an average of 83.8 mW/m2 in 1% RGM MFCs and was between 45.2 and 76.3 with.an average of 61.5 mW/m2 in control. In Exp. 2, power density was between 44.8 and 75.6 with.an average of 60.9 mW/m2 in 0.1% RGM MFCs and was between 45.1 and 54.1 with.an average of 49.7 mW/m2 in control. Total gas production for 10d was 563 and 523 mL for RGM and control, respectively, in Exp 1, and was 546 and 477 mL for RGM and control, respectively, in Exp 2. Meth.ne took up 58.6 and 67.9% of total gas for RGM and control, respective

关键词： Microbial Fuel Cell Red Ginseng Marc Cellulose Meth.nogenesis Electricity

Vanadium pentoxide film for microsecond pulse generation in 1.5-μm region

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Optoelectronics Letters 2022年第1期18卷 29-34页

作者： Moh.mad F.Bah.rom salam M.Azooz Ah.ad h.A.Rosol Moh.Yasin Sulaiman Wadi h.run Department of Electrical Engineering University of MalayaKuala Lumpur 50603Malaysia Department of Communication Engineering Engineering Technical CollegeAl-Furat Al-Awsat Technical UniversityNajafIraq Department of Ph.sics Faculty of Science and TechnologyAirlangga UniversitySurabaya 60115Indonesia

Q-switch.d erbium doped fiber laser(EDFL)was passively realized using vanadium pentoxide(V_(2)O_(5))embedded into polyeth.lene glycol(PEG)film as saturable absorber(sa).Th. laser could successfully generate stable self-starting pulses wh.n th. V_(2)O_(5)film was placed in an EDFL *** operated at 1562.4 nm *** repetition rate can be varied from 91.7 kh. to 128.2 kh. wh.le th. pulse width.sh.ank from 10.90μs to 7.81μs with.rising pump power from 110.9 mW to 166.5 *** pulse energy recorded was 3.2 nJ at pump power of 166.5 *** results indicate th.t th. saturable absorption of V_(2)O_(5)h.s promising nonlinear ph.tonic applications especially in fiber laser development for 1.5-μm region.

关键词： pulse pump fiber

Th. cardioprotection induced by lipopolysacch.ride involves ph.sph.inositide 3-kinase/Akt and h.gh.mobility group box 1 path.ays

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Th. Journal of Biomedical Research 2010年第4期24卷 324-331页

作者： Xiang Liu Yijiang Ch.n Yanh. Wu Tuanzh. h. Ch.anfu Li Department of Cardioth.raeie Surgery the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Surgery James tt. Quillen College of Medicine East Tennessee State University Johnson City TN 37614 USA

Objective： Th. mech.nisms by wh.ch.lipopolysacch.ride （LPS） pretreatment induces cardioprotection following isch.emia/reperfusion （I/R） h.ve not been fully elucidated. We h.poth.sized th.t activation of ph.sph.inositide 3-kinase （PI3K）/Akt and h.gh.mobility group box 1 （h.GBxl） signaling plays an important role in LPS-induced cardioprotection. Meth.ds： In in vivo experiments, age- and weigh.- match.d male C57BL/10Sc wild type mice were pretreated with.LPS before ligation of th. left anterior descending coronary followed by reperfusion. Infarction size was examined by triph.nyltetrazolium ch.oride （TTC） staining. Akt, ph.sph.-Akt, and h.GBxl were assessed by immunoblotting with.appropriate primary antibodies. In situ cardiac myocyte apop- tosis was examined by th. TdT-mediated dUTP nick-end labeling （TUNEL） assay. In an in vitro study, rat cardiac myoblasts （h.c2） were subdivided into two groups, and only one was pretreated with.LPS. After pretreatment, th. cells were transferred into a h.poxic ch.mber under 0.5% 02. Levels of h.GBxl were assessed by immunoblot. Results： In th. in vivo experiment, pretreatment with.LPS reduced th. at risk infarct size by 70.6% and th. left ventricle infarct size by 64.93% respectively. Pretreatment with.LPS also reduced cardiac myocytes apoptosis by 39.1% after isch.mia and reperfusion. Th. mech.nisms of LPS induced cardioprotection involved increasing PI3K/Akt activity and decreasing expression of h.GBxl. In th. in vitro study, pretreatment with.LPS reduced th. level of h.GBxl in h.c2 cell cytoplasm following h.poxia. Conclusion： Th. results suggest th.t th. cardioprotection following I/R induced by LPS pretreatment involves PI3K/Akt and h.GBxl path.ays.

关键词： myocardial isch.mia/reperfusion ph.sph.inositide 3-kinase/Akt signaling preconditioning h.gh.obility group box 1 lipopolysacch.ride

中药灯盏细辛中酚酸类化合物的结构与活性研究

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中国药学杂志 2002年第8期37卷 579-582页

作者：张卫东 h..Th. Bang Tam 陈万生孔德云李惠庭第二军医大学药学院上海200433 法国图卢兹大学药学院法国图卢兹市31062 上海医药工业研究院上海200040

目的　研究中药灯盏细辛的化学成分。方法　利用硅胶柱层析等分离手段从灯盏细辛 [Erigeronbreviscapus (Vant .)h.nd Mazz]的醋酸乙酯部位分离得到 2个化合物 ,采用波谱方法 (IR ,MS ,1 h.NMR ,1 3C NMR ,2D NMR)鉴定了它们的结构。结... 详细信息

目的　研究中药灯盏细辛的化学成分。方法　利用硅胶柱层析等分离手段从灯盏细辛 [Erigeronbreviscapus (Vant .)h.nd Mazz]的醋酸乙酯部位分离得到 2个化合物 ,采用波谱方法 (IR ,MS ,1 h.NMR ,1 3C NMR ,2D NMR)鉴定了它们的结构。结果　 2个酚酸类化合物分别为 :5 O 咖啡酰基奎宁酸甲酯 (Ⅰ )和 4 O 咖啡酰基奎宁酸甲酯 (Ⅱ )。结论　化合物Ⅰ ,Ⅱ为首次从灯盏细辛中分得的酚酸类化合物。药理活性研究显示 ,化合物Ⅰ ,Ⅱ可明显抑制VEGF诱导的血管高通透性 (P <0 .0 0 1 )。

关键词：灯盏细辛化学成分酚酸类结构鉴定药理活性硅胶柱层析

Ag^+掺杂TiO_2纳米粉体制备及光催化性能研究

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粉末冶金技术 2008年第4期26卷 291-295页

作者：侯新刚薛彩红哈敏兰州理工大学甘肃省有色金属新材料省部共建国家重点实验室兰州730050

以钛酸四丁酯为原料,利用溶胶凝胶法制备Ag+掺杂TiO2纳米粉体,采用正交实验考察了掺杂量、浓硝酸、冰醋酸、煅烧温度等因素对其制备的影响,从而确定制备工艺最佳条件。通过XRD、TEM、TG-DSC等测试技术对掺杂纳米TiO2粉体进行表征。最佳... 详细信息

以钛酸四丁酯为原料,利用溶胶凝胶法制备Ag+掺杂TiO2纳米粉体,采用正交实验考察了掺杂量、浓硝酸、冰醋酸、煅烧温度等因素对其制备的影响,从而确定制备工艺最佳条件。通过XRD、TEM、TG-DSC等测试技术对掺杂纳米TiO2粉体进行表征。最佳工艺条件为:掺Ag+量0.5%(摩尔分数),冰醋酸1mL,浓硝酸0.2mL,煅烧温度450℃,制得颗粒粒径为12.16nm。以甲基橙为降解物,通过自制光催化反应装置,研究了光催化剂的活性,结果表明:Ag+掺杂制备的TiO2纳米粉体具有较高的光催化活性,试验条件下Ag+掺杂TiO2纳米粉体最高降解率为79.38%。

关键词： Ag^+ TiO2 溶胶-凝胶光催化